LOCUS       NM_001168304            5828 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin dependent kinase 19 (Cdk19), transcript variant
            1, mRNA.
ACCESSION   NM_001168304
VERSION     NM_001168304.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5828)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5828)
  AUTHORS   Prieto,S., Dubra,G., Camasses,A., Aznar,A.B., Begon-Pescia,C.,
            Simboeck,E., Pirot,N., Gerbe,F., Angevin,L., Jay,P., Krasinska,L.
            and Fisher,D.
  TITLE     CDK8 and CDK19 act redundantly to control the CFTR pathway in the
            intestinal epithelium
  JOURNAL   EMBO Rep 24 (2), e54261 (2023)
   PUBMED   36545778
  REMARK    GeneRIF: CDK8 and CDK19 act redundantly to control the CFTR pathway
            in the intestinal epithelium.
REFERENCE   3  (bases 1 to 5828)
  AUTHORS   Dannappel,M.V., Zhu,D., Sun,X., Chua,H.K., Poppelaars,M.,
            Suehiro,M., Khadka,S., Lim Kam Sian,T.C., Sooraj,D., Loi,M.,
            Gao,H., Croagh,D., Daly,R.J., Faridi,P., Boyer,T.G. and
            Firestein,R.
  TITLE     CDK8 and CDK19 regulate intestinal differentiation and homeostasis
            via the chromatin remodeling complex SWI/SNF
  JOURNAL   J Clin Invest 132 (20), e158593 (2022)
   PUBMED   36006697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5828)
  AUTHORS   Zhang,Z., Lu,Y., Qi,Y., Xu,Y., Wang,S., Chen,F., Shen,M., Chen,M.,
            Chen,N., Yang,L., Chen,S., Wang,F., Su,Y., Hu,M. and Wang,J.
  TITLE     CDK19 regulates the proliferation of hematopoietic stem cells and
            acute myeloid leukemia cells by suppressing p53-mediated
            transcription of p21
  JOURNAL   Leukemia 36 (4), 956-969 (2022)
   PUBMED   35110726
REFERENCE   5  (bases 1 to 5828)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5828)
  AUTHORS   Postlmayr,A., Dumeau,C.E. and Wutz,A.
  TITLE     Cdk8 is required for establishment of H3K27me3 and gene repression
            by Xist and mouse development
  JOURNAL   Development 147 (11) (2020)
   PUBMED   32439758
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5828)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 5828)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   9  (bases 1 to 5828)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142273.3, AK053651.1, BC080280.1 and AC157652.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122421.1, AK052818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC142273.3         68806-68834
            30-255              AK053651.1         3-228
            256-256             AC142273.3         69061-69061
            257-800             AK053651.1         230-773
            801-3328            BC080280.1         675-3202
            3329-3547           AC157652.3         99376-99594         c
            3548-5828           BC080280.1         3419-5699
FEATURES             Location/Qualifiers
     source          1..5828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 21.94 cM"
     gene            1..5828
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /note="cyclin dependent kinase 19"
                     /db_xref="GeneID:78334"
                     /db_xref="MGI:MGI:1925584"
     exon            1..414
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1792
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 2-like 6 (CDK8-like); cyclin-dependent
                     kinase (CDC2-like) 11; cyclin-dependent kinase 11; cell
                     division protein kinase 19; CDC2-related protein kinase 6;
                     cell division cycle 2-like protein kinase 6"
                     /codon_start=1
                     /product="cyclin-dependent kinase 19 isoform 1"
                     /protein_id="NP_001161776.1"
                     /db_xref="CCDS:CCDS48545.1"
                     /db_xref="GeneID:78334"
                     /db_xref="MGI:MGI:1925584"
                     /translation="MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGK
                     DEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEH
                     DLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVM
                     GEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
                     AIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEY
                     PTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPY
                     FQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPAAPAQQTAAP
                     PQAPPPQQSSAQTNGTAGGATAGGGGAGAGLQHSQDPGLNQVPPNKKPRIGPSGANSG
                     GPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSQQSTQYHSSHQTHRY"
     exon            415..490
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            491..601
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            602..742
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            743..800
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            801..932
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1076
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1146
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1219
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1317
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1396
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1663
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..5807
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4070..4075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /note="hexamer: AATAAA"
     polyA_site      4090
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /note="major polyA site"
     regulatory      5787..5792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /note="hexamer: AATAAA"
     polyA_site      5807
                     /gene="Cdk19"
                     /gene_synonym="2700084L06Rik; Cdc2l6; CDK11; mKIAA1028"
                     /note="major polyA site"
ORIGIN      
        1 gaaagccgcg gcgcggccca ccaggttcca aaacaaggaa atgaagggag gaggcgggac
       61 tgtagatgcc tgcgggagcc gccgccgccg ccgcggagga ggaggaggcg gaggaggtgg
      121 ctgccgcggc cgccgaggag tcccttgctg aaggcggacc gcggagcggc gggcggcgcg
      181 cgcgcgcccg agcgacggct gttggagaag tggagcggcg gcggtggagg agggactgag
      241 tggcggcggc ccccgcgtcc cggtttctct atgggggaag cagacaatgg attatgattt
      301 caaggcgaag ctggcggcgg agcgggagcg ggtggaggat ctgtttgagt acgaagggtg
      361 caaagtggga cgcggcacct acgggcatgt ctacaaggcg aggcggaaag atggaaaaga
      421 tgaaaaggaa tatgcactta agcaaatcga aggcacagga atatctatgt cggcttgtag
      481 agagattgca cttttgagag aactgaagca ccctaatgtg atcgcattgc agaaggtgtt
      541 cctttctcac agcgacagga aggtgtggct gctgtttgac tatgcagaac atgacctttg
      601 gcatattatt aagtttcacc gtgcatcaaa agcaaataaa aagcccatgc agttaccaag
      661 atccatggtt aaatcactgc tgtaccagat cctcgatggc atccattacc tccacgcaaa
      721 ctgggtgctc cacagggacc tgaaaccagc aaatatccta gtaatgggag aaggtcctga
      781 aagggggaga gtcaaaatag ctgacatggg ttttgccagg ttattcaatt ctcccctaaa
      841 gccactcgca gatttggatc cagtggttgt gacattttgg tatcgggctc cggaactttt
      901 acttggtgcc aggcattaca caaaggccat tgacatctgg gcaataggct gcatatttgc
      961 tgaactcttg acttcagaac ccatttttca ctgtcgtcag gaggatataa aaacaagcaa
     1021 tccttttcat catgatcagt tagatcgaat atttagtgtc atggggtttc ctgcagataa
     1081 agactgggaa gatattagaa aaatgccaga gtacccaaca cttcagaaag actttcgaag
     1141 aacaacgtac gccaacagca gcctcataaa atacatggag aagcacaagg tcaagcctga
     1201 cagcaaagtg ttcctcctgc ttcagaaact cctcaccatg gatccaacca agagaatcac
     1261 ctcagagcag gctctgcagg acccttactt ccaggaagac cccctgccaa cattagatgt
     1321 gttcgctggc tgccagattc cgtaccccaa aagagaattc cttaatgaag atgaaccaga
     1381 agagaaaggt gacaagaacc agccacagca gcagaaccca catcagcaac ctgcagcccc
     1441 cgcacagcag acagcagccc ccccacaggc tcctccacca cagcagagca gtgcccaaac
     1501 caatggaact gctgggggag ccactgcggg aggcgggggc gctggagcgg ggctgcagca
     1561 cagccaggac cccgggctga atcaggtgcc tccaaacaag aagccccgga ttgggccttc
     1621 cggtgcaaac tcaggcgggc ccgttatgcc gtcggattat cagcattcca gttctcgcct
     1681 gaattaccaa agcagcgtac aggggtcctc tcagtcccag agtacgctag gctactcttc
     1741 atctcaacag agtacccagt accactcatc tcaccagacc caccggtact gacccactcc
     1801 ctctgcttgg ccttggactc cagcagggtg gtatttgtgt tacaaagacc cccagaatga
     1861 agactgacac catgcaaagt gcagaccctt gagaggaaac ctttgcatgc taagtgtttt
     1921 gaaggactaa gctctcttct tcattgacta aaagaggatt cttgtgaagt gtccccgccc
     1981 tcttcccccg catgatttcc tctgtgactt tcctgatgaa gcctctgatc tacccagcac
     2041 ttctgcatcc ttcagcagtc tctgagggaa tttctggtgc acctttctca cgctgtagca
     2101 atcattataa tttatctttt cttagagttt caatgttgta ggcacagggt tccagtggtg
     2161 tatagtttta tacttcatga actgatttag caacaccagt gaaatgcacc ttttaaagca
     2221 ctccacagtc tccacagact aactgctctg ctcttggaag tcttcaaaag aaactgttac
     2281 tgtcccaaag tactttacta ttatgttttt atttatctct ttcagggaag gtgaaagaca
     2341 gtgtgggaca gacggtgccc acaaccaaaa acagtgtagg tctttgcagc tacctgctta
     2401 tgctatgaaa aactgaagta cttggtgatt tttatataat cattcatggg gaactcagtt
     2461 cccagaatca tcatattctg aataatattc agtaattaaa attataattt taacttcatg
     2521 tagctaagtc tactttaaaa gaggtttcaa gagctttgac ggaatccagt cctttgggac
     2581 tcacctggga agtctgaaga gcctgtttcc tgcactagga cctcacaagg agtcacgctg
     2641 atcaaagcac gcttcttcca cgtgaaggaa aagcttttcc catgtgtgtc ttcagacgct
     2701 tctctcaagg ggctgctggc tcttcagtct cttcacatct ggtcagcatg agtaactttc
     2761 ttccataatc aaggatactc aaatagaagc ttgttcattc atctgcaggg ttttccattt
     2821 gtgtgtacat taagcataaa gtgactattt ttaaagcatg ttaaaatttt aggtttcatt
     2881 catgtttgaa gtgtgtatta tgtatgcata attttgctgt tactgagact taacgctgtc
     2941 aagaatcttt tgtattgcac tgaatgcttt cttttgcccc taggacaaaa accttaataa
     3001 ttgtgcctaa gaactatggg cagatagtgt aaagtagatg aggtgaatat ttgcatttcc
     3061 atgatctacg aattagaggg gagttctatt ttagctactt ttgaggaacc cccacctcca
     3121 gaatcaagag gaaatgtaaa ggcttagagc tcccagtgta gtgcaggggc agaacacctg
     3181 tgttctgatg ctcctagcag caccagcctt gtttgcaatg tttcttgagc tagaaaaaaa
     3241 tagccaattg tatatgcaaa ctatatgcat ttttaaaaaa ctattcttgt gaacctatct
     3301 acctggttat gatactctgg ggtccatata caagtaaaat aagattttta gaagccagta
     3361 tacattttgc actattgatg tgatactgta gccagccagg accacactga tttcagcata
     3421 aggatgctta taaacagtaa taaaggctgt atggtggcat gcataccagg gccgaaaatg
     3481 aagtcattga catgtgacat gcttcactgg gaggaatctc tgactgtctc cttagacttt
     3541 tttttttaat cccttatatt tttttaaaat aagaatcagc cttgtgcata atgtcactat
     3601 caatataaag ttctgtcctg tgccctggag cctctttgtc cagggccact gctcccttct
     3661 cacaggctca gtgctctgct gggaagaaaa cataaagagt gggagacatt tccttattgc
     3721 agccagtcca gtgatcataa gctcctgtgg gctgtgcgcg ccctgtgact gacttataaa
     3781 tgccctgtga gatgaaggtc ctttgtttac ttctcaaccc acttggataa gtatgcttcc
     3841 gacttttatg gtaaacagtg ttatggggaa gcaggtctgt gtctgagcac ttgaggagaa
     3901 agccagtgat tagctgtcac aaaaggcatc tatgcatatt tgaaatgttc acagcagcct
     3961 tcagcagcag ttgggtggcc cttgtggaca gagcatattc tactaagtgg ttgtagagaa
     4021 ttacaatgaa aatagaagct ctgttcttgc cctcgaatga gctcaattta ataaaagaca
     4081 ttagccccta gtctgtgtat gtatgtgtat atatattaaa acagttcttt gtacacaaac
     4141 tggatacaca cttctggcag tatgcactta cacattcaca ggactgttct ggtaaaactg
     4201 actcaaacag ggcactttgt catttgcttc caatatagtg ttttccagga catagccaga
     4261 aaactccact ctctgtacag ctgggtgcca catcactgca ctgattctgg ccctttgatt
     4321 ttctcttctt gcctcagggt tggtaatgtg cccagtactc tcagaaataa tttctgttca
     4381 ttatttcctt tctctgtgaa ggaagcgaag cctttcgtat acatgaaggc catagtctat
     4441 ggggtgggtc ctctaatggg gcctgtgaag cttcttaagg gtggagctta cctctttgag
     4501 cctcgagtga tggttatttc tctttgaaca ttcagtagat actattttgt tctctacgga
     4561 cacggggagg cctcctctga cctaggagag cttcagagtc tagggaggat tgacgaattg
     4621 agttgaaagg tttctggtct ttgtattaag tcacttttag atgtagcttt gtggcaaggt
     4681 gtttgggaga aggattcggg cctctgggga cagagtagct caaagtagcg taatgtgagt
     4741 gggtgatgga ggctgaagca gtccatcgtg agtgagtgat gcgatagagg cggaagcaat
     4801 ccttttgatg gagtaaaccg tgatttgagc tgcagagatc aagagacaag tctatttatt
     4861 ctgtgctttt gaaaccttag gacttggagc tctgacattt tgcactctgt aacggagctt
     4921 catgatggga aggaatggcc tcttgttcac acttgctcgc cgcttcattc ctcgttctct
     4981 tgcctctaag atgatgctct gctctgctaa aaggaatggg agagtagggc ttgaagcttg
     5041 ctttgcttct gagttaagat gtagcagcaa ctatgcattg ttccctaggt gactgagaaa
     5101 gacaacgaat ggccattggg cttaatggag gctcggagga gtcgagtaca agtaataatt
     5161 ttctaaagag tgtagcagtt taggtcccca taatcatcaa gaatagttaa aaaacatcac
     5221 agccccaaag gctcgggatt tcagaagtgt atggtacccg ggggtactta cccttccagg
     5281 ctgttttcta tagggagtga tgctaatgtg ttacatggga aatacctaat gcactgttac
     5341 cacctacata gtgagtaaat taatactatt taattttttt taaaagcttt gtctgggtag
     5401 acactaaaag cattatatac aaagccagga ctgagatgtc ctttttaata acaactgaaa
     5461 gtacttttta tatatgttat acagtatgtc ctttctaaac tagtttgtat tcctgataat
     5521 tcctatttgt gaagtgtacc tgtctatctt tttggtcatt ttctgcacgc accccctctg
     5581 tatgattaga tattgccatg gctctccttg ctctgctgtg atgtgtgtat gccaagcctg
     5641 ctaccctcag cccactctgg ggatgcaggg cgcgtggtct cttcagaact gggtgctttt
     5701 gctctggatt tatccagcca cccttctcaa agtgactctt ccagctgcga taagttacat
     5761 cacatttatt ttatattctt ggttgaaata aaaattaatt gacttggaaa aaaaaaaaaa
     5821 aaaaaaaa
//
