LOCUS       NM_183417               2432 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Mus musculus cyclin dependent kinase 2 (Cdk2), transcript variant
            1, mRNA.
ACCESSION   NM_183417
VERSION     NM_183417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Chen,X., Wang,Y., Wang,J.N., Zhang,Y.C., Zhang,Y.R., Sun,R.X.,
            Qin,B., Dai,Y.X., Zhu,H.J., Zhao,J.X., Zhang,W.W., Ji,J.D.,
            Yuan,S.T., Shen,Q.D. and Liu,Q.H.
  TITLE     Lactylation-driven FTO targets CDK2 to aggravate microvascular
            anomalies in diabetic retinopathy
  JOURNAL   EMBO Mol Med 16 (2), 294-318 (2024)
   PUBMED   38297099
  REMARK    GeneRIF: Lactylation-driven FTO targets CDK2 to aggravate
            microvascular anomalies in diabetic retinopathy.
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Otto,J., Verwaayen,A., Penners,C., Hundertmark,J., Lin,C.,
            Kallen,C., Paffen,D., Otto,T., Berger,H., Tacke,F., Weiskirchen,R.,
            Nevzorova,Y.A., Bartneck,M., Trautwein,C., Sonntag,R. and
            Liedtke,C.
  TITLE     Expression of Cyclin E1 in hepatic stellate cells is critical for
            the induction and progression of liver fibrosis and hepatocellular
            carcinoma in mice
  JOURNAL   Cell Death Dis 14 (8), 549 (2023)
   PUBMED   37620309
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2432)
  AUTHORS   Arora,M., Moser,J., Hoffman,T.E., Watts,L.P., Min,M., Musteanu,M.,
            Rong,Y., Ill,C.R., Nangia,V., Schneider,J., Sanclemente,M.,
            Lapek,J., Nguyen,L., Niessen,S., Dann,S., VanArsdale,T.,
            Barbacid,M., Miller,N. and Spencer,S.L.
  TITLE     Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle
            plasticity
  JOURNAL   Cell 186 (12), 2628-2643 (2023)
   PUBMED   37267950
REFERENCE   4  (bases 1 to 2432)
  AUTHORS   Palmer,N., Talib,S.Z.A., Goh,C.M.F., Biswas,K., Sharan,S.K. and
            Kaldis,P.
  TITLE     Identification PMS1 and PMS2 as potential meiotic substrates of
            CDK2 activity
  JOURNAL   PLoS One 18 (3), e0283590 (2023)
   PUBMED   36952545
  REMARK    GeneRIF: Identification PMS1 and PMS2 as potential meiotic
            substrates of CDK2 activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2432)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2432)
  AUTHORS   Fautsch,M.P., Eblen,S.T., Anders,R.A., Burnette,R.J. and Leof,E.B.
  TITLE     Differential regulation of p34cdc2 and p33cdk2 by transforming
            growth factor-beta 1 in murine mammary epithelial cells
  JOURNAL   J Cell Biochem 58 (4), 517-526 (1995)
   PUBMED   7593274
REFERENCE   7  (bases 1 to 2432)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   8  (bases 1 to 2432)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 2432)
  AUTHORS   Said,T.K. and Medina,D.
  TITLE     Cell cyclins and cyclin-dependent kinase activities in mouse
            mammary tumor development
  JOURNAL   Carcinogenesis 16 (4), 823-830 (1995)
   PUBMED   7728962
REFERENCE   10 (bases 1 to 2432)
  AUTHORS   Tsai,L.H., Harlow,E. and Meyerson,M.
  TITLE     Isolation of the human cdk2 gene that encodes the cyclin A- and
            adenovirus E1A-associated p33 kinase
  JOURNAL   Nature 353 (6340), 174-177 (1991)
   PUBMED   1653904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN705407.1, AK148017.1, AK151979.1 and AK152922.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_183417.4.
            
            On Dec 5, 2007 this sequence version replaced NM_183417.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146845.1, BC005654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               CN705407.1         1-551
            552-1782            AK148017.1         491-1721
            1783-2426           AK151979.1         1733-2376
            2427-2432           AK152922.1         2237-2242
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.13 cM"
     gene            1..2432
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /note="cyclin dependent kinase 2"
                     /db_xref="GeneID:12566"
                     /db_xref="MGI:MGI:104772"
     exon            1..340
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1265
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2 isoform 1"
                     /protein_id="NP_904326.1"
                     /db_xref="CCDS:CCDS24289.1"
                     /db_xref="GeneID:12566"
                     /db_xref="MGI:MGI:104772"
                     /translation="MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGV
                     PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP
                     LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYT
                     HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHS
                     LCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWP
                     GVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
                     QDVTKPVPHLRL"
     exon            341..418
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            419..539
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            540..710
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..812
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..956
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1160
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..2432
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2408..2413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /note="putative"
     polyA_site      2426
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /note="putative"
     polyA_site      2432
                     /gene="Cdk2"
                     /gene_synonym="A630093N05Rik"
                     /note="putative"
ORIGIN      
        1 ggggcggggt ctcggatggc cgtctggagc agtgggggag gcggcaacat tgtttcaagt
       61 tggacaaatt gtcaagggct gagctctcct tgcgttccat cccgagctgg gactgccgtg
      121 ctcacccggg gtcccccagg tcctccgctc cgagtgtcgg gcccgctttc gtcagggttc
      181 ccgggccccg ctcccggggg cctgagccgc ctcactagcg ctccatggag aacttccaaa
      241 aggtggagaa gattggagag ggcacgtacg gagtggtgta caaagccaaa aacaagttga
      301 cgggagaagt tgtggcgctt aagaagatcc ggctcgacac tgagactgaa ggtgtaccca
      361 gtactgccat ccgagagatc tctctcctta aggaacttaa tcaccctaat atcgtcaagc
      421 tgctggatgt catccacaca gaaaataagc tttatctggt ttttgaattt ctgcaccagg
      481 acctcaagaa attcatggat gcctctgctc tcacgggcat tcctcttccc ctcatcaaga
      541 gctatctgtt ccagctgctc cagggcctgg ctttctgcca ttctcaccgt gtccttcacc
      601 gagaccttaa gccccagaac ctgcttatca atgcagaggg gtccatcaag ctggcagact
      661 ttggactagc aagagccttt ggagtccctg tccgaactta cactcatgag gtggtgaccc
      721 tgtggtaccg agcacctgaa attcttctgg gctgcaagta ctactccaca gccgtggata
      781 tctggagcct gggctgcatc tttgctgaaa tgcacctagt gtgtacccag caccatgcta
      841 agtgctgtgg ggaacacaga agaaatggaa gacacagtct ctgcccgctg tgctcctatc
      901 tagaagtggc tgcatcacaa ggagggggga tgaccgcagt gtctgcccca caccccgtga
      961 cccgcagggc cctattccct ggagattctg agattgacca actcttccgg atctttcgga
     1021 ctctggggac cccagatgag gtggtttggc caggagttac ttctatgcct gattataagc
     1081 caagtttccc caagtgggct cggcaagatt ttagcaaagt tgtgcctccc ctggatgaag
     1141 atggacggag cttgttatcg caaatgctgc actatgaccc caacaagcgg atttcagcca
     1201 aagcagccct ggctcaccct ttcttccagg atgtaactaa accagtgccc caccttcggc
     1261 tctgatgccc ttcccaaagc ccttttcacc cgtggtctga cttgaccctg ggccttttgg
     1321 acacaggtca gccttctgat gttttctggc tgtcttagca ttcgcctttt ctcttgccag
     1381 ccagttctgg ggattcagag gtgcagggaa gggttaggga aaagggggca aggttttggc
     1441 attagatgca cttaacccgg cttccaccag cttcttcccc tcttctcagt cattactgag
     1501 aaggattggt attcaaagca aaactgacag ttttcccctg tgtcaggttt tgccatccca
     1561 atcttaagac tgtctcataa ttaccatgtt gagggaaacg cccccagact cctgctgcca
     1621 ctgttttgtg aactaatgaa catgagcaga agcctaagtt gggacagctc agaaccaagc
     1681 aagagggggc cgttttaatg aattagattg aaaaataggc ctaagccgtt tgtaccttag
     1741 ttttagcgtt cggcctcacc tagcaatcaa gggcccgttt ggagaagcag aaatgattcc
     1801 ctccagtgcc ctgtctacct tccccaggca agaagagcca ggagggcaca gggcttgcac
     1861 gtcactctgg tctgttcatc gtggttcaca gggcaaggtg aaagacactt gaatttctct
     1921 ttttagcaat cttactgttt tctggtgctg actgctacac ccaggacttt gccctcacta
     1981 agcaaatgta ccaccaatga gccaggttcc tagccttcct tttggaagct cagttcttga
     2041 gttgtcagag ggcctcattg ccgtcctcct ctgagagcag tgatgcaggc caggagacat
     2101 catttgagaa tgctgatgct tttgtaaggc tttgacctgg ttaggtcatt gggggaaatt
     2161 ttctataaaa gagtgaacaa ttatatttat atttcaagtt aaagtagttt ggatacttta
     2221 gtggttttgt tgttgtttct tctttttcct tttttttttt tttttgtcag tgtggatgga
     2281 tttgttgcca tgtgcacttt gggattttgt aattgttaaa agaaaatatt tcttttatga
     2341 ttttcttctc ccactccctg tcctccagtg ttctgttaat attatttgta atttagtttg
     2401 taaattcatt aaaagaaaat attctcagct gt
//
