LOCUS       NM_026373                911 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin dependent kinase 2 associated protein 2
            (Cdk2ap2), mRNA.
ACCESSION   NM_026373
VERSION     NM_026373.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 911)
  AUTHORS   Kim,J.J., Khalid,O., Vo,S., Sun,H.H., Wong,D.T. and Kim,Y.
  TITLE     A novel regulatory factor recruits the nucleosome remodeling
            complex to wingless integrated (Wnt) signaling gene promoters in
            mouse embryonic stem cells
  JOURNAL   J Biol Chem 287 (49), 41103-41117 (2012)
   PUBMED   23074223
  REMARK    GeneRIF: cyclin-dependent kinase 2-associated protein 1 (CDK2AP1),
            an essential gene for early embryonic development, plays a role in
            pluripotency of ESC by engaging MBD3 to the promoter region of Wnt
            signaling genes
REFERENCE   3  (bases 1 to 911)
  AUTHORS   Deshpande,A.M., Khalid,O., Kim,J.J., Kim,Y., Lindgren,A.,
            Clark,A.T. and Wong,D.T.
  TITLE     Cdk2ap2 is a novel regulator for self-renewal of murine embryonic
            stem cells
  JOURNAL   Stem Cells Dev 21 (16), 3010-3018 (2012)
   PUBMED   22548356
  REMARK    GeneRIF: Cdk2ap2 under normal conditions has a biphasic expression,
            suggesting regulatory roles in early-versus-late stem cell
            differentiation.
REFERENCE   4  (bases 1 to 911)
  AUTHORS   Terret,M.E., Lefebvre,C., Djiane,A., Rassinier,P., Moreau,J.,
            Maro,B. and Verlhac,M.H.
  TITLE     DOC1R: a MAP kinase substrate that control microtubule organization
            of metaphase II mouse oocytes
  JOURNAL   Development 130 (21), 5169-5177 (2003)
   PUBMED   12944431
  REMARK    GeneRIF: identified a mitogen-activated protein kinase partner,
            DOC1R, a murine homologue of a potential human tumor suppressor
            gene; characterized DOC1R during mouse oocyte meiosis resumption
REFERENCE   5  (bases 1 to 911)
  AUTHORS   Zhou,W.Q., Jiang,L., Sheng,X.J. and Zhang,X.
  TITLE     [Construction and expression of mouse DOC-1R antisense gene vector]
  JOURNAL   Ai Zheng 21 (3), 240-244 (2002)
   PUBMED   12451986
  REMARK    GeneRIF: Mouse DOC-1R gene can significantly inhibit cell growth
            and colony formation capacity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109138.10.
            
            On Oct 19, 2007 this sequence version replaced NM_026373.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018035.1, BC025656.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC109138.10        105769-105925
            158-258             AC109138.10        106235-106335
            259-391             AC109138.10        106423-106555
            392-911             AC109138.10        106916-107435
FEATURES             Location/Qualifiers
     source          1..911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.8 cM"
     gene            1..911
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /note="cyclin dependent kinase 2 associated protein 2"
                     /db_xref="GeneID:52004"
                     /db_xref="MGI:MGI:1098779"
     exon            1..157
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..459
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /note="DOC-1 related protein; CDK2-associated protein 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2-associated protein 2"
                     /protein_id="NP_080649.1"
                     /db_xref="CCDS:CCDS29414.1"
                     /db_xref="GeneID:52004"
                     /db_xref="MGI:MGI:1098779"
                     /translation="MSYKPIAPAPSSTPGSSTPGPGTPVPTAGSVPSPSGSVPGAAAP
                     FRPLFNDFGPPSMGYVQAMKPPGSQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMER
                     LKRGIIHARALVRECLAETERNART"
     exon            158..258
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /inference="alignment:Splign:2.1.0"
     exon            259..391
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /inference="alignment:Splign:2.1.0"
     exon            392..911
                     /gene="Cdk2ap2"
                     /gene_synonym="5830466O21Rik; D19Ertd144e; Doc-1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtgcggc tgagctgccg gacagccaac cccagaggag cggccggctg gcggccgccg
       61 cactgaggag ttgggatgtc ctacaaacct atcgcgcccg cccccagcag taccccgggc
      121 tccagcaccc ccgggccagg caccccggtc cctacagccg ggagtgtccc atcgccatcg
      181 ggctcagtgc caggagctgc cgcacctttc agaccgctgt ttaacgactt tggtccgccc
      241 tccatggggt atgtacaggc gatgaagcca cctggttccc agggctctca gagcacctac
      301 acggacctgc tgtctgtcat agaggagatg ggcaaagaga tccggcccac ctatgctggt
      361 agcaagagtg ccatggagcg cctgaagaga ggcatcatcc acgctcgggc actagtcaga
      421 gagtgcttgg cagagacaga acgcaatgcc cgcacgtaac aggaagcacc ttgacctcct
      481 cgccgggacc tttctggcca ctgcagagcg cctgcttctc cctggccttc gcgccccaag
      541 ttgcttccta tcctgggctt cctgtcctgt gtcccttagt gggcaccctc caggaaccag
      601 gtagcagatc ttcgtccagt tggctgtaca aactggtctc ctccctctgt gggagtgctg
      661 ggaggccact gggagtccct tccatgacct gctcacagtg ctgatctgac gggagcttgc
      721 tcctctctgt ggccccacca cacagcactt actccttaac tcttagccca ggccacctcc
      781 tgcctcttca acaggagtgc agaagacctt cctgcctcat ctctggggcc acagccgact
      841 ctttttttgg tgtgtctttt actaaatatg tcctttttgt ataaataaaa gatgctttgg
      901 agtcattctc t
//
