LOCUS       NM_001301368            2066 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 2C (Cdkn2c),
            transcript variant 1, mRNA.
ACCESSION   NM_001301368 XM_006502698
VERSION     NM_001301368.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Bai,F., Liu,X., Zhang,X., Mao,Z., Wen,H., Ma,J. and Pei,X.H.
  TITLE     p18INK4C and BRCA1 inhibit follicular cell proliferation and
            dedifferentiation in thyroid cancer
  JOURNAL   Cell Cycle 22 (13), 1637-1653 (2023)
   PUBMED   37345432
  REMARK    GeneRIF: p18INK4C and BRCA1 inhibit follicular cell proliferation
            and dedifferentiation in thyroid cancer.
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Bai,F., Zheng,C., Liu,X., Chan,H.L., Liu,S., Ma,J., Ren,S.,
            Zhu,W.G. and Pei,X.H.
  TITLE     Loss of function of GATA3 induces basal-like mammary tumors
  JOURNAL   Theranostics 12 (2), 720-733 (2022)
   PUBMED   34976209
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Tampakakis,E., Gangrade,H., Glavaris,S., Htet,M., Murphy,S.,
            Lin,B.L., Liu,T., Saberi,A., Miyamoto,M., Kowalski,W.,
            Mukouyama,Y.S., Lee,G., Minichiello,L. and Kwon,C.
  TITLE     Heart neurons use clock genes to control myocyte proliferation
  JOURNAL   Sci Adv 7 (49), eabh4181 (2021)
   PUBMED   34851661
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Phelps,D.E., Hsiao,K.M., Li,Y., Hu,N., Franklin,D.S., Westphal,E.,
            Lee,E.Y. and Xiong,Y.
  TITLE     Coupled transcriptional and translational control of
            cyclin-dependent kinase inhibitor p18INK4c expression during
            myogenesis
  JOURNAL   Mol Cell Biol 18 (4), 2334-2343 (1998)
   PUBMED   9528803
REFERENCE   6  (bases 1 to 2066)
  AUTHORS   Zindy,F., Soares,H., Herzog,K.H., Morgan,J., Sherr,C.J. and
            Roussel,M.F.
  TITLE     Expression of INK4 inhibitors of cyclin D-dependent kinases during
            mouse brain development
  JOURNAL   Cell Growth Differ 8 (11), 1139-1150 (1997)
   PUBMED   9372237
REFERENCE   7  (bases 1 to 2066)
  AUTHORS   Zindy,F., Quelle,D.E., Roussel,M.F. and Sherr,C.J.
  TITLE     Expression of the p16INK4a tumor suppressor versus other INK4
            family members during mouse development and aging
  JOURNAL   Oncogene 15 (2), 203-211 (1997)
   PUBMED   9244355
REFERENCE   8  (bases 1 to 2066)
  AUTHORS   Magdaleno,S.M., Wang,G., Mireles,V.L., Ray,M.K., Finegold,M.J. and
            DeMayo,F.J.
  TITLE     Cyclin-dependent kinase inhibitor expression in pulmonary Clara
            cells transformed with SV40 large T antigen in transgenic mice
  JOURNAL   Cell Growth Differ 8 (2), 145-155 (1997)
   PUBMED   9040936
REFERENCE   9  (bases 1 to 2066)
  AUTHORS   Okuda,T., Hirai,H., Valentine,V.A., Shurtleff,S.A., Kidd,V.J.,
            Lahti,J.M., Sherr,C.J. and Downing,J.R.
  TITLE     Molecular cloning, expression pattern, and chromosomal localization
            of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases
  JOURNAL   Genomics 29 (3), 623-630 (1995)
   PUBMED   8575754
REFERENCE   10 (bases 1 to 2066)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627392.12, BG085472.2,
            AK003933.1 and AA189303.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_001301368.2.
            
            On Aug 15, 2014 this sequence version replaced XM_006502698.1.
            
            Summary: The protein encoded by this gene is a member of the INK4
            family of cyclin-dependent kinase (cdk) inhibitors, and contains
            five ankyrin repeats. This protein interacts with both Cdk4 and
            Cdk6 to inhibit their kinase activities, and prevent their
            interactions with D-type cyclins, thereby negatively regulating
            cell division. This gene is differentially expressed in a variety
            of tissues, and is cell cycle regulated. Deletion of this gene can
            lead to tumor growth. Maximal expression is observed at the G2/M
            phase. Alternative splicing and promoter usage results in multiple
            transript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (1, also known as p18(L))
            represents the longer transcript. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157209.1, SRR11927937.4836514.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1082              AL627392.12        5225-6306           c
            1083-1668           BG085472.2         1-586
            1669-1719           AK003933.1         654-704
            1720-2066           AA189303.1         1-347
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.32 cM"
     gene            1..2066
                     /gene="Cdkn2c"
                     /gene_synonym="INK4c; p18; p18-INK4c; p18-INK6; p18INK4c"
                     /note="cyclin dependent kinase inhibitor 2C"
                     /db_xref="GeneID:12580"
                     /db_xref="MGI:MGI:105388"
     exon            1..1147
                     /gene="Cdkn2c"
                     /gene_synonym="INK4c; p18; p18-INK4c; p18-INK6; p18INK4c"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1287
                     /gene="Cdkn2c"
                     /gene_synonym="INK4c; p18; p18-INK4c; p18-INK6; p18INK4c"
                     /inference="alignment:Splign:2.1.0"
     CDS             1159..1665
                     /gene="Cdkn2c"
                     /gene_synonym="INK4c; p18; p18-INK4c; p18-INK6; p18INK4c"
                     /note="cyclin-dependent kinase 6 inhibitor;
                     cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor C"
                     /protein_id="NP_001288297.1"
                     /db_xref="CCDS:CCDS18467.1"
                     /db_xref="GeneID:12580"
                     /db_xref="MGI:MGI:105388"
                     /translation="MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV
                     MKLGNPEIARRLLLRGANPNLKDGTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNE
                     GNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEVISLMEANG
                     VGGATSLQ"
     exon            1288..2038
                     /gene="Cdkn2c"
                     /gene_synonym="INK4c; p18; p18-INK4c; p18-INK6; p18INK4c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggagcc tccttaaaac tctgccgtta aaatgggggc gggtttttca actcaaaaag
       61 cgctcaattt ttttcttttc aaaaaaagct gatgaggtcg gaaaaaaggg ataagaaacc
      121 ggcacagtac cttcagaggc aaccgtagca gcagttgctt cagcggaaaa agaagcaaag
      181 gagggaggga agggaaagat cctaaaggaa agacgcgcaa gtgtctgtag cggagaaggg
      241 agcggcgatc agagatttgg gggagtcgga ctacaaaaga aactgtcagc tgcggctcgc
      301 gaccggccgg cgcagcctgc ctcggctccg gaacccaact ggctggcagc cgctgtcctg
      361 tccgcggcac tgataggggc acaggccgga ggaccgccaa gaactaactg gccaagtggc
      421 accgagcgcc cgagctgctg ggcggccgcc aagaagttgg cgggactggc tgcgcccggg
      481 atctgtggcg accgctccta cttccaaaga cccttcccat catcggacgc cccgggaaaa
      541 tctgaaaggg agggaacgac agcggcagag gcgacggccg cccctcagcg agcgcttgca
      601 gtgaagagcc tgagctagct cggtcgtagg cgggaagtta ctggtgagct ggccgggtgc
      661 aagagcgatg ctgccgcgag ctaccccagc ggctggagcc ccatagacgc ttcccccttc
      721 gccgtgcacc gtcttcaggc tgccgggagt cccgggaccc ggcggggccg gcatgacggg
      781 cttggcgggg gtctgccgca cacccaccag cctccggaga cccgcgccct gcccggctcc
      841 cacggcctct gaggctcggc ggggctgcgg cagctcggcg ggcgggctcc ggaggctctt
      901 ctgaagacgc cgagcccgct agggagtcgt tgagacctga gagttgaggg cttcagagct
      961 gctgctctgg tctgccctca gcgatcgtct ttaaccctcc cgagcacgtc agcatccagc
     1021 cagcgcggcg ctctgctagc gagcgagcag cactctggac tacccccttc ggctagacgg
     1081 atggaaagtg agctctgcga aggacctgac tctgaaattc tgcctcaaat caccactgtg
     1141 aacaagggac cctaaagaat ggccgagcct tgggggaacg agttggcgtc cgcagctgcc
     1201 aggggggacc tagagcaact tactagtttg ttgcaaaata atgtaaacgt caacgctcaa
     1261 aatggatttg ggagaactgc gctgcaggtt atgaaacttg gaaatccgga gattgccagg
     1321 aggcttctcc tcagaggtgc taatcccaat ttgaaagatg gaactggttt tgctgtcatt
     1381 catgatgctg ccagagcagg tttcctggac actgtacagg ctttgctgga gttccaggct
     1441 gatgttaaca ttgaagataa tgaagggaac ctgcccttgc acttggctgc caaagaaggc
     1501 cacctccctg tggtggagtt ccttatgaag cacacagcct gcaatgtggg gcatcggaac
     1561 cataaggggg acaccgcctt cgacttggcc aggttctatg gaagaaatga ggtcattagc
     1621 ctgatggagg caaatggggt tgggggagcc acaagcctgc agtgaatgtg tagaggtctc
     1681 tctcactgac ctcacactgt ccgttagttg gttggctgtc cgtttcacta tcacttatta
     1741 aaatataggg tttcctttcg ctttgttttc atattttaag cagccaaatc cttcaaaact
     1801 gcctaagtgg aaatcttact acaagtttat gaaatattta aacttctttt tcactgtcaa
     1861 aattctgatt tctaacatgt aatagctatt cctttttttc tggatatttt atctttgatt
     1921 ttttttttct ttgcttaccc tttttcattc tcagtgtctg acttggagac tttgttttaa
     1981 aaattatttg tcctgatgca tcttttgcct aattaaaaca catttttcca gaagaggaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
