LOCUS       NM_009875               2405 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 1B (Cdkn1b), mRNA.
ACCESSION   NM_009875
VERSION     NM_009875.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Kagoshima,H., Ohnishi,H., Yamamoto,R., Yasumoto,A., Tona,Y.,
            Nakagawa,T., Omori,K. and Yamamoto,N.
  TITLE     EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and
            Forms the Scala Tympani and Spiral Limbus during Inner Ear
            Development
  JOURNAL   J Neurosci 44 (7), e1060232023 (2024)
   PUBMED   38176908
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   Cook,A.G., Bishop,T.V., Crowe,H.R., Stevens,D.N., Reine,L.,
            Joyner,A.L. and Lawton,A.K.
  TITLE     Cell division angle predicts the level of tissue mechanics that
            tune the amount of cerebellar folding
  JOURNAL   Development 151 (3) (2024)
   PUBMED   38251865
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Kullmann,M., Gopfert,U., Siewe,B. and Hengst,L.
  TITLE     ELAV/Hu proteins inhibit p27 translation via an IRES element in the
            p27 5'UTR
  JOURNAL   Genes Dev 16 (23), 3087-3099 (2002)
   PUBMED   12464637
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Poon,R.Y., Toyoshima,H. and Hunter,T.
  TITLE     Redistribution of the CDK inhibitor p27 between different
            cyclin.CDK complexes in the mouse fibroblast cell cycle and in
            cells arrested with lovastatin or ultraviolet irradiation
  JOURNAL   Mol Biol Cell 6 (9), 1197-1213 (1995)
   PUBMED   8534916
REFERENCE   8  (bases 1 to 2405)
  AUTHORS   Stegmaier,K., Pendse,S., Barker,G.F., Bray-Ward,P., Ward,D.C.,
            Montgomery,K.T., Krauter,K.S., Reynolds,C., Sklar,J., Donnelly,M.
            et al.
  TITLE     Frequent loss of heterozygosity at the TEL gene locus in acute
            lymphoblastic leukemia of childhood
  JOURNAL   Blood 86 (1), 38-44 (1995)
   PUBMED   7795247
REFERENCE   9  (bases 1 to 2405)
  AUTHORS   Toyoshima,H. and Hunter,T.
  TITLE     p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is
            related to p21
  JOURNAL   Cell 78 (1), 67-74 (1994)
   PUBMED   8033213
REFERENCE   10 (bases 1 to 2405)
  AUTHORS   Polyak,K., Lee,M.H., Erdjument-Bromage,H., Koff,A., Roberts,J.M.,
            Tempst,P. and Massague,J.
  TITLE     Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a
            potential mediator of extracellular antimitogenic signals
  JOURNAL   Cell 78 (1), 59-66 (1994)
   PUBMED   8033212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122193.5 and U10440.1.
            
            On Oct 27, 2007 this sequence version replaced NM_009875.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.160745.1, AK162146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               AC122193.5         129429-130013
            586-743             U10440.1           284-441
            744-744             AC122193.5         130172-130172
            745-940             U10440.1           443-638
            941-941             AC122193.5         130369-130369
            942-1191            U10440.1           640-889
            1192-2405           AC122193.5         133340-134553
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.77 cM"
     gene            1..2405
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /note="cyclin dependent kinase inhibitor 1B"
                     /db_xref="GeneID:12576"
                     /db_xref="MGI:MGI:104565"
     exon            1..994
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1113
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /note="cyclin-dependent kinase inhibitor p27"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1B"
                     /protein_id="NP_034005.2"
                     /db_xref="CCDS:CCDS20642.1"
                     /db_xref="GeneID:12576"
                     /db_xref="MGI:MGI:104565"
                     /translation="MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVNHEELTRD
                     LEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVL
                     AQESQDVSGSRQAVPLIGSQANSEDRHLVDQMPDSSDNPAGLAEQCPGMRKRPAAEDS
                     SSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT"
     exon            995..1122
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..2405
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2371..2376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /note="hexamer: AATAAA"
     polyA_site      2393
                     /gene="Cdkn1b"
                     /gene_synonym="Kip1; p27; p27Kip1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcaatc atcttcttct tcgtcagcct cccttccacc gccatattgg gcaactaaaa
       61 aaggaggggg gctcgtgctt ttggggtgtt ttcccccctc atcccttgtc ccgactcact
      121 cgcggctccg agactcgcgc ggcggcaagg tttggagagg ggctgcgttc gcgggacaca
      181 cgggctcgcc ccagcctacg ctccgactgt ttgccacctc ctcctgcctc ctcccctccc
      241 ttccccgccc tccagtacac ttgatcactg aagcctcgag ctgcgcggcg gctggggtgt
      301 ccctgcgcct ctcttcccca gacctgcgcg ctactgcggc tcgggcggtc gctcgcctgg
      361 ctctgctcca tttgactgtc tgtgtgcagt cgcagaactt cgaagagggt tttgcgctcc
      421 atccgtggcg tttcgctttt gttcggtttt gttgtttatt tcattttttt ttttccggag
      481 agaggcgagg cggtggtcca cacccgcccg aggaggaaga tgtcaaacgt gagagtgtct
      541 aacgggagcc cgagcctgga gcggatggac gccagacaag cggagcaccc caagccttcc
      601 gcctgcagaa atctcttcgg cccggtcaat catgaagaac taacccggga cttggagaag
      661 cactgccggg atatggaaga agcgagtcag cgcaagtgga atttcgactt tcagaatcat
      721 aagcccctgg agggcagata cgagtggcag gaggtggaga ggggcagctt gcccgagttc
      781 tactacaggc ccccgcgccc ccccaagagc gcctgcaagg tgctggcgca ggagagccag
      841 gatgtcagcg ggagccgcca ggcggtgcct ttaattgggt ctcaggcaaa ctctgaggac
      901 cggcatttgg tggaccaaat gcctgactcg tcagacaatc cggctgggtt agcggagcag
      961 tgtccaggga tgaggaagcg acctgctgca gaagattctt cttcgcaaaa caaaagggcc
     1021 aacagaacag aagaaaatgt ttcagacggt tccccgaacg ctggcactgt ggagcagacg
     1081 cccaagaagc ccggccttcg acgccagacg taaacagctc cgaattaaga atatttcctt
     1141 gtttattaga tacatcactg ctttatgaag caaggaagat atacatgaaa aaatttaaat
     1201 acatatcgct gactccattg aatggacatc ctgtataagc actgagaaag caaaaacaat
     1261 aacactaaaa ttttaggcac tcttaaacca tctgcctcta aaagcattgg atgtagcatt
     1321 gcgcaattag gttgttcctt atttgctttg ttgtactacc tgtgtatata gtttttatct
     1381 tttactctgt agcacataaa cgttagggat gggagggcag ggtggggctg aggagtcagc
     1441 atgggggtga agaacttgct tcaatttgta gcaaggagaa aaatatttga cttgcataaa
     1501 gagaagcaac ctgggtgggg gtgggggggg gaagggtttg aattcctttc tttaaagatg
     1561 tagtgtccct ttcggtaaga atggatcctt tatttttaaa ataatcaaaa tttgaataat
     1621 tgctacacat ggttgctatt tatttctaca tgaagcttat tctcacttgg aggttctgaa
     1681 gattctgtta tagagcaaga aatggcttaa tttttttttt taattggaat ttaccagttt
     1741 attgtttagc agtaattacc ccaggtaaca ctgggcaaaa atctggggtg cataataggg
     1801 aattctgaat tcttagattt gattatccca gatcattttt gctaagaaaa attcttattt
     1861 ctttttttca cagtgaacat aatcctaaat ccttggatat ttttagaagt ctgtaacttt
     1921 acacaaataa tgaaataatt tttaattcaa agtttctcac cctacttgtt aatttgcccc
     1981 caaggaaagt tgtttttttt tttttttttt tttttaagga aaaaaggaca cttgtagagt
     2041 aagtgaaatg gatactacat ctttaaacag cgtttcttca ttgcctgtgt atgagaaaaa
     2101 cttggaagtg tgcctgtgta tataactctg taaagacact gaaaattata ctaacttatt
     2161 tatgttaaaa agagattttt ttttaatcta gacaatatac aagccaaagt ggcatgtttt
     2221 gtgcatttgt aaatgctgta ttggatagac tagccccccc cccgcctttg ttaaatagta
     2281 tggctgtgct taaaaggttg catactgagc caagtataat ttttgtaatg tgtgaaaaag
     2341 atgccaatta ttgttacaca tcaagcaatc aataaagaaa acttccgtag ttatttattg
     2401 agtgc
//
