LOCUS       NM_130860               3389 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus cyclin dependent kinase 9 (Cdk9), mRNA.
ACCESSION   NM_130860
VERSION     NM_130860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Xia,J., Zhang,T., Sun,Y., Huang,Z., Shi,D., Qin,D., Yang,X.,
            Liu,H., Yao,G., Wei,L., Chang,X., Gao,J., Guo,Y. and Hou,X.Y.
  TITLE     Suppression of neuronal CDK9/p53/VDAC signaling provides
            bioenergetic support and improves post-stroke neuropsychiatric
            outcomes
  JOURNAL   Cell Mol Life Sci 81 (1), 384 (2024)
   PUBMED   39235466
  REMARK    GeneRIF: Suppression of neuronal CDK9/p53/VDAC signaling provides
            bioenergetic support and improves post-stroke neuropsychiatric
            outcomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Sun,J., Yang,T., Wei,T., Zhou,L., Shan,T., Chen,J., Gu,L., Chen,B.,
            Liu,L., Jiang,Q., Du,C., Ma,Y., Wang,H., Chen,F., Guo,X., Ji,Y. and
            Wang,L.
  TITLE     CDK9 binds and activates SGK3 to promote cardiac repair after
            injury via the GSK-3beta/beta-catenin pathway
  JOURNAL   Front Cardiovasc Med 9, 970745 (2022)
   PUBMED   36082129
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Wang,S., Wang,L., Hu,H. and Dong,P.
  TITLE     MiR-224 ameliorates inflammation and symptoms in mouse model of
            allergic rhinitis by targeting CDK9
  JOURNAL   Allergol Immunopathol (Madr) 49 (6), 80-88 (2021)
   PUBMED   34761662
  REMARK    GeneRIF: MiR-224 ameliorates inflammation and symptoms in mouse
            model of allergic rhinitis by targeting CDK9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Akter,S., Sharma,R.K., Sharma,S., Rastogi,S., Fiebich,B.L. and
            Akundi,R.S.
  TITLE     Exogenous ATP modulates PGE2 release in macrophages through
            sustained phosphorylation of CDK9 and p38 MAPK
  JOURNAL   J Leukoc Biol 110 (4), 663-677 (2021)
   PUBMED   33438260
  REMARK    GeneRIF: Exogenous ATP modulates PGE2 release in macrophages
            through sustained phosphorylation of CDK9 and p38 MAPK.
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Barroco,R.M., De Veylder,L., Magyar,Z., Engler,G., Inze,D. and
            Mironov,V.
  TITLE     Novel complexes of cyclin-dependent kinases and a cyclin-like
            protein from Arabidopsis thaliana with a function unrelated to cell
            division
  JOURNAL   Cell Mol Life Sci 60 (2), 401-412 (2003)
   PUBMED   12678503
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Napolitano,G., Licciardo,P., Carbone,R., Majello,B. and Lania,L.
  TITLE     CDK9 has the intrinsic property to shuttle between nucleus and
            cytoplasm, and enhanced expression of cyclin T1 promotes its
            nuclear localization
  JOURNAL   J Cell Physiol 192 (2), 209-215 (2002)
   PUBMED   12115727
  REMARK    GeneRIF: CDK9 has the intrinsic property to shuttle between nucleus
            and cytoplasm, and enhanced expression of cyclin T1 promotes its
            nuclear localization.
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Simone,C., Stiegler,P., Bagella,L., Pucci,B., Bellan,C., De
            Falco,G., De Luca,A., Guanti,G., Puri,P.L. and Giordano,A.
  TITLE     Activation of MyoD-dependent transcription by cdk9/cyclin T2
  JOURNAL   Oncogene 21 (26), 4137-4148 (2002)
   PUBMED   12037670
  REMARK    GeneRIF: role in activating MyoD-dependent transcription
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Bagella,L., Stiegler,P., De Luca,A., Siracusa,L.D. and Giordano,A.
  TITLE     Genomic organization, promoter analysis, and chromosomal mapping of
            the mouse gene encoding Cdk9
  JOURNAL   J Cell Biochem 78 (1), 170-178 (2000)
   PUBMED   10797576
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Bagella,L., MacLachlan,T.K., Buono,R.J., Pisano,M.M., Giordano,A.
            and De Luca,A.
  TITLE     Cloning of murine CDK9/PITALRE and its tissue-specific expression
            in development
  JOURNAL   J Cell Physiol 177 (2), 206-213 (1998)
   PUBMED   9766517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143217.1 and AL772271.11.
            
            On Nov 24, 2007 this sequence version replaced NM_130860.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143217.1, AK144607.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1730              AK143217.1         2-1731
            1731-3389           AL772271.11        120644-122302       c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..3389
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /note="cyclin dependent kinase 9"
                     /db_xref="GeneID:107951"
                     /db_xref="MGI:MGI:1328368"
     exon            1..220
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            221..302
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            303..393
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            394..560
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            561..732
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            733..881
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     exon            882..3389
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1704..1709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /note="hexamer: ATTAAA"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /note="hexamer: AGTAAA"
     polyA_site      1733
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
                     /note="major polyA site"
     polyA_site      1754
                     /gene="Cdk9"
                     /gene_synonym="PITALRE"
ORIGIN      
        1 ggaagtggcc gtggaggcgg aagtggcgcg gccgcggagg ggcctggagt gtggcgggac
       61 cgggagcggc gggagctgcg gctgggggcg gcggcggcgg cggcggcgga ggcgcgctgg
      121 aggtggccat ggccaagcag tacgactcgg tggaatgccc gttctgcgat gaggtcacca
      181 agtacgagaa acttgccaag atcggccaag gcacattcgg ggaagtcttt aaagccaagc
      241 accgtcagac gggccagaag gtggctctga agaaagtgtt gatggagaat gagaaggagg
      301 ggttccccat cacagccttg agggaaatca agattctaca gctcctaaaa catgagaatg
      361 tggtgaacct aattgagatt tgtcggacca aagcctcacc gtataaccgc tgcaagggca
      421 gcatctatct ggtgtttgac ttctgtgagc atgaccttgc tgggctgctg agcaacgtct
      481 tagtcaagtt cacgttgtct gagatcaaga gagtgatgca gatgctgctg aacggcctct
      541 actacatcca caggaacaag atcctgcaca gggacatgaa ggctgcgaat gtgctcatta
      601 cccgggatgg ggtcctgaag ctggcagatt ttgggctggc ccgtgccttc agcctagcta
      661 agaatagcca gcccaaccga tacaccaacc gtgtggtgac attgtggtac cggcctccgg
      721 agctgctgct cggagagcgg gactacggcc cgcccattga cctttggggt gctgggtgca
      781 tcatggcaga gatgtggact cgtagcccta tcatgcaggg taacacagag cagcaccagc
      841 tcgccctcat cagccagctc tgtggctcca tcaccccaga ggtgtggcca aacgtagaca
      901 agtatgagct gtttgaaaag ctggaacttg tgaagggcca gaagcggaag gtgaaggacc
      961 gtctgaaggc ctacgtgcgc gacccctatg ctctggacct cattgacaag ctgctggtgc
     1021 tggaccccgc gcagcggatt gacagtgacg atgccctcaa ccacgacttc ttctggtcgg
     1081 accccatgcc ctcggacctc aagggcatgc tgtctactca cttgacgtct atgtttgagt
     1141 acctggcacc gccacggcgg aagggcagcc agatcaccca gcagtccacc aaccagagca
     1201 gaaatcccgc caccaccaac cagacggaat ttgaacgtgt cttctgaggc cggaactggc
     1261 cggtgttgtt cttaggttag gagtggattg cttcctttgc atggaacatg tgacatgatg
     1321 ggacatttga gattttctcc tccagtacat attaactccc accctggcac tgggaacagc
     1381 tgcctgagtg ggctggggtg gagctatcct gcctgcccct ctctggaggt ctcagcgtgg
     1441 acacaaagtg aggtgggaga ggctcaccca ctgtgacttt ctaagaacta cttgcatggt
     1501 gggaggaagg cacaggtccc tcgccatcgc cagctcttcc tctggatgag agtttgaggg
     1561 acagaggcgc ctccaaaatg ggctactttt ggtctggacc ttaggggcgt ggggctgtgt
     1621 gaactcctgg ttcctttaaa aggagaattt tattttgttt tgttaagttt agagacattc
     1681 ctggacgcag tttgattggt taaattaaaa gttggttatt tttttccagt aaatggctgc
     1741 gtttcctgtg ttcagacctt ccctcagctc ttgtctcagc tagaagctag ggtttggtca
     1801 gccaggacac tgccagttct tctgtaccac ccaacactct ggagacgttc agggtttgcc
     1861 ctcttctcct cctgggtacc ttccactgcg ctcttcaccc ccgctgaagg cgtgtccacg
     1921 gtgccagtgt cctgtgcttg gtgttggcaa gtgctgtaag ctgagctgga gtgagctgct
     1981 ggacccgggc tgctttggct cctaaatcct cagactggac tcataagcag ggcactgcag
     2041 ccttacagtc atggagtgac aagtgtagcc tgtagctcca gggcttgggg gaagcaggac
     2101 agaagtggcc agagtggggt caggtggcat gggttggggt gagggcagga tggaaggcca
     2161 gtgtggagat gggatggtcc taaggatgca gggtagggac ccttagggca ctgacctagg
     2221 cggtagattc cccaagagtt tcctggagtc ttctcacaga gctgcctgaa aaggacagtt
     2281 ttagtccgct agctagctct gggagctgat acagtacttg gcctgtgatt ttgtattttc
     2341 ttttttcctt gcatgtttat gctcttatgt attcctggta cccagggagg ccagaagagg
     2401 gctgattccc tggaactgga gttaaaggtg gttgtgcgct gctgccgtgt atgtgctggg
     2461 aattgaacca ggatcctctg gatttgcagc tagaactttt aaccatgcag ccatctctca
     2521 gccctttatt ttgagacaaa gctgtcatgt agactaggat gtccagaact gcaggtctcc
     2581 ctgcttcctc ctttatttag ggagctaggg ttacaggtgt gcgccatcac ttacacagca
     2641 atcttggtcc tggaaaccat ccgtcagcat cttctgtgta tgtatctgtg aggatatctg
     2701 tcgttgggtt tactgcccgg gataatccca tcttaatcag ttatgtctgc ggagactgtc
     2761 tccccgtaag gccacgtgct tagggcatga ttggagagga cattattcaa cccgctatag
     2821 cgagaactta gaaaagtctt tgtggctacc agcaggtttc aaatgctcag tggcatgaag
     2881 acaaactaat agagctgttc tgtttcagaa tatctcccct gaagtattca aggaattcag
     2941 ccctttgcta gagattgaac ccagaaccgg gtaagtgctc taccactgag ccacgcccag
     3001 tctcagggtt tgtattcact gactccctcc gcagcttcct ggaagtcact gtgtataata
     3061 gatttattgt tggatttaga cttcaccata gcccagggga ctttctccag tcgccatttt
     3121 ccggttaagt ttcatggctg ggaattcagg ctctagtagg ttccaattaa ttactctgat
     3181 ggagtagagt ccattagaag tgaaggcctg gggctggaga gatggctcag cagctaagag
     3241 cactgactgc tcttctggag gtcctgagtt caaattccag caaccacatg gtggctcaca
     3301 accatctgta atgagatctg atgccctctc tggtatgtct gaagacagct acagtgtact
     3361 tactatgtgt gataataaat aaatctttc
//
