LOCUS       NM_007659               4362 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus cyclin dependent kinase 1 (Cdk1), mRNA.
ACCESSION   NM_007659
VERSION     NM_007659.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4362)
  AUTHORS   Feng,J., Xie,L., Lu,W., Yu,X., Dong,H., Ma,Y. and Kong,R.
  TITLE     Hyperactivation of p53 contributes to mitotic catastrophe in
            podocytes through regulation of the Wee1/CDK1/cyclin B1 axis
  JOURNAL   Ren Fail 46 (2), 2365408 (2024)
   PUBMED   38874119
  REMARK    GeneRIF: Hyperactivation of p53 contributes to mitotic catastrophe
            in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
REFERENCE   2  (bases 1 to 4362)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4362)
  AUTHORS   Mahiny,D., Hauck,L., Premsingh,B., Grothe,D. and Billia,F.
  TITLE     Cdk1 Deficiency Extends the Postnatal Window of Cardiomyocyte
            Proliferation and Restores Cardiac Function after Myocardial
            Infarction
  JOURNAL   Int J Mol Sci 25 (19), 10824 (2024)
   PUBMED   39409153
  REMARK    GeneRIF: Cdk1 Deficiency Extends the Postnatal Window of
            Cardiomyocyte Proliferation and Restores Cardiac Function after
            Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4362)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4362)
  AUTHORS   Cui,X., Dong,H., Luo,S., Zhuang,B., Li,Y., Zhong,C., Ma,Y. and
            Hong,L.
  TITLE     Long Non-Coding RNA-Cardiac-Inducing RNA 6 Mediates Repair of
            Infarcted Hearts by Inducing Mesenchymal Stem Cell Differentiation
            into Cardiogenic Cells through Cyclin-Dependent Kinase 1
  JOURNAL   Int J Mol Sci 25 (6), 3466 (2024)
   PUBMED   38542439
  REMARK    GeneRIF: Long Non-Coding RNA-Cardiac-Inducing RNA 6 Mediates Repair
            of Infarcted Hearts by Inducing Mesenchymal Stem Cell
            Differentiation into Cardiogenic Cells through Cyclin-Dependent
            Kinase 1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4362)
  AUTHORS   Aoki,F., Choi,T., Mori,M., Yamashita,M., Nagahama,Y. and Kohmoto,K.
  TITLE     A deficiency in the mechanism for p34cdc2 protein kinase activation
            in mouse embryos arrested at 2-cell stage
  JOURNAL   Dev Biol 154 (1), 66-72 (1992)
   PUBMED   1426634
REFERENCE   7  (bases 1 to 4362)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 4362)
  AUTHORS   Surmacz,E., Nugent,P., Pietrzkowski,Z. and Baserga,R.
  TITLE     The role of the IGF1 receptor in the regulation of cdc2 mRNA levels
            in fibroblasts
  JOURNAL   Exp Cell Res 199 (2), 275-278 (1992)
   PUBMED   1371961
REFERENCE   9  (bases 1 to 4362)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   10 (bases 1 to 4362)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030231.1, AC131795.3 and BU756691.1.
            
            On Jun 22, 2018 this sequence version replaced NM_007659.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030231.1, SRR11927937.3871189.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2860              AK030231.1         2-2861
            2861-3724           AC131795.3         45942-46805         c
            3725-4362           BU756691.1         1-638               c
FEATURES             Location/Qualifiers
     source          1..4362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.07 cM"
     gene            1..4362
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /note="cyclin dependent kinase 1"
                     /db_xref="GeneID:12534"
                     /db_xref="MGI:MGI:88351"
     exon            1..77
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            78..140
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..997
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="cell division control protein 2 homolog; cell
                     division protein kinase 1; cell cycle p34 CDC2 kinase
                     protein; p34 protein kinase; cell division cycle control
                     protein 2a; cell division cycle 2 homolog A"
                     /codon_start=1
                     /product="cyclin-dependent kinase 1"
                     /protein_id="NP_031685.2"
                     /db_xref="CCDS:CCDS23908.1"
                     /db_xref="GeneID:12534"
                     /db_xref="MGI:MGI:88351"
                     /translation="MEDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGV
                     PSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDS
                     SLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY
                     THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR
                     ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRI
                     SGKMALKHPYFDDLDNQIKKM"
     exon            141..297
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            298..421
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            422..592
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            593..756
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            757..898
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     exon            899..4349
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /note="hexamer: AATATA"
     polyA_site      1191
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /note="major polyA site"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
                     /note="hexamer: AATAAA"
     polyA_site      4349
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a; p34<CDC2>"
ORIGIN      
        1 actcggcctc taagctcctg gagttgctgc gtccgcgcag tccggaactg cggtgtggcc
       61 ccagccggga cagagagggt ccgtcgtaac ctgttgagta actatggaag actatatcaa
      121 aatagagaaa attggagaag gtacttacgg tgtggtgtat aagggtagac acagagtcac
      181 tggccagata gtggccatga agaagatcag acttgaaagc gaggaagaag gagtgcccag
      241 tactgcaatt cgggaaatct ctctattaaa agaacttcga catccaaata tagtcagcct
      301 gcaggatgtg ctcatgcagg actccaggct gtatctcatc tttgagttcc tgtccatgga
      361 cctcaagaag tacctggact ccatccctcc tgggcagttc atggattctt cactcgttaa
      421 gagttactta caccaaatcc tccagggaat tgtgttttgc cactcccggc gagttcttca
      481 cagagacttg aaacctcaaa atctattgat tgatgacaaa ggaacaatca aactggctga
      541 tttcggcctt gccagagcgt ttggaatacc gatacgagtg tacacacacg aggtagtgac
      601 gctgtggtac cgatctccag aagtgttgct gggctcggct cgttactcca ctccggttga
      661 catctggagt atagggacca tatttgcaga actggccacc aagaagccgc ttttccacgg
      721 cgactcagag attgaccagc tcttcaggat cttcagagct ctgggcactc ctaacaacga
      781 agtgtggcca gaagtcgagt ccctgcagga ctacaagaac acctttccca agtggaagcc
      841 ggggagcctc gcatcccacg tcaagaacct ggacgagaac ggcttggatt tgctctcaaa
      901 aatgctagtc tatgatcctg ccaaacgaat ctctggcaaa atggccctga agcacccgta
      961 ctttgatgac ttggacaatc agattaagaa gatgtagccc tctggatgga tgtccctgtc
     1021 tgctggtcgt aggggaagat cgtgttgttt accgttggct ctcttcctgt cttgtatagt
     1081 tttctttgtt tgtaaactgt catctggact tttcttaatt tcctacgtat aacttaatta
     1141 acatgtaaat attattccat atgaatttaa atataattct gtatatgtgc agatgtcact
     1201 gtggtggctg ttaattacta taacacaagt gttaattact acaacataag acttgagtct
     1261 ccctagactt cccagcagcc attcctgcag ctcggagcac agttgaagga gctgagctca
     1321 ggcctcgtga tgctttcaag tgcctccgtg ttctggatat atatgattcc tggtcagttt
     1381 cttgccattt ggaaactaca acccacctac ggacagtgtt tttctacttg tgcttaagca
     1441 gttgggatga gaaggccaaa gacccgagga tgtctagagt aatgaccccc agatggaagt
     1501 gcaccaaagc tggctgggtt tcacagctag agatcagggg ctgtccagag caggacagct
     1561 tagaacattt atgaagactc cctattttta ggtttgttgt aaagctgttg tctagttgga
     1621 ttcctgtgct ctgcatggtc agaggtaggt tagaggattt gccttggctt ctaaatccaa
     1681 tttgaaaact gcttaaaatc tcctgtcctc tcttagcagt gtctaaaaat gtccttgtcc
     1741 aaatatttag ctgagattcc tcactttgga aaaggagccg tatcgctgtg ctgcttagtg
     1801 taattcttag aagcagcctg acttatctgc tagcagtcaa agggatgcct gagacgactg
     1861 ctcctcttag aactaaaggc tgggatgctt aagtttgtct actgtttgga ggatctcggt
     1921 aagactgagc ccctgttcct gtggccacct cagtttacca gtacctcagc ctcagcctcc
     1981 tgcatttgct ggagtcaggg aaggtcccca gccctgagcc ctgacgctcc tgattgtaga
     2041 gactgtcagt tggaggtaaa acgttcattg aagtagtcag cagccacatg catttagggc
     2101 actccagtgt cagagaccat cctggaggtt tctaaccctg ccgctggcag tctactccca
     2161 agacagatca gttagagtgg tcagcaaaca ccaactgctg cagaaacctg tgttggtgtg
     2221 gttccctgct gctgctggga actgggccca agactagaga gcttggggct gcggttgatc
     2281 atgggttctg ttcctgcatt acaccttgaa atccaagcct tctaatatct cccttcggat
     2341 cataagttgt gaatttggtc ctccgccccc gccaggtttt ctatacttgg gtttgtcttg
     2401 ctgacatttt caagagtcct gactaagacg gtgattagtg tgacatgact tgagaactac
     2461 cgatttgaag cacacttgaa gttaacaaat tctctcatga ttatactttt aactttttat
     2521 aagattgctt gagctcaccc agatctctgt tgggaagtaa ctgggtaaca aaagccgttg
     2581 cactggtttg acagctaaca actgttggta ctttgtattc agaaggaatg aggtagcgat
     2641 tgaatggctg gggtgttgtt tccacagttt atacactaaa aatttgggta gccaggaggt
     2701 agtggcgcgc aatctttaat ctcagcagag gcagtcctat ctcttgagtt ggaggccagc
     2761 ctgcctgagt tccagaccag ccagggctac aggaagaagt cttaaaaaaa ttttttttcc
     2821 ctgtggatgt aaacccatga gaatgactgc tgtatctatc actttctgta taatagaggt
     2881 ttcttccgcc gcagcgctcc attggtctca gcccctcatg ttgggggcgg gaaggagggg
     2941 caagcgtccc caagcacagg aaggcctgct gaagagttgg cggctttgag ggttcaaatc
     3001 ctgcttgggt ctgaggagtc ccccaaacga tcttggactg taaaaacctg ccaggaacaa
     3061 gcgctaaggg atggttctca acctgtgggt cgcgaccccc tggggagttg gacagccctt
     3121 tcctgaggat cagaacaaac atcctgcata tcagatatta acgtggcatt tcataactgc
     3181 aaacttacag ttaggaagta gcagtgacaa agaattttat gggtggggtg gggtgggggc
     3241 tcaccaccat attaaagggt tacagcatta ggagggttga caacagaacc atcgcactga
     3301 gggaaagtga gttagcacga agagatgagc atttcccaga acacagaata agacacgttt
     3361 aaccaacatc agtctgtaac cccagcggac tgtgacaagc tctcacccat gccgtggagc
     3421 tcagaactag cattgcacgc ttttacccca tctttggttg cctcactccc tttgagtagt
     3481 aagtccctct tcaaagtaat agcctctaaa cagcctgctg cgcatgctct agtcctttgc
     3541 tttcctccac gggtaggcca caggcttaag cagcagttgg aaatggaact tgggctttct
     3601 ggctcctggt ttagaaaact cttgaaatgg acaagattta gtcctaggca agttctgtgt
     3661 agtcagcaat ggaagcaaag gggggtgggg caaacattcc agtcaggtgg aatctgagcc
     3721 cttgagagtg tgaggcagga ggatcactag gcaggagttc tcaaccagcc tagacgacag
     3781 cttggaaccc atcgcactcc acaatgagga cccctcagct tctgaagaga ggagagctgc
     3841 tagctctgag aagggtgtat aaaatgggct tttggttccc agacatcaga cttgaagagg
     3901 caaccgagta agccagctat agactaagta agattgtcgt acctagccta ctccttggga
     3961 gctcattctt cagagtatgt tgatggatga cctaacgcca tctcagatgc tggagcattt
     4021 tgctggaaag gctctcagca ctagcgaggc tgcctcaatg taatcctgcc tcagcctgag
     4081 aactgattat gagttaccgt ttggtacttt atgtattttt ctctcttcct agtaaccaag
     4141 gacaaacctg cttccttcca gccacgtggc agacactagc tgtactaaag tattattaca
     4201 caccggtccc ctgctgccag aacaaagaac tcagcctcga gaaatttctc ctattatatt
     4261 tgggatccag catgtcccaa gacagggacg actcaataat ttaatgtgcc taatggcacg
     4321 gaataaaagg attattcaca aacagaaaaa aaaaaaaaaa aa
//
