LOCUS       NM_007669               1913 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 1A (Cdkn1a),
            transcript variant 1, mRNA.
ACCESSION   NM_007669
VERSION     NM_007669.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Sedmera,D., Olejnickova,V., Sankova,B., Kolesova,H., Bartos,M.,
            Kvasilova,A., Phillips,L.C., Bamforth,S.D. and Phillips,H.M.
  TITLE     Morphological, electrophysiological, and molecular alterations in
            foetal noncompacted cardiomyopathy induced by disruption of ROCK
            signalling
  JOURNAL   Front Cell Dev Biol 12, 1471751 (2024)
   PUBMED   39435333
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Bedelbaeva,K., Snyder,A., Gourevitch,D., Clark,L., Zhang,X.M.,
            Leferovich,J., Cheverud,J.M., Lieberman,P. and Heber-Katz,E.
  TITLE     Lack of p21 expression links cell cycle control and appendage
            regeneration in mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (13), 5845-5850 (2010)
   PUBMED   20231440
  REMARK    GeneRIF: tested the hypothesis that p21 down-regulation could
            functionally induce a regenerative response in an appendage of an
            otherwise nonregenerating mouse strain
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Brugarolas,J., Chandrasekaran,C., Gordon,J.I., Beach,D., Jacks,T.
            and Hannon,G.J.
  TITLE     Radiation-induced cell cycle arrest compromised by p21 deficiency
  JOURNAL   Nature 377 (6549), 552-557 (1995)
   PUBMED   7566157
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Deng,C., Zhang,P., Harper,J.W., Elledge,S.J. and Leder,P.
  TITLE     Mice lacking p21CIP1/WAF1 undergo normal development, but are
            defective in G1 checkpoint control
  JOURNAL   Cell 82 (4), 675-684 (1995)
   PUBMED   7664346
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Macleod,K.F., Sherry,N., Hannon,G., Beach,D., Tokino,T.,
            Kinzler,K., Vogelstein,B. and Jacks,T.
  TITLE     p53-dependent and independent expression of p21 during cell growth,
            differentiation, and DNA damage
  JOURNAL   Genes Dev 9 (8), 935-944 (1995)
   PUBMED   7774811
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Matsuoka,S., Edwards,M.C., Bai,C., Parker,S., Zhang,P., Baldini,A.,
            Harper,J.W. and Elledge,S.J.
  TITLE     p57KIP2, a structurally distinct member of the p21CIP1 Cdk
            inhibitor family, is a candidate tumor suppressor gene
  JOURNAL   Genes Dev 9 (6), 650-662 (1995)
   PUBMED   7729684
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Huppi,K., Siwarski,D., Dosik,J., Michieli,P., Chedid,M., Reed,S.,
            Mock,B., Givol,D. and Mushinski,J.F.
  TITLE     Molecular cloning, sequencing, chromosomal localization and
            expression of mouse p21 (Waf1)
  JOURNAL   Oncogene 9 (10), 3017-3020 (1994)
   PUBMED   8084607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC167363.3, AK149910.1 and
            AK007630.1.
            
            On Sep 25, 2015 this sequence version replaced NM_007669.4.
            
            Summary: This gene encodes a potent cyclin-dependent kinase
            inhibitor. The encoded protein binds to and inhibits the activity
            of cyclin-cyclin-dependent kinase2 or cyclin-dependent kinase4
            complexes, and thus functions as a regulator of cell cycle
            progression at the G1 pahse. The expression of this gene is tightly
            controlled by the tumor suppressor protein p53, through which this
            protein mediates the p53-dependent cell cycle G1 phase arrest in
            response to a variety of stress stimuli. This protein can interact
            with proliferating cell nuclear antigen, a DNA polymerase accessory
            factor, and plays a regulatory role in S phase DNA replication and
            DNA damage repair. This protein was reported to be specifically
            cleaved by CASP3-like caspases, which thus leads to a dramatic
            activation of cyclin-dependent kinase2, and may be instrumental in
            the execution of apoptosis following caspase activation. Mice that
            lack this gene have the ability to regenerate damaged or missing
            tissue. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007630.1, AK170467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC167363.3         112085-112087
            4-753               AK149910.1         2-751
            754-782             AK007630.1         749-777
            783-1913            AK007630.1         779-1909
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.12 cM"
     gene            1..1913
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /note="cyclin dependent kinase inhibitor 1A"
                     /db_xref="GeneID:12575"
                     /db_xref="MGI:MGI:104556"
     exon            1..93
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..534
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..584
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /note="CDK-interacting protein 1; melanoma
                     differentiation-associated protein"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1"
                     /protein_id="NP_031695.1"
                     /db_xref="CCDS:CCDS28591.1"
                     /db_xref="GeneID:12575"
                     /db_xref="MGI:MGI:104556"
                     /translation="MSNPGDVRPVPHRSKVCRCLFGPVDSEQLRRDCDALMAGCLQEA
                     RERWNFDFVTETPLEGNFVWERVRSLGLPKVYLSPGSRSRDDLGGDKRPSTSSALLQG
                     PAPEDHVALSLSCTLVSERPEDSPGGPGTSQGRKRRQTSLTDFYHSKRRLVFCKRKP"
     exon            535..1913
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /note="hexamer: AATAAA"
     polyA_site      1913
                     /gene="Cdkn1a"
                     /gene_synonym="CAP20; CDKI; Cdkn1; CIP1; mda6; P21;
                     p21Cip1; p21WAF; SDI1; Waf1"
                     /note="major polyA site"
ORIGIN      
        1 tgcagcagcc gagaggtgtg agccgccgcg gtgtcagagt ctaggggaat tggagtcagg
       61 cgcagatcca cagcgatatc cagacattca gagccacagg caccatgtcc aatcctggtg
      121 atgtccgacc tgttccgcac aggagcaaag tgtgccgttg tctcttcggt cccgtggaca
      181 gtgagcagtt gcgccgtgat tgcgatgcgc tcatggcggg ctgtctccag gaggcccgag
      241 aacggtggaa ctttgacttc gtcacggaga cgccgctgga gggcaacttc gtctgggagc
      301 gcgttcggag cctagggctg cccaaggtct acctgagccc tgggtcccgc agccgtgacg
      361 acctgggagg ggacaagagg cccagtactt cctctgccct gctgcagggg ccagctccgg
      421 aggaccacgt ggccttgtcg ctgtcttgca ctctggtgtc tgagcggcct gaagattccc
      481 cgggtgggcc cggaacatct cagggccgaa aacggaggca gaccagcctg acagatttct
      541 atcactccaa gcgcagattg gtcttctgca agagaaaacc ctgaagtgcc cacgggagcc
      601 ccgccctctt ctgctgtggg tcaggaggcc tcttccccat cttcggcctt agccctcact
      661 ctgtgtgtct taattattat ttgtgtttta atttaaacgt ctcctgtata tacgctgcct
      721 gccctctccc agtctccaaa cttaaagtta tttaaaaaaa gaacaaaaca aaacaaaaaa
      781 aaccaaaaca aaacaaacct aaattagtag gacggtaggg cccttagtgt gggggatttc
      841 tattatgtag attattatta tttaagcccc tcccaaccca agctctgtgt ttcctatacc
      901 ggaggaacag tcctactgat atcaacccat ctgcatccgt ttcacccaac ccccctcccc
      961 ccattccctg cctggttcct tgccacttct tacctggggg tgatcctcag acctgaatag
     1021 cactttggaa aaatgagtag gactttgggg tctccttgtc acctctaagg ccagctagga
     1081 tgacagtgaa gcagtcacag cctagaacag ggatggcagt taggactcaa ccgtaatatc
     1141 ccgactcttg acattgctca gacctgtgaa gacaggaatg gtccccactc tggatcccct
     1201 ttgccactcc tggggagccc acctctcctg tgggtctctg ccagctgccc ctctattttg
     1261 gagggttaat ctggtgatct gctgctcttt tcccccaccc catacttccc cttctgcagg
     1321 tcggcaggag gcatatctag gcacttgccc cacagctcag tggactggaa gggaatgtat
     1381 atgcagggta cactaagtgg gattccctgg tcttacctta ggcagctcca gtggcaaccc
     1441 cctgcattgt gggtctaggg tgggtccttg gtggtgagac aggcctccca gagcattcta
     1501 tggtgtgtgg tggtgggggt gggcttatct gggatgggga ccccagttgg ggttctcagt
     1561 gacttctccc atttcttagt agcagttgta caaggagcca ggccaagatg gtgtcttggg
     1621 ggctaaggga gctcacagga cactgagcaa tggctgatcc tttctcagtg ttgaataccg
     1681 tgggtgtcaa agcacttagt gggtctgact ccagccccaa acatccctgt ttctgtaaca
     1741 tcctggtctg gactgtctac ccttagcccg caccccaaga acatgtattg tggctccctc
     1801 cctgtctcca ctcagattgt aagcgtctca cgagaaggga cagcaccctg cattgtcccg
     1861 agtcctcaca cccgacccca aagctggtgc tcaataaata cttctcgatg att
//
