LOCUS       NM_007668               2122 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus cyclin dependent kinase 5 (Cdk5), transcript variant
            1, mRNA.
ACCESSION   NM_007668
VERSION     NM_007668.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2122)
  AUTHORS   Kwon,H.J., Hahn,K.R., Moon,S.M., Yoo,D.Y., Kim,D.W. and Hwang,I.K.
  TITLE     PFKFB3 ameliorates ischemia-induced neuronal damage by reducing
            reactive oxygen species and inhibiting nuclear translocation of
            Cdk5
  JOURNAL   Sci Rep 14 (1), 24694 (2024)
   PUBMED   39433564
  REMARK    GeneRIF: PFKFB3 ameliorates ischemia-induced neuronal damage by
            reducing reactive oxygen species and inhibiting nuclear
            translocation of Cdk5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2122)
  AUTHORS   Zhang,J., Wang,S., Zhang,H., Yang,X., Ren,X., Wang,L., Yang,Y.,
            Yang,Y. and Wen,Y.
  TITLE     Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes
            cerebral ischemic injury via facilitating mitochondrial fission
  JOURNAL   Mol Med 30 (1), 173 (2024)
   PUBMED   39390372
  REMARK    GeneRIF: Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis
            promotes cerebral ischemic injury via facilitating mitochondrial
            fission.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2122)
  AUTHORS   Ren,Y., Wu,X., Bai,T., Yang,N., Yuan,Y., Xu,L., Wen,Y., Wen,Y.,
            Wang,Z., Zhou,L., Zou,F. and Li,W.
  TITLE     CDK5-USP30 signaling pathway regulates MAVS-mediated inflammation
            via suppressing mitophagy in MPTP/MPP+ PD model
  JOURNAL   Ecotoxicol Environ Saf 279, 116446 (2024)
   PUBMED   38772138
  REMARK    GeneRIF: CDK5-USP30 signaling pathway regulates MAVS-mediated
            inflammation via suppressing mitophagy in MPTP/MPP[+] PD model.
REFERENCE   4  (bases 1 to 2122)
  AUTHORS   Zhang,Y., Xia,S., Tian,X., Yuan,L., Gao,Y., Liu,D., Qi,H., Wang,S.,
            Liu,Z., Li,Y., Zhao,Z. and Liu,W.
  TITLE     miR-4645-3p attenuates podocyte injury and mitochondrial
            dysfunction in diabetic kidney disease by targeting Cdk5
  JOURNAL   FASEB J 38 (10), e23668 (2024)
   PUBMED   38742811
  REMARK    GeneRIF: miR-4645-3p attenuates podocyte injury and mitochondrial
            dysfunction in diabetic kidney disease by targeting Cdk5.
REFERENCE   5  (bases 1 to 2122)
  AUTHORS   Fei,Q., Im,D.S., Xu,Y., Huang,T. and Qu,D.
  TITLE     Timing dependent neuronal migration is regulated by Cdk5-mediated
            phosphorylation of JIP1
  JOURNAL   Front Cell Dev Biol 12, 1371568 (2024)
   PUBMED   38606319
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2122)
  AUTHORS   Ohshima,T., Nagle,J.W., Pant,H.C., Joshi,J.B., Kozak,C.A.,
            Brady,R.O. and Kulkarni,A.B.
  TITLE     Molecular cloning and chromosomal mapping of the mouse
            cyclin-dependent kinase 5 gene
  JOURNAL   Genomics 28 (3), 585-588 (1995)
   PUBMED   7490100
REFERENCE   7  (bases 1 to 2122)
  AUTHORS   Ino,H., Ishizuka,T., Chiba,T. and Tatibana,M.
  TITLE     Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein
            kinase, in the mature and developing mouse central and peripheral
            nervous systems
  JOURNAL   Brain Res 661 (1-2), 196-206 (1994)
   PUBMED   7834371
REFERENCE   8  (bases 1 to 2122)
  AUTHORS   Tsai,L.H., Delalle,I., Caviness,V.S. Jr., Chae,T. and Harlow,E.
  TITLE     p35 is a neural-specific regulatory subunit of cyclin-dependent
            kinase 5
  JOURNAL   Nature 371 (6496), 419-423 (1994)
   PUBMED   8090221
REFERENCE   9  (bases 1 to 2122)
  AUTHORS   Demetrick,D.J., Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase
            genes
  JOURNAL   Cytogenet Cell Genet 66 (1), 72-74 (1994)
   PUBMED   8275715
REFERENCE   10 (bases 1 to 2122)
  AUTHORS   Eiden,L.E., Huttner,W.B., Mallet,J., O'Connor,D.T., Winkler,H. and
            Zanini,A.
  TITLE     A nomenclature proposal for the chromogranin/secretogranin proteins
  JOURNAL   Neuroscience 21 (3), 1019-1021 (1987)
   PUBMED   3627430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY126868.1, AK051790.1 and AI550418.1.
            
            On May 9, 2018 this sequence version replaced NM_007668.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052007.1, AK051790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY126868.1         2-35
            35-2092             AK051790.1         1-2058
            2093-2122           AI550418.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..2122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.73 cM"
     gene            1..2122
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /note="cyclin dependent kinase 5"
                     /db_xref="GeneID:12568"
                     /db_xref="MGI:MGI:101765"
     exon            1..116
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..958
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /EC_number="2.7.11.1"
                     /note="cell division protein kinase 5; TPKII catalytic
                     subunit; serine/threonine-protein kinase PSSALRE; tau
                     protein kinase II catalytic subunit; CR6 protein kinase;
                     cyclin-dependent-like kinase 5"
                     /codon_start=1
                     /product="cyclin-dependent kinase 5"
                     /protein_id="NP_031694.1"
                     /db_xref="CCDS:CCDS51434.1"
                     /db_xref="GeneID:12568"
                     /db_xref="MGI:MGI:101765"
                     /translation="MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV
                     PSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI
                     VKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA
                     EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL
                     LGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS
                     AEEALQHPYFSDFCPP"
     exon            117..205
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            206..273
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            274..334
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            335..391
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            392..487
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            488..562
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            563..659
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            660..729
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            730..790
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            791..871
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     exon            872..2106
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /note="hexamer: CATAAA"
     polyA_site      1149
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /note="major polyA site"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /note="hexamer: AATAAA"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
                     /note="hexamer: TATAAA"
     polyA_site      2093
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
     polyA_site      2106
                     /gene="Cdk5"
                     /gene_synonym="Crk6"
ORIGIN      
        1 gtgagtacca cctcctctgc aacgccaggg ccgggagtct tagaaccgag ggcccgcagg
       61 ggtccccgcg gccgctgcaa tgcagaaata cgagaaactg gagaagattg gggaaggcac
      121 ctatggaact gtgttcaagg ctaaaaaccg ggaaactcat gagattgtgg ctctgaagcg
      181 tgtcaggctg gatgatgacg atgagggtgt gccaagttca gccctccggg agatctgtct
      241 actcaaagaa ctgaagcaca aaaacattgt caggcttcat gatgtcctgc atagtgacaa
      301 gaagctgaca ctggtttttg agttctgtga tcaggacctg aagaaatatt tcgacagctg
      361 caatggtgac ctggaccctg agattgtgaa gtcattcctc ttccagctgc tgaaaggcct
      421 gggattctgt cacagccgca acgtgctaca tagggacctg aagccccaga acctgctcat
      481 aaacaggaat ggggagttga aattggctga ttttggcctg gcccgagcct ttggtatccc
      541 cgtccgctgc tactctgctg aggtggtcac gctgtggtac cgcccaccgg atgtcctctt
      601 tggggccaag ctgtactcca cgtccatcga catgtggtca gccggctgca tctttgcaga
      661 gctggctaat gcaggacgac ctctcttccc tggcaatgat gtggatgacc agctgaagag
      721 gatcttccga ctgctaggga caccgactga ggaacaatgg cctgccatga ccaagctgcc
      781 agactataag ccctacccaa tgtacccagc tacaacatcc ttggtgaacg tcgtgcccaa
      841 gctcaatgcc acggggaggg acctgttgca gaacctattg aagtgtaacc ctgtgcagcg
      901 catctcagca gaggaggcct tgcagcaccc ctacttctct gacttctgtc ccccataggc
      961 tctctgaacc ccagtggcca ggctggggcc tggcctgttt aagcctccct cccaggaggg
     1021 tggaagagtc gggtgtggga tgctgagcgc cagctgtgct gggccagcca gggcagagtt
     1081 accctggccc gcggctttcc ctccctccgt ggactttatt taatttcata aattggctcc
     1141 tttcccacag tctgatgata tggtggtggg gtggctctgg agggtgactg gggactcctg
     1201 caatgtgatg tggcccacag cttgtgcact gagctactca cgtctgctct atctctttac
     1261 gtatcctgag accaggaata ggaggcaatg gtccctgttc ttttgattgt gtcatggcag
     1321 tcctgtctcc acactcagct tacataatcc tccacacttt tttcctctgc ctagaaggcc
     1381 agatacagtc ctgaggtagg atgcctgagt gcaaagctga gtctttgcca gaaggggaga
     1441 atgggccagg cctctctagc tctgcatcct atatagagcc ttccacatct gtcttctcac
     1501 acttggagtt gtcagctggg gcagaagaga tccagagctg tgtgggtctc ttccataagc
     1561 acagcccttc ccagttcctg tttgtcactt ttccaggggt tggggtacag tgagagtagg
     1621 aaactggagc tgaggcgaaa ctccaggagt gccctcttga caggaagggg aagggagggc
     1681 tctcttgggc ccactgtctt agcaggttgt cagctcctat ggagaggttg gaaaggcgag
     1741 aaccttcgaa ggcgagacac cagtttgtgt tcttgcacat ggactagttc tcatgtaacc
     1801 tgccacttcc accttctcgc tgagctagtt agaacctcgt tccagctctc caccgttggt
     1861 gcaatgaata cctactgacc atgcccacta tgggccgtca cctaagctct gggcatggag
     1921 agactacctt cttagatttt ggtaggaggt aagcctagtg tataggcctg cattccaatc
     1981 taccaaggag cccgaggcag tgctgcaagg gcagtgtggg cttgggagtg agttcaaggt
     2041 aatctggaaa acctagtgag actctgtttc taaataaaca agatataaaa aggtctggga
     2101 agccaaaaaa aaaaaaaaaa aa
//
