LOCUS       NM_194446               1661 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cyclin dependent kinase 10 (Cdk10), transcript variant
            1, mRNA.
ACCESSION   NM_194446
VERSION     NM_194446.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Windpassinger,C., Piard,J., Bonnard,C., Alfadhel,M., Lim,S.,
            Bisteau,X., Blouin,S., Ali,N.B., Ng,A.Y.J., Lu,H., Tohari,S.,
            Talib,S.Z.A., van Hul,N., Caldez,M.J., Van Maldergem,L., Yigit,G.,
            Kayserili,H., Youssef,S.A., Coppola,V., de Bruin,A., Tessarollo,L.,
            Choi,H., Rupp,V., Roetzer,K., Roschger,P., Klaushofer,K.,
            Altmuller,J., Roy,S., Venkatesh,B., Ganger,R., Grill,F., Ben
            Chehida,F., Wollnik,B., Altunoglu,U., Al Kaissi,A., Reversade,B.
            and Kaldis,P.
  TITLE     CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation,
            Spine Malformations, and Developmental Delays
  JOURNAL   Am J Hum Genet 101 (3), 391-403 (2017)
   PUBMED   28886341
  REMARK    GeneRIF: CDK10 Mutations are associated with Severe Growth
            Retardation, Spine Malformations, and Developmental Delays.
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Guen,V.J., Gamble,C., Flajolet,M., Unger,S., Thollet,A.,
            Ferandin,Y., Superti-Furga,A., Cohen,P.A., Meijer,L. and Colas,P.
  TITLE     CDK10/cyclin M is a protein kinase that controls ETS2 degradation
            and is deficient in STAR syndrome
  JOURNAL   Proc Natl Acad Sci U S A 110 (48), 19525-19530 (2013)
   PUBMED   24218572
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Khanal,P., Yun,H.J., Lim,S.C., Ahn,S.G., Yoon,H.E., Kang,K.W.,
            Hong,R. and Choi,H.S.
  TITLE     Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of
            cyclin-dependent kinase 10 to induce tamoxifen resistance in breast
            cancer cells
  JOURNAL   Oncogene 31 (34), 3845-3856 (2012)
   PUBMED   22158035
  REMARK    GeneRIF: Data indicate that peptidyl-prolyl isomerase Pin1(-/-)
            mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent
            kinase 10 (CDK10) expression than Pin1(+/+) MEFs.
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Bagella,L., Giacinti,C., Simone,C. and Giordano,A.
  TITLE     Identification of murine cdk10: association with Ets2 transcription
            factor and effects on the cell cycle
  JOURNAL   J Cell Biochem 99 (3), 978-985 (2006)
   PUBMED   16741970
  REMARK    GeneRIF: Data show that murine cdk10 binds Ets2 transcription
            factors in vitro, does not show a direct involvement in the G2/M
            transition and, therefore, does not affect the proliferation rate
            of the cell lines analyzed.
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Grana,X., Claudio,P.P., De Luca,A., Sang,N. and Giordano,A.
  TITLE     PISSLRE, a human novel CDC2-related protein kinase
  JOURNAL   Oncogene 9 (7), 2097-2103 (1994)
   PUBMED   8208557
  REMARK    GeneRIF: Discusses PISSLRE, the human ortholog of mouse
            cyclin-dependent kinase 10.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ102037.1 and DQ288857.1.
            
            On May 21, 2009 this sequence version replaced NM_194446.1.
            
            Summary: The protein encoded by this gene belongs to the CDK
            (cyclin-dependent kinase) subfamily of the Ser/Thr protein kinase
            family. The CDK subfamily members are highly similar to the gene
            products of S. cerevisiae cdc28, and S. pombe cdc2, and are known
            to be essential for cell cycle progression. The human ortholog has
            been shown to play a role in cellular proliferation. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. A related pseudogene exists on chromosome 1. [provided
            by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ288857.1, AK144801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 CJ102037.1         1-1
            2-1661              DQ288857.1         1-1660
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.09 cM"
     gene            1..1661
                     /gene="Cdk10"
                     /note="cyclin dependent kinase 10"
                     /db_xref="GeneID:234854"
                     /db_xref="MGI:MGI:2448549"
     exon            1..128
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1124
                     /gene="Cdk10"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin-dependent kinase (CDC2-like) 10; cell division
                     protein kinase 10"
                     /codon_start=1
                     /product="cyclin-dependent kinase 10 isoform 1"
                     /protein_id="NP_919428.1"
                     /db_xref="CCDS:CCDS22751.1"
                     /db_xref="GeneID:234854"
                     /db_xref="MGI:MGI:2448549"
                     /translation="MAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNR
                     IGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELK
                     EVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFII
                     HRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTT
                     SIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYS
                     LRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATSGDCLESSYFKEKPLPCEPEL
                     MPTFPHHRNKRAAPAAAEGQSKRCRP"
     exon            129..201
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            202..273
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            274..376
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            377..458
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            459..526
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            527..579
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            580..649
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            650..709
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            710..833
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            834..973
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1026
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1649
                     /gene="Cdk10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk10"
                     /note="hexamer: GATAAA"
     polyA_site      1647
                     /gene="Cdk10"
                     /note="major polyA site"
ORIGIN      
        1 gttacgcctg cgcgctggaa gagggcggca gcggcttggg catggcagag gtggacctgg
       61 agtcggatca gatccgattg aagtgtatcc gtaaggaagg tttcttcacc gtgcctccag
      121 aacacaggct gggaagatgc cgaagcgtta aggagtttga gaagctgaac cggattggcg
      181 agggcaccta tggcatcgtg tatcgggcca gggataccca gacagatgaa attgtcgccc
      241 tgaagaaggt gcggatggac aaagagaagg atggcatccc catcagcagc ctgcgtgaga
      301 tcacactgct cttgcgtctc cgccatccaa acattgtgga gctgaaggag gtggttgtgg
      361 gcaaccacct ggagagcatc ttcctggtca tgggttactg cgaacaagat ctggccagcc
      421 tattggaaaa tatgccaaca cccttctcgg aggcccaggt taaatgcatc atgctacagg
      481 tgcttcgtgg ccttcagtac ctgcacagga acttcatcat ccacagggac ctgaaggtgt
      541 ccaacttgct catgacagac aagggctgtg taaagacagc tgattttggc ctggctcggg
      601 cctatggtgt tccagtaaag ccaatgactc ccaaggttgt taccctctgg taccgagccc
      661 cagagctgct gcttggaact accacccaga ctaccagcat tgacatgtgg gctgtcggct
      721 gcatcctggc agagctgctg gcccataagc ccctcctccc tggcacttcc gagatccacc
      781 agatcgactt gattgtacag ctgttgggga caccgagtga gaatatctgg ccgggtttct
      841 ccaagctgcc gctggccggc cagtacagct tgaggaaaca gccctataac aacctcaagc
      901 acaagttccc gtggctctca gaggccggac tccgtctgct caacttcctc ttcatgtatg
      961 accctaagaa aagggcaacc tcgggagact gcctggagag ctcctacttc aaggagaagc
     1021 ccctgccctg tgaaccggag ctcatgccta ccttccccca ccaccgcaat aagcgtgctg
     1081 ccccagctgc cgctgaaggg cagagcaaac gatgccggcc ctgagcctgg atccagccca
     1141 cccctccaca tcctcacgga tcatcagccg acgactggga ggccccagca ggcctttggc
     1201 tcctccagtt ggctgactcc tccctgatat ttccctctgt ccagatgcag aggggatttg
     1261 tggacaggga tgtggctgag tggggtaccc aggatagact gggcagttgt agcaccatct
     1321 ggtggcctgt cttgtctatc attgaaggcc cgcttctggg ggaacagagc tagtgctgag
     1381 aggcctaaag gtcccattca gtgtgtgtga gaactggagc tgggcactag cctggaatga
     1441 gtaggcctgg gagataactc ttcttggaga ctaggagctg cccaggacag atgggctata
     1501 gtgaccccgg gcaggaggga gcaagggttg gttaactgga gtaggatact tgtaagactg
     1561 tcagaatgga agcccttggt ggacgcggct ggcactggtg cccaaggaga ggattggtgg
     1621 actgagagat aaaaagcctt tccagaagaa aaaaaaaaaa a
//
