LOCUS       NM_016912               4079 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cyclin dependent kinase like 2 (Cdkl2), transcript
            variant 1, mRNA.
ACCESSION   NM_016912
VERSION     NM_016912.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4079)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 4079)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4079)
  AUTHORS   Gomi,H., Sassa,T., Thompson,R.F. and Itohara,S.
  TITLE     Involvement of cyclin-dependent kinase-like 2 in cognitive function
            required for contextual and spatial learning in mice
  JOURNAL   Front Behav Neurosci 4, 17 (2010)
   PUBMED   20428496
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4079)
  AUTHORS   Sassa,T., Gomi,H. and Itohara,S.
  TITLE     Postnatal expression of Cdkl2 in mouse brain revealed by LacZ
            inserted into the Cdkl2 locus
  JOURNAL   Cell Tissue Res 315 (2), 147-156 (2004)
   PUBMED   14605869
  REMARK    GeneRIF: cdkl2 functions mainly in mature neurons and that
            mechanisms governing regulation of this gene expression in mice are
            distinct from those of immediate-early genes.
REFERENCE   6  (bases 1 to 4079)
  AUTHORS   Sassa,T., Gomi,H., Sun,W., Ikeda,T., Thompson,R.F. and Itohara,S.
  TITLE     Identification of variants and dual promoters of murine
            serine/threonine kinase KKIAMRE
  JOURNAL   J Neurochem 74 (5), 1809-1819 (2000)
   PUBMED   10800923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165433.5, CJ047658.1, AB029065.1, CD348339.1 and AB029066.1.
            
            On Jan 30, 2013 this sequence version replaced NM_016912.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as beta).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144574.1, AB029065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC165433.5         172461-172461       c
            2-24                CJ047658.1         1-23
            25-3984             AB029065.1         1-3960
            3985-4047           CD348339.1         401-463
            4048-4048           AB029066.1         3923-3923
            4049-4079           CD348339.1         465-495
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 45.73 cM"
     gene            1..4079
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /note="cyclin dependent kinase like 2"
                     /db_xref="GeneID:53886"
                     /db_xref="MGI:MGI:1858227"
     exon            1..244
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            245..443
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1982
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin dependent kinase like 2 (CDC2 related kinase)"
                     /codon_start=1
                     /product="cyclin-dependent kinase-like 2 isoform 1"
                     /protein_id="NP_058608.1"
                     /db_xref="CCDS:CCDS19426.1"
                     /db_xref="GeneID:53886"
                     /db_xref="MGI:MGI:1858227"
                     /translation="MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMV
                     KKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQV
                     VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTD
                     YVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCL
                     GNLIPRHQELFYKNPVFAGVRLPEVKDAEAEPLESRYPKLPEAVISLAKKCLHIDPDK
                     RPFCADLLRHDFFQMDGFAERFSQELQLKIEKDARNNSLPKKSQNRKKEKDDALGEER
                     KTLVVQDTNADPKIKDSKVFKVKGSKIDVEKMEKGSRASNANCLHDNGTNHKGLASTS
                     LRDCSNVNIDHSRNPGTAIPPLTHNLSAVAPGINAGMGTIPGVQNYRVDEKTKKYCNP
                     FVKPNQPPPAGIYNMNVSTSVSGEKYLLQANKKRKEYPKADVRLPELNYNHLPELRAL
                     EGIARNSRLIKKENKCLSESRIPSLAAIDLHVSSVASHQGAGSPLSDDSEADLPRMEH
                     QH"
     exon            444..638
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            639..817
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            818..930
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1076
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1165
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1295
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1591
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1685
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1809
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1916
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2005
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..4066
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3959..3964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /note="hexamer: AATAAA"
     polyA_site      3978
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /note="major polyA site"
     regulatory      4045..4050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="Cdkl2"
                     /gene_synonym="5330436L21Rik; KKIAMRE; Kkm"
ORIGIN      
        1 ggaacctccc cgggtggggc ccgcgccccg cagcgccccg ccgcgccgcg ggcgggcaag
       61 ctgggaaatc tcatggtctc ctcagtccca gcgaaccgtc accttggctc tcctcgtggc
      121 cactggggca acctgcggtc ccctgagagc agaggtctcc tggcgccggc agaaaggtcc
      181 ctacaaactt aagaccgtag gtgtggggac gaggccgtca gctgagcgaa cctgcgagct
      241 ccagcaagaa aaattcctac tggttttaaa gcaaaatgga gaagtacgag aacctaggat
      301 tggttggaga ggggagttac ggaatggtga tgaagtgtag gaacaaagac agtggaagaa
      361 ttgtggccat taagaagttc ctagaaagtg acgatgataa aatggttaag aagatcgcaa
      421 tgcgagagat caagttacta aagcaactgc ggcatgaaaa tttggtgaat ctgttggaag
      481 tatgtaagaa aaaaaaacgt tggtacctag tctttgaatt tgttgaccac acgattcttg
      541 atgacttgaa actctttcca aatggactag actatcaagt agttcaaaaa tatttgtttc
      601 agattattaa tggaattgga ttttgccaca gtcacaatat catacacaga gatataaagc
      661 ctgagaatat attagtctcc cagtctggcg ttgtaaaatt atgtgacttt ggatttgcac
      721 ggaccctggc ggctccaggg gaggtttaca ctgactatgt ggccacccgg tggtacagag
      781 ctccagaact gctggtcggt gacgtcaagt atggcaaggc tgtggatatc tgggccattg
      841 gttgtctggt cattgaaatg cttatggggc agccactgtt tccaggagaa tctgatattg
      901 atcagctaca tcatattatg acatgtttag gtaatttaat tccaagacac caggagctat
      961 tttataaaaa tcctgtgttt gctggagtaa ggttgcctga ggtcaaagat gcagaagcag
     1021 agcctcttga gagccgctat cctaagctcc ctgaagctgt gatcagttta gcaaagaaat
     1081 gcttgcacat tgacccagac aaaaggccct tctgtgctga ccttctgcgc catgacttct
     1141 ttcaaatgga tggatttgct gagaggtttt ctcaagaatt gcagttaaaa atagagaaag
     1201 atgccaggaa taattcttta cctaaaaagt ctcaaaacag aaagaaagaa aaagacgatg
     1261 ccttaggtga agaaagaaaa acccttgtgg tacaggatac caatgctgac cccaaaatta
     1321 aggattcaaa agtatttaaa gtaaaggggt caaaaattga tgttgagaaa atggaaaaag
     1381 gaagtagagc ttcaaatgcc aactgtctcc atgacaatgg gacaaaccac aaaggcttgg
     1441 cttccaccag cctcagagat tgcagcaatg tcaacattga tcactcaagg aacccaggca
     1501 cagcgattcc tcccctcaca cacaatcttt ctgcagttgc tcctggcatt aatgctggaa
     1561 tggggactat tcctggcgtt cagaattaca gagtggatga gaaaacaaag aaatactgta
     1621 atccatttgt taaaccaaat cagcctcctc cagcagggat ttataatatg aatgtgagca
     1681 catccgtctc aggtgaaaag tacctccttc aggcaaacaa gaaaaggaag gaatatccca
     1741 aagcagacgt gcggttgcct gaactaaact ataaccatct tcctgaactg agagctttag
     1801 aaggcatagc tcgaaattct aggctaataa agaaagagaa caaatgcctt tcagaatctc
     1861 gaattccctc tctggctgcc attgatctgc acgtgtccag tgttgcatca caccagggag
     1921 caggatcacc cctgtcagat gattctgagg ctgatttgcc tcggatggaa caccaacact
     1981 gagactcatt ttaatcctga acaggatgct gccagccctg gagatgacgt cctcttgcac
     2041 gagagcactg ataccctaga ggagatctgc agtttgactg tttccttctg gaaacctatg
     2101 ctttctaaga aaggctttgt agaagaaggg aagacagact tccaaagact tcaaaggaag
     2161 attgaacaag tgccccttca cctttccaac ctatgatgct atttcaagat atatccatgg
     2221 aacaacagtg acatggttat tgttacatga atgtgtattt gatattagta gattgtgtat
     2281 ttaaagttat atgagattaa aagtcagtaa aaaaaggaga gaatcattat aaaaggtcat
     2341 gattttatgc attgaacttt gtgtattatc tatataaatg tttacagatg aaaatgaaaa
     2401 aaagctagga tctgtaagag aaaagtttcc tttaccttaa ctataagaac acattttaaa
     2461 agtttgctta tgggcatgag agtagtgtaa gactgtggtc gggcgggtta gacgtgcgtc
     2521 tttgtttcct gtcattgtcg actgacttgt ctctacagat ctaagatctg tgctattgca
     2581 aatctgccag agaacccttg tttctaatga ctgtgctgtt ggctagtctt ctgtactgag
     2641 agattctggt gctaatgttc tgcatgaaag gacaaggtgg gggtggtgtg gggagagttt
     2701 tgtgggtaca ccgttgagtg aagaactttt tctccttgag gaaaaacgta taaaatataa
     2761 aaataagaga tgggtgcaga gctgcctggc agtctgtctg gttctcctgg ctaggccagt
     2821 tgccactgag tcactcaacc aaagaggctt ttggaggctt tgatggagtc cactcttgtc
     2881 tctgatagtt tgaggttgat agtggacaaa ccacagaagt tcctattgcc ctgttacctc
     2941 agatacttag ccttacccca aagcctttta ccaaggtggg aagtcatcat gtgtgctcca
     3001 catatgcttt ctgatgtata ggtttaaaac ctttcaggca ggaggattag gccattttga
     3061 ttccagggtc tcagtgtctg tgtttccagc catgctcctc attgatcatt tgggaaaata
     3121 gctgttcagg ggcccatatt tgtgtagtgt ttttgcatta gccaactaat gggatctttt
     3181 ttctttttta agctgttgac tagaacttag cctaagaatt gaacaagaat tcttcattct
     3241 gctgagggaa gtaaaaataa aatcgtaaac ttggacactt ggagtagaca ttcaggatga
     3301 ggcaaaataa agggttctaa cataaaacaa atctgttggt aatagttgaa taaatgttga
     3361 tttttattca aaagctgtat tttaaacctg tgaccaaggg tttgcctaga ttagtaagac
     3421 taatatgctg ataaaactca ctgtgtcagt agtaataggc tttctactaa aataccacta
     3481 tttattgtta ttttgaaaat attgccagca gctagcagcg tggggaggag acagtactcg
     3541 aagctgattg gcacccagct agtttcaggg ctgttctcat gtaaaggccg acgtgagaat
     3601 atcagcctga caacggaggg actgcgtcag ctaccttata atgtgcagtc ttgagtttgc
     3661 tatctttggc ctattaagat actttatgaa ctttacagtt aaaagattaa aaatcatttc
     3721 ttaagtcctt attgatatct gaagatcata ttttgttaga ccttggtgag gaactaaaga
     3781 agtcaatgct gttcagatga agtctctagg taccaaacca acatgttctc ttttatcaat
     3841 gctcgggtgt ttagtctctt ctcacaggga tgtgctttat gtaaacatgc taatgtgaaa
     3901 tcagttcatg tacttttgga gaccgtgggc ttgctgtgcc cacctgtgtt ttaaaattaa
     3961 taaatattgt ctaactaagc acgatatatg gctttaattc atattaagag attataagta
     4021 atatacatac cagtgtatgg tactaataaa taaaattgaa atagttaaaa aaaaaaaaa
//
