LOCUS       NM_153599               3011 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus cyclin dependent kinase 8 (Cdk8), transcript variant
            1, mRNA.
ACCESSION   NM_153599
VERSION     NM_153599.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3011)
  AUTHORS   Halter,K., Chen,J., Priklopil,T., Monfort,A. and Wutz,A.
  TITLE     Cdk8 and Hira mutations trigger X chromosome elimination in naive
            female hybrid mouse embryonic stem cells
  JOURNAL   Chromosome Res 32 (4), 12 (2024)
   PUBMED   39390295
  REMARK    GeneRIF: Cdk8 and Hira mutations trigger X chromosome elimination
            in naive female hybrid mouse embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3011)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3011)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3011)
  AUTHORS   Li,J., Bai,Y., Liu,Y., Song,Z., Yang,Y. and Zhao,Y.
  TITLE     Transcriptome-based chemical screens identify CDK8 as a common
            barrier in multiple cell reprogramming systems
  JOURNAL   Cell Rep 42 (6), 112566 (2023)
   PUBMED   37235474
  REMARK    GeneRIF: Transcriptome-based chemical screens identify CDK8 as a
            common barrier in multiple cell reprogramming systems.
REFERENCE   5  (bases 1 to 3011)
  AUTHORS   Prieto,S., Dubra,G., Camasses,A., Aznar,A.B., Begon-Pescia,C.,
            Simboeck,E., Pirot,N., Gerbe,F., Angevin,L., Jay,P., Krasinska,L.
            and Fisher,D.
  TITLE     CDK8 and CDK19 act redundantly to control the CFTR pathway in the
            intestinal epithelium
  JOURNAL   EMBO Rep 24 (2), e54261 (2023)
   PUBMED   36545778
  REMARK    GeneRIF: CDK8 and CDK19 act redundantly to control the CFTR pathway
            in the intestinal epithelium.
REFERENCE   6  (bases 1 to 3011)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22. PMID: 36255214]
REFERENCE   7  (bases 1 to 3011)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   8  (bases 1 to 3011)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 3011)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3011)
  AUTHORS   Ahuja,H.S., Zhu,Y. and Zakeri,Z.
  TITLE     Association of cyclin-dependent kinase 5 and its activator p35 with
            apoptotic cell death
  JOURNAL   Dev Genet 21 (4), 258-267 (1997)
   PUBMED   9438340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113316.14.
            
            On Jan 24, 2018 this sequence version replaced NM_153599.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1009534.1,
                                           SRR11927938.3818702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AC113316.14        98766-99336         c
            572-647             AC113316.14        71006-71081         c
            648-758             AC113316.14        62261-62371         c
            759-899             AC113316.14        58851-58991         c
            900-957             AC113316.14        46900-46957         c
            958-1089            AC113316.14        44347-44478         c
            1090-1233           AC113316.14        37819-37962         c
            1234-1303           AC113316.14        35354-35423         c
            1304-1376           AC113316.14        34155-34227         c
            1377-1474           AC113316.14        31686-31783         c
            1475-1553           AC113316.14        31010-31088         c
            1554-1712           AC113316.14        30736-30894         c
            1713-3011           AC113316.14        27712-29010         c
FEATURES             Location/Qualifiers
     source          1..3011
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 85.19 cM"
     gene            1..3011
                     /gene="Cdk8"
                     /note="cyclin dependent kinase 8"
                     /db_xref="GeneID:264064"
                     /db_xref="MGI:MGI:1196224"
     exon            1..571
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            572..647
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            648..758
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            759..899
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            900..957
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1089
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1233
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1303
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1376
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1474
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1553
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1712
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..3011
                     /gene="Cdk8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk8"
                     /note="hexamer: AATAAA"
     polyA_site      2973
                     /gene="Cdk8"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk8"
                     /note="hexamer: AATAAA"
     polyA_site      3011
                     /gene="Cdk8"
                     /note="major polyA site"
ORIGIN      
        1 ggaggagcta ccggctgttg tgtggcgtcg ctggtctgtc cgggcggatg gcagcctgag
       61 tgttcgtgag cgcgtgtggg agaaggtgag gcgcggacgc gcgtgggcga ggagcagagt
      121 cagccgtggc cgccccgcgt cgcacccgca gcagcacgcg cggccaaccg cgcgcgagcc
      181 ggcgccccgg gagcgcgggg acaagggcgg acgctgctcc ccgcccccag cgcgtccctc
      241 ggctgtcgcg cgcccgcggg gaccgcccgg cgctcccctg gatgtccccg gcgcccgcgc
      301 ggggcctcct gccgtcgcct cgtgaggcgg gctggtgctg cggccggcgg gtgtagctcg
      361 ggggctgcgg ctgctgcgcg gcccggtccc caccgcggcc ctcggccccc cgccccagca
      421 ccccggcctt ggaggctgtg acaatggact atgactttaa agtgaagctg agcagcgagc
      481 gggagcgggt cgaggacctg tttgaatacg agggctgcaa agttggtcga ggcacttacg
      541 ggcacgtcta caaggcgaag aggaaagatg ggaaggacga taaagactac gctttaaaac
      601 aaatagaagg aactggaatt tctatgtcgg catgcagaga gatagcatta ctccgagagc
      661 ttaagcaccc aaacgtcatc tcccttctga aggtgtttct gtctcatgct gatcggaaag
      721 tatggcttct ctttgactat gctgagcatg acctctggca tataattaag tttcacagag
      781 cttcgaaagc caacaagaag ccagttcagt tacctcgggg aatggtgaag tcactgttgt
      841 accagatcct agatgggatt cactatcttc atgccaactg ggtgttgcac agggatttga
      901 aacctgctaa tattttagtt atgggtgaag gtcctgagcg aggaagagta aaaattgctg
      961 acatgggctt tgcccgatta tttaattcac ctttgaagcc tttagcagat ttggatccag
     1021 tggttgtaac attctggtac cgagctccag aattactcct cggagcgcga cattatacca
     1081 aagcaattga tatttgggct atagggtgta tatttgcaga actactaacg tcagaaccaa
     1141 tatttcactg tcgacaagag gacatcaaaa ctagtaatcc ttatcaccat gaccagctgg
     1201 acagaatatt caatgtaatg ggattccctg cagataaaga ttgggaagat ataaaaaaga
     1261 tgcccgaaca ttcaacatta atgaaagatt tcagaagaaa tacgtatacc aattgcagcc
     1321 ttatcaagta tatggaaaag cataaagtta aacccgatag taaagcattc cacttgcttc
     1381 agaagttgct cactatggac ccaataaagc gaattacctc agagcaggcc atgcaggacc
     1441 cctacttcct agaagaccca cttcccacgt cagatgtttt cgccggttgt cagatcccat
     1501 atcccaaacg agaattttta acagaagaag agcctgatga gaaaggagac aaaaagaccc
     1561 agcagcagca gcagggcaac aaccacacta acggaactgg ccatccgggg aaccaggaca
     1621 gcggccacgc acaggggccc cccttgaaaa aagtgagagt tgtccctcct accactacct
     1681 caggtggact catcatgacc tccgactatc agcgttccaa tccacatgct gcttatccca
     1741 accctggacc aagcacatca cagccccaga gcagcatggg atactcagct acctcccagc
     1801 agcctccaca gtactcacat cagacacatc ggtactgagc tgtgctggag tctgtcagtg
     1861 cactgttgct catgctgcag gactggctgc ggcactcgcg ggaacctggt gtgggccatg
     1921 cgaatgtact gtacaaccac atcttcacaa tgtccagtag ccgagttcca ccagttgtca
     1981 cagattgggg tggtagcttc caggttgtac ctaagtttgg agttagactt gaaatgaaag
     2041 tgctagcaca gttgtgttgt gggtttgcta cttccatagt ttacttgaca tggttcagac
     2101 tgaccaagca tagttttcag tgacagtctg tagcagttga agctgtgaaa tgtgctaggg
     2161 cgagcatttg tcctcgtgtg tggtgacttt gagtgtaaca gcgtgatctg accaatagta
     2221 cacacagacg caaggtttaa ctggtacttg aaacacagat tatgttaaca aaataaccaa
     2281 gatttaaaga ttattttggt acacctttct ttttagtgtc ttatcagtgg gttgattcat
     2341 cttctacata aatcagtgtt ttatgaccaa gaatattgct tggattgttt tgaaagtaca
     2401 aaagaaccac atagtttcta ctgacaggtt tcagagctcc caaagattaa tttccaactt
     2461 agaggtttgt ttttattttc aacctatgac gacttgactg gtcttaaagc tgctatttga
     2521 tagtaattaa atatgttgtc attgatagaa gcctgttggt tcagcaaact gaaatgagtg
     2581 ttgcagacag ggttttcttt tcctcgttgg tgttgctgat ttgtgagcat gctttctgaa
     2641 tacaaaagca tgagtggcga cctccgtgag gcacggtgac ctcctcgagg cacggtgacc
     2701 tctgcgaggc acggcgtcag tccgcactct tctgtcctga tttgaagctg cctagtgtag
     2761 tgctattaca attttgttca gttaactttc tttttaaaag gttgttcgca catttttagg
     2821 gtgcccttac ttcagcaaag gagagggagt aggagagcct tagaactttt gaggggaaaa
     2881 taaaaagcta taacatacaa cgtactgtat caaactattt tacatgaatg acacaagtat
     2941 tctgaataaa aaaaaattga acattgttaa aaacaaggtg ttatgtaata aatttatttt
     3001 tcataaatca a
//
