LOCUS       NM_001412230            1926 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 1C (Cdkn1c),
            transcript variant 4, mRNA.
ACCESSION   NM_001412230 XM_006508467
VERSION     NM_001412230.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Prodani,C., Irvine,E.E., Sardini,A., Gleneadie,H.J., Dimond,A., Van
            de Pette,M., John,R., Kokkinou,M., Howes,O., Withers,D.J.,
            Ungless,M.A., Merkenschlager,M. and Fisher,A.G.
  TITLE     Protein restriction during pregnancy alters Cdkn1c silencing,
            dopamine circuitry and offspring behaviour without changing
            expression of key neuronal marker genes
  JOURNAL   Sci Rep 14 (1), 8528 (2024)
   PUBMED   38609446
  REMARK    GeneRIF: Protein restriction during pregnancy alters Cdkn1c
            silencing, dopamine circuitry and offspring behaviour without
            changing expression of key neuronal marker genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1926)
  AUTHORS   Sun,Q., Li,J., Ma,J., Zheng,Y., Ju,R., Li,X., Ren,X., Huang,L.,
            Chen,R., Tan,X. and Luo,L.
  TITLE     JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens
            Fiber Maturation in Murine Lens Development
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 15 (2023)
   PUBMED   38095908
REFERENCE   6  (bases 1 to 1926)
  AUTHORS   Andrews,S.C., Wood,M.D., Tunster,S.J., Barton,S.C., Surani,M.A. and
            John,R.M.
  TITLE     Cdkn1c (p57Kip2) is the major regulator of embryonic growth within
            its imprinted domain on mouse distal chromosome 7
  JOURNAL   BMC Dev Biol 7, 53 (2007)
   PUBMED   17517131
  REMARK    GeneRIF: Cdkn1c, an imprinted gene with expression only from the
            maternal allele, is the major regulator of embryonic growth in the
            IC2 imprinted domain on mouse distal chromosome 7.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1926)
  AUTHORS   Hatada,I. and Mukai,T.
  TITLE     Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor,
            in mouse
  JOURNAL   Nat Genet 11 (2), 204-206 (1995)
   PUBMED   7550351
REFERENCE   8  (bases 1 to 1926)
  AUTHORS   Matsuoka,S., Edwards,M.C., Bai,C., Parker,S., Zhang,P., Baldini,A.,
            Harper,J.W. and Elledge,S.J.
  TITLE     p57KIP2, a structurally distinct member of the p21CIP1 Cdk
            inhibitor family, is a candidate tumor suppressor gene
  JOURNAL   Genes Dev 9 (6), 650-662 (1995)
   PUBMED   7729684
REFERENCE   9  (bases 1 to 1926)
  AUTHORS   Lee,M.H., Reynisdottir,I. and Massague,J.
  TITLE     Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique
            domain structure and tissue distribution
  JOURNAL   Genes Dev 9 (6), 639-649 (1995)
   PUBMED   7729683
REFERENCE   10 (bases 1 to 1926)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023248.20.
            
            On Sep 26, 2022 this sequence version replaced XM_006508467.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1309830.1,
                                           SRR7652917.6997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 17517131
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC023248.20        64751-64896
            147-1104            AC023248.20        65033-65990
            1105-1243           AC023248.20        66499-66637
            1244-1926           AC023248.20        66728-67410
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.22 cM"
     gene            1..1926
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /note="cyclin dependent kinase inhibitor 1C"
                     /db_xref="GeneID:12577"
                     /db_xref="MGI:MGI:104564"
     exon            1..146
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1104
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1238
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /note="isoform 3 is encoded by transcript variant 4;
                     cyclin-dependent kinase inhibitor p57; cyclin dependent
                     kinase inhibitor 1C (P57)"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1C isoform 3"
                     /protein_id="NP_001399159.1"
                     /db_xref="GeneID:12577"
                     /db_xref="MGI:MGI:104564"
                     /translation="MGMSDVYLRSRTAMERLASSDTFPVIARSSACRSLFGPVDHEEL
                     GRELRMRLAELNAEDQNRWDFNFQQDVPLRGPGRLQWMEVDSESVPAFYRETVQVGRC
                     RLQLGPRPPPVAVAVIPRSGPPAGEAPDGLEEAPEQPPSAPASAVVAEPTPPATPAPA
                     SDLTSDPIPEVTLVATSDPTPDPIPDANPDVATRDGEEQVPEQVSEQGEESGAEPGDE
                     LGTEPVSEQGEEQGAEPVEEKDEEPEEEQGAEPVEEQGAEPVEEQNGEPVEEQDENQE
                     QRGQELKDQPLSGIPGRPAPGTAAANANGAIKKLSGPLISDFFAKRKRTAQENKASND
                     VPPGCPSPNVAPGVGAVEQTPRKRLR"
     exon            1105..1243
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1926
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="Cdkn1c"
                     /gene_synonym="CDKI; Kip2; p57(kip2); p57Kip2"
                     /note="major polyA site"
ORIGIN      
        1 acaggccgag tgcgctgtgc tcgaggggtg ccggctaggc ccgactgaga gcaagcgaac
       61 aggcaggcaa gctccgaggg ggcgcggccc aagctggaca ggacaagcga tccagacgca
      121 ggagccgtcc atcaccaatc agccagcctt cgaccatggg catgtccgac gtgtacctcc
      181 gcagcagaac agcgatggaa cgcttggcct ccagcgatac cttcccagtg atagcgcgta
      241 gcagcgcctg ccgcagcctc ttcgggcctg tagaccacga ggagctgggc cgcgagctgc
      301 ggatgcgcct ggccgagctg aacgccgagg accagaaccg ctgggacttc aacttccagc
      361 aggatgtgcc tcttcgaggc cctggtcgtc tgcagtggat ggaggtggac agcgagtctg
      421 tgcccgcctt ctaccgcgag acggtgcagg tggggcgctg tcgcctgcag ctggggcccc
      481 ggccaccccc ggtggccgtg gctgtcatcc cgcgttctgg gccgccggct ggcgaggccc
      541 ccgacggcct agaggaggcg cctgagcagc cgcccagcgc cccagcctcg gccgtggtcg
      601 cggagcccac cccacccgcg accccggccc cggcttcaga tctgacctca gacccaattc
      661 cggaggtgac cctggtcgcg acctccgacc cgactccgga cccgatcccg gacgcgaacc
      721 cggacgtggc gactcgggac ggcgaggaac aggtccctga gcaggtctct gagcagggcg
      781 aggagtcggg tgctgagccg ggtgatgagc tgggaactga gccggtctct gagcagggcg
      841 aggagcaggg cgcagagccg gtcgaggaga aggacgagga gccggaggag gagcagggcg
      901 cggagccggt cgaggagcag ggtgcggagc cggtcgagga gcagaatggg gagccggtcg
      961 aggagcagga cgagaatcaa gagcagcgcg gccaggagct gaaggaccag cctctctcgg
     1021 ggattccagg acgtcctgca cccgggactg ctgcggccaa tgcgaacggt gcgatcaaga
     1081 agctgtcggg gcctctcatc tccgacttct tcgccaagcg caagagaact gcgcaggaga
     1141 acaaggcgtc gaacgacgtc cctccagggt gtccctctcc aaacgtggct cctggggtgg
     1201 gcgcggtgga gcagaccccg cgcaaacgtc tgagatgagt tagtttagag gctaacggcc
     1261 agagagaact tgctgggcat ctgggcagcg gacgatggaa gaactctggg cttcggctgg
     1321 gacctttcgt tcatgtagca ggaaccggag atggttgcgt agagcagccc acggttttgt
     1381 ggaaatctga aaactgtgca atgtattgag aacactctgt accatgtgca aggagtacgc
     1441 tggtcccaag gtgtaaagct ttaaatcatt tatgtaaaat gtttaatctc tactcgctct
     1501 cagtgcaaaa caaaaagaga aactagaaaa tgtagaacga aggaaaaaga tgagaaaaag
     1561 gaaaaagcat gtatatttgt acaaaaagtt aaaaaattat gctaatttaa tatttgtatt
     1621 tatccatgcg tggatccctc tgccacgcaa ctgctgggtt attgattatt accaaaggca
     1681 ctagaaatca ccagcttcag attacccaca aatgtaaatc tacttttata ttagactcta
     1741 ggggaatggt tgttgagtaa aagcccccac acattcatct tcagttagct tacagtgtcc
     1801 cccacttcat tagattgctc ttaaacttgg tgaccagaca gtcgaaatgg ttcctgtact
     1861 gcccatacca actgcccagg gctcctcgtc cgccaggttc taaataaaga ggcccaacaa
     1921 aaatca
//
