LOCUS       NM_001109626            7669 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus cyclin dependent kinase 12 (Cdk12), transcript variant
            1, mRNA.
ACCESSION   NM_001109626
VERSION     NM_001109626.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7669)
  AUTHORS   Zhang,H., Zhou,Y., Feng,Y., Hou,W., Chen,Y., Xing,Z., Zhang,Y.,
            Wei,Q., Yin,Y., Guo,J. and Hu,H.
  TITLE     Cyclin-dependent kinase 12 deficiency reprogrammes cellular
            metabolism to alleviate ferroptosis potential and promote the
            progression of castration-resistant prostate cancer
  JOURNAL   Clin Transl Med 14 (5), e1678 (2024)
   PUBMED   38736108
  REMARK    GeneRIF: Cyclin-dependent kinase 12 deficiency reprogrammes
            cellular metabolism to alleviate ferroptosis potential and promote
            the progression of castration-resistant prostate cancer.
REFERENCE   2  (bases 1 to 7669)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7669)
  AUTHORS   Zhang,Y.L., Tang,T.T., Ni,W.J., Li,Z.T., Jiang,L.Y., Wang,Y.,
            Zhou,X., Cao,J.Y., Yin,Q., Jiang,W., Zhao,Y.J., Gan,W.H.,
            Zhang,A.Q., Li,Z.L., Wen,Y., Lv,L.L., Liu,B.C. and Wang,B.
  TITLE     Tubule-specific cyclin-dependent kinase 12 knockdown potentiates
            kidney injury through transcriptional elongation defects
  JOURNAL   Int J Biol Sci 20 (5), 1669-1687 (2024)
   PUBMED   38481813
  REMARK    GeneRIF: Tubule-specific cyclin-dependent kinase 12 knockdown
            potentiates kidney injury through transcriptional elongation
            defects.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7669)
  AUTHORS   Liu,S., Wu,J., Lu,X., Guo,C., Zheng,Q., Wang,Y., Hu,Q., Bian,S.,
            Luo,L., Cheng,Q., Liu,Z. and Dai,W.
  TITLE     Targeting CDK12 obviates the malignant phenotypes of colorectal
            cancer through the Wnt/beta-catenin signaling pathway
  JOURNAL   Exp Cell Res 428 (1), 113613 (2023)
   PUBMED   37100369
  REMARK    GeneRIF: Targeting CDK12 obviates the malignant phenotypes of
            colorectal cancer through the Wnt/beta-catenin signaling pathway.
REFERENCE   5  (bases 1 to 7669)
  AUTHORS   Liu,M., Ruan,X., Liu,X., Dong,W., Wang,D., Yang,C., Liu,L.,
            Wang,P., Zhang,M. and Xue,Y.
  TITLE     The mechanism of BUD13 m6A methylation mediated
            MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry
            in glioblastoma cells
  JOURNAL   Cell Death Dis 13 (12), 1017 (2022)
   PUBMED   36463205
  REMARK    GeneRIF: The mechanism of BUD13 m6A methylation mediated
            MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry
            in glioblastoma cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7669)
  AUTHORS   Dai,Q., Lei,T., Zhao,C., Zhong,J., Tang,Y.Z., Chen,B., Yang,J.,
            Li,C., Wang,S., Song,X., Li,L. and Li,Q.
  TITLE     Cyclin K-containing kinase complexes maintain self-renewal in
            murine embryonic stem cells
  JOURNAL   J Biol Chem 287 (30), 25344-25352 (2012)
   PUBMED   22547058
REFERENCE   7  (bases 1 to 7669)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7669)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 7669)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 7669)
  AUTHORS   Seykora,J.T., Mei,L., Dotto,G.P. and Stein,P.L.
  TITLE     'Srcasm: a novel Src activating and signaling molecule
  JOURNAL   J Biol Chem 277 (4), 2812-2822 (2002)
   PUBMED   11711534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA066711.1, BC116645.1, AK049376.1 and AL591205.13.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049376.1, SRR9219382.186987.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AA066711.1         1-17
            18-3338             BC116645.1         1-3321
            3339-4629           AK049376.1         2986-4276
            4630-7669           AL591205.13        133588-136627
FEATURES             Location/Qualifiers
     source          1..7669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..7669
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /note="cyclin dependent kinase 12"
                     /db_xref="GeneID:69131"
                     /db_xref="MGI:MGI:1098802"
     exon            1..1106
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4518
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDC2-related kinase 7; protein kinase for splicing
                     component; cell division protein kinase 12; CDC2-related
                     protein kinase 7; cell division cycle 2-related protein
                     kinase 7; CDC2-related kinase, arginine/serine-rich"
                     /codon_start=1
                     /product="cyclin-dependent kinase 12 isoform 1"
                     /protein_id="NP_001103096.1"
                     /db_xref="CCDS:CCDS48901.1"
                     /db_xref="GeneID:69131"
                     /db_xref="MGI:MGI:1098802"
                     /translation="MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKR
                     HKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDTAFKSDRRENEERRGT
                     DRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDY
                     GKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRR
                     SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISP
                     PYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSP
                     FLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNS
                     SLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKS
                     EKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEV
                     IVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQ
                     PPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLP
                     PLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSP
                     EPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA
                     KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDF
                     KKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDI
                     KCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAID
                     VWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK
                     QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLP
                     HWQDCHELWSKKRRRQRQSGIVIEDPPPSKASRKETTSGTTAEPVKNNSPAPPQPAPV
                     KAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQL
                     EALNQSISALTEASSQQQDSESIAPEESLKEVPSVPVVLPPAEQTTPEASNTPADMQN
                     VLAVLLSQLMKTQEPAGNLEENTNDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRP
                     PEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALR
                     PMEYSTRSHPNRTYGNTDGPETGFSSADTDERSSGPALTESLVQTPVKNRTFSGSVSH
                     LGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNY
                     GELGPGTTGANSSGTTLQWGGPAQSYGKPYRGAARVLPRGGRGRGVPY"
     exon            1107..1982
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2159
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2299
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2470
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2660
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2717
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2819
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2897
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3014
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3146
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3358
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3811
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..7669
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5152..5157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /note="hexamer: AATAAA"
     polyA_site      5177
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /note="major polyA site"
     regulatory      5470..5475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /note="hexamer: AATAAA"
     polyA_site      5497
                     /gene="Cdk12"
                     /gene_synonym="1810022J16Rik; Crk7; Crkrs; D11Ertd752e;
                     Pksc"
                     /note="major polyA site"
ORIGIN      
        1 gagggtgggg ctttttggag cgccggggaa ctttttcccc tgcttcaggc ccggggaaag
       61 ggaatgccca attccgagag acatgggggc aagaaggacg ggagcggagg agcttctgga
      121 acttcgcagc cgtcatcggg aggtggcagc tccaacagca gggagcgtca ccgcttggtg
      181 tcgaagcaca agcggcataa gtccaagcac tccaaagacg tggggctggt gacccccgaa
      241 gcggcatctt tgggtaccat aatcaaacca ctggtggagt acgatgacat cagctctgat
      301 tcagacacct tctccgatga cacggccttc aaatcagacc ggagggagaa cgaggaacgt
      361 cggggaacgg atcggagcga tcgcctgcac cgacatcgtc accaccagca ccggcggtcc
      421 cgagacttgc taaaaactaa acagacggaa aaggaaaaaa atcaggaagt ctccaaatct
      481 ggatctatga aggaccgggt atcgggcagt tccaaacggt ccgtggaggg gagtgatgat
      541 tatgggaagg cccagctatc caaaagcggc agcaaggaat ccaggtcgtc caaaatgcac
      601 aaggagaaga cccgcaaaga gcgagagtta aagtctggat acaaggaccg gagtaaaagt
      661 catcggaaaa gggaaacacc caaaagttac aaaaccgtgg ctagccctaa acggagatcc
      721 aggagtcccc ataggaaatg gtctgacagt tccaagcaag atgacagccc ttccggagct
      781 tcttatggcc aagactacga tcttagcccc ccaaggtctc acacttctag caactatgac
      841 tcctacaaga agagtcctgg aagtacctca agaaggcagt caatcagccc accttacaaa
      901 gagccttctg cttaccagtc cagcactcgg tcacccagtc cttacagccg acgacagagg
      961 tctgtgagtc cctatagccg gagacggtcc tccagctatg aaaggagcgg ctcttacagc
     1021 gggagatcac ccagccccta tggccgaagg cgatcaagca gccctttcct gagcaagagg
     1081 tctctgagtc ggagtccact ccccagtagg aaatccatga agtccagaag tagaagtcct
     1141 gcatattcaa gacactcatc ttctcatagt aaaaagaagc gatccgggtc acgcagtcgt
     1201 cattccagta tctcacctgt caggcttcca ttgaattcca gcctgggagc tgaactcagt
     1261 agaaaaaaga aggaaagagc agcagctgct gcagcagcaa aaatggatgg aaaagagtcc
     1321 aagagttcac ctataatttt gcctaaaaaa gagaaacttg aggtgaagga gtcagggtta
     1381 gagtctaaaa agttacccag aagtataaaa tcagaaaaat cgaccccaga tactgaactg
     1441 gttactgtag cacattcaaa cccagaggta aaacattgtt tagacacagg gaaggttagg
     1501 ttggatgaga acttgcagaa gcatcctgct aaggatttga aagcacaggg aacaaaggac
     1561 gttaaacctg tagcaccgaa agaggtgatt gttacttcaa aggagacaga gacatcagaa
     1621 aaggagaccc ttccacctct tcccacaatt acttctccac cccctttacc agctactacc
     1681 cctccacctc agacaccccc tttgccacct ttgcctccac taccagctat tccgctgcag
     1741 ccacctctgc ctcctcccca accaccattt agtcaagttc ctgtttcaag tacttcaatt
     1801 ttaccctctt ctcctcaccc aaggacatct actctatcct ctcagacaaa ttctcagccc
     1861 cctgtacagg tttctatgaa gactcaagta tctataacag ctgctattcc acatctgaag
     1921 acttcaacat tgcctcctct gcccctccct cccctattac ctggagatga tgacatggat
     1981 agtccaaaag aaacacttcc ttcaaagcct gcaaagaaag agaaggaaca gaggactcgc
     2041 cacttgctta cagacttgcc tcttcctcct gagctaccag gaggagatcc atcgcctcca
     2101 gattctccag agccaaaggc aattacacca cctcaacaac catataaaaa gagaccaaaa
     2161 atttgttgtc cacgttatgg agaaagaaga caaacagaaa gtgattgggg gaagcgctgt
     2221 gtggacaagt ttgacattat tgggattatt ggagagggga cctatggcca agtatataaa
     2281 gccaaggaca aagacacagg agaactagta gctctgaaga aggttcggct ggacaatgag
     2341 aaagagggct tcccaatcac agccatccgg gagatcaaga ttcttcgtca attagttcac
     2401 cagagtgttg taaacatgaa ggaaattgtc acagacaaac aagatgcact ggatttcaag
     2461 aaggacaaag gtgcctttta ccttgtattt gaatatatgg accatgactt aatgggactg
     2521 cttgaatcag gtttggtgca cttttctgag gaccatatca agtcatttat gaaacagcta
     2581 atggaaggac tggattactg tcacaaaaag aatttcctcc atcgggatat taaatgttct
     2641 aacattttgc tgaataacag cgggcaaatc aaactggcag attttggact tgctcggctc
     2701 tataactctg aagagagtcg cccttacaca aacaaagtca tcactctttg gtatcgacct
     2761 ccagagcttc ttcttggaga ggaaagatac acaccagcca ttgatgtttg gagctgtggg
     2821 tgcatccttg gagaactgtt cacaaagaaa cctatttttc aagccaattt agaactggct
     2881 cagctagaac ttatcagtcg tctctgtggt agtccttgtc cagcagtgtg gcctgatgtt
     2941 atcaagctgc cctacttcaa caccatgaaa ccgaagaagc aatacaggag acgcctaaga
     3001 gaagaattct ctttcattcc ttcagcggca cttgatctat tggaccacat gctgacactg
     3061 gatcctagca agaggtgcac agctgaacag accctacaga gtgactttct taaagatgtg
     3121 gaactcagca aaatggcacc tccagaccta cctcactggc aggattgcca tgaattgtgg
     3181 agtaagaaac gtcgacggca gcgacagagt ggtattgtga tagaagatcc acctccgtcc
     3241 aaagcttcta gaaaagaaac tacctcaggg acaacagctg agcctgtgaa aaacaatagc
     3301 ccagcaccac ctcagcctgc tcctgtcaag gcagagcctg gtccagggga tgcagtaggc
     3361 cttggtgaca tcacacagca gttgaatcaa agtgaattgg cagtgttatt aaacctgctt
     3421 cagagccaaa ctgacctgag catccctcag atggcacagc tgcttaatat ccactccaat
     3481 ccagagatgc aacagcagct tgaagccttg aatcagtcta ttagtgcact gactgaagcc
     3541 agttcccagc agcaggactc agaatccata gcccctgaag aatcattgaa ggaggtacct
     3601 tctgtacctg tggtcctgcc tcctgctgaa cagacaactc ctgaagcttc aaacacacca
     3661 gctgacatgc agaatgtgtt ggcagttctc ttgagtcagc tgatgaaaac ccaagagcca
     3721 gcaggtaacc tggaggaaaa caccaatgac aagaatagtg ggccacaggg gccccgaaga
     3781 actcctacaa tgccacagga ggaggcagca gcatgtcctc ctcacattct tccaccagag
     3841 aagaggcccc ctgagccccc tggacctcca ccgccgccac ctccaccccc tctggttgaa
     3901 ggcgatcttt ccagcgcccc ccaggagttg aatcccgccg tgacagccgc cttgctgcaa
     3961 cttttatccc agcctgaagc agagcctcct ggccacctgc cacatgagca ccaggccttg
     4021 agaccaatgg aatactccac ccgatcccat ccaaacagga cttacggaaa tactgatggg
     4081 cctgagacag ggttcagttc cgctgacact gatgaacgca gttctggtcc agccttgaca
     4141 gaatctttgg ttcagacccc ggtgaagaac aggaccttct caggctctgt gagccacctt
     4201 ggggagtcca acagctacca gggcacaggg tcagtgcagt tcccagggga ccaggacctc
     4261 cgttttacca gggttccctt agcattacac tcagtggttg ggcaaccatt cctcaagtct
     4321 gagggaaata gcaactctgt ggtacatgca gagaccaaat tgcaaaacta tggggagctg
     4381 ggaccgggaa ccactggggc caacagctca ggaacaacgc ttcagtgggg gggcccagct
     4441 cagtcttatg gaaaacccta caggggggct gcaagagtcc taccacgagg gggaagaggg
     4501 agaggagttc cttattaaca cagagacatc aaatgccctg aaagattcct tccctatcca
     4561 tctttccatc tagttctatg aacctttaat gaaatcacct gccagagcaa ggtaatcatc
     4621 tgcatttggc tactacaatg ctgtctgttg ttttcacttg ctgctagcag gcaagtcaac
     4681 catgttggca ccagttcttc caaaatgggg caatagccag aatatttact tccgctctgt
     4741 gtacgagcta tagtagaaat atatggagag aaagacacat tcaattgaaa aataattgtt
     4801 ccattagctc attgcctgca cttgagcaga agagaactat tttgttttga gatggctctg
     4861 gagaggcttt gatttttttt aaaattattt gttttatttt cttgtgtgtg tatgtatgtg
     4921 tgtgtgtata tagtttgttt tgaattttta tttagtttcc taccccaaac tccctaccgc
     4981 ccttgaaaga gaagagtatt caaaagatct gagctcctct aaggcctttg ctagaagggt
     5041 aacagtggac tggctggctc aaatgtttcc ttcctctcta ccatctcata tttttgcttc
     5101 agtgatcact ccctttaccc ctgttgagta tcttgtacat acctttttcc aaataaatca
     5161 tccttatgtt tgctcaattt tgacaaaagt tatgtccctc ttcctgcaca cgcagcaggc
     5221 tgtagacagt ggcgttctca ggcgaggagg cagacttcac ccaatccttg gtttttgctt
     5281 gtttacttgt ccctctctcc ctcttttctt tttttctcct tcctcccttg tgtgttcacc
     5341 cctattattc tctttgtctc tttttgaggc atttgtttga aaaaaataca tagtagagat
     5401 gcccgggaac ctggaataat actttgccct tttctttttc cttttttctt ttcttttttt
     5461 ttttttttta ataaaggaaa ggaaattcaa actcctacat tgttctccgt aactcttcaa
     5521 ttctaagatt tttgttttgt ttttgttttt ttaagccacg ttctgatggg aagttgattt
     5581 gttaatggac agcataggac attgctgctg agccatggtt agaaatgata ccaccatacc
     5641 tacctagagg ggtaataaga tcagtaagca tgtttacatg aatatttttg tgttttaaaa
     5701 aaagaagaaa actttagaac agagccttgt gatattgtca gaggaaattc ctgaaaatac
     5761 atgagcacat aacctagttt aggttatata tctgaagatt tatcagttcc tgataccttt
     5821 aaagaacaat ttttaacaga gtccatcaga aagaacagta ttgataagta tatgtctcag
     5881 catgtacatc caaccatttc ttacagggat catttttgat tgtggtaaag agtgtagtac
     5941 ggtatgactt ccggaaaaga actttgcctt tgcagaacag gaaatggatg agaggaagga
     6001 tttcagggtg gggtaacttg agagacttct catggcttcc atttctcagt atcagcatct
     6061 ggagtatttt aaaaacagat tgatatcatg taattgagct gcaccgtttt aggcattcgt
     6121 gaactgtagg gtaagctccc ttttacaaag gcaaacatac ttcaccgtct cagagaatag
     6181 ttttcagaaa ctcaaataaa tttcatgttt caataccaag ttcttatgtt aaaatatatt
     6241 tagaaagata tattaatttt ttaaaaattt agaggtgaaa ataccctctt cagctacatt
     6301 aaaaagttat ttttcccttg ttagtgataa agctaccagt gtgaatattt ctttattttc
     6361 tgattttggt ctggttttgt cataggccaa acactaagtg aaccttctag ccatttggct
     6421 ttgatagctt tttatgccaa tatgtctggt taaatattct agacacactg gcatgctatc
     6481 catagactgc attacggttt atctatacct tcagtcttct gactagttag tcctcagacg
     6541 tgggccttat tttaaaattt tttaacgtaa ggtattgggc cccagactcc tatttttgat
     6601 taaagaaact gagctgggat acattaagta tctgttcagt gaaaaagaat tgttttccca
     6661 tcaaatagga ataaatttct ctatatattt tcattgtatt ttggttatca acagtcatca
     6721 ataatgtttt cccttcccct gtcacactat atttttaatt atgccaaata gtctaaataa
     6781 tttatgtaag cttccattcc ctgtccctag ggaaggggaa tgagtgtatg tgaatgcgtg
     6841 tatatgtgtg tatgatccca ttatgccccg ccccattttg ggagtctaga ctttaaaaaa
     6901 tatttttata ataattttga ctacttctga aagctgagaa aaatctcatt tatatatcct
     6961 gaaacctgtg tagaagaaaa ggaatttggt catttttttc agctatatta cctgtaaaca
     7021 taatggaagt aaaaatttgg cttaattttc aacctgaaaa gtagtaatct ggttaattcc
     7081 attaaaaagt ggtttgagtt ttaaaaaact attacattat tttgaacaga tttgaaatct
     7141 gattctgttc atgaataaga agcaaaactg gcttgaccat gatctttttt tttttttttt
     7201 tttaatgtgg ttttaatagc agatttgctt aacccagttt ctttagtttt ttcatctgtc
     7261 tatagggaac aggattctca aataacatca gatctatgta tttaaaacca gggcggtcag
     7321 cacaaatttg tatgtaggat tttttttgtt agcttataaa catcaccgtg tgtgtgtgtg
     7381 tgtgtgtgtg tgtgtgtgtg tgtgtaatat gcatatataa gtacagtgct aaagtggtta
     7441 ccagcaggtt ttgagagaga atggtgcatt gggaaagtgt cagttgccac ctccttcttc
     7501 ctgatttaca ggtctctgac actgtattcc tttctctctc ttgtttttga cccccattgg
     7561 gtgtaccttg tctatgtaca gatattttgt aatatattaa attttttctt tcagtttata
     7621 aagatggaaa gtggagattg gaaaattaaa tatttcctgt taatatacc
//
