LOCUS       NM_009878               1193 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 2D (Cdkn2d),
            transcript variant 1, mRNA.
ACCESSION   NM_009878
VERSION     NM_009878.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Safwan-Zaiter,H., Wagner,N., Michiels,J.F. and Wagner,K.D.
  TITLE     Dynamic Spatiotemporal Expression Pattern of the
            Senescence-Associated Factor p16Ink4a in Development and Aging
  JOURNAL   Cells 11 (3), 541 (2022)
   PUBMED   35159350
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1193)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1193)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   4  (bases 1 to 1193)
  AUTHORS   Zhu,Q., Chen,L., Li,Y., Huang,M., Shao,J., Li,S., Cheng,J.,
            Yang,H., Wu,Y., Zhang,J., Feng,J., Fan,M. and Wu,H.
  TITLE     Rack1 is essential for corticogenesis by preventing p21-dependent
            senescence in neural stem cells
  JOURNAL   Cell Rep 36 (9), 109639 (2021)
   PUBMED   34469723
REFERENCE   5  (bases 1 to 1193)
  AUTHORS   Shapiro,M.J., Anderson,J., Lehrke,M.J., Chen,M., Nelson Holte,M.
            and Shapiro,V.S.
  TITLE     NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic
            Progenitors
  JOURNAL   Front Cell Dev Biol 7, 214 (2019)
   PUBMED   31632967
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1193)
  AUTHORS   Luh,F.Y., Archer,S.J., Domaille,P.J., Smith,B.O., Owen,D.,
            Brotherton,D.H., Raine,A.R., Xu,X., Brizuela,L., Brenner,S.L. and
            Laue,E.D.
  TITLE     Structure of the cyclin-dependent kinase inhibitor p19Ink4d
  JOURNAL   Nature 389 (6654), 999-1003 (1997)
   PUBMED   9353127
REFERENCE   7  (bases 1 to 1193)
  AUTHORS   Zindy,F., Quelle,D.E., Roussel,M.F. and Sherr,C.J.
  TITLE     Expression of the p16INK4a tumor suppressor versus other INK4
            family members during mouse development and aging
  JOURNAL   Oncogene 15 (2), 203-211 (1997)
   PUBMED   9244355
REFERENCE   8  (bases 1 to 1193)
  AUTHORS   Okuda,T., Hirai,H., Valentine,V.A., Shurtleff,S.A., Kidd,V.J.,
            Lahti,J.M., Sherr,C.J. and Downing,J.R.
  TITLE     Molecular cloning, expression pattern, and chromosomal localization
            of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases
  JOURNAL   Genomics 29 (3), 623-630 (1995)
   PUBMED   8575754
REFERENCE   9  (bases 1 to 1193)
  AUTHORS   Chan,F.K., Zhang,J., Cheng,L., Shapiro,D.N. and Winoto,A.
  TITLE     Identification of human and mouse p19, a novel CDK4 and CDK6
            inhibitor with homology to p16ink4
  JOURNAL   Mol Cell Biol 15 (5), 2682-2688 (1995)
   PUBMED   7739548
REFERENCE   10 (bases 1 to 1193)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122525.4.
            
            On Jul 21, 2022 this sequence version replaced NM_009878.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013898.1, AK132906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC122525.4         120589-120911
            324-1193            AC122525.4         122388-123257
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.76 cM"
     gene            1..1193
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /note="cyclin dependent kinase inhibitor 2D"
                     /db_xref="GeneID:12581"
                     /db_xref="MGI:MGI:105387"
     exon            1..323
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..683
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin-dependent kinase 4 inhibitor D; p19-INK4d;
                     cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor D isoform 1"
                     /protein_id="NP_034008.2"
                     /db_xref="CCDS:CCDS22901.1"
                     /db_xref="GeneID:12581"
                     /db_xref="MGI:MGI:105387"
                     /translation="MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKT
                     ALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNA
                     LDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQG
                     HMMIPM"
     exon            324..1193
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1168..1173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /note="hexamer: TATAAA"
     polyA_site      1193
                     /gene="Cdkn2d"
                     /gene_synonym="INK4d; p19; p19INK4d"
                     /note="major polyA site"
ORIGIN      
        1 agctgcgagc gctggggtcg tacgggcgga gggcgcaggc tctgaggccg gcaaatgatc
       61 atagagttgg ccctggtggc accgcagtcc ctagagttct gatccagctc ttgctggttc
      121 cccagccctg accttaactg ggcttggggc tgggtgggtt tcacagtcca ccggtatcca
      181 ctatgcttct ggaagaagtc tgcgtcggcg accggttgag tggcgcagcg gcccgtggcg
      241 acgtgcaaga ggtccgccgc cttcttcacc gggagctggt gcatcctgac gccctgaacc
      301 gctttggcaa gacggccttg caggtcatga tgtttggaag tccagcagtt gctttggagc
      361 tcctgaagca aggtgccagc cccaatgtcc aagatgcctc cggtactagt cctgtgcatg
      421 atgcggctcg caccgggttc ctggacaccc tgaaggttct ggtggagcat ggtgctgatg
      481 tcaatgccct ggacagcact gggtcgctcc ccatccatct ggcgataaga gagggccata
      541 gctccgtggt cagcttccta gctcctgaat ctgatctcca ccacagggac gcttccggtc
      601 tcactcccct ggagttggct cggcagagag gggctcagaa cctcatggac attctgcagg
      661 ggcacatgat gatcccaatg tgacccaagg ccactgtctc cagccttact gggttacttg
      721 tcaacaaaag aggaaagaaa ctttctcttt tcacacctgt ccattgaaga agggagtggg
      781 aggagcagtt tgtggtttat tggtgttgat ttcttgagtg tgtgtgtttg gggggtgttt
      841 ctcatttgtt tttctcaccc cttttggtgt gttggacaaa gaaggggctc ctacaggcaa
      901 cagccatcta aacggttcag tttcctctgc actggggctg caccagggca ggggtttaaa
      961 gccctagcct cagagtgagg tcatcacttc ccgggcccct tggaagctgg tgaccttggc
     1021 aggctgtgct cagagagccc tgaagtgtga gccatctact ttgggcatgt gagggggaag
     1081 ggaaagcatt tcaaatcaat taaaaggata acatgagttc atttttcttt cttggaaggt
     1141 ttccagtctg ttgtacagag tttgaaatat aaatatttat tgctttatgg aaa
//
