LOCUS       NM_145990              11840 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus CDK5 regulatory subunit associated protein 2
            (Cdk5rap2), transcript variant 1, mRNA.
ACCESSION   NM_145990
VERSION     NM_145990.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11840)
  AUTHORS   Kang,D., Shin,B., Kim,G.N., Hea,J.H., Sung,Y.H. and Rhee,K.
  TITLE     Roles of Cep215/Cdk5rap2 in establishing testicular architecture
            for mouse male germ cell development
  JOURNAL   FASEB J 38 (22), e70188 (2024)
   PUBMED   39569992
REFERENCE   2  (bases 1 to 11840)
  AUTHORS   Ma,D., Lin,K.Y., Suresh,D., Lin,J., Gujar,M.R., Aung,H.Y.,
            Tan,Y.S., Gao,Y., Vincent,A.S., Chen,T. and Wang,H.
  TITLE     Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to
            regulate cortical development via microtubule organization
  JOURNAL   PLoS Biol 22 (8), e3002751 (2024)
   PUBMED   39137170
  REMARK    GeneRIF: Arl2 GTPase associates with the centrosomal protein
            Cdk5rap2 to regulate cortical development via microtubule
            organization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 11840)
  AUTHORS   Tatrai,P. and Gergely,F.
  TITLE     Centrosome function is critical during terminal erythroid
            differentiation
  JOURNAL   EMBO J 41 (14), e108739 (2022)
   PUBMED   35678476
REFERENCE   5  (bases 1 to 11840)
  AUTHORS   Wang,X., Sipila,P., Si,Z., Rosales,J.L., Gao,X. and Lee,K.Y.
  TITLE     CDK5RAP2 loss-of-function causes premature cell senescence via the
            GSK3beta/beta-catenin-WIP1 pathway
  JOURNAL   Cell Death Dis 13 (1), 9 (2021)
   PUBMED   34930892
  REMARK    GeneRIF: CDK5RAP2 loss-of-function causes premature cell senescence
            via the GSK3beta/beta-catenin-WIP1 pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11840)
  AUTHORS   Taney,F.H., Vasilenko,P., Steinetz,B.G., Weiss,G., Cole,D. and
            Goldsmith,L.T.
  TITLE     The role of estrogen and relaxin in the reproductive abnormalities
            of mice with Hertwig's anemia
  JOURNAL   Biol Reprod 45 (5), 719-726 (1991)
   PUBMED   1756209
REFERENCE   7  (bases 1 to 11840)
  AUTHORS   Russell,E.S., McFarland,E.C. and Peters,H.
  TITLE     Gametic and pleiotropic defects in mouse fetuses with Hertwig's
            macrocytic anemia
  JOURNAL   Dev Biol 110 (2), 331-337 (1985)
   PUBMED   4018402
REFERENCE   8  (bases 1 to 11840)
  AUTHORS   Eppig,J.T. and Barker,J.E.
  TITLE     Chromosome abnormalities in mice with Hertwig's anemia
  JOURNAL   Blood 64 (3), 727-732 (1984)
   PUBMED   6466874
REFERENCE   9  (bases 1 to 11840)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
REFERENCE   10 (bases 1 to 11840)
  AUTHORS   Bannerman,R.M., Edwards,J.A. and Pinkerton,P.H.
  TITLE     Hereditary disorders of the red cell in animals
  JOURNAL   Prog Hematol 8, 131-179 (1973)
   PUBMED   4596202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF738512.1, CN698992.1, BC086696.1 and AL929409.5.
            
            On Sep 1, 2015 this sequence version replaced NM_145990.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129411.1, BC086696.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CF738512.1         1-5
            6-166               CN698992.1         1-161
            167-3444            BC086696.1         1-3278
            3445-3445           AL929409.5         127347-127347       c
            3446-5672           BC086696.1         3280-5506
            5673-11840          AL929409.5         77267-83434         c
FEATURES             Location/Qualifiers
     source          1..11840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..11840
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:214444"
                     /db_xref="MGI:MGI:2384875"
     exon            1..224
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..5637
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /note="isoform 1 is encoded by transcript variant 1; CDK5
                     activator-binding protein C48"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2
                     isoform 1"
                     /protein_id="NP_666102.2"
                     /db_xref="CCDS:CCDS38779.1"
                     /db_xref="GeneID:214444"
                     /db_xref="MGI:MGI:2384875"
                     /translation="MDSGMEEEGALPGTLSGCSGLHPVLPSDLDVISDTSGLGNGVLP
                     SMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKTN
                     IELKVEVESLKRELQEKDQLLVKASKAVESLAERGGSEVQRVKEDARKKVQQVEDLLT
                     KRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEK
                     DRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEEW
                     QKERNHFEERIQALQEDLREKEREIATEKKNNLKSYKAIQGLTMALKSKEREVEELDS
                     KIKEVTTDSTKGREDPLKTQIPRFQLREGSEDCEAALVEKEALLAKLHSENVTKSTEN
                     HRLLRNVKKVTQELNDLKKEKLRLEQALEEAHQEGNRGARTIHDLRNEVEKLRKEVSE
                     REKAVEKHYKSLPGESKTKFHTQEQVVRSLTGSGSQEDLLLQKSNEKDLEAIQQNCYL
                     MTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKAEQNIYAHLAKT
                     QDTDSVSNLQAELKEVLALRKQLEQDVLAYRNLQKALQEQLSEIRSREEEPFSFYSDQ
                     TSYLSICLEEHNQFQLEHFSQEELKKKVSDLIQLVKDLHTDNQHLKKTIFDLSSVGFQ
                     GSDRLELTKQEELVASKEDEDTLKFEADVETPFQSDQHLEQSREIMEDYAEGGCKSGY
                     GRHMDSNILGHDGAQTPGASEEHTLEDELLGLLATLFSKKATPLLESRPDLLKALGAL
                     LLERICLAEQGRPGDHLDSKTEKALQQVAVQLRDELGHSFPANSFSKSYNEVKSMWGN
                     WLVKTGDEDTVELKSVSVQTMAIEDTPHGFKPQSKRDAWAEKQEEAIFSTELESEALG
                     EMPGQQATHLSFPSAINPDAEKTGLLIQLKTPELLENLYNLPASPEVVVAQLQGQVLE
                     LQRELKEFKTRNKQLHEKLILAEAMMEGLPVPNSALVNVPAAQAVVRTAFQDNPGEQE
                     GPETTQSAGRDKDMDSDQYTSFEIDSEICPPDDLALLPACKENLEDLLGPSSIATYLD
                     SKSQLSVKVSVNGTDQSENINIPDDTEDLKQKIHDLQTELEGYRNIIVQLLKHSQCSE
                     AIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEMIDGKML
                     ESLKQQLVDQEQELQKEQDLNLELFGEIHDLQNKFQDLSPSRYDSLVQSQARELSLQR
                     QQIKDSHGICVIYRQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLERL
                     FLHGKSARVEPHPQNELLKGLRTVEGNLPYHHLLPESPEPSASHALSDDEMSEKSFLS
                     RDPKPDSDTEKYPAMASHFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGSE
                     TDQGSRNVSACGLALHSSLTSEIHFLRKQNEALSMMLEKGSKDKQKESEKLRESLARK
                     AESLEQLQLEYTSVREENERLQRDIIEKERHNQELTEEVCSSRQELSRVQEEAKSRQQ
                     LLSQKDKLLQSLQMELKVYEKLAEEHPRLQQDGSKCPEASDNSFDLFESTQAMAPKSA
                     SETPLLSGTDVDSLSCDSTSSATSPTSMPCLVAGHHMWASKSGHHMLGLIEDYDALYK
                     QISWGQTLLAKMDVQTQEALSPTSHKLGPKGSSSVPLSKFLSSMNTAKLVLEKASRLL
                     KLFWRVSVPTNGQCSLHCEQIGEMKAENTKLHKKLFEQEKKLQNTAKLLQQSKHQEKV
                     IFDQLVITHQVLRKARGNLELRPGATRPGASSPSRPGS"
     exon            225..292
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            293..360
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            361..471
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            472..548
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            549..672
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            673..827
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            828..990
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1032
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1152
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1254
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1473
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1644
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1785
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1880
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2011
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2121
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2250
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2346
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2531
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2964
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3199
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3331
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3905
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4138
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4187
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4366
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4486
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4603
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4604..4793
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..4918
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..4996
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..5262
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5406
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            5407..5533
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5580
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..11840
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5653..5658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /note="hexamer: AATAAA"
     polyA_site      5672
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /note="major polyA site"
     regulatory      11814..11819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
                     /note="hexamer: ATTAAA"
     polyA_site      11839
                     /gene="Cdk5rap2"
                     /gene_synonym="2900018K03Rik; an; mKIAA1633"
ORIGIN      
        1 gccgggaaag atggcggcgg ctgcggtttg aattccagcg gcgccgcttg actgagaaca
       61 agagctgggt tggagggggc gggacctggg gaaccgagcg cgccgcgact gccggggaac
      121 cagtggcgct gccgccgccg acaccggcgc caccactctg cgttcacgat ggactcgggg
      181 atggaagagg aaggcgccct gcctgggacc ctcagcggtt gcagtggcct tcaccctgtt
      241 ctgccaagtg acctggatgt catcagtgac acttctggct tgggaaatgg agtgctccca
      301 agcatgtcag aagaaaaggt ttctcccacc agagcccgga acatgaagga ctttgaaaac
      361 caaatcactg agctgaagaa ggagaacttc aatctaaagc tccggatcta cttcctggag
      421 gagagaatcc agcaggagtt tgctggcccc accgagcaca tctacaagac gaacattgaa
      481 ctcaaggtgg aagtggaaag tctgaagcgc gagctccagg agaaagatca gttgctcgtc
      541 aaagcctcca aagcggtgga gagcctagca gaacggggtg gttctgaagt ccagcgggtg
      601 aaagaagatg caaggaagaa ggtgcagcag gtggaagacc tcctaacgaa aaggatacat
      661 cttctagaag aagatgtgaa agccgcccag gcagaactgg agaaggcctt tgcggggaca
      721 gaaacagaga aggctcttcg gctcagctta gaaagcaagc tctcggcgat gaagaagatg
      781 caggaggggg acctggagat gactctggct ctggaagaga aggacagact gattgaggag
      841 ttgaagctgt ctttgaagag caaagaagct ttaattcagt gccttaaaga ggaaaaatct
      901 cagatggcat ctcctgacga gaacgtgtca tctggagaac tccgaggact ttctgccact
      961 ctgagggaag aaaaagagag agacgctgag gaatggcaga aggagagaaa ccactttgaa
     1021 gagaggatcc aggcacttca ggaggacctg agagagaagg aaagagaaat tgctacagag
     1081 aagaaaaata acttaaagag ttataaagcc attcagggtc taaccatggc attaaaatca
     1141 aaggaaagag aggttgaaga acttgattcc aaaatcaaag aggtcactac ggactccacc
     1201 aaaggcagag aggatccctt aaaaacccag atccccagat tccagctaag agaggggtct
     1261 gaggactgtg aagctgcgct ggtagagaag gaagccctat tggccaagct acactcagaa
     1321 aatgtcacaa agagcactga gaaccatagg ttgctcagga atgttaaaaa ggtcacccag
     1381 gagttgaatg acttgaagaa ggagaagttg agactagagc aggccctgga ggaagcccac
     1441 caagagggga acagaggagc ccgaaccatt cacgacctta gaaatgaagt tgagaaacta
     1501 cgcaaggaag tgagtgagag agagaaggct gtggaaaaac attacaagag tcttccaggt
     1561 gaaagcaaga caaagtttca tactcaagaa caagtggtca gaagtctgac aggcagtggc
     1621 agtcaggagg acctgctgct tcagaaatcc aatgaaaaag atttggaagc aatacagcag
     1681 aactgctatt taatgactgc agaggagctc aagtttggga gcgatggctt aataacagaa
     1741 aagtgttctc agcagtcacc agacagcaaa ctcatcttct ccaaggaaaa gcaacaatca
     1801 gagtatgaag ggctgactgg ggacttaaaa gcagaacaga acatctatgc ccatctggca
     1861 aagactcagg acacagacag tgtcagcaac ctgcaggctg agctgaaaga ggtccttgcc
     1921 cttcggaagc agctggagca ggatgttctt gcctaccgga acctgcagaa ggccctgcag
     1981 gagcagctca gtgagattcg gagtcgagaa gaagagccgt tttcatttta tagcgatcaa
     2041 acatcgtatc tgagtatttg ccttgaagag cacaatcagt tccaattgga gcatttttct
     2101 caagaagaac tcaagaaaaa ggtcagtgac ctcatacagc ttgtgaagga cctgcacaca
     2161 gacaaccagc acctgaagaa aaccattttt gatctctctt ctgtgggttt ccagggaagt
     2221 gacagacttg agttaacaaa acaagaagag cttgtggcta gcaaggagga tgaggacaca
     2281 ctcaaatttg aagcggacgt tgagactcct ttccagagtg accagcattt ggagcaaagt
     2341 cgtgagatca tggaggacta tgctgagggt ggctgcaaaa gtggatatgg aaggcacatg
     2401 gattccaata ttttaggtca tgatggggcc caaactcctg gtgcctctga agagcacacc
     2461 ctagaagatg agctcctggg cctgcttgcc actctcttca gtaagaaggc cacaccgttg
     2521 ctggaatcca ggccagatct tctgaaagca ctcggtgccc tacttttgga acgcatatgc
     2581 ttggcagagc agggtcgtcc tggagatcac cttgatagta aaactgagaa ggcacttcag
     2641 caagtagctg ttcagttgag agatgaactt ggccattcct tccctgccaa ctcgttctcc
     2701 aagtcataca atgaagtcaa gtcaatgtgg ggaaattggc tggtaaagac aggagacgaa
     2761 gacacggtgg agctgaagag tgtttcagtg cagaccatgg ccatagagga caccccgcat
     2821 ggattcaaac ctcaaagcaa gagagatgct tgggcagaga aacaagaaga ggccattttc
     2881 agcactgagc ttgagtcaga ggcgttgggt gagatgccag ggcaacaggc cactcacctc
     2941 tcattcccca gtgccatcaa cccggatgcc gagaagacgg gcttgttgat ccaattaaag
     3001 acacctgagt tattggaaaa tttatataat cttcctgctt cgccagaggt ggtggtggct
     3061 caactccaag gccaggttct agagctgcag agggagctga aagaattcaa aacccgcaac
     3121 aagcaactcc atgagaagct aattctggca gaggcaatga tggaggggct gccggtgccc
     3181 aactctgcgc tggtgaatgt gcctgcagcc caggctgttg tgagaacagc cttccaggac
     3241 aacccaggcg agcaagaagg acctgaaacc acacagtctg ctgggagaga caaggacatg
     3301 gacagtgacc aatatacaag ctttgagatc gattctgaaa tctgtccacc tgatgacctt
     3361 gccttattac cagcatgcaa agagaatctt gaagacctcc taggcccatc ctccatagcc
     3421 acttacctgg attccaagag tcagctctct gttaaagtca gcgtgaatgg aactgaccag
     3481 tctgagaata tcaatatccc tgatgacaca gaagacttaa aacagaaaat ccacgacttg
     3541 caaaccgagc tggaaggcta ccggaacatc attgtccagc tactgaagca ctctcagtgc
     3601 agtgaggcta ttatcacagt tttgtgtggg acagaagggg cccaagatgg cttgaacaag
     3661 cctaagggcc atattgatga ggaagagatg acattttcaa gtttgcacca agtacgatat
     3721 gtgaagcata tgaaaatcct ccgtccacta accccggaga tgattgatgg caagatgcta
     3781 gagagcctca agcagcagct ggtggaccag gagcaggagc tacagaagga gcaggacttg
     3841 aacttggaac ttttcggtga aatccatgac ctgcagaaca agttccaaga cctctcgcca
     3901 tcaagatacg attcattggt tcagtcccaa gcgagggagc tctcccttca gcgacagcaa
     3961 attaaggata gccatggcat ctgtgtcatt taccgtcaac acatgagcac catgatcaag
     4021 gcgtttgagg agcttctgca ggccagtgat gtggacagtt gcgtggccga gggcttccgg
     4081 gagcagctga cacagtgtgc tggactgcta gagcaactgg agaggctgtt tctccatgga
     4141 aaatcagcca gagtggaacc acatccccag aatgaactgc tcaaggggtt aaggactgtg
     4201 gaaggcaact taccctacca ccatctcctg cctgaatctc ctgagccttc tgcctcccat
     4261 gctctgtcag atgatgaaat gtctgagaag tccttcctgt ctagagaccc gaagccagac
     4321 agcgatactg agaagtaccc agcaatggcg agccattttc ctcaagactt actaatggaa
     4381 cacatacagg aaattcgaac tttgagaaag catttggaag aatctattaa aacaaatgag
     4441 aagctccgga aacagctgga acggcagggg tctgagactg accaaggctc cagaaatgtt
     4501 tctgcttgtg gcttagcact gcacagctct ctgacgtcag agatacattt cctgaggaag
     4561 cagaacgagg ccctcagtat gatgctcgag aaggggtcca aagataaaca gaaagagagt
     4621 gaaaaattac gtgagtccct ggctaggaaa gctgagagtc ttgagcaact tcagctagag
     4681 tacaccagtg taagggaaga aaatgaaagg ttacagagag acatcattga gaaggagaga
     4741 cacaaccagg agctgactga ggaggtctgc agcagccgcc aggaactgag cagggtgcag
     4801 gaagaggcga agtcaagaca gcagctgctc tcacagaagg acaagctgct tcagtccctc
     4861 caaatggagc tcaaggtgta tgagaaactg gccgaggaac atccgaggct acagcaagat
     4921 ggcagcaaat gtcctgaggc cagcgacaat tcatttgatc tatttgaatc cacccaggca
     4981 atggcaccta aatcagcttc tgagactcct ctgctctcag gaactgatgt tgactcgctc
     5041 tcctgtgaca gtaccagttc tgccaccagc cctactagca tgccctgcct ggttgctggc
     5101 caccacatgt gggccagcaa gagtggccac catatgctgg gcctgattga ggactatgat
     5161 gccctctata agcagatcag ctggggccag acactgcttg ccaagatgga tgttcaaacc
     5221 caagaggctc tgagccccac aagtcacaag ctgggaccaa agggttcttc atccgtgcct
     5281 ctgagcaagt ttctttccag tatgaacaca gccaagctgg tcctggaaaa agcatccagg
     5341 ttgctgaagc tcttctggag ggtctcagtc cccaccaacg gccagtgttc ccttcactgt
     5401 gagcagattg gagaaatgaa ggcagagaac acgaaactac acaaaaaatt gtttgaacaa
     5461 gaaaagaagc tgcagaacac agcaaaacta ttgcagcaga gcaagcacca ggagaaagtc
     5521 atctttgatc agttggtcat cacccaccaa gtccttcgga aggccagggg aaacctggag
     5581 ctcaggcctg gggccacccg tccaggagca tccagtccca gcagaccggg ctcatgagga
     5641 gacctttcag ctaataaagc ttgtggccct gagatcagct gcctctgtcc tcactgtggc
     5701 tcctggtggt gagggaagca aaggctgctg gccagaggaa gtgcgcggtg atttttgtct
     5761 gaaaatgggc ttgaggctat tgtctcaaag gatccattgc tctgcagtca ggcaccagaa
     5821 agaccttggc gctggattgt gattaacctg gagcaccttg cacactggtg ggcttcacat
     5881 tcaccctcag gtctgagagc tcaggtttta gccagcactg cagttagaag tacttaagtg
     5941 agtcattcca tttcaaatgt gtgattcaca tattctgggt ggacctcaaa gcccaggtcc
     6001 cttgcaagac acaggactgt ctggggaccc acatggacct cagatctcac atacctctaa
     6061 gcccactcca ggatccaggg agaaatgagt ccatgtggga ttgcgttggc actgtgcctc
     6121 cccaggcagg cactcagctc ctgacatcct gtcctagaac catcttctac agggaagtgg
     6181 tttcagatac aacaaacagc ccagagctgg ttctcggctt ttgcctgtct cctgtctgct
     6241 caactgtgtt ggtgcctggt gcattggctt gctgcaaccc tgccactgac ttcgtattta
     6301 actgttctta gccttgtcct gcatgcatgg gtttctgagc actaaacaaa gctggcctgg
     6361 ccctggttat agctcttttc tttcctgctg gagtccatca cgctgacatg ttgtttctta
     6421 tcatctgtcc ttccattttg cctgctactt catctcttct cagagccctt tttctgctct
     6481 ggtccatcgg cctttcccct tctctaggct cctttcgagt ctttggttct tttcctcgag
     6541 tcttctccct ccttccccta aagcagccaa ggtgcagagg ccagtcatgc atgtgatcag
     6601 gcctgcccat gttagcagct tcctgctgtt ctctggttcc aggcagggcc cctggcaggg
     6661 atcacacagc tgctaccact cttccctctt ctcttgcctc cttgtttcca gctgactgtg
     6721 tcagcctaag atgccccttc tgttcttagc ctttttctgc ctttcctttc ctagccagca
     6781 ctgagtggtc cttaggaaat ctcttcccat gctgaagtcc tcagagtcct gatgctggac
     6841 actgactttc tctgtgccca cctcccagcc cccgatcaga cacttcctgt ttgctaatcc
     6901 tcggtgagct attagagagc aactgtgtcc atactgaatg gacacacaca cacacagaat
     6961 tgctggctgt gctggcaatt aaaattaccc atttctataa ccagactggc ttcttccata
     7021 ctctgggctg gctttccttg ctgccccatg gctacccaac aaggcagctg tcagggccct
     7081 cagctgcttg gccagagagc tgaagcccag gtgcctgctc tctgcctctg tctgctcagt
     7141 cagggcagcc tcttccttag tgggctgctg tcatctgtac tctttctgta cagttgcatc
     7201 attttctgat gtgtcaatgt gtgcaaagca ggtttaggta ctgcttcgag tgaggttctt
     7261 ttctccacaa gttcctttcc ctgagaagct tgtctgctga ggagggcagc agatctgtct
     7321 tctagtctct agccacatgc ttctgtcctc agtttgcata acctgttcag tgggagttat
     7381 ctttccccct aaccctgatg tcttaagctg taaaaattga agttagctga actgtaaggc
     7441 tcttgtccta aatcaacatc ttttcttcag tatctctcgg tggctattct tgccagtttt
     7501 agaagtgccc tctggagtgc ctgctatcag atgttcacaa gtgtgtgggg ggggggggtg
     7561 agggcggggg attttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     7621 tacgcgcaca cagtactttg tacaggatca ggaggagtac ccagacctgg ctggaagata
     7681 aacctggatt caggtgtacc tgtggtatac agtgttacct tacctggcac atgcgtagta
     7741 cattgctcat tggcatgggt gggaggggtt ttggaacctc tggtcactaa acctggggag
     7801 cctgggagta ggccctgcag ggctgaacct ctgggagttc aggttacctc acttcaggtc
     7861 tcctacaagc tttcagcaac acagtcatcc aaagcaactg tgatgttatt ctctacccta
     7921 aaatactccc agacttgggc taggggaggc cctccctcgt ctgggaggtg tgggagcatt
     7981 ctggtttgtt ttgactggat gcaggccaag aacaaactgc aaataaggac agtttggacc
     8041 ttggaaaatg ctccattgtc cctggtgagt taattttacc agcagctgaa ttcaggaggc
     8101 tctgaagcag taatcagggg gaaaaaaagc atcaatttcc cgttggtgaa atttaatcgc
     8161 cacgtgttcc tgagcagctg cacctgagag acccagctgc aaggctacat atagagagac
     8221 cggagggatg ggctgtgtct ccttccctgt ctgccttggg agtggccttc agtgtttatc
     8281 ccactaggaa gtccaatgta cagtagctct ctgcagaact tcctttattt gaacccctgc
     8341 acatttcacc acagaggaaa ctgaatcttc agagcctgct agatcgttct cccaagaatg
     8401 ttgtctgtta aatacataga tagatggatg gatggataga tagatagata gatagatgta
     8461 gccattcctc tgtattatga tcctttcttc ctaacagttt ctggcacaat gtcctggata
     8521 gccaaggcag gggctcagag acccacaatt gaattccttg acacagcagc cccaagaact
     8581 gcttgtaaat gacccatgaa aggagaaaga gtgatcttgt taataaggtc tcagtattgt
     8641 ggaggccaag aagcccgcct tcgggaacct ggccctgcca gattgcctct tcaatcttgg
     8701 ctgtatttta agtcgaagta aaaaattcaa ttatcacagt gactcatcct gtctcttgag
     8761 aaacccaggc tcagcctcag cagcagcaag gcagctcccc tctcaccaca aacaggtcgt
     8821 ccactctacc tgtgctgtca ggtgccaggt aggtgactgt ggacaaacct tgggacccag
     8881 gatcttgctg agacctcagg gctcttggtt ggagcaagcc tgttttctca tcagcagatg
     8941 taatgggcac tatgcagcca gactggccag accctggggt atctcttcaa ccacagtccc
     9001 ttcttcaaca gagtagcata agctagtgac cctgatacct ctggacttaa cagaggacca
     9061 aggagatgaa atgtggctgg aactccaaac atgagcctgg atatgaacag ctttgagatc
     9121 tgtgtattat tggggaaatc acttgtgata tgtttgtagg atgaagggga tagtctaggg
     9181 agaagatggc ttttagaagc taggcatgtg gcttgtacct ctaattacaa tatcactaga
     9241 gagacaaagg aaggttcctg gggcctgttt aacttaaaga cctcaaacct atgagagacc
     9301 ctttcaacaa acaaggtggt tggtaagtaa gaaatgatac ccaagattgt ctatgacctc
     9361 cctgtatgta catccatcca aacattcaca taaacctgga gatgagtcct atcagcgggc
     9421 aggtgacagc cctggaacat ccgcaagagg ccagctctat acccaggagg acccgacctt
     9481 tctgatcctg gtagctgcaa ggcagatgct agcaggatga gagagagcct atgaagcagg
     9541 gggtttcgac ctgaaggtga tttccaaggc ttgcctggca ccttctgtaa atgccacctc
     9601 tgggctgtgg cctaggggag ccaagaagct gtttgggaag ggctgttttt gctctccgaa
     9661 tctgaattgc cctcaggtaa tgatccaaat acccctgtct ctcttcagcc ttccttgccc
     9721 aggtttcttt ttgtggtggg tgtttcctgg ctttttctcc tctcaccagc cttggatctg
     9781 ctttcaccct tgacctcttt ctatgcttca ctctctttct cctctccatt cctgcccatc
     9841 cttacagcag accattacag catgcagctg gttgtagaag aaagtaacag tcttcctctg
     9901 ggcagcgtat ctccagctta tacctggttt ctgcagagtc agggtgagct ccactactca
     9961 ccagtgaggc ttccaatcca ggcatcattc tctcgatact tagccctcca gggtgacaac
    10021 ttcatctccc atccatgtgg taccagtctt accattctct tcataagctc tggattcacc
    10081 tgcaactcac agctgtgtat atgtcactcc tagtttaaaa tggtcatccc ccaggtgtcc
    10141 agcccatcta ccacagacaa caaaaggctc ccccaagcat cacctctagg catctgtttc
    10201 aatcacagtt ttcccctaga aaatgcatca gaattaagtt acaactatag gcagctaagt
    10261 taattgagac ccaagaatgg atctaaatag gtaacgggca aagtgggtta tatatcagtt
    10321 tactgcattt acatgcatac ttctcatcca ttgaacatct gggccagaaa ctacatctta
    10381 tgttatcata attaatgtga ttgagcacaa gtatgaactt taatttttat gtgtaagagt
    10441 gttttgcctg catggcataa catatgcatc atatgtatgc agttcctgta gagaccagaa
    10501 gatggtatcg gaacccgtag gactagttac aaatggttgt ggtcctctgt gtgggtgctc
    10561 ttaacccctg ggccatctct tcagccctga tattatgacc ttttaataga ggaagaggaa
    10621 gtcacagcct cttcggtatt ataaactggt gcttgtggca ggcagaacac tggcccctta
    10681 agatgcccat acctgccacc ttccatttct ctggaattgg aaatgtgctt ctttatttgc
    10741 aaacagacat gcacagaggt tctccacatt tcagaccttg tcttggagag gtttcttttt
    10801 acccaggtgg gcccagtcta accagagtcc ttagaagaac cgattttcct tgatcaaaga
    10861 gagcagtgac attttcagga tgaggggcag ggtcgtggtg gagggcaggg ccaggagccc
    10921 aggaatgcag gttaccttga gaaactggga agagctgcaa gccaatcctc ccctgtagtc
    10981 aatgcttttt tgtccgtgtt acaaagtaag agggaaattt aaggaaaagc tgcatagttc
    11041 atcaggagaa gaaggcatgg taggtggaaa agcggtctgt aatggcagga gcttgtgtta
    11101 tcaacttgtt tacatggcac agactggaag cagaagcctg tagaaccttc aaggccagcc
    11161 tctaatgatc agtctgccag ctacacccat gtgcacaaaa gactcttgaa atatctgcaa
    11221 cagctggaga ccaagcattc aaacacttga gcctgtgggg cacactgtac attaaaacca
    11281 tggcatcact gcactccagg aggggagaaa aaaacccacc tttgtactca gtgaaacccc
    11341 ttccagtctt ctgcctgaag atctgttagg acaatgaggt caggtattca acgaatctgt
    11401 ttgtgataat ctctgatgac agcaatggaa aactaacatg ccttagtgaa catgaatgtg
    11461 actccacagg ccgcgtgtca ttttcttgta gcagtgacag ggcatattga atacctggcc
    11521 tgggaagtca cgagctgctg tcactgagag ggagctacag agactggata gaagagaata
    11581 taatagaata ctgcctgggt gggcagatgc tgccacaggg ctttttgtga agagcctcca
    11641 gagatgagag ccagaagcca tgtgcccagg gctgagagac tgattctccc actccagcct
    11701 cttccaccac cttcagcatc ctcccctcag gcaggttgtt atgtatggtt atgggactcc
    11761 attacttcag aatgtgtcta tgtaatttgt tgaaggaatt attgaaatgt ataattaaag
    11821 tgtgcattgc aatataaaac
//
