LOCUS       NM_001360143            2974 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus cyclin dependent kinase like 4 (Cdkl4), transcript
            variant 2, mRNA.
ACCESSION   NM_001360143 XM_006524526
VERSION     NM_001360143.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2974)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2974)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131712.3.
            
            On Jan 27, 2018 this sequence version replaced XM_006524526.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.55352.1,
                                           SRR7652917.706288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC131712.3         62504-62656
            154-378             AC131712.3         79414-79638
            379-500             AC131712.3         83560-83681
            501-573             AC131712.3         89090-89162
            574-664             AC131712.3         92206-92296
            665-862             AC131712.3         96171-96368
            863-945             AC131712.3         100402-100484
            946-1002            AC131712.3         104538-104594
            1003-1137           AC131712.3         106056-106190
            1138-2974           AC131712.3         114602-116438
FEATURES             Location/Qualifiers
     source          1..2974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.9 cM"
     gene            1..2974
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /note="cyclin dependent kinase like 4"
                     /db_xref="GeneID:381113"
                     /db_xref="MGI:MGI:3587025"
     exon            1..153
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            154..378
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1239
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /EC_number="2.7.11.22"
                     /codon_start=1
                     /product="cyclin-dependent kinase-like 4"
                     /protein_id="NP_001347072.1"
                     /db_xref="CCDS:CCDS28992.1"
                     /db_xref="GeneID:381113"
                     /db_xref="MGI:MGI:3587025"
                     /translation="MEKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVV
                     RKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVSDGV
                     IKSVLWQTLQALNFCHKHNCIHRDVKPENILITKQGMIKICDFGFARILIPGDAYTDY
                     VATRWYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG
                     KLIPRHQSIFRSNQFFRGISIPEPEDMETLEEKFSNVQPVALSFMKGCLKMNPDERLT
                     CAQLLDSAYFESFQEDQMKRKARSEGRSRRRQQNQLLPLIPGSHISPTPDGRKQVVQL
                     KFDHLPNI"
     exon            379..500
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            501..573
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            574..664
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            665..862
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            863..945
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1002
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1137
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..2974
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2944..2949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /note="hexamer: AATAAA"
     polyA_site      2974
                     /gene="Cdkl4"
                     /gene_synonym="Gm942"
                     /note="major polyA site"
ORIGIN      
        1 gtgtggaagc tgcgcagcct gcgcgtcctg gttgccctgg agacaccgca gaggctcggt
       61 ctctcgggag ttctgtggtg gcagcagact gcgcgggctg gggctccccg aagctgaaca
      121 ccattgtgtc accgtcgccg gaggctgtgc cgtgtgcaac gctgaacttc aagtcgaccg
      181 gtacactaaa attaagtcgc tgtaactaaa atggaaaagt atgaaaagct agctaagatc
      241 ggagaagggt cttatggcgt tgtattcaag tgcagaaaca aatcttctgg acaagtagta
      301 gcgatcaaaa aattcgtgga atctgaagat gatcgtgtcg ttaggaaaat agccctgcgg
      361 gaaatccgta tgctgaagca gttgaaacac ccaaacctcg tgaacctcat cgaggtgttc
      421 agaagaaaga gaaagatgca tctagttttt gagtactgtg atcacacact gttaaacgag
      481 ctggagagaa acccaaacgg agtttctgat ggagtgatta aaagtgtgct atggcaaacc
      541 cttcaagccc ttaacttctg tcacaagcac aattgtattc atcgggatgt aaaacctgaa
      601 aacatcctaa taaccaagca agggatgata aagatttgtg actttggatt tgcacgaatt
      661 ctaattccag gagacgccta cacagactat gttgccacca ggtggtaccg agcccccgaa
      721 cttctcgtgg gagacacgaa gtacggttcc tctgtagacg tgtgggccgt cggctgtgtt
      781 tttgcagagc tcctgacggg tcagccactc tggccgggaa aatccgacgt ggaccagctt
      841 tacctgatca tcaggacgtt ggggaagctg attccaagac accagtctat ctttaggagt
      901 aaccagtttt tccgcggcat cagcatacct gaaccagagg acatggagac tcttgaagaa
      961 aaattctcaa atgttcagcc tgtggcttta agtttcatga agggatgcct gaagatgaat
     1021 cctgatgaga ggctgacctg tgcccagctg ctggacagtg cctactttga gtcttttcaa
     1081 gaggatcaaa tgaaaagaaa agcccgcagt gaggggagaa gccgaaggcg ccagcagaat
     1141 caactgctgc ctcttattcc tggaagccac atctccccca cacctgatgg aaggaaacaa
     1201 gtcgtccagt taaagttcga tcatcttcca aacatttagg ggactcatcc ttcccagcac
     1261 atccttttaa tattgtctac ataggaataa gacgggaatc ctcagcatct caaatacagt
     1321 gagcgacgtg aacaccaggg cacctctaat caccacgggc tcctcccctg tgctttttcc
     1381 acgccagctc catctcctaa aacattctct ttaaatgttg cagtatcaaa atggcacatc
     1441 cgaaagagat gcttccagtt tcaccagagc cgggcttcct caggcaatcg gtactgtgca
     1501 tctgtggact tatgctccga cctagggaaa gatttccacg tagccgtctc acttcagccg
     1561 accagtggtg tcctgaagca gacccagatc tgctggctgc tgtttgtgga ggggatggcc
     1621 ctgagccctc tcactggagt ttcttctccg tgcagccagg tcttacttta gactacattt
     1681 gtgttattgt ggcatggcaa tcgtgaaagg tggtctaggt ttacccttga ctccacagca
     1741 gatgctagtc tccttctcgt gaggagctga caagtctgct tctaaaacga actagagaaa
     1801 attccaaacg tgaccagtta gtggacagac tacaaggaat cgaccaccat accacagtaa
     1861 cgcccctgga tccctggctg cccacccact ctaaggctat cctggttcac catggtttct
     1921 ctttcttttc ttctttttta atctatttgt acatatgaga aagaggcaga ggggcgagag
     1981 aaacctcgtg tgtgaaaatc aaaagacaag caggaggcca gcctaagcta catagcaagg
     2041 ccttttctct acacccattc tctaaggttg cttaaaccca agtccctgct gctgattgta
     2101 taaactatga ataagttcta catatgtagg acatattgtt gtcattgttg aaatatctaa
     2161 ggatcttggt agaagcagaa gtgttctaaa tattctccac actggtgagt atcttggcat
     2221 ttcatttctg acctcatcac agatgaacac atcaaaggat gagtatgtat cactttgcat
     2281 cttagaattc tacctgtttt agctgcgtta aaccttgtga aagggcgggg ccataactga
     2341 acctgtggag ttcttgcctg tgtgcaggaa accctctggt tttgtctcca gcatggaaga
     2401 aaacagctat agtcacacct acctgaaagt agaaattcaa agtcactgtc cttgactaca
     2461 tatgcagtcc aaggccacgc tgggctacac ttctccaggc atgaaggtcc gtgtttgtat
     2521 caaggggcag gaaaggagag tccaaggtca aggccagccg aggctgcata gtgagttgag
     2581 gctcttcagc aaaagaaaag caaactaata ggagtcgttg aaggtagcca ccggccattt
     2641 ctctaaatat cattctgctg aaaagggggc ttagtttagt ttagaatgca ttaatgtatg
     2701 tagaagctgg gctatttcag attatttgaa attgtagcta ttgttaatta gcacttaata
     2761 actaactagc attatggtag tctaaactat tagagtttac tacaaagagg ttttgattga
     2821 attatattaa acatataata tggattttaa aaatttaaga tgtttaagaa agctatataa
     2881 agattaaaca tttttgtggc tgtatatttg tgtatatacc ttggttgttc tttaaattat
     2941 tttaataaaa gccagaaaca tttctgtctc ctaa
//
