LOCUS       NM_025876               1970 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CDK5 regulatory subunit associated protein 1
            (Cdk5rap1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025876
VERSION     NM_025876.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Miwa,T., Katsuno,T., Wei,F.Y. and Tomizawa,K.
  TITLE     Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice
            with age-related hearing loss
  JOURNAL   FEBS Open Bio 13 (7), 1365-1374 (2023)
   PUBMED   37258461
  REMARK    GeneRIF: Mitochondrial alterations in the cochlea of
            Cdk5rap1-knockout mice with age-related hearing loss.
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Miwa,T., Wei,F.Y. and Tomizawa,K.
  TITLE     Cdk5 regulatory subunit-associated protein 1 knockout mice show
            hearing loss phenotypically similar to age-related hearing loss
  JOURNAL   Mol Brain 14 (1), 82 (2021)
   PUBMED   34001214
  REMARK    GeneRIF: Cdk5 regulatory subunit-associated protein 1 knockout mice
            show hearing loss phenotypically similar to age-related hearing
            loss.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Zou,J., Ma,W., Li,J., Littlejohn,R., Zhou,H., Kim,I.M.,
            Fulton,D.J.R., Chen,W., Weintraub,N.L., Zhou,J. and Su,H.
  TITLE     Neddylation mediates ventricular chamber maturation through
            repression of Hippo signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E4101-E4110 (2018)
   PUBMED   29632206
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Wei,F.Y., Zhou,B., Suzuki,T., Miyata,K., Ujihara,Y., Horiguchi,H.,
            Takahashi,N., Xie,P., Michiue,H., Fujimura,A., Kaitsuka,T.,
            Matsui,H., Koga,Y., Mohri,S., Suzuki,T., Oike,Y. and Tomizawa,K.
  TITLE     Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs
            governs protein translation and contributes to myopathy in mice and
            humans
  JOURNAL   Cell Metab 21 (3), 428-442 (2015)
   PUBMED   25738458
REFERENCE   5  (bases 1 to 1970)
  AUTHORS   Koss,M., Bolze,A., Brendolan,A., Saggese,M., Capellini,T.D.,
            Bojilova,E., Boisson,B., Prall,O.W., Elliott,D.A., Solloway,M.,
            Lenti,E., Hidaka,C., Chang,C.P., Mahlaoui,N., Harvey,R.P.,
            Casanova,J.L. and Selleri,L.
  TITLE     Congenital asplenia in mice and humans with mutations in a
            Pbx/Nkx2-5/p15 module
  JOURNAL   Dev Cell 22 (5), 913-926 (2012)
   PUBMED   22560297
REFERENCE   6  (bases 1 to 1970)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL928894.12
            and AL732601.16.
            
            On Nov 17, 2006 this sequence version replaced NM_025876.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010097.1, AK010081.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL928894.12        2971-3009           c
            40-359              AL732601.16        191271-191590       c
            360-463             AL732601.16        189447-189550       c
            464-498             AL732601.16        188849-188883       c
            499-599             AL732601.16        186597-186697       c
            600-810             AL732601.16        181192-181402       c
            811-931             AL732601.16        174725-174845       c
            932-1162            AL732601.16        173825-174055       c
            1163-1260           AL732601.16        172817-172914       c
            1261-1316           AL732601.16        171453-171508       c
            1317-1447           AL732601.16        169286-169416       c
            1448-1597           AL732601.16        166501-166650       c
            1598-1738           AL732601.16        162936-163076       c
            1739-1970           AL732601.16        156021-156252       c
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 76.46 cM"
     gene            1..1970
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /note="CDK5 regulatory subunit associated protein 1"
                     /db_xref="GeneID:66971"
                     /db_xref="MGI:MGI:1914221"
     exon            1..39
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            40..359
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1825
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /EC_number="2.8.4.3"
                     /note="CDK5 activator-binding protein C42;
                     mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase;
                     mt-tRNA-N6-(dimethylallyl)adenosine(37)
                     methylthiotransferase"
                     /codon_start=1
                     /product="mitochondrial tRNA methylthiotransferase
                     CDK5RAP1"
                     /protein_id="NP_080152.1"
                     /db_xref="CCDS:CCDS16931.1"
                     /db_xref="GeneID:66971"
                     /db_xref="MGI:MGI:1914221"
                     /translation="MHPLRCVLQVQRLSAPFTSMCWVLLRTCRAQSSVSSTPCPSPEA
                     KSSEAQKDFSSRLATGPTFQHFLRSASVPQEKPSSPEVEDPPPYLSGDELLGRQRKVY
                     LETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQ
                     LKVLKTKRPRSRVPLRIGILGCMAERLKGEILNREKMVDLLAGPDAYRDLPRLLAVVE
                     SGQQAANVLLSLDETYADIMPVQTSPSATSAFVSIMRGCDNMCSYCIVPFTRGRERSR
                     PVASILDEVRKLSEQGLKEVTLLGQNVNSFRDNSEVQFNNAGSANLSRGFTTNYKPKQ
                     GGLRFSHLLDQVSRIDPEMRIRFTSPHPKDFPDEVLQLIRERHNICKQIHLPAQSGSS
                     RVLDAMRRGYSREAYVALVHHVRETIPGVSLSSDFITGFCGETEDDHRQTVSLLREVQ
                     YNTGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITVFREEASKANKTSVGCSQL
                     VLVEGFSKRSTTDLCGRNDANLKVIFPDAEVEDITNPGLKVRAQPGDYVLVKITSASS
                     QTLKGHILCRTTMKDSLTYCTT"
     exon            360..463
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..498
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            499..599
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..810
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            811..931
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1162
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1260
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1316
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1447
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1597
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1738
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1970
                     /gene="Cdk5rap1"
                     /gene_synonym="2310066P17Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttccggt ttcggacgcg gaccttgcag ttgtgggaga tttggggctg caggtgccat
       61 gcatccttta cggtgtgtcc tccaagtaca gaggttgtca gcaccattca cctccatgtg
      121 ctgggtgttg cttaggacct gcagagcaca aagcagtgtg tccagcactc cttgtcccag
      181 tccagaggcg aagagctcag aagctcagaa ggacttcagc tccaggctag ccactggacc
      241 gacttttcag cattttttaa gaagtgcttc agttcctcaa gagaaaccat cttctccaga
      301 ggtggaggac ccacctccct atctctcggg ggatgaactt ctaggaaggc agagaaaagt
      361 ctacctcgag acctatggct gtcagatgaa cgtgaacgac acagagatag cctggtccat
      421 cttacagaag agtggctacc ttcggaccag caacctccaa gaggctgatg tgatccttct
      481 tgtcacgtgt tctatcaggg agaaggccga gcagaccatc tggaaccgct tacatcagct
      541 caaagtcctg aagacaaagc ggccacgctc tcgagtacct ctgaggattg ggattctagg
      601 ctgcatggct gagaggctga agggagagat cctcaacagg gagaagatgg tagatctctt
      661 ggctggtcca gacgcctacc gagaccttcc ccggctgctg gctgtggtgg agtcaggtca
      721 gcaagcagca aatgtgcttc tctctctgga tgagacctac gcagatatca tgccagtcca
      781 gacgagcccc agtgccactt ctgcctttgt atccattatg cggggctgcg acaacatgtg
      841 cagttactgt atcgtgccgt tcacgcgtgg ccgggagagg agccggccag ttgcctccat
      901 tctcgatgaa gtgaggaagc tgtccgagca gggcctaaaa gaagtgacac ttcttggtca
      961 gaatgttaat agttttcggg acaattcgga agtccagttc aataatgcag ggtctgctaa
     1021 cctcagccgt ggctttacca ccaactataa acccaaacaa ggagggcttc gtttttctca
     1081 ccttctggat caggtttcaa gaatcgatcc tgaaatgagg atccgattca cctctcctca
     1141 ccccaaggat tttcctgatg aggttcttca gctgattcgt gagagacaca acatctgtaa
     1201 gcagatccac ctgccagccc agagtggaag cagccgtgta ctggatgcca tgcggagagg
     1261 atattcaaga gaagcatatg tggcattagt tcatcatgtc agagagacta tcccaggtgt
     1321 gagccttagc agcgacttca tcactggctt ttgtggagag acagaggatg atcaccggca
     1381 gacagtgtct ttacttagag aagtgcagta taataccggt tttctctttg catacagcat
     1441 gaggcaaaag acacgagcat atcacaggct gaaggatgat gttccagaag aagtaaaatt
     1501 aaggcgtttg gaggaactca ttactgtctt cagagaagaa gcttcaaaag ccaataagac
     1561 ctcagtgggt tgtagccagc tggtactggt tgaagggttc agcaaacgtt ctaccacaga
     1621 cctttgtggc cggaatgatg caaaccttaa ggtgattttc cctgacgcag aggtggagga
     1681 tatcactaac cctgggctca aggtcagagc tcaacctggg gactatgtgc tggtgaagat
     1741 cacctctgcc agctctcaga ccctgaaagg acacattctc tgcaggacca ctatgaaaga
     1801 ctcattgacg tattgcacga cctgagctgc tggattagga gtggacttgg gcaggttttt
     1861 ctcatgcttt ggagacatgt aatagtcttg aagcaccttt gcaccaaatg gaagagtaca
     1921 tttctttgtt gtcgatagaa caactgttac aataataaat ttcataaatt
//
