LOCUS       NM_009870               1420 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus cyclin dependent kinase 4 (Cdk4), transcript variant
            1, mRNA.
ACCESSION   NM_009870
VERSION     NM_009870.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Grahammer,F., Dumoulin,B., Gulieva,R.E., Wu,H., Xu,Y.,
            Sulaimanov,N., Arnold,F., Sandner,L., Cordts,T., Todkar,A.,
            Moulin,P., Reichardt,W., Puelles,V.G., Kramann,R., Freedman,B.S.,
            Busch,H., Boerries,M., Walz,G. and Huber,T.B.
  TITLE     Cyclin-dependent kinase 4 drives cystic kidney disease in the
            absence of mTORC1 signaling activity
  JOURNAL   Kidney Int 106 (5), 856-869 (2024)
   PUBMED   39218392
  REMARK    GeneRIF: Cyclin-dependent kinase 4 drives cystic kidney disease in
            the absence of mTORC1 signaling activity.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Knight,H., Abis,G., Kaur,M., Green,H.L.H., Krasemann,S.,
            Hartmann,K., Lynham,S., Clark,J., Zhao,L., Ruppert,C., Weiss,A.,
            Schermuly,R.T., Eaton,P. and Rudyk,O.
  TITLE     Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell
            Proliferation
  JOURNAL   Circ Res 133 (12), 966-988 (2023)
   PUBMED   37955182
  REMARK    GeneRIF: Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular
            Cell Proliferation.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Pedraza,N., Monserrat,M.V., Ferrezuelo,F., Torres-Rosell,J.,
            Colomina,N., Miguez-Cabello,F., Parraga,J.P., Soto,D.,
            Lopez-Merino,E., Garcia-Vilela,C., Esteban,J.A., Egea,J. and
            Gari,E.
  TITLE     Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation
            of GABAA receptors
  JOURNAL   Cell Mol Life Sci 80 (10), 280 (2023)
   PUBMED   37684532
  REMARK    GeneRIF: Cyclin D1-Cdk4 regulates neuronal activity through
            phosphorylation of GABAA receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Gilardi-Hebenstreit,P., Nieto,M.A., Frain,M., Mattei,M.G.,
            Chestier,A., Wilkinson,D.G. and Charnay,P.
  TITLE     An Eph-related receptor protein tyrosine kinase gene segmentally
            expressed in the developing mouse hindbrain
  JOURNAL   Oncogene 7 (12), 2499-2506 (1992)
   PUBMED   1281307
  REMARK    Erratum:[Oncogene. 1993 Apr;8(4):1103.. PMID: 8455939]
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Matsushime,H., Ewen,M.E., Strom,D.K., Kato,J.Y., Hanks,S.K.,
            Roussel,M.F. and Sherr,C.J.
  TITLE     Identification and properties of an atypical catalytic subunit
            (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
  JOURNAL   Cell 71 (2), 323-334 (1992)
   PUBMED   1423597
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Ershler,M.A., Nagorskaia,T.V., Fisser,Ia.V. and Beliavskii,A.V.
  TITLE     [Identification of new protein kinase genes, similar to kinases of
            the cdc2 family and expressed in murine hematopoietic stem cells]
  JOURNAL   Dokl Akad Nauk 324 (4), 893-897 (1992)
   PUBMED   1459009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134329.3.
            
            On Sep 2, 2017 this sequence version replaced NM_009870.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046336.1, AK153465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC134329.3         21237-21461         c
            226-459             AC134329.3         20543-20776         c
            460-595             AC134329.3         20276-20411         c
            596-763             AC134329.3         19994-20161         c
            764-873             AC134329.3         19732-19841         c
            874-924             AC134329.3         18993-19043         c
            925-1060            AC134329.3         18760-18895         c
            1061-1420           AC134329.3         17708-18067         c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..1420
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /note="cyclin dependent kinase 4"
                     /db_xref="GeneID:12567"
                     /db_xref="MGI:MGI:88357"
     exon            1..225
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            226..459
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..595
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            596..763
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..873
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            874..924
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1060
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1420
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /note="hexamer: AACAAG"
     polyA_site      1417
                     /gene="Cdk4"
                     /gene_synonym="Crk3"
                     /note="major polyA site"
ORIGIN      
        1 aacgtccggc gcccgccccg ccccccgggt ttccgcgcgc ctctctggca gctggtcaca
       61 tggtgagggt gggggtgagg gggcctctct agctcgcggc ctgtgtctat ggtctggccc
      121 gaagcgtcca gctgcccggg accgatcccc ggtgtatggc gccgcaggaa ccggctcccg
      181 ggcccagata aagggccacc tccagagctc ttagccgagc gtaagatccc ctgcttcgag
      241 aatggctgcc actcgatatg aacccgtggc tgaaattggt gtcggtgcct atgggacggt
      301 gtacaaagcc cgagatcccc acagtggcca ctttgtggcc ctcaagagtg tgagagttcc
      361 taatggagga gcagctggag ggggccttcc cgtcagcaca gttcgtgagg tggccttgtt
      421 aaggaggctg gaggcctttg aacatcccaa tgttgtacgg ctgatggatg tctgtgctac
      481 ttcccgaact gatcgggaca tcaaggtcac cctagtgttt gagcatatag accaggacct
      541 gaggacatac ctggacaaag cacctccacc gggcctgccg gttgagacca ttaaggatct
      601 aatgcgtcag tttctaagcg gcctggattt tcttcatgca aactgcattg ttcaccggga
      661 cctgaagcca gagaacattc tagtgacaag taatgggacc gtcaagctgg ctgactttgg
      721 cctagctaga atctacagct accagatggc cctcacgcct gtggtggtta cgctctggta
      781 ccgagctcct gaagttcttc tgcagtctac atacgcaaca cccgtggaca tgtggagcgt
      841 tggctgtatc tttgcagaga tgttccgtcg gaagcctctc ttctgtggaa actctgaagc
      901 cgaccagttg gggaaaatct ttgatctcat tggattgcct ccagaagacg actggcctcg
      961 agaggtatct ctacctcgag gagcctttgc ccccagaggg cctcggccag tgcagtcagt
     1021 ggtgccagag atggaggagt ctggagcgca gctgctactg gaaatgctga cctttaaccc
     1081 acataagcga atctctgcct tccgagccct gcagcactcc tacctgcaca aggaggaaag
     1141 cgacgcagag tgagaagagg ggctgccttt cccagtcttg gtggagaaac cctcgctgaa
     1201 gcggcagcct ctgtttcccc ccaaggctgt ggagaatcct ccagtttttt acagagaata
     1261 ttttaagcct taaataacaa gtccccacct ctccttacga ggttcacccc cattaccctc
     1321 ccctagctct acactaaagg gcaggtgtat ctgtcttctt ccctccctga tttatactgg
     1381 gatctttttt atacaggaaa acaagacaag acaaagagta
//
