LOCUS       NM_011049               3125 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cyclin dependent kinase 16 (Cdk16), transcript variant
            1, mRNA.
ACCESSION   NM_011049 XM_908232 XM_920731 XM_920739 XM_920745 XM_920751
            XM_920756 XM_920762 XM_920768 XM_920773
VERSION     NM_011049.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3125)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   2  (bases 1 to 3125)
  AUTHORS   Campbell,G.J., Hands,E.L. and Van de Pette,M.
  TITLE     The Role of CDKs and CDKIs in Murine Development
  JOURNAL   Int J Mol Sci 21 (15), 5343 (2020)
   PUBMED   32731332
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3125)
  AUTHORS   Zi,Z., Zhang,Z., Li,Q., An,W., Zeng,L., Gao,D., Yang,Y., Zhu,X.,
            Zeng,R., Shum,W.W. and Wu,J.
  TITLE     CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate
            Spermatogenesis in Mouse
  JOURNAL   PLoS Genet 11 (8), e1005485 (2015)
   PUBMED   26305884
  REMARK    GeneRIF: CCNYL1 regulates spermatogenesis through the interaction
            and modulation of CDK16.
            Erratum:[PLoS Genet. 2019 Mar 4;15(3):e1008021. doi:
            10.1371/journal.pgen.1008021.. PMID: 30830908]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3125)
  AUTHORS   Shimizu,K., Uematsu,A., Imai,Y. and Sawasaki,T.
  TITLE     Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast
            migration and fusion
  JOURNAL   FEBS Lett 588 (17), 3030-3037 (2014)
   PUBMED   24931367
  REMARK    GeneRIF: Pctaire1 exerts promyogenic effects by regulating myoblast
            migration and process formation during skeletal myogenesis
REFERENCE   5  (bases 1 to 3125)
  AUTHORS   Chen,X.Y., Gu,X.T., Saiyin,H., Wan,B., Zhang,Y.J., Li,J.,
            Wang,Y.L., Gao,R., Wang,Y.F., Dong,W.P., Najjar,S.M., Zhang,C.Y.,
            Ding,H.F., Liu,J.O. and Yu,L.
  TITLE     Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1
            negatively regulates glucose-stimulated insulin secretion in
            pancreatic beta-cells
  JOURNAL   J Biol Chem 287 (36), 30368-30375 (2012)
   PUBMED   22798068
  REMARK    GeneRIF: a novel function of BRSK2 in the regulation of GSIS in
            beta-cells via a PCTAIRE1-dependent mechanism and suggest that
            BRSK2 is an attractive target for developing novel diabetic drugs.
REFERENCE   6  (bases 1 to 3125)
  AUTHORS   Carrel,L., Clemson,C.M., Dunn,J.M., Miller,A.P., Hunt,P.A.,
            Lawrence,J.B. and Willard,H.F.
  TITLE     X inactivation analysis and DNA methylation studies of the
            ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and
            mouse
  JOURNAL   Hum Mol Genet 5 (3), 391-401 (1996)
   PUBMED   8852665
REFERENCE   7  (bases 1 to 3125)
  AUTHORS   Rhee,K. and Wolgemuth,D.J.
  TITLE     Cdk family genes are expressed not only in dividing but also in
            terminally differentiated mouse germ cells, suggesting their
            possible function during both cell division and differentiation
  JOURNAL   Dev Dyn 204 (4), 406-420 (1995)
   PUBMED   8601034
REFERENCE   8  (bases 1 to 3125)
  AUTHORS   Okuda,T., Valentine,V.A., Shapiro,D.N. and Downing,J.R.
  TITLE     Cloning of genomic loci and chromosomal localization of the human
            PCTAIRE-1 and -3 protein kinase genes
  JOURNAL   Genomics 21 (1), 217-221 (1994)
   PUBMED   8088790
REFERENCE   9  (bases 1 to 3125)
  AUTHORS   Ershler,M., Nagorskaya,T.V., Visser,J.W. and Belyavsky,A.V.
  TITLE     Novel CDC2-related protein kinases produced in murine hematopoietic
            stem cells
  JOURNAL   Gene 124 (2), 305-306 (1993)
   PUBMED   8444355
REFERENCE   10 (bases 1 to 3125)
  AUTHORS   Okuda,T., Cleveland,J.L. and Downing,J.R.
  TITLE     PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related
            protein kinase gene family
  JOURNAL   Oncogene 7 (11), 2249-2258 (1992)
   PUBMED   1437147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807240.12.
            
            On Aug 31, 2022 this sequence version replaced NM_011049.5.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer protein (isoform 1). Variants 1
            and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.103990.1, AK145483.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AL807240.12        42362-42755
            395-602             AL807240.12        47273-47480
            603-736             AL807240.12        47987-48120
            737-862             AL807240.12        48220-48345
            863-919             AL807240.12        48438-48494
            920-1034            AL807240.12        48581-48695
            1035-1129           AL807240.12        49459-49553
            1130-1192           AL807240.12        49648-49710
            1193-1316           AL807240.12        49967-50090
            1317-1437           AL807240.12        50296-50416
            1438-1535           AL807240.12        50497-50594
            1536-1641           AL807240.12        50680-50785
            1642-1684           AL807240.12        50871-50913
            1685-1775           AL807240.12        51069-51159
            1776-1853           AL807240.12        52400-52477
            1854-3125           AL807240.12        52558-53829
FEATURES             Location/Qualifiers
     source          1..3125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 16.18 cM"
     gene            1..3125
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /note="cyclin dependent kinase 16"
                     /db_xref="GeneID:18555"
                     /db_xref="MGI:MGI:97516"
     exon            1..394
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..602
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..1891
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 16; serine/threonine-protein
                     kinase PCTAIRE-1; PCTAIRE-motif protein kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 16 isoform 1"
                     /protein_id="NP_035179.1"
                     /db_xref="CCDS:CCDS30045.1"
                     /db_xref="GeneID:18555"
                     /db_xref="MGI:MGI:97516"
                     /translation="MDRMKKIKRQLSMTLRGGRGIDKTNGVPEQIGLDESGGGGGSDL
                     GEAPTRIAPGELRSVRGPLSSAPEIVHEDMKMGSDGESDQASATSSDEVQSPVRVRMR
                     NHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFG
                     KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL
                     KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAY
                     CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILL
                     GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSN
                     EEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDARKHPFFLSLG
                     ERIHKLPDTTSIFALKEVQLQKEANIRSTSMPDSGRPAFRVVDTEF"
     exon            603..736
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..862
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..919
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1034
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1129
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1192
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1316
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1437
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1535
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1641
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1684
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1775
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1853
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..3125
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /note="hexamer: AACAAA"
     polyA_site      2131
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /note="major polyA site"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /note="hexamer: ATTAAA"
     polyA_site      3125
                     /gene="Cdk16"
                     /gene_synonym="Crk5; Pctaire1; Pctk1"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcggag cgcggcgcgc gcggctgttg ggccgctggc tggggggctc tgggatatgc
       61 tgcgtctccg ctagctgtct gctgtgagtc acgagccgcc gtgaacaccc ggattccagc
      121 gggcgcttgc gagcacgggg gcatcgcccg cagtggccaa gctcatggcc ggctgagcgg
      181 gacgccgccg ccgcctcagc cgccgccgcc gccgccgcct cttcctcctc agccggcggc
      241 ggcccgggcc cagcagccat ggccgaagac tactgggacg ggcgcctgcg gcgaactgga
      301 ggaaaaggag gtcgcgcggc ctcatcccgg gccgccgccc caggcgccac cgcgccggcc
      361 ccgcggctct gaggttactc gcgcgccccc tccggtcgcc atggatcgga tgaagaagat
      421 caaacggcag ctgtcaatga cactccgagg gggccgaggc atagataaga ccaatggtgt
      481 ccctgagcag ataggcctgg atgagagtgg tggcggtggt ggcagtgacc ttggagaagc
      541 tcccacccgt attgcccctg gggagcttcg ctctgttcgg ggcccactca gctctgcacc
      601 agagattgtg cacgaggaca tgaagatggg atctgatggg gagagtgacc aggcttcagc
      661 cacatcctca gatgaggtgc agtctccagt gagagtgcgc atgcgcaacc accccccacg
      721 caagatctcc actgaggaca tcaacaaacg cctgtcacta ccagctgaca tacggctgcc
      781 tgagggctac cttgagaagc tgaccctcaa tagccccatc tttgataagc ctcttagccg
      841 gcgcctccgc cgagtcagtt tgtctgagat tggctttgga aaactggaga cctacatcaa
      901 gctagacaag ctgggtgagg gtacctatgc cactgtctac aaaggcaaaa gcaagctcac
      961 agacaacctt gtagcactta aggagatcag actggaacac gaagaagggg caccctgtac
     1021 tgctatccgg gaagtatccc tgcttaagga cctcaagcat gccaacatcg tcacactaca
     1081 tgacattatc cacacagaga agtccctcac acttgtcttt gaatacttgg acaaggacct
     1141 gaagcagtac ctggatgact gtggaaatgt catcaacatg cacaatgtga aactgttcct
     1201 gttccagttg ctccgtggcc tggcctactg ccacaggcag aaggtgctac accgagacct
     1261 caagccccag aacctactca tcaacgagag gggagagctc aaactggcag attttggcct
     1321 ggctcgtgcc aagtcaattc ctactaaaac atactccaac gaagtggtga cactgtggta
     1381 ccggccccct gacatcctac ttgggtccac agactactct acccaaattg acatgtgggg
     1441 tgtaggctgc atcttctatg agatggccac cggccggccc ctcttcccag gctccacagt
     1501 ggaagaacag ctgcacttca tcttccgcat tttgggaacc ccaactgagg agacatggcc
     1561 aggtatcctg tccaatgagg agtttagaac atacaactac cccaagtacc gagccgaggc
     1621 ccttctgagc catgcacccc gacttgatag cgatggagct gacctcctca ccaagctgct
     1681 gcagtttgag ggtcgcaatc ggatctctgc tgaggatgcc aggaaacatc cattctttct
     1741 cagcttgggg gagcggatcc acaaacttcc tgacactact tccatatttg cactaaagga
     1801 ggtacagcta caaaaggagg ccaacattcg gtccacttct atgcctgact caggcaggcc
     1861 agctttccgt gtggtggata ccgagttcta agccaagttt taagccacag acagaccaag
     1921 gccccagcag gcagcggctg gagggatgcc acacccctta cagggcagcc cccatctgca
     1981 atcctccctg cttgttgcct gcttacctgc ctgagccaca ctcccctgcc aacttgtccc
     2041 ctgccacctg cccaaacacc aaaccactgg cctggcctgt caacccaacc attggcctgt
     2101 ctgctgggtg ctaacaaagc tctcaccact actttgcttg atgtgtctgt ctctgtcttg
     2161 gtagttgctg gtgaacagaa tggccatgcc aggtttccac actaaggcta ggccttcccc
     2221 tctaaatcac actctctccc aggaccacta ccccatggcc agccagggat ttggagctag
     2281 cccaggccag gctcttaatt gactttgact agaaggtagt gagtgatgcc ttgggtctga
     2341 gcatcctctg cctgcttgcc acctgtccca cttgcctctg ttgtatgggc cttctttttt
     2401 gttagtttct tttattgttt ttttattatt ttaaatgagg ttctcacttt ttaatgcaat
     2461 atctctgtat acagactggt tgggcgctac tccctgagta tggccctcct acagtatttt
     2521 gtgcaatgaa gtcccactcc cagcctttga gaggtaggga cccagaccct attcagatcc
     2581 tgaccatcac tataccctgg gattggctat gggaaagcat gcctcagcca ctcaccttcc
     2641 tcccctacct agtgtcccca gctatagggg gacctgagaa ctaccagaga ctgggagatg
     2701 gacatggtgg gggctacttt ttccctcctt tagtcccgta gccagggcct ctttccttct
     2761 cagggtcttc cccagcccag ctctgcctag ccctcctgtc ctgtcctact cggtgctgtt
     2821 gagtaggggc tctgccagga attgaccagc ttagtgagga gccatatata atatgtgcac
     2881 aagcaggggg acatgtgcga gcttgtgccc aattgtaaca ctccagtccc taggagggta
     2941 aggcaggcca aggacagtct cctggatgta tggtttgctc cccttcctcc accttaagcc
     3001 ttgggaccct taagcggggt gggagggcaa gggagggtgc cctcctagtg gggtttgggg
     3061 ggattgggtt cctgaatgca ccataattgc tgtatgaaat attaaaaaaa agtctaaagt
     3121 tcaaa
//
