LOCUS       NM_007670               1393 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 2B (Cdkn2b), mRNA.
ACCESSION   NM_007670 XM_989888
VERSION     NM_007670.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   de Lope,C., Garcia-Lucena,R., Magarinos,M., Leon,Y.,
            Casa-Rodriguez,N., Contreras,N., Escudero-Iriarte,C.,
            Varela-Nieto,I., Maire,P. and Palmero,I.
  TITLE     Dysfunction of programmed embryo senescence is linked to genetic
            developmental defects
  JOURNAL   Development 150 (9) (2023)
   PUBMED   37017267
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Comerford,S.A., Hinnant,E.A., Chen,Y. and Hammer,R.E.
  TITLE     Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed
            bile duct development and loss of hepatocyte viability; a
            ribosomopathy-like phenotype that is partially p53-dependent
  JOURNAL   PLoS Genet 19 (1), e1010595 (2023)
   PUBMED   36656901
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Thompson,P.K., Chen,E.L.Y., de Pooter,R.F., Frelin,C., Vogel,W.K.,
            Lee,C.R., Venables,T., Shah,D.K., Iscove,N.N., Leid,M.,
            Anderson,M.K. and Zuniga-Pflucker,J.C.
  TITLE     Realization of the T Lineage Program Involves GATA-3 Induction of
            Bcl11b and Repression of Cdkn2b Expression
  JOURNAL   J Immunol 209 (1), 77-92 (2022)
   PUBMED   35705252
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Chakraborty,S., Martines,C., Porro,F., Fortunati,I., Bonato,A.,
            Dimishkovska,M., Piazza,S., Yadav,B.S., Innocenti,I., Fazio,R.,
            Vaisitti,T., Deaglio,S., Zamo,A., Dimovski,A.J., Laurenti,L. and
            Efremov,D.G.
  TITLE     B-cell receptor signaling and genetic lesions in TP53 and
            CDKN2A/CDKN2B cooperate in Richter transformation
  JOURNAL   Blood 138 (12), 1053-1066 (2021)
   PUBMED   33900379
  REMARK    GeneRIF: B-cell receptor signaling and genetic lesions in TP53 and
            CDKN2A/CDKN2B cooperate in Richter transformation.
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Herzog,C.R., Soloff,E.V., McDoniels,A.L., Tyson,F.L.,
            Malkinson,A.M., Haugen-Strano,A., Wiseman,R.W., Anderson,M.W. and
            You,M.
  TITLE     Homozygous codeletion and differential decreased expression of
            p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor
            cells
  JOURNAL   Oncogene 13 (9), 1885-1891 (1996)
   PUBMED   8934534
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Jiang,P., Stone,S., Wagner,R., Wang,S., Dayananth,P., Kozak,C.A.,
            Wold,B. and Kamb,A.
  TITLE     Comparative analysis of Homo sapiens and Mus musculus
            cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15
            (MTS2)
  JOURNAL   J Mol Evol 41 (6), 795-802 (1995)
   PUBMED   8587124
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Linardopoulos,S., Street,A.J., Quelle,D.E., Parry,D., Peters,G.,
            Sherr,C.J. and Balmain,A.
  TITLE     Deletion and altered regulation of p16INK4a and p15INK4b in
            undifferentiated mouse skin tumors
  JOURNAL   Cancer Res 55 (22), 5168-5172 (1995)
   PUBMED   7585567
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Quelle,D.E., Ashmun,R.A., Hannon,G.J., Rehberger,P.A., Trono,D.,
            Richter,K.H., Walker,C., Beach,D., Sherr,C.J. and Serrano,M.
  TITLE     Cloning and characterization of murine p16INK4a and p15INK4b genes
  JOURNAL   Oncogene 11 (4), 635-645 (1995)
   PUBMED   7651726
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Hannon,G.J. and Beach,D.
  TITLE     p15INK4B is a potential effector of TGF-beta-induced cell cycle
            arrest
  JOURNAL   Nature 371 (6494), 257-261 (1994)
   PUBMED   8078588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01036593.1, AF059567.1 and DT919921.1.
            
            On Dec 4, 2008 this sequence version replaced NM_007670.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059567.1, AK144132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                CAAA01036593.1     1185-1275
            92-690              AF059567.1         1-599
            691-915             DT919921.1         430-654
            916-1393            AF059567.1         824-1301
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.15 cM"
     gene            1..1393
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="cyclin dependent kinase inhibitor 2B"
                     /db_xref="GeneID:12579"
                     /db_xref="MGI:MGI:104737"
     exon            1..367
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..628
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="cyclin-dependent kinase inhibitor p15INK4b;
                     cyclin-dependent kinase inhibitor protein; p14-INK4b;
                     p15-INK4b; cyclin-dependent kinase inhibitor 2B (p15,
                     inhibits CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor B"
                     /protein_id="NP_031696.1"
                     /db_xref="CCDS:CCDS18351.1"
                     /db_xref="GeneID:12579"
                     /db_xref="MGI:MGI:104737"
                     /translation="MLGGSSDAGLATAAARGQVETVRQLLEAGADPNALNRFGRRPIQ
                     VMMMGSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVCD
                     AWGRLPVDLAEEQGHRDIARYLHAATGD"
     exon            368..1393
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="major polyA site"
     regulatory      1361..1366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="hexamer: AAGAAA"
     polyA_site      1382
                     /gene="Cdkn2b"
                     /gene_synonym="INK4b; MTS2; p15; p15(INK4b); p15INK4b"
                     /note="major polyA site"
ORIGIN      
        1 gagggggcgg ggccggcggc ggtgcagaac gctgcagctc agtgcctgcg ggctccctac
       61 ccggcgtgag tcgtctgtgc cggcggtgcg gttcccaggc gctagcgctc gagcgttccc
      121 aggacgctca ccgaagctac tgggtctcca gaggggagga gccgctcaga gaccaggctg
      181 tagcaatctc acggccggcg aaggaccatt tctgccacag accggggaca agggcatgtt
      241 gggcggcagc agtgacgcgg gcctggccac cgccgcggcg cgggggcaag tggagacggt
      301 gcggcagctc ctggaagccg gcgcagatcc caacgccctg aaccgcttcg ggaggcgccc
      361 aatccaggtc atgatgatgg gcagcgccca ggtggcagag ctgctgctgc tccacggagc
      421 agaacccaac tgcgccgacc ctgccaccct taccagacct gtgcacgacg cagctcggga
      481 aggcttcctg gacacgcttg tcgtgctgca ccgggcaggg gcgcggctgg atgtgtgtga
      541 cgcctggggc cgcctgccgg tagacttggc tgaagagcag ggccaccgtg acattgcgag
      601 gtatctgcac gctgccactg gagattgact gcgggttccc tccgccttcc gcaaggactt
      661 ctttctcccc agccccatct aggaagactg caagcacgaa gagggccacc agcgcccagc
      721 ctgcaggcct tccaaaactt gaaccctacc cagtaagaca aagccaatca gaaataactt
      781 cctacgcatt ttctgcagct ggatctggtc cttgagcctc accttgaagc caaggggatc
      841 accaaggaga tttagtattg tatgaagttc ccgggccctc tacctttcag gacgcggtgt
      901 aaaatagcaa gggaaattct tggatctcca caagctgctg ctgcagggga actggagaca
      961 gcttgacatt tgtttgacat ttgggtgggt gcagtcagta ccttcccctg tgaactgaaa
     1021 atgcagatga tccacaggct aaatgggaaa cctggagagt agatgagagg cactgaagtg
     1081 gttttatgta ctgtcatgtg tggggattca cctgcaaaat ggcatttata gaaactgaga
     1141 agtcacctcc agctcgacaa ggaaatagtg aaattgaaga caataaattt ccactaaact
     1201 gtgacccaca gttgccttga tgcctggatt ctgacagact caacgtccac aaagcccagt
     1261 gatgaattgt agtggtagca ggttactcta tgcaaaatag tttaataacc actttagaaa
     1321 tttcctacat ttgagttgct ctttaataac agtgtattta aagaaaaaaa aatttaaaga
     1381 aacagtgaag ttc
//
