LOCUS       NM_008795               3061 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin dependent kinase 18 (Cdk18), mRNA.
ACCESSION   NM_008795
VERSION     NM_008795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Matsuda,S., Kominato,K., Koide-Yoshida,S., Miyamoto,K., Isshiki,K.,
            Tsuji,A. and Yuasa,K.
  TITLE     PCTAIRE kinase 3/cyclin-dependent kinase 18 is activated through
            association with cyclin A and/or phosphorylation by protein kinase
            A
  JOURNAL   J Biol Chem 289 (26), 18387-18400 (2014)
   PUBMED   24831015
  REMARK    GeneRIF: The activity of PCTK3 is increased via interaction with
            cyclin A2 and phosphorylation by PKA.
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Rhee,K. and Wolgemuth,D.J.
  TITLE     Cdk family genes are expressed not only in dividing but also in
            terminally differentiated mouse germ cells, suggesting their
            possible function during both cell division and differentiation
  JOURNAL   Dev Dyn 204 (4), 406-420 (1995)
   PUBMED   8601034
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Okuda,T., Valentine,V.A., Shapiro,D.N. and Downing,J.R.
  TITLE     Cloning of genomic loci and chromosomal localization of the human
            PCTAIRE-1 and -3 protein kinase genes
  JOURNAL   Genomics 21 (1), 217-221 (1994)
   PUBMED   8088790
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Okuda,T., Cleveland,J.L. and Downing,J.R.
  TITLE     PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related
            protein kinase gene family
  JOURNAL   Oncogene 7 (11), 2249-2258 (1992)
   PUBMED   1437147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ070016.1, AK004998.1 and BQ177094.1.
            
            On Dec 13, 2007 this sequence version replaced NM_008795.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004998.1, SRR1660819.121850.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                CJ070016.1         2-58
            58-3043             AK004998.1         2-2987
            3044-3061           BQ177094.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.24 cM"
     gene            1..3061
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /note="cyclin dependent kinase 18"
                     /db_xref="GeneID:18557"
                     /db_xref="MGI:MGI:97518"
     exon            1..276
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            277..425
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1657
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 18;
                     serine/threonine-protein kinase PCTAIRE-3; PCTAIRE-motif
                     protein kinase 3"
                     /codon_start=1
                     /product="cyclin-dependent kinase 18"
                     /protein_id="NP_032821.1"
                     /db_xref="CCDS:CCDS15281.1"
                     /db_xref="GeneID:18557"
                     /db_xref="MGI:MGI:97518"
                     /translation="MNKMKNFKRRLSLSVPRPETIEESLAEFTEQFNQLHTQTNEDGT
                     DEPEQLSPGMQYQQRQNQRRFSMEDLNKRLSLPMDIRLPQEFLQKLQLENPGLPKPLT
                     RMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA
                     PCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMNMHN
                     VKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSN
                     EVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLL
                     GTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPRLDTEGINLLSSLLLYESKSRMS
                     AEAALNHPYFQSLGDRVHQLHDTASIFSLKEIQLQKDPGYRGLAFQHPGRGKSRRQSI
                     F"
     exon            426..505
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..631
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            632..688
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            689..803
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..898
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..961
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1085
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1206
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1304
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1410
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1453
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1544
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1622
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..3046
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2912..2917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /note="hexamer: AATATA"
     polyA_site      2939
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
                     /note="major polyA site"
     polyA_site      3046
                     /gene="Cdk18"
                     /gene_synonym="Ctk18; Pctk3"
ORIGIN      
        1 tgccttcctc ctcctcttac ccaccttcct gcacccctcc cttctccctt ctcccgcagc
       61 tcaggttaca gcttctttgg ggggaaaacc gctcaccttt ccagggccag gaagagccag
      121 ggtcccgagt agggaccccg gcggggcgcg gggcagggca cctaagcctg gcagcgcggc
      181 cgcggagggc gggagccggc tcgccacgac cgggacacgc gcagagtccg ccgcggcggc
      241 cagagagggg caccgcgccg ggcaagctga gcaaaggacc catcttggac ccctgctgat
      301 catgaacaag atgaagaact tcaagcgaag gctttccctg tccgtgcccc gcccagagac
      361 cattgaggag tcgttggctg agttcactga gcagttcaac caactccaca ctcagacgaa
      421 tgaggatggc acagatgagc ctgagcagct gtctcctggc atgcagtatc aacaacggca
      481 gaaccagcgc cgattctcca tggaggacct caacaagagg ctctctctgc ccatggacat
      541 ccgcctaccc caggaattcc tgcagaagct acagctggag aacccagggc tgcccaagcc
      601 tctcacccgc atgtcccgcc gtgcctccct gtcagatatc ggctttggga aactggaaac
      661 atatgtgaaa ctggacaaac tgggggaggg tacctatgcc accgtcttca agggacgcag
      721 caagctgaca gagaacctcg tggccctgaa ggagatccgg ctggagcatg aggaaggggc
      781 gccctgcact gctattcgag aggtgtctct gctgaaggac ctgaaacacg ccaatattgt
      841 gaccctgcat gacctcattc acacagatcg gtccctcacc ctggtgtttg agtacctgga
      901 cagtgacctg aaacagtacc tagaccactg tgggaacctc atgaacatgc acaatgtcaa
      961 gatattcatg ttccagctgc tccggggtct ggcctactgc caccaccgca agatcctgca
     1021 ccgggacctg aagccccaga acctactcat caatgagagg ggcgagctga agctggccga
     1081 ctttggcctg gcccgggcca aatcagtgcc tacaaagacc tattccaatg aggtggtgac
     1141 cctctggtac aggcccccag atgtgctgct gggatccaca gagtactcca cccccattga
     1201 catgtggggc gtgggctgca tcctctatga gatggccacc ggcaagcccc tcttcccggg
     1261 ctctactgtc aaggaggagt tgcacctcat cttccgtctc ctagggacac ctacagaaga
     1321 gtcgtggccg ggtgtgacgt ccatctctga gtttcgagcc tacaacttcc cccgatacct
     1381 accacagcca ctgctcagcc acgcccccag gttggatact gaaggcatca acctcctgag
     1441 cagcctcctc ctgtatgaat ccaagagtcg catgtcagca gaggcagccc tcaatcaccc
     1501 ctacttccag tctctcggag accgagttca tcagctccat gacactgcct ccatcttctc
     1561 cctgaaggag atccagctcc aaaaggaccc aggctatcgt ggcctggcct tccagcaccc
     1621 agggcgaggg aagagccggc ggcagagcat cttctgaacc atgcccaccc tgctgcacct
     1681 tgagggatga gaggccacac ggaacatgaa ctcaggaagt atatggggcc tgtgtggcca
     1741 tcagagggct gaacaatgaa tgcctgtggc cagcctggag ggccactcgg cagccctgtt
     1801 ggtagcattt gcttccttcc cttgcttgcc acacagctct gtggtggcct ctacccggat
     1861 accattcccc ttgtcaccca ctgtgggatg gggcgtgagg tcacttcccg aggggaagtg
     1921 aggtcacgga ggtccttggg accctttccc aatggaagtg caggagaatg tgggggccct
     1981 ggccctgccg actcatcggc ttgacaaacc cccttcttat tccttggacc ctgacttcat
     2041 cttcttcccc tctgagaacg aggaatatgg cacctgacct gggaccctgg aattgttccc
     2101 atgggtgtgc tgaccccacc caaaggcaga cattcctgga acatcagaaa aaagtagtac
     2161 ctcctcttgt cacctccccc accatgctat tgtcccctcc ttgccagaag ccctgtaccc
     2221 tctggcttga cccaaggcta aaaagcacca gcatgctgcc catgtccagc tgcatccgga
     2281 agtgttctgg tactccaaga tgtactccta cagcctcagc cagcccctgc ccgtcccccc
     2341 agtctggaaa gggttgcctt aaactggcag gtggtagagt gcactctgtc cttggaactc
     2401 tgacctagca cctatgtcct tcttccctaa gccactccta tgagtgttat cattcctgag
     2461 ggctgataag acaaccctgt ctcagggtcc tgaggctggc acccagatag gcaaggtcac
     2521 cttgacactg gtaccatggt aaccttggct ctttagggct ggtgcagcct cctctccaca
     2581 ccccaccact ttcccagccc tgtctacctg accctggcac tggcctccac agaaagggtg
     2641 ggaagggagt ccgcactgca gcctaagctg gagagaggtg agattgcagc aggtttgatc
     2701 ctgagagcct catcctacat ccctagagaa ggcacccttc ctctgtactc ctctcatggt
     2761 gtagggtctc tccaacattt ggctgaactt gaagggcaaa gaccaagggg aggtcaagcc
     2821 ccaatgcctg tcctaacccc tgggagcctg ggttctccct aacccccttt cccactgact
     2881 gtgaatgtcg tgactcagag caaagacaga gaatatattt aattcatgtt gtacaaaaag
     2941 cagtgagcag tctcattcag aaaaggagac tgataggaca atgccagaga cagaggactc
     3001 tgggtgtctg ggtttgctga cacatacata cgacccatta aagagaaaaa aaaaaaaaaa
     3061 a
//
