LOCUS       NM_013812               1283 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cyclin dependent kinase 2 associated protein 1
            (Cdk2ap1), mRNA.
ACCESSION   NM_013812 XM_991893
VERSION     NM_013812.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Dehghan,Z., Mohammadi-Yeganeh,S., Rezaee,D. and Salehi,M.
  TITLE     MicroRNA-21 is involved in oocyte maturation, blastocyst formation,
            and pre-implantation embryo development
  JOURNAL   Dev Biol 480, 69-77 (2021)
   PUBMED   34411594
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Modzelewski,A.J., Shao,W., Chen,J., Lee,A., Qi,X., Noon,M.,
            Tjokro,K., Sales,G., Biton,A., Anand,A., Speed,T.P., Xuan,Z.,
            Wang,T., Risso,D. and He,L.
  TITLE     A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform
            essential for development
  JOURNAL   Cell 184 (22), 5541-5558 (2021)
   PUBMED   34644528
  REMARK    GeneRIF: A mouse-specific retrotransposon drives a conserved
            Cdk2ap1 isoform essential for development.
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Spruijt,C.G., Bartels,S.J., Brinkman,A.B., Tjeertes,J.V., Poser,I.,
            Stunnenberg,H.G. and Vermeulen,M.
  TITLE     CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex
  JOURNAL   Mol Biosyst 6 (9), 1700-1706 (2010)
   PUBMED   20523938
  REMARK    GeneRIF: Results indicate that DOC-1 is a bona fide subunit of the
            Mi-2/NuRD chromatin remodeling complex.
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Kim,Y., McBride,J., Zhang,R., Zhou,X. and Wong,D.T.
  TITLE     p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin
  JOURNAL   Oncogene 24 (3), 407-418 (2005)
   PUBMED   15543230
  REMARK    GeneRIF: (CDK2-AP1) is a potential gene therapeutic agent for
            oral/head and neck cancer in conjunction with DNA-damaging agents
            such as cisplatin.
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Pravtcheva,D.D. and Wise,T.L.
  TITLE     Disruption of Apc10/Doc1 in three alleles of oligosyndactylism
  JOURNAL   Genomics 72 (1), 78-87 (2001)
   PUBMED   11247669
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Cox,G.A., Mahaffey,C.L. and Frankel,W.N.
  TITLE     Identification of the mouse neuromuscular degeneration gene and
            mapping of a second site suppressor allele
  JOURNAL   Neuron 21 (6), 1327-1337 (1998)
   PUBMED   9883726
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Tsuji,T., Duh,F.M., Latif,F., Popescu,N.C., Zimonjic,D.B.,
            McBride,J., Matsuo,K., Ohyama,H., Todd,R., Nagata,E., Terakado,N.,
            Sasaki,A., Matsumura,T., Lerman,M.I. and Wong,D.T.
  TITLE     Cloning, mapping, expression, function, and mutation analyses of
            the human ortholog of the hamster putative tumor suppressor gene
            Doc-1
  JOURNAL   J Biol Chem 273 (12), 6704-6709 (1998)
   PUBMED   9506968
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Gordon,H.M., Kucera,G., Salvo,R. and Boss,J.M.
  TITLE     Tumor necrosis factor induces genes involved in inflammation,
            cellular and tissue repair, and metabolism in murine fibroblasts
  JOURNAL   J Immunol 148 (12), 4021-4027 (1992)
   PUBMED   1602141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE623061.1, AK004852.1 and AA190126.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_991893.1, NM_013812.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083075.1, AK004852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               BE623061.1         1-234
            235-1248            AK004852.1         279-1292
            1249-1283           AA190126.1         202-236
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.53 cM"
     gene            1..1283
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /note="cyclin dependent kinase 2 associated protein 1"
                     /db_xref="GeneID:13445"
                     /db_xref="MGI:MGI:1202069"
     exon            1..312
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..602
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /note="CDK2-associated protein 1; putative oral cancer
                     suppressor; deleted in oral cancer 1; CDK2
                     (cyclin-dependent kinase 2)-associated protein 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2-associated protein 1"
                     /protein_id="NP_038840.2"
                     /db_xref="CCDS:CCDS39279.1"
                     /db_xref="GeneID:13445"
                     /db_xref="MGI:MGI:1202069"
                     /translation="MSYKPNLTAHMPAAALNAGSVHSPSTSMATSSQYRQLLSDYGPP
                     SLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARSLVR
                     ECLAETERNARS"
     exon            313..407
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /inference="alignment:Splign:2.1.0"
     exon            408..534
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1250
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /note="putative"
     polyA_site      1248
                     /gene="Cdk2ap1"
                     /gene_synonym="Apc10; Cdkap1; doc-1; Doc1; DORC1; p12;
                     ST19"
                     /note="putative"
ORIGIN      
        1 gcggccgccc ctgcgccgcg cgcccgatgt atgggtgatc tactgcggcg gcggcggcgg
       61 cggcggcggc agggtgaggg acggccatat ttgccggcgc ggcccgagcc ggcgacaaca
      121 aaaagtgcgc gggctcccgg cgggcgctcg gacggctgcg gggacgtggg gccgcccggc
      181 ccgggcctcg gcctcggcct cgccggcgcg ctcgcggcct ggcccggctc tgcccggcgc
      241 gcccgccgcc cgcggggatg tcgtacaagc cgaacttgac cgcgcacatg cccgccgccg
      301 ccctcaacgc cggaagtgtc cactcaccct ctactagcat ggcgacctcc tcccaatatc
      361 gccagctgct gagtgactat gggcctccat cgctaggcta cacccaggga actggaaata
      421 gccaggtgcc tcagagtaaa tatgcagagc tgctggccat cattgaagag ttggggaaag
      481 agatcagacc gacgtatgca gggagcaaga gcgccatgga gaggctaaaa cgaggcatca
      541 ttcatgcccg gagcctggtt cgggagtgct tggctgaaac ggaacggaat gccaggtcct
      601 agcccctggc tggtctgaag gcccatctca ctaccccgtg gagatgagag gctttgtgca
      661 aaatggcagt catttttcta ccacagtcat taagctctga acccacactc aaaagattgg
      721 gaggacattt tgcagtaact gacgatgtgc attttaagta gttaggaatg acccagctct
      781 ttttttcttt ccaaacattt gaaagatgtt tgtgaagcca cttcacagca agctattgtt
      841 tgtccccaaa taccagtgtc ccctctaacc tgcctttgga tacgcatcac cccagctgac
      901 ttcctttccc tgagctcacc tgcctccgag gagttgagtg caaaccacag cgcctttgct
      961 cagtagctgg cccgcctgtg tacagtgtag accctgcttc atggagcttc tctgcctaag
     1021 cgtttgcatg actgagtgct tggaagtcaa tctttaaaat gcacaggtta cacatgcaga
     1081 agaaagagcc atctacccaa cctcccaagc accctgcaga tgtccatcct gaggctgtag
     1141 atctcagttc tgtgtttact gtgagcccat cacaacatct ggaagaaagc gactgaaact
     1201 gttgcatctt tgtatttatt acttgatgta ataaagctta ttttcattaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaaaaaaa aaa
//
