LOCUS       NM_001033373            1606 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus cyclin dependent kinase 15 (Cdk15), transcript variant
            1, mRNA.
ACCESSION   NM_001033373 XM_194683 XM_901069 XM_909213 XM_921189
VERSION     NM_001033373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1606)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 1606)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153652.3, AC116995.3 and AC132361.4.
            
            [WARNING] On Jul 10, 2024 this sequence was replaced by
            NM_001033373.4.
            
            On Oct 4, 2017 this sequence version replaced NM_001033373.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147763.1, SRR5189685.166571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC153652.3         11342-11534         c
            194-334             AC153652.3         10484-10624         c
            335-429             AC153652.3         9643-9737           c
            430-509             AC153652.3         2757-2836           c
            510-604             AC116995.3         139674-139768
            605-667             AC116995.3         140514-140576
            668-791             AC116995.3         146867-146990
            792-912             AC116995.3         148764-148884
            913-1006            AC116995.3         160300-160393
            1007-1070           AC116995.3         169901-169964
            1071-1119           AC132361.4         28485-28533
            1120-1259           AC132361.4         32673-32812
            1260-1378           AC132361.4         46062-46180
            1379-1606           AC132361.4         54084-54311
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.47 cM"
     gene            1..1606
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /note="cyclin dependent kinase 15"
                     /db_xref="GeneID:271697"
                     /db_xref="MGI:MGI:3583944"
     exon            1..193
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1369
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 7; cell division protein kinase 15;
                     serine/threonine-protein kinase ALS2CR7;
                     serine/threonine-protein kinase PFTAIRE-2; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 7
                     protein homolog; PFTAIRE protein kinase 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 15 isoform 1"
                     /protein_id="NP_001028545.2"
                     /db_xref="CCDS:CCDS48273.1"
                     /db_xref="GeneID:271697"
                     /db_xref="MGI:MGI:3583944"
                     /translation="MGQELCAKRLQPGCSCYHRSEGGEAHSCQRSQPGSTEPAVFELT
                     EASSSTASFHPRGLEAASAQKLKSKRPRSNSDSFQEENLRQGLPWKKSLPFGAASSYL
                     NLEKLGEGSYAKVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIV
                     LLHDIVHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQRV
                     LHRDLKPQNLLLSHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYS
                     SELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP
                     EWFPPPKPQSLQIVWDRLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSVLPSQL
                     YQLPDEESLFAVSGVKLKPEMCDLSASYRKRHHLVGVNKCW"
     exon            194..334
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..429
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..509
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..604
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..667
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..791
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..912
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1006
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1070
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1119
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1259
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1378
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1606
                     /gene="Cdk15"
                     /gene_synonym="Als2cr7; Pftk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaaatga gaagaggcgg gtgggaagag gttcaagggc gggttttctc cttgaacctg
       61 ggctagtatg ggtcaagagc tgtgtgcaaa gaggctacag ccaggatgca gttgctacca
      121 ccgttcggag ggaggggagg cgcacagctg tcagagaagc cagcctggaa gcaccgagcc
      181 tgctgtattc gagctaacag aagcatccag ttccacggct tcatttcacc ccaggggact
      241 ggaggctgcc agtgcccaga agttgaagag taaaaggccc cggagtaaca gtgattcttt
      301 tcaggaagag aatctgaggc aggggttgcc atggaagaag agcctccctt ttggggcagc
      361 ctcatcttac ttgaacttgg agaagctggg tgaaggttct tatgccaaag tttacaaggg
      421 catcagcagg ataaatggac aactagtagc tctcaaggtc atcagcatga atgcagagga
      481 gggagtccct ttcacagcca tccgggaagc atctctcctg aagggcttga agcatgccaa
      541 tattgtcctc ttgcatgaca ttgttcacac caaagagact ctgacattcg tatttgaata
      601 catgcatacc gacctggccc agtacatgtc tcagcatcct ggagggcttc atcctcacaa
      661 tgtcaggctt ttcatgtttc aacttctgcg gggcctggca tacatccacc accagcgtgt
      721 tctccacagg gacctgaaac ctcagaactt gctcctcagt cacctgggag agctcaaact
      781 ggctgatttt ggtcttgctc gagccaagtc cattcctagc cagacatact cctcagaagt
      841 ggtgacactc tggtaccggc cacctgacgc tttgctggga gccactgagt actcctctga
      901 gctagacata tggggcgcag gctgcatctt cattgaaatg ttccagggtc aacctctgtt
      961 tcctggggta tccaacatcc tcgaacagct ggagaagatc tgggaggttc tgggagtccc
     1021 tacagaggat acctggcctg gagtctccaa actgcctaac tacaatccag aatggttccc
     1081 gccacctaaa cctcaaagcc tgcagattgt ctgggacagg ctgggtggag ttcctgaagc
     1141 tgaagacctg gcctcccaga tgctaaaagg cttccccagg gaccgtgtct cagcccaaga
     1201 agcgctcgtt catgattatt tcagtgtctt gccatcccag ttgtaccagc ttcctgatga
     1261 ggagtctctg tttgcagttt cgggagtgaa gctaaagcca gaaatgtgtg acctttcggc
     1321 ttcctacagg aagagacacc acctagtcgg ggttaacaaa tgttggtgaa aagaaaaggc
     1381 ctgtagccac acggtctcct tgtgtcagct tacgacgaag cttcgtgccc tatttcatac
     1441 tggatcagag atctgtgttc tctctctggc tgcctggaat atttaaaaca tgatgttcaa
     1501 gacaaggata taatacagga agagtgcaat gaaaggttat tgctattatt gttacctaaa
     1561 aacaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaa
//
