LOCUS       NM_011074               4928 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Mus musculus cyclin dependent kinase 14 (Cdk14), transcript variant
            1, mRNA.
ACCESSION   NM_011074
VERSION     NM_011074.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4928)
  AUTHORS   Zhang M, Zhang L, Geng A, Li X, Zhou Y, Xu L, Zeng YA, Li J and Cai
            C.
  TITLE     CDK14 inhibition reduces mammary stem cell activity and suppresses
            triple negative breast cancer progression
  JOURNAL   Cell Rep 40 (11), 111331 (2022)
   PUBMED   36103813
  REMARK    GeneRIF: CDK14 inhibition reduces mammary stem cell activity and
            suppresses triple negative breast cancer progression.
REFERENCE   2  (bases 1 to 4928)
  AUTHORS   Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch-Brauninger M, Herbst
            J, Vidal V, Schedl A, Huttner WB and Niehrs C.
  TITLE     Mitotic WNT signalling orchestrates neurogenesis in the developing
            neocortex
  JOURNAL   EMBO J 40 (19), e108041 (2021)
   PUBMED   34431536
REFERENCE   3  (bases 1 to 4928)
  AUTHORS   Youlten SE, Kemp JP, Logan JG, Ghirardello EJ, Sergio CM, Dack MRG,
            Guilfoyle SE, Leitch VD, Butterfield NC, Komla-Ebri D, Chai RC,
            Corr AP, Smith JT, Mohanty ST, Morris JA, McDonald MM, Quinn JMW,
            McGlade AR, Bartonicek N, Jansson M, Hatzikotoulas K, Irving MD,
            Beleza-Meireles A, Rivadeneira F, Duncan E, Richards JB, Adams DJ,
            Lelliott CJ, Brink R, Phan TG, Eisman JA, Evans DM, Zeggini E,
            Baldock PA, Bassett JHD, Williams GR and Croucher PI.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4928)
  AUTHORS   Pollack D, Xiao Y, Shrivasatava V, Levy A, Andrusier M, D'Armiento
            J, Holz MK and Vigodner M.
  TITLE     CDK14 expression is down-regulated by cigarette smoke in vivo and
            in vitro
  JOURNAL   Toxicol Lett 234 (2), 120-130 (2015)
   PUBMED   25680692
  REMARK    GeneRIF: Cigarette smoke down regulates CDK14 levels and impairs
            Wnt signaling.
REFERENCE   5  (bases 1 to 4928)
  AUTHORS   Quina LA, Wang S, Ng L and Turner EE.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   6  (bases 1 to 4928)
  AUTHORS   Thomas JW, Lee-Lin SQ and Green ED.
  TITLE     Human-mouse comparative mapping of the genomic region containing
            CDK6: localization of an evolutionary breakpoint
  JOURNAL   Mamm Genome 10 (7), 764-767 (1999)
   PUBMED   10384057
REFERENCE   7  (bases 1 to 4928)
  AUTHORS   Besset V, Rhee K and Wolgemuth DJ.
  TITLE     The identification and characterization of expression of Pftaire-1,
            a novel Cdk family member, suggest its function in the mouse testis
            and nervous system
  JOURNAL   Mol Reprod Dev 50 (1), 18-29 (1998)
   PUBMED   9547506
REFERENCE   8  (bases 1 to 4928)
  AUTHORS   Lazzaro MA, Albert PR and Julien JP.
  TITLE     A novel cdc2-related protein kinase expressed in the nervous system
  JOURNAL   J Neurochem 69 (1), 348-364 (1997)
   PUBMED   9202329
REFERENCE   9  (bases 1 to 4928)
  AUTHORS   Lazzaro MA and Julien JP.
  TITLE     Chromosomal mapping of the PFTAIRE gene, Pftk1, a cdc2-related
            kinase expressed predominantly in the mouse nervous system
  JOURNAL   Genomics 42 (3), 536-537 (1997)
   PUBMED   9205131
REFERENCE   10 (bases 1 to 4928)
  AUTHORS   Lluch Fernandez MD, Pena Grinan MJ, Perez Cano R, Ramos Sanchez I
            and Montoya Carcia MJ.
  TITLE     [Phosphorus-calcium metabolism in children under long-term
            anticonvulsant therapy]
  JOURNAL   An Esp Pediatr 35 (2), 103-107 (1991)
   PUBMED   1952457
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045083.1, AK051283.1, AK139386.1, BC068134.1 and BE948428.1.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_011074.4.
            
            On Jul 14, 2015 this sequence version replaced NM_011074.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129226.1, AF033655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK045083.1         2-28
            28-1165             AK051283.1         2-1139
            1166-2355           AK139386.1         1327-2516
            2356-4905           BC068134.1         2560-5109
            4906-4928           BE948428.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.61 cM"
     gene            1..4928
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /note="cyclin dependent kinase 14"
                     /db_xref="GeneID:18647"
                     /db_xref="MGI:MGI:894318"
     exon            1..217
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1536
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 14; serine/threonine-protein
                     kinase PFTAIRE-1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 14 isoform 1"
                     /protein_id="NP_035204.2"
                     /db_xref="CCDS:CCDS19073.1"
                     /db_xref="GeneID:18647"
                     /db_xref="MGI:MGI:894318"
                     /translation="MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKEDTTFDEICV
                     TKMSTRNCQGTDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACIN
                     FKSSSAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKL
                     VALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC
                     QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFG
                     LARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPG
                     MKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHA
                     EDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES
                     MRAFGKNNSYGKSLSNSKH"
     exon            218..249
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..495
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..590
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..670
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..828
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..952
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1073
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1167
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1231
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1280
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1420
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1564
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..4912
                     /gene="Cdk14"
                     /gene_synonym="mKIAA0834; Pftk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggcggag gagcaggacg aggcgccgcc ttccccgcgc cgcgcgccct cgcccgccgt
       61 tgtctgcgct gcgctgcgct gcgctggacc agtttcgcga agttgccggg gccctacgcc
      121 gcccagatgt gcgacctcat tgaaccgcag ccggccgaga agatcggcaa gatgaagaag
      181 ttgaggagaa ctttgtccga gagtttcagc cgcatcgctc tgaagaaaga ggacaccacc
      241 tttgatgaga tatgtgtcac aaagatgtct acccggaact gccaggggac agattcagtg
      301 atcaagcacc tggacacaat tcctgaagac aagaaagtca gggttcagag gacgcagagc
      361 acttttgacc catttgagaa accagccaac caagtcaaaa gggtccattc tgagaacaat
      421 gcatgcatta actttaaatc ctcctctgct ggcaaagagt cacctaaagt tcggcggcac
      481 tccagcccca gctcgccaac gagtcccaaa tttggaaaag ctgactcata cgaaaaactg
      541 gaaaaactgg gggaaggatc ttatgcaaca gtgtacaaag ggaaaagcaa agtgaatggg
      601 aagctggtgg ctctaaaggt gatccggctg caggaagaag agggcacacc tttcacagcc
      661 atcagggaag cttccctgtt gaaaggacta aagcacgcca acatcgtgtt gcttcacgac
      721 atcatccaca ctaaggaaac cctgaccctt gtctttgaat acgtgcacac tgatttatgt
      781 cagtacatgg acaagcaccc tggaggactc catccagata atgtgaagtt gtttttattt
      841 cagctgctgc gaggactgtc ttacatccac cagcgttata ttttgcacag agacctgaaa
      901 ccgcagaacc ttctcatcag cgatacgggg gagttgaagc tggcagattt cggtctggca
      961 agagcaaaat ccgtccctag ccacacatac tccaatgaag tggttacctt gtggtacaga
     1021 cctccagatg ttcttctggg ctctacagaa tattccacct gccttgacat gtggggagtt
     1081 ggctgtatct tcgttgagat gatccaagga gttgctgcgt ttccaggaat gaaagacatt
     1141 caggatcaac ttgaacggat atttctggtt cttggaacac cgaatgagga cacgtggcct
     1201 ggagttcatt ctttaccaca ttttaagcca gaacgcttta ccgtgtacag ctctaaaagc
     1261 cttagacaag catggaataa gctcagctat gtaaatcatg ctgaagactt ggcctccaag
     1321 cttctccagt gttccccaaa gaacaggcta tcagcacagg ccgccttgag ccatgagtat
     1381 ttcagcgatc tgcctccacg gctatgggag ctgactgata tgtcttctat ttttaccgtc
     1441 ccaaatgtga gattgcaacc agaagctgga gagagcatga gggcctttgg aaaaaacaat
     1501 agttatggga aaagcctatc gaacagcaaa cactgacaag cccggcactc tcaggagagc
     1561 acaggattaa gttgtcatca ttctgggaag aagaagaaga gataaaaata aatcaatcaa
     1621 taaaaaccac taatgaagtg gctcagtgcg agggccctga atcggttctc ttctgcccgg
     1681 tgcagtggat ttcactgaca tgaaaatgga agctggcaag aacctgtttc ctctgcaatt
     1741 tatttaaaac cttgcacgca tttggatacc ttgtgacttc caagaactac gtgacgatta
     1801 agctttgctt actgctacat ggcatgtatt cttttccgtc ttttgtgtct ggttctgttt
     1861 gcttccccct gccgcacagt gtccatcgca cggtgtctct gtgaagggtt ttgctgcttt
     1921 cagcagcctc gtcttaagta cattaagaca acacatttgg tgttcacact tcctcagcca
     1981 tgtctgcact tgaaagccac acagcggcag gagacaatgt gtgttttccc tgagagcagg
     2041 gtgcattctg caacctccag gaagaacatt ctttttgcta aaacaaactc catgctttct
     2101 gacagactag acagcgtggt cccagacagt ggggccctac ctgttgcctg ccttggagga
     2161 catttagaaa tgtaagggtt tttttgtttt gttttgtttt tcgtttttta ttggaaatga
     2221 gcacacattt acacaggaga ccaaaatcca cttgctattt caatagcctg actgtttctg
     2281 agcaggtaga gaaataaaca tggaaaacaa agacagggtg actgaaggtt aataagcatt
     2341 actatcattt tttttagcct gtagaaagca aggcaacttt ttcatgtgtc ttgtccacat
     2401 cttacctttt cccatcagct ctgtattatt aaactgttac actctatttt taaactggag
     2461 aaaatagtag caaatatcat tcttaaaacc tgggtacata gaaaaaaaaa atctgtctgt
     2521 cagggtaggt cctgaatgca gccttggctg attaaagctt agaaatcaca ttttaaaatt
     2581 atccagactt taaaatgtgc ttatttacga caaaggacct ttgaattcga tgttcagaaa
     2641 cattccaggc cgttcggaag gcatcactgg gtaccagact tgaaaccagt cttcagtaac
     2701 aagtgttcaa aggcagatct tacaagcaat gcaggaattt tgctttaaga ataaaaatgg
     2761 ccaagaaagg cccttgtttt aaggaccttt gggaccttgc aaagcgtagg caagtctgct
     2821 ctagcataca ttgaaccttg atctggggca gccgcccagt gctggctact ttcatggaca
     2881 gcctcactgc agaatcccag gggcagttag gaagctatgt gaagcatgcc cttgctcctc
     2941 ctgacataaa tccccatgga aacccaacac atctgtgtac ggtggtctgt gttttactcc
     3001 tcctgagaaa aaggagacgc aggctacaag cctgaaatgt gacacaattt taggaccaag
     3061 actagaaatc acaaggctga tttgacaagg gctttctgat tctccaatga ggggcaagct
     3121 tccttatact caaacccagt gtatccctgg aagtagaccc aggtttccaa gtcttcaaag
     3181 gcactgtgtc tgagtaagag gtgtaaccca gcccccagcc cctccgagcg ggtcactcac
     3241 tgcagcctca caaacactga gaaaggaact gcttacagga tggtttgggg aaaaaagcat
     3301 aagataccca aggtaacaat gtttattctt cactagctgg gaatcggtct ccatccctct
     3361 tttgtacatt ccttccatgg gaagtcttta caggtatctt gatttaaagt ataattaaat
     3421 tgggagttct ttaagtgggg agaaaacttt atgtgtaatt aaaaacagtc tccctgtgat
     3481 ttgcttagaa tcctccatac atctggggac gggggaagat tatgtttgta tttcactaag
     3541 tagaagtcag gagctcacag gaatgctggg aggtttcagt aagaacataa aggcaacccc
     3601 atgtccttgc cctcgtctag acagcttctc ctgggaagca agacataaca ctgctcagtg
     3661 tgcggtctgc ttcacgacag ggacaggcac acctctcaag tttaaagggt ttcagtttcc
     3721 tgtccttgtc accagtgaag gaaatgcaaa gtgtctgccc ccacccctcc acccaacaca
     3781 gtcccccttc tctggctttg ctctcctggc ctctccaagg gtgtcatgaa aatcagtata
     3841 gactttgttt cattaacatg tcatatgttg agagagcact ggaatgtttg gtgagtttat
     3901 ttttctatga acgcgtagct tgagtttgga caactagtaa ggaatgcacc aacactttgg
     3961 catgacaatt gtatgaaagc aacctcactg cacaaagtat ttggaaaaga agtatgggac
     4021 ttagtttcta tcttcttaag gggagccgtt taattaaata caacatccat gggacaggaa
     4081 aatgtgtttg ctataaaatt agagatataa ggcaggggca gcaatctgcc caccatgcaa
     4141 ggatgaaaat ctgtttccag ctctcaagtg gctaaaagtt tccaagagag tccgtgggat
     4201 tataggaaaa ccagggcctc ttggtaccct gtcctcagag tgtgtgacag ccactgtaat
     4261 cagtgctcta tgtatgcgtc catagcagac actcatctgt gaatatcgct gggtttgtaa
     4321 tcttttgtta tataagagga tgtttaggct gtacatactg gggtagatca ttgcctgccc
     4381 ctatacatag aaatatgctg cataattgtg cataacttcc ttctccgtgg ctggcttgta
     4441 gacagaggaa actgtatgtt agccttcagt ttcctcatat accaaactga aaacgtttaa
     4501 atctcaaatg aagtaagcaa ggttctgttc tcactgccca ctttctcagc agcatatatt
     4561 agaggcacat aaaaaaaaga aaaagaaaaa aagaaaaaaa ctttataagt ggactttcaa
     4621 tttcttcttc tcttctcttt tttttttttt ttttttttgt cattttgtca cacactccaa
     4681 cccccactgg tttatataac gcactgagat gtgtactttt tattggggtt agtacctcag
     4741 agactcatta tgcttcaaca tgacacatag caaggagaat ggaatactac atgttgcata
     4801 tgtgttgcca attgtaattc gtctgtatta tgaaggatgt aatggtttgt cagctgtcat
     4861 tgttttctgt aacatgatat ggaataaaat atagccaaat ctgcatatat caaaaaaaaa
     4921 aaaaaaaa
//
