LOCUS       NM_146239               3643 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin dependent kinase 17 (Cdk17), mRNA.
ACCESSION   NM_146239
VERSION     NM_146239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Campbell,G.J., Hands,E.L. and Van de Pette,M.
  TITLE     The Role of CDKs and CDKIs in Murine Development
  JOURNAL   Int J Mol Sci 21 (15), 5343 (2020)
   PUBMED   32731332
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Mokalled,M.H., Johnson,A., Kim,Y., Oh,J. and Olson,E.N.
  TITLE     Myocardin-related transcription factors regulate the Cdk5/Pctaire1
            kinase cascade to control neurite outgrowth, neuronal migration and
            brain development
  JOURNAL   Development 137 (14), 2365-2374 (2010)
   PUBMED   20534669
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Kerr,N., Pintzas,A., Holmes,F., Hobson,S.A., Pope,R., Wallace,M.,
            Wasylyk,C., Wasylyk,B. and Wynick,D.
  TITLE     The expression of ELK transcription factors in adult DRG: Novel
            isoforms, antisense transcripts and upregulation by nerve damage
  JOURNAL   Mol Cell Neurosci 44 (2), 165-177 (2010)
   PUBMED   20304071
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Yamochi,T., Nishimoto,I., Okuda,T. and Matsuoka,M.
  TITLE     ik3-1/Cables is associated with Trap and Pctaire2
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1045-1050 (2001)
   PUBMED   11527406
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Okuda,T., Cleveland,J.L. and Downing,J.R.
  TITLE     PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related
            protein kinase gene family
  JOURNAL   Oncogene 7 (11), 2249-2258 (1992)
   PUBMED   1437147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ117086.1, CD350146.1, BC064815.1, BY130550.1, BQ442862.1,
            CX242491.1, BU841444.1, DV646930.1 and BB085519.1.
            
            On Nov 15, 2007 this sequence version replaced NM_146239.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.39904.1,
                                           SRR1660815.221183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               CJ117086.1         1-467
            468-504             CD350146.1         98-134
            505-1055            BC064815.1         490-1040
            1056-1101           BY130550.1         280-325
            1102-1526           BC064815.1         1087-1511
            1527-2134           BQ442862.1         111-718
            2135-2822           CX242491.1         53-740
            2823-3262           BU841444.1         217-656
            3263-3618           DV646930.1         365-720
            3619-3643           BB085519.1         313-337
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 47.89 cM"
     gene            1..3643
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /note="cyclin dependent kinase 17"
                     /db_xref="GeneID:237459"
                     /db_xref="MGI:MGI:97517"
     exon            1..325
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            326..472
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1926
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 17; PCTAIRE-motif
                     protein kinase 2; Pctaire2; serine/threonine-protein
                     kinase PCTAIRE-2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 17"
                     /protein_id="NP_666351.2"
                     /db_xref="CCDS:CCDS48670.1"
                     /db_xref="GeneID:237459"
                     /db_xref="MGI:MGI:97517"
                     /translation="MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEESSSKDNEPIVK
                     NGRPPTSHSVHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLK
                     MGSDGESDQASGTSSDEVQSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEK
                     LQISSPPFDQPMSRRSRRASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLV
                     ALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQ
                     YMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGL
                     ARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGS
                     TVEDELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPRLDSEGIELI
                     TKFLQYESKKRVPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSY
                     PETGHGKNRRQSMLF"
     exon            473..637
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..771
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..897
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..954
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1069
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1164
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1227
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1351
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1472
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1570
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1676
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1719
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1810
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1888
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..3643
                     /gene="Cdk17"
                     /gene_synonym="6430598J10Rik; Pctk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagacgaac gagagcggcg gctgcggtct acccagcgcc cggcagtccg gcagcccgcg
       61 ccccgccgcc tcgctccgcc ccggctcggt ggccgggagt actgggccgt ccgcgaggct
      121 ccgcggcccg ggagccatgt tgagcggggg gctctgccac gcgtgaggcg gccggcggcc
      181 ctcgcggagc ggaaggcgcg aggttggggg gtggggggag gcctgagcct gaggcgcctc
      241 ggcgcgtccg ccaccaccgg acctgcatcc gctcgctcgc tctgcgcgcc cgccggtccg
      301 gagcccgcgg tccccgcact tgctgaattt ttcaaaccac atccaactga taggatgaaa
      361 aagtttaaga ggagactgtc cctcacgctc aggggaagcc agacgattga tgagtcgctg
      421 tcagagctgg ctgagcagat gaccatagag gagagcagta gcaaggacaa cgagcccatt
      481 gtgaagaatg gcaggccgcc cacgtctcac agcgtgcatt ccttcctcca tcagtacaca
      541 ggctccttca agaagccccc gttgcggaga ccccacagtg ttattggagg aagccttggt
      601 tccttcatgg caatgcccag gaatggaagc agactagata ttgttcatga aaatctgaag
      661 atgggatcag atggtgagag tgaccaagct tctgggacat catctgatga agtccagtca
      721 cctacaggtg tttgcctcag aaatcgtata catagacgga tctcaatgga ggacttgaat
      781 aagcggctgt cgctgcctgc agacatcagg atacctgatg gctacctgga gaagctgcag
      841 atcagcagcc caccctttga ccagcccatg agccgcaggt cccgcagagc ttccttatca
      901 gaaattgggt ttgggaaaat ggaaacctac atcaaattgg aaaagctcgg agagggtaca
      961 tatgcaacag tatataaagg aagaagtaaa ctgacagaaa atttggtggc attaaaagag
     1021 atccgcttgg aacacgaaga aggtgcaccc tgtacagcta taagagaagt ttcactgtta
     1081 aaggatttaa aacatgcaaa tatagtaacc ttgcacgaca tcgttcacac agacaaatct
     1141 ttgactctgg tctttgagta cctggacaaa gacctgaagc aatacatgga tgactgtggg
     1201 aacatcatga gcatgcacaa tgtcaagctg ttcctgtacc aaattctccg tggtctggca
     1261 tattgccata gaagaaaagt gttgcaccgg gacttgaaac cacagaacct cctcattaat
     1321 gagagaggag aactaaagct ggctgacttt ggactagcca gagccaagtc agttcccaca
     1381 aagacctact caaatgaagt tgtcaccctg tggtatcgac cacctgatgt gcttcttggt
     1441 tcctcagaat actcaacaca gatcgacatg tggggagttg gctgtatttt ctttgaaatg
     1501 gcttctggaa gaccactgtt tccagggtca actgtggaag atgaactgca tttaatattt
     1561 cgactactag gaactccatc tcaggaaact tggccaggtg tttcttcaaa tgatgaattc
     1621 aagaactaca acttcccaaa atacaagcca caacctctaa ttaatcatgc acccaggtta
     1681 gattctgaag gaattgaatt gataacaaaa tttcttcagt atgaatctaa gaagagggtt
     1741 ccggcagaag aggccatgaa gcacgtgtac ttccgcagcc tggggccgag gatccatgct
     1801 ttgcccgaga gcgtatcaat attcagtttg aaagagattc agttgcaaaa ggacccgggt
     1861 tttcgaaact cttcttatcc agagacagga catgggaaga acagaagaca gagcatgctc
     1921 ttttaagtct ggtaacttgg tctcaagccc agctccagcc tttcttatca gccatggact
     1981 cagagctgaa ggcagtcatt tcttgtgctg gacttgggaa ctccgtgtgt cagcactgtc
     2041 ctcttcccag tggagtcttt ttatttcaga cctacagatt gtttttatat ttgttgtcac
     2101 agtgtgacaa tttttttttt tgtacagttg gttttaaggt cttctccgcc agtagagcca
     2161 gtaggttaca gctatcaatg taactgtagc tgcagatttg tgccggactg agaaacacag
     2221 tgcattattt atttgcggaa tcattgctgc taaataacta ctgtctgttt atttaacaca
     2281 acagttgaat gcctgaagaa gttgcagtgg ctttattata tgtgaacgca tctgtttctc
     2341 ctcacaaatt gtttgactgc tgcattttgt tgttgtttgt ttgtttgttt gtttgtttgt
     2401 tttttaaaag attaaactgc agtgtttcct ggaatgtata ttttagcttt gcttagcagt
     2461 agaataagtg agccatcgtg aacactcgaa gtccgtgcta catatcattt cttaggcgca
     2521 ttggccaata gccaggctga gagggggtca gcacagtgtg tttcgggagc atgcaatgtg
     2581 agggttgatg caagcaaatg agtagcagac attttgggtt ctcatgtcaa ataccaataa
     2641 actaaaacac ggagttattt atttttacct attcctcctc ttagaaatgt ctgcatatgt
     2701 gtatgctcct acacttggtt agctctttct cactgtgctt ttagttaaaa tttagccaca
     2761 taagtcattc aaacaggaag ggccttgccg ctgttcatca taagcacatt tctcttatta
     2821 gaggatactt cattttgagg gaccgtttct ttcatttggg gactgtgtgt gtttcaataa
     2881 cgttcacttg gaatgagctg aaagctgtgc tgtgtcttta aatggagcca cgatgaatta
     2941 gaaatgagaa agaagaaccc agaggactgc tttagtgttg tgggtattat ctgctcatca
     3001 gagacactaa cagtgtaact tgaattatgc atctccttga acatcacaga cacttggtgt
     3061 tggtaatcgt gtcttaggca tttgcgctca ttgttaagga ctattggtta gtgcatctta
     3121 caactataaa tcttaattgg ttatagtttg caatggtcat gtgtttgcct tatatcatga
     3181 aaatagttat aacttaattt ttgtcctgcc attcactgta aacattcagg gtcctctcat
     3241 ttctgttcag gaaatcctgt agtttattgt ttgttattta acagtattaa gtgagttttt
     3301 gtatatttca ttttaacttt atttgtgaat agtgattgtg gcatgtttgg ggatgttatt
     3361 ttaatatttc acaatactga aattttaatt tttttttaaa aaaaaagaaa gttctggaag
     3421 aaacagattc atatgtaatg gtgaatattg gaccactgct gctttcacag ttgtcagctg
     3481 gttttatgtt aagccctgta gcctaactgc tgttatttct aactgacaga catgtattaa
     3541 tattgtactt tgaaggttat aaatattatg tgaaaattcc ttcatttgtt ttgaaattta
     3601 taataactaa atctctgtgt tatataaaat gtgatttttg tgg
//
