LOCUS       NM_172407               3494 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus CDKN2A interacting protein (Cdkn2aip), transcript
            variant 1, mRNA.
ACCESSION   NM_172407
VERSION     NM_172407.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3494)
  AUTHORS   Fan,X., Ma,X., Cui,L., Dang,S., Qu,J., Zhang,J., Wang,X. and Mao,Z.
  TITLE     CARF activates beta-catenin/TCF signaling in the hepatocellular
            carcinoma
  JOURNAL   Oncotarget 7 (49), 80404-80414 (2016)
   PUBMED   27829235
  REMARK    GeneRIF: Oncogenic functions of CARF in hepatocellular carcinoma
            tumorigenesis is a result of activation of beta-catenin/TCF
            signaling.
REFERENCE   3  (bases 1 to 3494)
  AUTHORS   Cheung,C.T., Hasan,M.K., Widodo,N., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF: an emerging regulator of p53 tumor suppressor and senescence
            pathway
  JOURNAL   Mech Ageing Dev 130 (1-2), 18-23 (2009)
   PUBMED   18555516
  REMARK    GeneRIF: CARF may act as a novel key regulator of the p53 pathway
            at multiple checkpoints
            Review article
REFERENCE   4  (bases 1 to 3494)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3494)
  AUTHORS   Wadhwa,R., Sugihara,T., Hasan,M.K., Duncan,E.L., Taira,K. and
            Kaul,S.C.
  TITLE     A novel putative collaborator of p19ARF
  JOURNAL   Exp Gerontol 38 (3), 245-252 (2003)
   PUBMED   12581788
REFERENCE   6  (bases 1 to 3494)
  AUTHORS   Hasan,M.K., Yaguchi,T., Sugihara,T., Kumar,P.K., Taira,K.,
            Reddel,R.R., Kaul,S.C. and Wadhwa,R.
  TITLE     CARF is a novel protein that cooperates with mouse p19ARF (human
            p14ARF) in activating p53
  JOURNAL   J Biol Chem 277 (40), 37765-37770 (2002)
   PUBMED   12154087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133831.1, AK048437.1 and AK078329.1.
            
            On May 7, 2009 this sequence version replaced NM_172407.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133831.1, AK048437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AK133831.1         1-600
            601-2214            AK048437.1         570-2183
            2215-3197           AK048437.1         2187-3169
            3198-3494           AK078329.1         3164-3460
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.88 cM"
     gene            1..3494
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="CDKN2A interacting protein"
                     /db_xref="GeneID:70925"
                     /db_xref="MGI:MGI:1918175"
     exon            1..412
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1853
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     collaborates/cooperates with ARF (alternate reading frame)
                     protein; collaborator of ARF"
                     /codon_start=1
                     /product="CDKN2A-interacting protein isoform 1"
                     /protein_id="NP_765995.1"
                     /db_xref="CCDS:CCDS22299.1"
                     /db_xref="GeneID:70925"
                     /db_xref="MGI:MGI:1918175"
                     /translation="MAQEVSEYLSQNPRVAAWVETLRCEGETDKHWRHRREFLLRNAG
                     DLVPATDETADAESGARTRQLQQLVSFSMAWANHVFLGCRYPQKVMDKILSMAEGIKV
                     TDAPIHTTRDELVAKVKKRGISSSNEGVEEPSKKRAVEGKNNSSVERDHGKKSAKTDR
                     SAAQQENSSPSRGSSTKSESGGTSARSSSSGSHQDSATSEGDRSVCSQSSSNSSQVTA
                     GSGKALESEAPHKRGSASFVSSLLKSSMNSHMTQSTDNRQQSGSPKKGALEGSSGSAS
                     QSSSEIEVPLLGSSGSAEVELPLLSCKSSSETASSGLTSKSSSEANISSSVSKNSSSS
                     GSSLLTPQSSSTNPSLLTSKSTAQVAASLLATKSGASLGSVSQLAAKSGSQSSTSQLP
                     SKSTSQASESSVKFACRKLTNEDIKQKQPFFNRLYKTVAWKLVAVGGFSPTVNHGELL
                     NAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKA
                     VASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEEARPVNLPPALKHPQELL"
     exon            413..543
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..3494
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2049
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="major polyA site"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2612
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3393
                     /gene="Cdkn2aip"
                     /gene_synonym="4921511I16Rik"
ORIGIN      
        1 gaagtgggcg gttcgtcggc gccttgttct gttgtttggg gtttgggctc ctggaggggc
       61 gttctcggga gggccgccgg tgcaggccgc gctgacacag ggccgcttcg cccccggggc
      121 tccgtgcgct tgcgctctcc ccgtcccgca gggtccccaa catggcgcag gaggtgtccg
      181 agtacctgag ccaaaacccg cgggtagccg cctgggtgga gacgctgcgc tgcgagggcg
      241 agacggacaa acactggcgc caccgccggg agtttctgct tcgcaatgcc ggggacctgg
      301 tccccgccac cgacgagact gcggacgcgg agagcggagc ccgcactcgg cagctccagc
      361 agctggtctc cttctccatg gcctgggcga accatgtctt cctagggtgc cggtaccctc
      421 aaaaagttat ggataaaatt cttagtatgg ctgaaggcat caaagtgaca gatgctccaa
      481 tccataccac acgagacgaa ctggttgcca aggtgaagaa aagagggata tcaagtagca
      541 atgaaggggt agaggagcca tccaaaaaac gagccgtaga aggaaaaaac aattcttcag
      601 ttgagcgaga tcatgggaaa aaatctgcca aaacggatcg ttcagcagct cagcaagaaa
      661 acagttcgcc gtccaggggg tcgtccacca aatccgagag tggtgggacc tcagctcgga
      721 gcagctccag tggctcccat caggatagcg ccacaagtga aggagacaga tctgtgtgca
      781 gccagagcag cagcaattcc tctcaggtaa ccgcagggtc tggaaaggct ttggagtcag
      841 aagctccaca taaacgtggt tcagcgtcat ttgtttcttc cctgttgaag tccagtatga
      901 atagtcatat gacccagtcc actgataaca gacaacagag tgggtcacct aaaaagggtg
      961 ctctggaagg ttcttcaggc tcagcctctc agagcagctc agagattgag gtgcccttgt
     1021 tgggctcctc tggaagtgca gaagtagagt tgccattact gtcttgtaag tctagttcag
     1081 agacagcttc cagtgggtta acatctaaat ctagttcaga ggcaaacatt tcatcatcag
     1141 tttcaaaaaa cagttcatcg tcaggcagct ctttactaac cccccagagc agttccacaa
     1201 atccatcgct gctgacatcc aaaagcacgg ctcaggtagc tgcttcactg ctagcgacca
     1261 aaagtggcgc ttccttagga agcgtgtctc agctagctgc caagagtggt tctcagagta
     1321 gcacttcaca gttgccttcg aaaagtacct cccaggccag tgagagttct gtcaagtttg
     1381 cttgtcggaa gttaaccaat gaagacataa aacagaagca acctttcttc aatagactgt
     1441 ataagacggt ggcgtggaag ttagtagcag ttggtggctt cagccccact gtgaatcacg
     1501 gagagctgct gaacgcggct attgaggctc tgaaagcaac actggatgtg ttttttgtcc
     1561 cactgaaaga actggcagat ctgcctcaaa ataagagctc tcaagaaagt attgtctgtg
     1621 aattgaggtg taagtcggta tatttgggca ctggctgtgg aaaaagcaaa gaaaacgcaa
     1681 aagccgtcgc atcgagagaa gcactgaagt tatttctcaa gaagaaggtg gtggtgaaga
     1741 tctgtaagag gaagtaccga ggcagcgaga tcgaggatct agtactcctg gatgaagaag
     1801 caagacccgt aaacttacct ccagcactga aacatcctca agaattactg taacttctcc
     1861 aagtaggcac tgaatccagt atctggtgtt tgaagagaaa aactggcttt tatataagac
     1921 actggctttc acagatttta tattgctttt ttccagtttt gcagaaaatt taaattctcg
     1981 ttctcttcac taaagtagag ctgtaaataa tttatgacag tgcatattaa agggtgtaca
     2041 ttgacagcat accagcgtgc tgttttattt gctgaagaaa atactatctt ctatttttaa
     2101 tgatatatta ggtacgatgt gtagttctgt agaatcttaa aatttttgta ctactactac
     2161 caatttggta gaaatgtatt aagttgtcta ccatgccttt tttttttttt tttcctaact
     2221 tgattgaatc acataaaaga agggggacca cagtatttga atgtgtgaaa ctatacaacc
     2281 taaggtttaa aaatgttgct catgatgctg aacagctctt aaagaacaag aagagttgtc
     2341 tcaaactatt ttcatgaaaa gctgtaaact tttttttaga tataaagcag tataaagtac
     2401 ttattgttat tttattctaa agttgtttaa aattcaccat gattttgacg gctgcagatt
     2461 cttaagcagg ttaatttatg ttttgaggta aatttcaatt tacactttat taagacataa
     2521 tgttggtttc tataggaagc atattttgtg actactatga acagactgat ttgtttagat
     2581 attaaatgct ttaagctatt ttaccttttc aagaagttgt gttttttttt ctcctaccct
     2641 ggtcataact aaggctcctc actactattc aaactacaac caagtagttt tcatagtata
     2701 aaacatattc ttataaatag ggaagtttat atctagaacc gggtggtttt tgtatttgta
     2761 gatttcagaa gaatatggag aagactagag agctatggtc agttctttaa tgactgtgta
     2821 ttcatgtgga ttgcatctgt tagtaatata gtagaatctt gtttctgtgt cttaggtaat
     2881 tctattaatc tgacatggtt tattttaaaa gtcttgtcta aggtatatga cttttggcct
     2941 tctggctttc taggaactgc acactggaca ataatggaga taatatatgt agaaaaagac
     3001 ctttcatatt tactagttat attggtattg gaaggttgaa cataagcaca atttaagtgt
     3061 gtaaaaatta gtttgtagtt taggaataat aaagacactt aatgtactga gtttaaactg
     3121 aaataatcag ggatgtttgt attttgccag ataacatttt taaattattt gttttttttt
     3181 ttgttttttt tttttttttg agaatagctc attggatacc agagcaaaat ctatattctg
     3241 taaatggtct gactgccctt atatagtgtg gaaaacacta acataagtga gttgtaaaaa
     3301 acactgtcaa gtttcttctg ttgtgtattt tgtaaactaa tgcttaccag aaaagtgagc
     3361 caaaaattat aataaataca tttttgaaat acatcttatt agatgattgg gtaattttct
     3421 aaagtgattt gttttaaaca aatttataaa ggcattttat attgaaaatc ctttaaataa
     3481 taatcttttg atgt
//
