LOCUS       NM_007661               2617 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript
            variant 1, mRNA.
ACCESSION   NM_007661 NM_007660
VERSION     NM_007661.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2617)
  AUTHORS   Sala E, Vived C, Luna J, Saavedra-Avila NA, Sengupta U, Castano AR,
            Villar-Pazos S, Haba L, Verdaguer J, Ropero AB, Stratmann T,
            Pizarro J, Vazquez-Carrera M, Nadal A, Lahti JM and Mora C.
  TITLE     CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells
            Independently of Glucose Concentration and Is Regulated by
            Inflammation in the NOD Mouse Model
  JOURNAL   Front Immunol 12, 634797 (2021)
   PUBMED   33664748
  REMARK    GeneRIF: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic
            Beta Cells Independently of Glucose Concentration and Is Regulated
            by Inflammation in the NOD Mouse Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2617)
  AUTHORS   Campbell GJ, Hands EL and Van de Pette M.
  TITLE     The Role of CDKs and CDKIs in Murine Development
  JOURNAL   Int J Mol Sci 21 (15), 5343 (2020)
   PUBMED   32731332
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2617)
  AUTHORS   Shen B, Gu T, Chen H, Zhao Q, He Y, Zhu L, Fu W and Cui Z.
  TITLE     CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3
            Nuclear Localization
  JOURNAL   Inflammation 40 (2), 636-644 (2017)
   PUBMED   28101846
  REMARK    GeneRIF: suggested that CDK11p58 acted to regulate microglia
            activation through CDK11p58 and cyclin D3 interaction
REFERENCE   4  (bases 1 to 2617)
  AUTHORS   Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge
            A, Salvenmoser S, Trono D, Hufnagel L and Hiiragi T.
  TITLE     Venus trap in the mouse embryo reveals distinct molecular dynamics
            underlying specification of first embryonic lineages
  JOURNAL   EMBO Rep 16 (8), 1005-1021 (2015)
   PUBMED   26142281
REFERENCE   5  (bases 1 to 2617)
  AUTHORS   Rakkaa T, Escude C, Giet R, Magnaghi-Jaulin L and Jaulin C.
  TITLE     CDK11(p58) kinase activity is required to protect sister chromatid
            cohesion at centromeres in mitosis
  JOURNAL   Chromosome Res 22 (3), 267-276 (2014)
   PUBMED   24436071
REFERENCE   6  (bases 1 to 2617)
  AUTHORS   Autieri MV, Kozak CA, Cohen JA and Prystowsky MB.
  TITLE     Genomic organization and genetic mapping of the neuroimmune gene
            I2rf5 to mouse chromosome 4
  JOURNAL   Genomics 25 (1), 282-284 (1995)
   PUBMED   7774930
REFERENCE   7  (bases 1 to 2617)
  AUTHORS   Malek SN and Desiderio S.
  TITLE     A cyclin-dependent kinase homologue, p130PITSLRE is a
            phosphotyrosine-independent SH2 ligand
  JOURNAL   J Biol Chem 269 (52), 33009-33020 (1994)
   PUBMED   7528743
REFERENCE   8  (bases 1 to 2617)
  AUTHORS   Eipers PG, Barnoski BL, Han J, Carroll AJ and Kidd VJ.
  TITLE     Localization of the expressed human p58 protein kinase chromosomal
            gene to chromosome 1p36 and a highly related sequence to chromosome
            15
  JOURNAL   Genomics 11 (3), 621-629 (1991)
   PUBMED   1774066
REFERENCE   9  (bases 1 to 2617)
  AUTHORS   Kidd VJ, Luo W, Xiang JL, Tu F, Easton J, McCune S and Snead ML.
  TITLE     Regulated expression of a cell division control-related protein
            kinase during development
  JOURNAL   Cell Growth Differ 2 (2), 85-93 (1991)
   PUBMED   2069872
REFERENCE   10 (bases 1 to 2617)
  AUTHORS   Bunnell BA, Heath LS, Adams DE, Lahti JM and Kidd VJ.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627405.17, AK135402.1, AK077668.1 and AA210166.1.
            
            [WARNING] On Apr 25, 2023 this sequence was replaced by
            NM_007661.5.
            
            On Sep 20, 2017 this sequence version replaced NM_007661.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077668.1, AK147133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL627405.17        123291-123299
            10-15               AK135402.1         2-7
            16-2604             AK077668.1         2-2590
            2605-2617           AA210166.1         436-448
FEATURES             Location/Qualifiers
     source          1..2617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.73 cM"
     gene            1..2617
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /note="cyclin-dependent kinase 11B"
                     /db_xref="GeneID:12537"
                     /db_xref="MGI:MGI:88353"
     exon            1..88
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            89..212
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2456
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 2 homolog-like 1; cell division cycle 2
                     homolog-like 2; cell division cycle 2-like 1; cell
                     division protein kinase 11; cyclin-dependent kinase 11;
                     cell division cycle 2-like protein kinase 1; PITSLRE
                     serine/threonine-protein kinase CDC2L1;
                     galactosyltransferase-associated protein kinase p58/GTA;
                     cell division cycle 2-like 2; PITSLRE proteins"
                     /codon_start=1
                     /product="cyclin-dependent kinase 11B isoform 1"
                     /protein_id="NP_031687.2"
                     /db_xref="CCDS:CCDS19033.1"
                     /db_xref="GeneID:12537"
                     /db_xref="MGI:MGI:88353"
                     /translation="MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSK
                     RDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKD
                     EKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH
                     SRRERDRLEQLERKRERERKLREQQKEQREQKERERRAEERRKEREARREVSAHHRTM
                     REEYSDKGKVGHWSRSPLRPPRERFEMGDNRKPVKEEKVEERDLLSDLQDISDSERKT
                     SSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEAS
                     EQSAEEVSDEEMSEDEDRENENHILVVPESRFDRDSGDSEEGEEEVGEGTPQSSAPTE
                     GDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTD
                     EIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV
                     EHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILK
                     VGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQK
                     PLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLS
                     DQGFDLMNKFLTYYPGRRINAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGT
                     SPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF"
     exon            213..328
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            329..456
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            457..595
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            596..732
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            733..855
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            856..951
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1116
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1182
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1358
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1449
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1571
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1677
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1799
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1907
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2024
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2173
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2363
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2607
                     /gene="Cdk11b"
                     /gene_synonym="Cdc11b; Cdc2l1; Cdc2l2; Cdk11; CDK11-p110;
                     CDK11-p46; CDK11-p58; p58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaagtg acgacaatcc tggcgcgcgc cgggcgctgt tccttcccag actccaggac
       61 cggctgcggc ggctgtagcg gcgcagggtg ttttaactca aatgggtgat gaaaaggact
      121 cttggaaagt gaaaacgtta gatgaaattc tccaggaaaa gaaacgaagg aaagaacaag
      181 aggagaaagc agagataaaa cgcttaaaaa attctgatga ccgcgattcc aaaagggatt
      241 cccttgagga gggggagctg agagatcacc gaatggagat cacaatcagg aactcaccat
      301 atagaagaga ggattctatg gaagacagag gagaggagga tgattctctg gccatcaaac
      361 caccccagca aatgtctcgg aaagaaaagg ctcatcacag aaaagacgag aaaagaaaag
      421 agaaacgtcg acatcgtagc cattcagcag agggagggaa acatgccaga gtgaaagaga
      481 aagaaaggga gcacgaacgc cggaaacgcc accgagaaga acaagataaa gctcgaaggg
      541 agtgggaaag acagaagagg agggaaatgg cgagagaaca ttccagaaga gagagggacc
      601 gcctggagca gttagaaagg aagagggagc gggagcgcaa gctgagggag cagcagaagg
      661 agcagcggga gcagaaggag cgggaacgga gggcagagga gcgccgcaaa gagagagaag
      721 cgcgtaggga agtctctgca catcaccgta ccatgaggga ggagtacagt gataagggga
      781 aggttggcca ctggagccgc agccctctga ggccaccaag agagcgcttt gagatgggag
      841 acaaccggaa gccagtaaaa gaagagaagg tggaagagag agacttgttg tcagacctcc
      901 aagacatcag tgacagcgag aggaaaacca gctcagctga gtcttcatca gcagaatcag
      961 gctcaggttc tgaagaggag gaggaggaag aagaagagga agaagaagaa gaagggagca
     1021 ccagtgaaga atcagaggaa gaagaggaag aagaagagga ggaggaagaa gaggagactg
     1081 ggagcaactc tgaggaggcc tctgaacagt ccgcagaaga agtcagtgat gaggaaatga
     1141 gtgaagatga agacagagaa aacgagaacc acatcttggt tgttccagag tcacgatttg
     1201 accgagattc tggggacagt gaagaagggg aggaagaagt tggtgaaggg actccacaga
     1261 gcagtgcccc caccgaagga gactatgttc ctgactctcc agcactgtca cctattgagc
     1321 taaaacaaga actgcccaaa tacctgccag ccctgcaggg atgcaggagt gtagaggagt
     1381 ttcagtgtct gaacaggatt gaagaaggca cctatggggt ggtctacaga gcaaaggaca
     1441 agaaaacaga tgaaattgtg gctctgaagc ggttaaagat ggagaaggag aaggaaggct
     1501 tcccaatcac gtcgctgagg gaaatcaaca ccatcctcaa ggcccagcac cccaacatcg
     1561 tcaccgtcag ggaaattgtt gtgggaagta acatggacaa gatctacatt gtgatgaact
     1621 acgtggaaca tgacctcaag agcctaatgg agaccatgaa gcagcccttc ctgccagggg
     1681 aggtgaagac cctgatgatt cagctgctga gtggggtaaa gcacctccat gacaattgga
     1741 tcctacaccg tgacctgaag acctctaacc tcctgctgag ccatgctggc attctcaagg
     1801 tgggcgactt tgggctggct cgggagtatg gttcacccct aaaggcctac actccagttg
     1861 ttgtaaccct gtggtatcgt gccccagaac tactgcttgg tgctaaggaa tactccacag
     1921 ctgtggacat gtggtcggta ggctgcatat ttggagaact gctgacacag aaacctctgt
     1981 tccctgggaa gtcagatatt gatcagatta acaagatttt caaggacctg ggtactccta
     2041 gtgagaaaat ctggcctggc tataatgacc tcccagccgt caagaagatg accttcagcg
     2101 agtatcccta taacaacctc cgcaagagat ttggggcttt gttatcagat caaggctttg
     2161 atctcatgaa caagttcctg acatactacc ctggcaggag gatcaacgca gaagatggcc
     2221 tcaagcacga atatttccga gagactcccc tccccatcga cccatccatg ttccccacgt
     2281 ggcctgccaa gagtgagcag cagagagtga agcgaggcac gagtccacgg cctcctgagg
     2341 gcggcctggg ctacagccag ctgggtgatg atgacctgaa ggagacgggc ttccacctca
     2401 ccaccaccaa ccagggagcc tcagctgcag gccctggctt cagcctcaag ttctgaggtc
     2461 ggcttgatgg acgtggcccg actaggtggt gacagccaga cctgctgatg ctgaatcagg
     2521 gcagcttggt tgttttttcc acgttgtttg ttttggggca ggttgtaaat ttgtagaatt
     2581 aaatgaaatt ttccttttgg agggaaaaaa aaaaaaa
//
