LOCUS       NM_001040654             850 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 2A (Cdkn2a),
            transcript variant 2, mRNA.
ACCESSION   NM_001040654
VERSION     NM_001040654.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Schmid,S., Russell,Z.R., Yamashita,A.S., West,M.E., Parrish,A.G.,
            Walker,J., Rudoy,D., Yan,J.Z., Quist,D.C., Gessesse,B.N.,
            Alvinez,N., Hill,K.D., Anderson,L.W., Cimino,P.J., Kumasaka,D.K.,
            Parchment,R.E., Holland,E.C. and Szulzewsky,F.
  TITLE     ERK signaling promotes resistance to TRK kinase inhibition in NTRK
            fusion-driven glioma mouse models
  JOURNAL   Cell Rep 43 (10), 114829 (2024)
   PUBMED   39365700
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Kloosterman,D.J., Erbani,J., Boon,M., Farber,M., Handgraaf,S.M.,
            Ando-Kuri,M., Sanchez-Lopez,E., Fontein,B., Mertz,M., Nieuwland,M.,
            Liu,N.Q., Forn-Cuni,G., van der Wel,N.N., Grootemaat,A.E.,
            Reinalda,L., van Kasteren,S.I., de Wit,E., Ruffell,B.,
            Snaar-Jagalska,E., Petrecca,K., Brandsma,D., Kros,A., Giera,M. and
            Akkari,L.
  TITLE     Macrophage-mediated myelin recycling fuels brain cancer malignancy
  JOURNAL   Cell 187 (19), 5336-5356 (2024)
   PUBMED   39137777
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Watson,S.S., Zomer,A., Fournier,N., Lourenco,J., Quadroni,M.,
            Chryplewicz,A., Nassiri,S., Aubel,P., Avanthay,S., Croci,D.,
            Abels,E., Broekman,M.L.D., Hanahan,D., Huse,J.T., Daniel,R.T.,
            Hegi,M.E., Homicsko,K., Cossu,G., Hottinger,A.F. and Joyce,J.A.
  TITLE     Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma
            recurrence
  JOURNAL   Cancer Cell 42 (9), 1507-1527 (2024)
   PUBMED   39255775
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Wee,Y., Wang,J., Wilson,E.C., Rich,C.P., Rogers,A., Tong,Z.,
            DeGroot,E., Gopal,Y.N.V., Davies,M.A., Ekiz,H.A., Tay,J.K.H.,
            Stubben,C., Boucher,K.M., Oviedo,J.M., Fairfax,K.C., Williams,M.A.,
            Holmen,S.L., Wolff,R.K. and Grossmann,A.H.
  TITLE     Tumour-intrinsic endomembrane trafficking by ARF6 shapes an
            immunosuppressive microenvironment that drives melanomagenesis and
            response to checkpoint blockade therapy
  JOURNAL   Nat Commun 15 (1), 6613 (2024)
   PUBMED   39098861
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 850)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   6  (bases 1 to 850)
  AUTHORS   Linardopoulos,S., Street,A.J., Quelle,D.E., Parry,D., Peters,G.,
            Sherr,C.J. and Balmain,A.
  TITLE     Deletion and altered regulation of p16INK4a and p15INK4b in
            undifferentiated mouse skin tumors
  JOURNAL   Cancer Res 55 (22), 5168-5172 (1995)
   PUBMED   7585567
REFERENCE   7  (bases 1 to 850)
  AUTHORS   Quelle,D.E., Ashmun,R.A., Hannon,G.J., Rehberger,P.A., Trono,D.,
            Richter,K.H., Walker,C., Beach,D., Sherr,C.J. and Serrano,M.
  TITLE     Cloning and characterization of murine p16INK4a and p15INK4b genes
  JOURNAL   Oncogene 11 (4), 635-645 (1995)
   PUBMED   7651726
REFERENCE   8  (bases 1 to 850)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 850)
  AUTHORS   Lee,G.H., Bennett,L.M., Carabeo,R.A. and Drinkwater,N.R.
  TITLE     Identification of hepatocarcinogen-resistance genes in DBA/2 mice
  JOURNAL   Genetics 139 (1), 387-395 (1995)
   PUBMED   7705639
REFERENCE   10 (bases 1 to 850)
  AUTHORS   Hussussian,C.J., Struewing,J.P., Goldstein,A.M., Higgins,P.A.,
            Ally,D.S., Sheahan,M.D., Clark,W.H. Jr., Tucker,M.A. and
            Dracopoli,N.C.
  TITLE     Germline p16 mutations in familial melanoma
  JOURNAL   Nat Genet 8 (1), 15-21 (1994)
   PUBMED   7987387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L76150.1 and AL831719.6.
            
            Transcript Variant: This variant (2) contains an alternate open
            reading frame, when compared to variant 1. Transcripts 1 and 2,
            encoding p19ARF and p16INK4a, have distinct first exons which
            contain the translation start codon, and share a common second
            exon, which is translated in different reading frames. Thus, the
            p16INK4a protein encoded by this variant (2) lacks sequence
            similarity to the protein product of variant 1 (p19ARF).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF044335.1, BI412461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               L76150.1           1-116
            117-119             AL831719.6         23115-23117
            120-593             L76150.1           117-590
            594-789             AL831719.6         30462-30657
            790-850             L76150.1           786-846
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 42.15 cM"
     gene            1..850
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
                     /note="cyclin dependent kinase inhibitor 2A"
                     /db_xref="GeneID:12578"
                     /db_xref="MGI:MGI:104738"
     exon            1..207
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..588
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
                     /note="isoform p16INK4a is encoded by transcript variant
                     2; mitochondrial smARF; cyclin-dependent kinase inhibitor
                     protein; CDK4I; p16-INK4; p16-INK4a; cyclin-dependent
                     kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A
                     (p16, inhibits CDK4); alternative reading frame"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 2A isoform
                     p16INK4a"
                     /protein_id="NP_001035744.1"
                     /db_xref="CCDS:CCDS38812.1"
                     /db_xref="GeneID:12578"
                     /db_xref="MGI:MGI:104738"
                     /translation="MESAADRLARAAAQGRVHDVRALLEAGVSPNAPNSFGRTPIQVM
                     MMGNVHVAALLLNYGADSNCEDPTTFSRPVHDAAREGFLDTLVVLHGSGARLDVRDAW
                     GRLPLDLAQERGHQDIVRYLRSAGCSLCSAGWSLCTAGNVAQTDGHSFSSSTPRALEL
                     RGQSQEQS"
     exon            208..548
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..850
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      850
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1;
                     p16; p16(INK4a); p16INK4a; p19<ARF>; p19ARF; Pctr1"
ORIGIN      
        1 actggtcaca cgactgggcg attgggcggg cactgaatct ccgcgaggaa agcgaactcg
       61 aggagagcca tctggagcag catggagtcc gctgcagaca gactggccag ggcggcggcc
      121 cagggccgtg tgcatgacgt gcgggcactg ctggaagccg gggtttcgcc caacgccccg
      181 aactctttcg gtcgtacccc gattcaggtg atgatgatgg gcaacgttca cgtagcagct
      241 cttctgctca actacggtgc agattcgaac tgcgaggacc ccactacctt ctcccgcccg
      301 gtgcacgacg cagcgcggga aggcttcctg gacacgctgg tggtgctgca cgggtcaggg
      361 gctcggctgg atgtgcgcga tgcctggggt cgcctgccgc tcgacttggc ccaagagcgg
      421 ggacatcaag acatcgtgcg atatttgcgt tccgctgggt gctctttgtg ttccgctggg
      481 tggtctttgt gtaccgctgg gaacgtcgcc cagaccgacg ggcatagctt cagctcaagc
      541 acgcccaggg ccctggaact tcgcggccaa tcccaagagc agagctaaat ccggcctcag
      601 cccgcctttt tcttcttagc ttcacttcta gcgatgctag cgtgtctagc atgtggcttt
      661 aaaaaataca taataatgct ttttttgcaa tcacgggagg gagcagaggg agggagcaga
      721 aggagggagg gagggaggga gggacctgga caggaaagga atggcatgag aaactgagcg
      781 aaggcggccg cgaagggaat aatggctgga ttgtttaaaa aaataaaata aagatacttt
      841 ttaaaatgtc
//
