LOCUS       NM_009873              11534 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cyclin dependent kinase 6 (Cdk6), mRNA.
ACCESSION   NM_009873 NM_001312879
VERSION     NM_009873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11534)
  AUTHORS   Dinakaran,S., Qutaina,S., Zhao,H., Tang,Y., Wang,Z., Ruiz,S.,
            Nomura-Kitabayashi,A., Metz,C.N., Arthur,H.M., Meadows,S.M.,
            Blanc,L., Faughnan,M.E. and Marambaud,P.
  TITLE     CDK6-mediated endothelial cell cycle acceleration drives
            arteriovenous malformations in hereditary hemorrhagic
            telangiectasia
  JOURNAL   Nat Cardiovasc Res 3 (11), 1301-1317 (2024)
   PUBMED   39487364
REFERENCE   2  (bases 1 to 11534)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11534)
  AUTHORS   Mayer,I.M., Doma,E., Klampfl,T., Prchal-Murphy,M., Kollmann,S.,
            Schirripa,A., Scheiblecker,L., Zojer,M., Kunowska,N., Gebrail,L.,
            Shaw,L.E., Mann,U., Farr,A., Grausenburger,R., Heller,G.,
            Zebedin-Brandl,E., Farlik,M., Malumbres,M., Sexl,V. and Kollmann,K.
  TITLE     Kinase-inactivated CDK6 preserves the long-term functionality of
            adult hematopoietic stem cells
  JOURNAL   Blood 144 (2), 156-170 (2024)
   PUBMED   38684032
  REMARK    GeneRIF: Kinase-inactivated CDK6 preserves the long-term
            functionality of adult hematopoietic stem cells.
REFERENCE   4  (bases 1 to 11534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 11534)
  AUTHORS   Hu,A.J., Li,W., Dinh,C., Zhang,Y., Hu,J.K., Daniele,S.G., Hou,X.,
            Yang,Z., Asara,J.M., Hu,G.F., Farmer,S.R. and Hu,M.G.
  TITLE     CDK6 inhibits de novo lipogenesis in white adipose tissues but not
            in the liver
  JOURNAL   Nat Commun 15 (1), 1091 (2024)
   PUBMED   38316780
  REMARK    GeneRIF: CDK6 inhibits de novo lipogenesis in white adipose tissues
            but not in the liver.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11534)
  AUTHORS   Quelle,D.E., Ashmun,R.A., Hannon,G.J., Rehberger,P.A., Trono,D.,
            Richter,K.H., Walker,C., Beach,D., Sherr,C.J. and Serrano,M.
  TITLE     Cloning and characterization of murine p16INK4a and p15INK4b genes
  JOURNAL   Oncogene 11 (4), 635-645 (1995)
   PUBMED   7651726
REFERENCE   7  (bases 1 to 11534)
  AUTHORS   Chan,F.K., Zhang,J., Cheng,L., Shapiro,D.N. and Winoto,A.
  TITLE     Identification of human and mouse p19, a novel CDK4 and CDK6
            inhibitor with homology to p16ink4
  JOURNAL   Mol Cell Biol 15 (5), 2682-2688 (1995)
   PUBMED   7739548
REFERENCE   8  (bases 1 to 11534)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 11534)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
REFERENCE   10 (bases 1 to 11534)
  AUTHORS   Ershler,M.A., Nagorskaia,T.V., Fisser,Ia.V. and Beliavskii,A.V.
  TITLE     [Identification of new protein kinase genes, similar to kinases of
            the cdc2 family and expressed in murine hematopoietic stem cells]
  JOURNAL   Dokl Akad Nauk 324 (4), 893-897 (1992)
   PUBMED   1459009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026478.5, AK078973.1,
            AC090443.4 and BQ176468.1.
            
            On or before Aug 25, 2015 this sequence version replaced
            NM_001312879.1, NM_009873.2.
            
            Summary: This gene encodes a member of the cyclin dependent kinase
            family of proteins that play important roles in the progression and
            regulation of the cell cycle. The encoded protein binds to a D-type
            cyclin to form an active kinase complex to regulate progression
            through the G1 phase of the cell cycle. Mice lacking the encoded
            protein exhibit thymic and splenic hypoplasia, and hematopoietic
            defects such as reduced number of megakaryocytes and erythrocytes.
            A pseudogene of this gene has been defined on chromosome 4.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154197.1, SRR7345562.3778509.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC026478.5         14018-14096         c
            80-162              AC026478.5         13788-13870         c
            163-1966            AK078973.1         2-1805
            1967-10985          AC090443.4         129449-138467       c
            10986-11534         BQ176468.1         1-549               c
FEATURES             Location/Qualifiers
     source          1..11534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.04 cM"
     gene            1..11534
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /note="cyclin dependent kinase 6"
                     /db_xref="GeneID:12571"
                     /db_xref="MGI:MGI:1277162"
     exon            1..79
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..560
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1308
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 6;
                     serine/threonine-protein kinase PLSTIRE; CR2 protein
                     kinase"
                     /codon_start=1
                     /product="cyclin-dependent kinase 6"
                     /protein_id="NP_034003.1"
                     /db_xref="CCDS:CCDS19062.1"
                     /db_xref="GeneID:12571"
                     /db_xref="MGI:MGI:1277162"
                     /translation="MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR
                     VRVQTSEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD
                     QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK
                     LADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPL
                     FRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL
                     LLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLNSHLPSNQSTSELNTA"
     exon            561..696
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            697..864
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..974
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1025
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1161
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..11525
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1586
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
     regulatory      7133..7138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /note="hexamer: AATAAA"
     polyA_site      7154
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
     regulatory      11499..11504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /note="hexamer: AATAAA"
     polyA_site      11525
                     /gene="Cdk6"
                     /gene_synonym="Crk2"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgctgc gctcatcccc gaggggcccc agcaacctct ccttcgtgaa gactgcacga
       61 gccctgctgt ggaagaaaag tgcagagatt gtgggcagac tatgtaatcg ctgcggaggg
      121 ggaagaggag ggatcggcgc tctcctgcgg cggcggcgcg gcgactcggc taggcggagt
      181 ttcgcagcgg ctgcgcccgg cttgcacccg cgggcgagaa ggtcggtccg tctagcccgg
      241 cggccgcgag tccgactccc cgaggcgtgt aaggcagcga gtgagcaccc cggttccact
      301 gtgccgcacc cgcagcctga agccagcatg gagaaggaca gcctgagtcg cgccgatcag
      361 cagtatgagt gcgtggcgga gatcggcgaa ggcgcctatg ggaaggtgtt caaggcccgc
      421 gacctgaaga acggcggccg cttcgtggct ctgaagcgcg tgcgagtgca gaccagtgag
      481 gagggcatgc cgctctccac catccgcgag gtggcggtgc tgaggcacct ggagaccttc
      541 gagcacccca acgtggtcag gttgtttgat gtgtgcacag tgtcacggac ggacagagaa
      601 accaagctta cactagtgtt tgagcatgtt gatcaagact tgaccactta cttggataaa
      661 gttccagagc ccggcgtacc cacagaaacc ataaaggata tgatgtttca gcttctccga
      721 ggtctggact ttcttcattc tcacagagta gtgcatcgtg atctgaaacc gcagaacatt
      781 ctggtgacca gcagtggaca gataaagctg gctgactttg gccttgcccg catctatagt
      841 tttcagatgg cccttacctc ggtggtcgtc acgctgtggt accgagcccc agaagtcctg
      901 ctccagtcca gctatgccac ccctgtggac ctctggagtg tcggttgcat ctttgcagaa
      961 atgtttcgca gaaagcctct ttttcgtgga agttcagacg tggatcaact aggaaaaatc
     1021 ttggacatca ttggactccc aggagaggaa gactggccta gggacgtggc ccttccccgg
     1081 caggcttttc attccaaatc tgctcaaccc atcgagaagt ttgtgacaga tattgacgaa
     1141 ctaggcaaag acctacttct gaaatgcctg acgtttaatc cagctaaaag gatatccgcc
     1201 tacggcgccc tgaatcaccc gtacttccaa gatctggaga gatacaagga caacctgaac
     1261 tctcacctgc catccaacca gagcacctcg gagctgaaca cagcctgagg ttccacgggg
     1321 atgcccatga gctcgtcatc tgaacacatt ggcggctgcg agtcccctaa gcaagcctct
     1381 cagagcagtt gaagattgct ggctgccaac cttctggctg ccagcttctg ggtgggctct
     1441 gccttaccaa ggaaaccacc tagtttactg ttcagagatc aatgcaaggg tgattgcagc
     1501 tttatgttcg tttgtacact tgtttgtttt gtctgtttgt ttcaagaacc tggaaaactt
     1561 ccagaagaag agaagctgct gaccaattgt gctgccattt cgttttctaa ccttgaatgc
     1621 tgccagtgta gggtgggaat ccaggcccag ctgagttatg atgtaatccg cctgcagctg
     1681 ctgggcctgc tttggtactt gtgagtgtgt gtgcatgcgt atgtgtgtgt aagagagaag
     1741 aggaggggag agaaagaccc ctgatctcgt caagtgttac tttttttttg tagaaaacaa
     1801 gaataattga gttttaaaga gtagaggtga ctgatagtaa gaagggcttg ttcagtgaaa
     1861 ggtgattcac aatggagtct tgttaggaag gttggaccta agtcctcaga gttgccttcc
     1921 tgtccaaaag cttttgctag cagtaaacaa taaaggttta gatgccacaa aaaatggggg
     1981 gaaccacaat attttttaag agacttttta aggcatacat cttctattta ctctttggaa
     2041 agctgaactt aatgtgtccc aggccctata tatagtacag tatgtactta attgtttctt
     2101 tggggaaaga tgctataagt atcttattac ttgcaataca tttaaggagt gagtgtacct
     2161 cagataggtt ttaaagatag agagcacctg ttttctggtg tgagatgtta tcattttctt
     2221 cacgtctctt gataccttga taccttgtca ccttagggaa tcacttcctg ctctgactag
     2281 aggcgggaat accatctagc tgtctccacc acccaccatg gcgcatctgc cttgtgctgc
     2341 cttgtgtagt gcgaagctct caaccaccag cacttctaat tcattttcct gccactgcct
     2401 ggctaacgac agatggccca gctgccccaa tcccacaccc gcttgcacgc ttaccgtctt
     2461 tcaccgaatg ctttgggcgt aggctcccat tccgaaaccc taacagtatc cccttgtgcc
     2521 tttgtaatac agtcttcccc ctgccgcagc tgaggtcacc taggcagtga agagtgcttg
     2581 ttctgtgtgt gtatagacta ctaccgactg tcacttggtg tttcctatct ttaagtgtat
     2641 gttgtcagtg taatgtctga ggaaatgtct tttcctctct tctagagata actacttact
     2701 ctctaaagtg atctctctgt ctgtccgcag gatgtgtttc tgggtttttg ttcttttttt
     2761 tttttttttt ttttttttgt ctgaggcctc atgtcagccc tgctttctgc agagccagcc
     2821 taccctgggc attataaaca actgtacctt actgttttct ttcagtcctt tacattctgt
     2881 gccacctttg ccttattata tccgtggctt agtgctaagc tggcactact ccatagaagg
     2941 tgtagaaggc agctttcggg aagcgtagct gagttttgtt tgaatcgtgt ttgagcacat
     3001 ttaagtaaac gctagatgat gcttcactgt agagctttga aagactgcct gatgtttcac
     3061 acggcagtgt aggctccaga tggtgtttgt atgttatgga ccttactgtg tttctcgtag
     3121 ctgaacaatg catgtggtta tttgtttgtt tgttttttgg tttctctgtg tagccctggc
     3181 tgtcctggaa ctcactctgt agaccaggct ggcctcgaat tcagaaatgc gcctgcctct
     3241 gcctcccaag tgctgggatc aaaggcgtgc gccaccacgc ccggctttgc atatggttat
     3301 ctgtatggag aagaattaga tgtctttcct gagagctttg gaggttggga atcatcttct
     3361 tctgtttatt tttattttta acattacatt acattcttct gattcagtat cgcaagaaag
     3421 gattttttct tttttcaaaa acaaaacttt aagaagccag aggctaggct gagaatgttc
     3481 tgcgctcgtc ctcacagctc tgctgccgac actgccaacg ctcgagacag tcagcctgga
     3541 acctctggga caaggtctac tcgaggtctc acttggacag cgagttctgc cttgtcattg
     3601 aacaaggtcc aaaatacaga catttttgct agggcctaga aatcgaccat aaaactcact
     3661 gcattgaggc ctaatccatt ctatattaac atccatgtga taaagtgaaa ataattttga
     3721 gggttttgct ttcgccaaaa aaaaaaaaga aagaaagaaa aaaaaagaaa ggaagaaaaa
     3781 gaaaaaagaa aggattgttt tccttagctt tgctcaagaa aaatacagct atcctaaact
     3841 ggaatcttcc cgtattcttt agagtcttaa gtatagagtt taacttcact tttgtcagct
     3901 gtcttgagct tatttctaag tagttttgtt ttggcttttg gtgagtgagg tagtgggagg
     3961 ttaattttgg ggtctttttt ttttttggct ttgtttgtgt gtgtgtgtgt gtgtgtgtgt
     4021 ttatgtgttt ggcttttggg tttggttggt tagttgttta gtttgttttt ttgttgttgt
     4081 ttaatttgct ttttctaggc agggtttctc tatgtggccc tggctgtcct agaacttgct
     4141 ctgtagacca ggctagcctc aaactcagag atccacttgc ctctgtctcg agtgtgcttg
     4201 aactaaaggc atgagctacc ctcctcagcc cactccaaac tttgagtaat atttttaaat
     4261 catagacatg ttggtattag aaacatggcg tattgtggtg gatggtagag aaagggcgcc
     4321 gcaacctctc aggacatcat atgtctggcc agctcttcat tcatataggt gctctctgga
     4381 tatgtcttta catcagactc acacctctga aacccggttt tcacacaagg agacttgcca
     4441 ttggggtctt tagtagccca gggaaacata gagtaaactg aagagcttac tgtgtgccgc
     4501 ttatccttag atggcctcat ccagtcacag gtctttgtca gaatctaacc attgattcac
     4561 tgaggagacc ctactgccct gaggttccac tgaagcagct tttagtgaga ctagggcaag
     4621 aatataccga atagcttctg ttcaaggttt ggttccagag actctaccat ttacaggact
     4681 ggctggagtt acaacaacct cttaaagagg gtagggcggg ttctccagtt agacccccta
     4741 acctcacagg tgagtagtcc taacctgaca gccttagaaa cacagttgcc gagtacctga
     4801 gagcacccag tggcccgccg cctcctattc agcccctctt taaagacgac agacggttaa
     4861 gccatggaga agctgttcag gtagcacggg gccatttctg cccccagctt gtcatgtttt
     4921 ttctctcagg acccactctc tgaccagtag acttgaattt agccccaagt gatttactaa
     4981 actcagctca gaagctcact taaaaatagg acctccacat ggtcgtgcta agtaaaaatg
     5041 aagaccccaa gttgcacagg gtgctgctat ctcaaagaca atactttcct ttgaatagaa
     5101 agctgtgccg tccaccctgc aatgggtgct agccaacttg cttgagaaag tcaggagcaa
     5161 gcattttgag ttttaaagaa tgtcctgaac ttgtctttta agtaaacata gctgctttat
     5221 taaaagctgt gactactaaa gccagtcaca gccatcgtca ctgtgggagt taaatcatgt
     5281 caactttcaa acatcacagt tgtttcaatc ttctgtccaa agaactcctc ttctggagaa
     5341 aacctgattt tggttttggc tttttgtctt gtcttgtttt gtttttcctg agatggggtc
     5401 tctctgtgaa gccctggcta tcctggaact cagtgtgtag accaggctgg ccttgaactc
     5461 atgtagatct gcctgctaaa actaaagaca tgcaccacca tgacagctga ctatttttta
     5521 tgatgagcac agaagtggct cacattttct taaagcacac ttttgtcaca tagtagagtc
     5581 taggaaagaa taacattgaa aatccccatc ccagtgtgac acttgtgtaa gcacatatgg
     5641 atagccattg gaagaataca tgcttgcttg taacatgaaa ttaaagacat tgtataattt
     5701 cttaatcttt aaaaattacc aaaaaagtgg caacagtatg tttaaggtta ttttaatttt
     5761 tacataaatt gttaaccata tttgtttgcc tttaagtata ttctaagaat tataattaag
     5821 tataattata agtcatcccg cacattcagc acttatggac taggtatgtc aaaatacaca
     5881 aattctgtat ttcttgtttc ataggaagaa agcagccatc tgaagctcta ctcatatata
     5941 tgcctaagaa tatctataca aaattaaagt ttaaaaggcc tttgcctctc gtgcagctga
     6001 gaatagacaa cttataagcc ttatccaaaa accatgataa agggatcatg tgcatcctta
     6061 caaaaacccc ttatcctgtg catacttaca tccaagtaca tcctaaggaa ggtgtccgtg
     6121 cattcatctg ccacagtggg gaagctgcct ggtgcaaggt gtgagtcctg gaatgattag
     6181 tgatagtggt ctcaaatgag gacaccttcg tctcccacca gtttccttcc tatggacagg
     6241 ctcagtccag ttatacaggc caggaggggc tggtgcccac agcctcccgc ctctgcaagg
     6301 taggattgca tatctcaaac atctctaact cagtttcggc tttgttggtc ttgtttaagg
     6361 aaataagcca gtaagccaaa actatttttg ttgttgttct cttgtcttct gaaagagagg
     6421 ggatatcaat tttaaatgtt tctctcaatt tgatctttca aatttttcta ataaagtgcc
     6481 aaattgctgc tgcttcttct tcttctttct tcttcttctt cttcttcttc ttcttcttct
     6541 tcttcttctt cttcttcttc ttcttcttct tcttcttcat gttttctgct agggttttct
     6601 tgttttgttt tggtttcagt ttgttttatt ttcagcaagt taggtaactt gagaggactt
     6661 ccactaggat gttcacacct ctgtgctctg gtcctctgac ccctccaaaa aatagccacc
     6721 tgggaataaa tgcaagctcc ccccctccag catctaccaa aatactgttg cagcaattcc
     6781 aagttcaaat ggtggggatg gaaggtagtt tggagttggg ttgggttggg ttgggttagg
     6841 ttggacagaa gtcagtttta aaattcacag cgccctaagg tcagtgtggg gtttattcct
     6901 ctatcccaat gtgtttcaca aggtggcgct ttcagagaaa actctaaacc tgaccaagac
     6961 tgagaggtat tctagagaca gtacttgtaa ctattttcct gcacatctgt aactatcacc
     7021 tagcatattc cttcagacaa ttaacagcct tcataatatt ctacagctta tatgttttgc
     7081 tttttagcta ggttctgagt gactaagtta ggcttgagag tgatgtttaa gcaataaaga
     7141 aggcctttac ttaagagaca tttttgatgt acccaaataa cctgaaattc taggacatac
     7201 aactaaaaac ttccctgaag ccggccctcg tctgtgagca gcacggtttc attagaaatg
     7261 gcaaaactcc ttgcggggtt gggagtgggg gacagtccta actctcacag cccttgacat
     7321 gtctgctgcg gttcacccct cactatccat gaccttttga cactgtcatt tctaaactca
     7381 agtgaacaaa ggaagcactg catctgtaac tgagtatgca gaccattttc taaagaacca
     7441 cagtgctcga caaatactgg aagaactggt atgttttaca cgcacataaa ctacaagtgc
     7501 aaactcttac attccaattc ctaaattaca gttatatagt acatatgaac attacagttt
     7561 agacaggaac ctgcataagg ctttggtttt tctactctcg aggtcacttt tatactacat
     7621 tttaaattca cacttttctc agagacccag ccccctgagc caatagtgac agtacactgg
     7681 gatgaacaga cacagtacca caccatggca gaaagcagtt tattccttat gagtcacaca
     7741 cacacacaca cacaccctgc ctgacttcac acacacacac acacactgcc tgacttcaca
     7801 cacacacacc ctgcctgact tcactccaga aaggctggca gggaggtttc agtcatttac
     7861 acagaccagg tgctcaagca ttgagaaatc gattctttca accctctgct ctcactgaag
     7921 cagatctcag gttaagcccc tcagtgaaag gccaagggtc ccctgggtct gccaccattc
     7981 tggagttcct gagcctgacc ccacccctac tcctgctgaa tgacaggggg cggggcagcg
     8041 gagccaggcc aagcaggata ttgtgggagg accagtgacc tgctgcacct cagccatctg
     8101 ttgtgccatc ttaggaagca gggtgctcga gaaacacaga gctgtcctct gagctacaat
     8161 aactacagtt tgctcactag gctagctagc tctggtgtag agatgcaagc cctatatgaa
     8221 atgtctccca ctcaaagttt tgctgggggg tgggggttga gatgtataat tgcaggagaa
     8281 attctgactt tactgttttc tatctgatac atccatggtg gggaaaagat atgaaactgt
     8341 ctcagtttga aaagctcttc tacttcaatt ggcaaacgca tggagttcgt tactttctac
     8401 tttcttcttt tttctccttt agtgagcaaa ttattccttg aacagaaaga ggattttccc
     8461 atttagagga agcttctgtg tgaattgtca ggtcacacaa ataatgccat tatattgttg
     8521 agtgtagggc tttggttttt caggggacac atagccaagc agtgatggtc aggaattatg
     8581 tctcactcta tcatttctta ctcaagcagg gttccagcca gattctattg tgagctgagg
     8641 ttagtcgggg gaccctgtgc tctacttgaa gtttcataat ctttagttct atgaaatgca
     8701 ataacatata ttagccagca atattcctgt ggtcgccagc atctctgagt ttgaccttca
     8761 gtctctggat ggttaaaata gatcccagca gtaatccatt tcttgacatc agtgcttaag
     8821 tcaagtatct ttccactctg gtcctatttg caacaatgta ttcatgtatg tttcatttcc
     8881 tttattcatt attttcctat gaacagtgat aaatgtatta gcacattgaa ttaatagcat
     8941 aatagaaaga gcacttagca gatggggatt ttttatcaag tcccacattt acataagtta
     9001 tttctattat tattcatgta tattatttat tgctaagcct cacaccattc ctgtgaaagt
     9061 gcaactaaag gcagatatta gggcttggat ttaatgttcc ttatcatggt cttgaacaaa
     9121 aaattcagtg atgcccccaa ataagctgcc tgcgttttta acacgactgc tagatttcag
     9181 taggttaagt gtaacacttt tggtgtctag gtgtcttttt acattaaaag aggcaaagca
     9241 gcagaactct gtagctattg cttctggcag agatttgttt agcatagtgt ggtattaatt
     9301 atagcaaatg ttaaggtagc atgtagaggt tgccttcaat aagggactgt gccaggtggc
     9361 cagcaaagtg gattctaggc agagcaggcg tctaggtgct gcctcctgtc tggttgtgtg
     9421 aagagagctg ctccgagcaa tgtagtgccc ccgtgccccc gtaggtgtcc tgggcagcgg
     9481 tgggaacacg tggtactgta gagaagggat cagcgtgagg ggtgttctgt aggaacagaa
     9541 ctggtagcgt atgccttgag gcttcctgcc cgtgttttca gattccaggc atacattctg
     9601 tatacagaag cagtccatcc tagcaataaa acctaggaat ccccaacaac tcaaaaggca
     9661 gttgccctgc tgtggtttct gtcctgagct gaaggttaac gggcaagtgt taggcacaga
     9721 agagcatcgt gtgctggggt gccgtgccac ggcccagggt gcgtgttagc agtagagact
     9781 gttacagggt tgtcccttct aggtgcgtag aagtatatgg cttcactgta aagtgtgtat
     9841 tgtttctgta ttcccacagg gacttgttaa agcttctaga ggcttcagca aagctgtaga
     9901 ccacagtaag ctgctttttg tttgacttat tcttagacta ggaaatgttt aaaggttaaa
     9961 aaaaaaaaaa aaagaatctt catttagaca ctgaactcgc tattttctgg actgaaatca
    10021 tggtcctaga actgtagaaa tcacacccat tagatgctaa tctaggttgt gtaagccagc
    10081 cccaagagtc tagcatcccc acactgtatc tgcatcttcc tgcatcttac cttccttccc
    10141 gaaggtgctc cctaccacta ccctgacctg tccctttggt gcttcccatc tccttggctg
    10201 aaagttaggc atcaagcatg tgatgagaaa tactttcagc accaagtatg cctgcctagg
    10261 cctagccacc gcccccactt tgcctttggc tagccatagt caacaagaga taatacctgg
    10321 tgctgggcac agaatgaacc catgatgtca gtcagaaaag ccctcaagca tatttctcct
    10381 gtacgtcctg atctttaaac ccagtcatta tgcagagcgt tcgctgttgg ctatagtccc
    10441 aggttaaaaa aaaaaaaaac attccaggct gctgtaggct gtccatatgc agtctctgct
    10501 tttaccttgc tttttcatac ttgaaattcg ttctgccatt ttgatttcac ggtgcagaca
    10561 tcagggtaca cgttccctct gggtgcataa ttgctctcat tccgtttgct cacactgcta
    10621 caggatgctc tgttttggtg ctttgggttc agcgggtcaa aaagcactgt gggaaatcac
    10681 tgcctagaac acagtcttaa aagcatttgg gcaggagtct tggtgttgat gtcgcttctg
    10741 ctcttctctg tgccctccag atggagttac caggttggcc tgccaggtcc cccactccca
    10801 cccccaagac ctttctctga atggcctgtg aaccctgtgc tgtatccaag ggtgaatgtg
    10861 acgtatctcc tctggcgacc ctacctttcc tggttactca ccatcagaaa caacctaggt
    10921 tacatatagc aaactctaca cagccttcct gagggaaagc ataaaaggat atctctaagg
    10981 ttgctcttca aagccctgag ctgaaggcct ttgctcccgt ccttggagct gatgaaaata
    11041 ctggtcaatt tatccaagcc cttcccactt acaagaatgg gaaagtagag gtttgtgtcg
    11101 ataccatcta aagaccacaa cttctagcca tagggtattt catatatgtc cattttcaaa
    11161 agcagctcag gtgagtggtg actccaggct ccatgcaggc atcttaacat gggacttccc
    11221 tagagagagc tacagtgttc attctatgtc acagggcagg agaggagacc ggcaggaaat
    11281 ttggagggta acagatcaat actcctttgg aaactggatg tcttactggg tgctagaatg
    11341 caaatttatg tatttattgt ctggtcattg aattcattgc ctttcaaaac cattgttcaa
    11401 atgtcactat cattggcctc acttgtatgc cagccgaatt ggttgaaagc aaaccagaga
    11461 atggtttgtg catttgcctt accatttgta cttcttacaa taaaaatgtc agtagcaaat
    11521 aaaaaaaaaa aaaa
//
