LOCUS       NM_030248               2269 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus CDK5 regulatory subunit associated protein 3
            (Cdk5rap3), transcript variant 1, mRNA.
ACCESSION   NM_030248
VERSION     NM_030248.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Yan,H., Xu,J.J., Ali,I., Zhang,W., Jiang,M., Li,G., Teng,Y., Zhu,G.
            and Cai,Y.
  TITLE     CDK5RAP3, an essential regulator of checkpoint, interacts with
            RPL26 and maintains the stability of cell growth
  JOURNAL   Cell Prolif 55 (5), e13240 (2022)
   PUBMED   35509151
  REMARK    GeneRIF: CDK5RAP3, an essential regulator of checkpoint, interacts
            with RPL26 and maintains the stability of cell growth.
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Quintero,M., Liu,S., Xia,Y., Huang,Y., Zou,Y., Li,G., Hu,L.,
            Singh,N., Blumberg,R., Cai,Y., Xu,H. and Li,H.
  TITLE     Cdk5rap3 is essential for intestinal Paneth cell development and
            maintenance
  JOURNAL   Cell Death Dis 12 (1), 131 (2021)
   PUBMED   33504792
  REMARK    GeneRIF: Cdk5rap3 is essential for intestinal Paneth cell
            development and maintenance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Yang,S., Yang,R., Wang,H., Huang,Y. and Jia,Y.
  TITLE     CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial
            Hepatectomy Triggering Endoplasmic Reticulum Stress
  JOURNAL   Am J Pathol 190 (12), 2403-2416 (2020)
   PUBMED   32926856
  REMARK    GeneRIF: CDK5RAP3 Deficiency Restrains Liver Regeneration after
            Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Shen,Y., Zou,Y., Li,J., Chen,F., Li,H. and Cai,Y.
  TITLE     CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates
            HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial
            Cells from Heat Injury
  JOURNAL   Int J Mol Sci 21 (21), 8400 (2020)
   PUBMED   33182370
  REMARK    GeneRIF: CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates
            HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial
            Cells from Heat Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Horejsi,B., Vinopal,S., Sladkova,V., Draberova,E., Sulimenko,V.,
            Sulimenko,T., Vosecka,V., Philimonenko,A., Hozak,P., Katsetos,C.D.
            and Draber,P.
  TITLE     Nuclear gamma-tubulin associates with nucleoli and interacts with
            tumor suppressor protein C53
  JOURNAL   J Cell Physiol 227 (1), 367-382 (2012)
   PUBMED   21465471
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Lemaire,K., Moura,R.F., Granvik,M., Igoillo-Esteve,M.,
            Hohmeier,H.E., Hendrickx,N., Newgard,C.B., Waelkens,E., Cnop,M. and
            Schuit,F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Shiwaku,H., Yoshimura,N., Tamura,T., Sone,M., Ogishima,S.,
            Watase,K., Tagawa,K. and Okazawa,H.
  TITLE     Suppression of the novel ER protein Maxer by mutant ataxin-1 in
            Bergman glia contributes to non-cell-autonomous toxicity
  JOURNAL   EMBO J 29 (14), 2446-2460 (2010)
   PUBMED   20531390
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Novel interaction between nuclear co-activator CBP and the CDK5
            activator binding protein - C53
  JOURNAL   Int J Mol Med 16 (2), 251-256 (2005)
   PUBMED   16012757
  REMARK    GeneRIF: Results suggest that C53 might play a role in regulating
            neuronal proliferation, migration and/or differentiation in
            embryonic development.
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK625767.1, AK149765.1 and BM211958.2.
            
            On Apr 28, 2015 this sequence version replaced NM_030248.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002318.1, AK149765.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CK625767.1         1-4
            5-1907              AK149765.1         2-1904
            1908-2269           BM211958.2         2-363               c
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.16 cM"
     gene            1..2269
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="CDK5 regulatory subunit associated protein 3"
                     /db_xref="GeneID:80280"
                     /db_xref="MGI:MGI:1933126"
     exon            1..131
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1637
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 3
                     isoform 1"
                     /protein_id="NP_084524.1"
                     /db_xref="CCDS:CCDS25306.1"
                     /db_xref="GeneID:80280"
                     /db_xref="MGI:MGI:1933126"
                     /translation="MQDHQHVPIDIQTSKLLDWLVDRRHCNLKWQSLVLTIREKINTA
                     IQDMPESQEIAQLLSGSYIHYFHCLRIVDLLKGTEASTKNIFGRYSSQRMKDWQEIVS
                     LYEKDNTYLVELCSLLVRNVSYEIPSLKKQIAKCQQLQQEYSRKEEEGQAGAAEMREQ
                     FYHSCKQYGITGDNVRRELLALVKDLPSQLAEIGAGAQSLGEAIDLYQACVEFVCDSP
                     TEQVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEEPPEQVQEDEIDWGDFGVEAV
                     SDSGIVAETPGIDWGISLESEAKDAGADKIDWGDDAAAASEITVLETGTEAPEGVARG
                     SDALTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEADILSVSQFQLAPAILQGQTK
                     EKMLSLVSTLQQLIGRLTSLRMQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKEL
                     MVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYSGRPVNLMGTSL"
     exon            132..177
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            178..309
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            310..410
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            411..459
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            460..638
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            639..775
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            776..920
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1022
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1104
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1193
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1399
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1571
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2269
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="major polyA site"
     polyA_site      1931
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="major polyA site"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
                     /note="hexamer: GATAAA"
     polyA_site      2267
                     /gene="Cdk5rap3"
                     /gene_synonym="1810007E24Rik; C53; HSF-27; IC53; LZAP;
                     MST016"
ORIGIN      
        1 cgctgaagac ggcgacgtgg ctgaaggagg ccggtttgtt tcggaactga ggctcaagca
       61 cagccgctca ggattggtgc taggctgggc cggggtcttt ggccggaagc ggaagtggag
      121 aaaggatgca ggaccatcag cacgtgccca tcgacatcca gaccagcaag ctgctcgact
      181 ggctggtgga cagaagacac tgtaacctaa aatggcagag cctggtgctg accatccggg
      241 aaaaaatcaa cactgccatc caggacatgc cagagagcca ggagattgcc cagctgctct
      301 ctggatccta cattcattac ttccactgcc taagaatagt ggaccttctt aaaggcaccg
      361 aggcgtccac caaaaatatt tttggccggt actcttcaca acggatgaaa gattggcagg
      421 agatcgtaag cctgtatgag aaggacaaca cctatttagt ggaactctgt agcctcctgg
      481 ttcggaatgt cagctatgag atcccctcgc tgaagaagca gattgccaag tgccagcaac
      541 tgcagcaaga atacagccgc aaggaggagg agggccaggc tggggccgct gagatgcgag
      601 agcaattcta ccactcctgc aaacagtatg gcatcacggg agacaatgtc cgaagagaac
      661 ttctggccct ggtgaaggac ctgccaagtc agctggctga gataggggca ggggctcagt
      721 ccctggggga ggccattgac ctgtaccagg cctgtgtgga gtttgtgtgt gacagcccca
      781 cagagcaagt gctgcccatg ctgcggtatg tgcagaagaa gggaaactcg acggtgtatg
      841 agtggaggac ggggacagag ccctctgtgg tggagcgacc acagctggag gagcctcctg
      901 agcaggtgca agaggatgag atcgactggg gtgactttgg ggtggaagct gtttccgact
      961 ctggcatcgt tgctgagact cctggaatag actggggtat ctccctggag tcagaggcca
     1021 aggatgctgg ggctgacaag atagactggg gtgacgatgc tgctgctgct tcagagatca
     1081 ccgtgctgga gacaggaact gaggctccgg agggtgtagc tcggggctca gacgctctga
     1141 ctcttctgga ataccctgaa actcggaatc agttcattga tgagctcatg gagcttgaga
     1201 tcttcttgtc tcagagagca gtagagatga gcgaggaggc cgacatcctg tccgtgagcc
     1261 agttccagct ggctcctgcc atcctccagg gccagaccaa agagaagatg ctcagcctgg
     1321 tgtccacgct gcagcagctg atcggccggc tcaccagtct gcggatgcag cacctgttta
     1381 tgattctggc ctcgccaagg tatgtggacc gagtgacaga gttcctccag cagaagctga
     1441 agcagtcgca gctgttggct ttgaagaagg agctgatggt ggagaagcag caggaggcgc
     1501 ttcaggagca ggcagctctg gagcccaagc tggacctgct gctggagaag accagagagc
     1561 tgcagaaact gattgaagcc gacatctcca agagatacag tggccgtcct gtgaacctga
     1621 tggggacctc tctgtgacgc gctccctctg tgtcctccac cctccttccc agctaccagg
     1681 aggaggtggg acagcccagg ctgatgctac tgggcctcac cagcaagaag tcaggcggac
     1741 ttggagacag agccatgagg aagggtcaca ccatgatctc tgcaagcagt tgtcttgagt
     1801 ggctctggcc tgtcagcctt aaggcacact tgctgcttct agttgtcaag tgaggcttaa
     1861 taaaaggaag tgactctcct tcgtggctgg cagtcacttg caccaccacg ctgagcctgc
     1921 ttgaagttga agctgtgcac atgttttctt aattcttgat ccaaggaggc cttgagcaat
     1981 tgtagagccc caggttagag gcttttcttc ctggcttttg gtggtacctg accccataag
     2041 catttataaa tggttcagca tgtggtttgg ggctggccag tacagctttg cccccttctg
     2101 tcaccaggct catgctgtcc tgccccagtc ggcagcccag ggggagcagt cagcctgccc
     2161 tgtgagaccc tgcagaggtg tatttttcct cttaatcact gcttactggc tagtcagggg
     2221 gaaatgtggt ttggggaggc agggtctgat aaacaaggtg gagacaaga
//
