LOCUS       NM_026638               1767 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CDP-diacylglycerol--inositol 3-phosphatidyltransferase
            (Cdipt), transcript variant 1, mRNA.
ACCESSION   NM_026638 NM_138754
VERSION     NM_026638.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1767)
  AUTHORS   Buccafusca,R., Venditti,C.P., Kenyon,L.C., Johanson,R.A., Van
            Bockstaele,E., Ren,J., Pagliardini,S., Minarcik,J., Golden,J.A.,
            Coady,M.J., Greer,J.J. and Berry,G.T.
  TITLE     Characterization of the null murine sodium/myo-inositol
            cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is
            independent of expression of its cognate mitochondrial ribosomal
            protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels
            in neonatal brain
  JOURNAL   Mol Genet Metab 95 (1-2), 81-95 (2008)
   PUBMED   18675571
REFERENCE   4  (bases 1 to 1767)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122863.4.
            
            On Mar 27, 2020 this sequence version replaced NM_026638.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089109.1, AK079226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AC122863.4         117192-117540
            350-484             AC122863.4         117652-117786
            485-638             AC122863.4         118996-119149
            639-720             AC122863.4         119649-119730
            721-802             AC122863.4         120056-120137
            803-1767            AC122863.4         120269-121233
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.26 cM"
     gene            1..1767
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /note="CDP-diacylglycerol--inositol
                     3-phosphatidyltransferase"
                     /db_xref="GeneID:52858"
                     /db_xref="MGI:MGI:105491"
     exon            1..349
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..948
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /EC_number="2.7.8.11"
                     /note="isoform 1 is encoded by transcript variant 1; PI
                     synthase; ptdIns synthase; phosphatidylinositol synthase"
                     /codon_start=1
                     /product="CDP-diacylglycerol--inositol
                     3-phosphatidyltransferase isoform 1"
                     /protein_id="NP_080914.1"
                     /db_xref="CCDS:CCDS21853.1"
                     /db_xref="GeneID:52858"
                     /db_xref="MGI:MGI:105491"
                     /translation="MPEENIFLFVPNLIGYARIVFAIISFYFMPCCPFTASSFYLLSG
                     LLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLYPRATLLFQLSMSLDV
                     ASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFNF
                     SEGPLVGSVGLFRMGLWVTAPIALLKSVISVIHLITAARNMAALDAADRAKKK"
     exon            350..484
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..638
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..720
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..802
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1767
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /note="hexamer: AATAAA"
     polyA_site      1767
                     /gene="Cdipt"
                     /gene_synonym="9530042F15Rik; D7Bwg0575e; Pis; Pis1"
                     /note="major polyA site"
ORIGIN      
        1 gttcttaacg tcccggacag aagagtaggc tccagaagcc aggcgcagcg gagctgcgga
       61 gcccgctgct ggagacgtca gctcctgccc atcggaaggc caggtgtgcg tgagctgtgc
      121 ccaggggtgt cccgcacccc ggcgccctgc gggctctaac agctgggatt gcccggggga
      181 actgggccca gggctcaggt ggagcggctg atgcccggag ctgaaaggtg agaccacgct
      241 ggtaaggctg gtaccaagac cttgcccctc cagacctggg ccgagacgac aaggggagcc
      301 gccaagatgc cagaggaaaa tatcttcctg ttcgtgccta accttatcgg ttatgcccgg
      361 attgtcttcg ccatcatttc cttctacttt atgccctgct gccccttcac ggcctcctcc
      421 ttctatctac tcagcggact cctagacgct ttcgatggac acgcagctcg agcccttaat
      481 caaggaaccc ggtttggggc catgctcgac atgctgacgg accgttgcgc caccatgtgt
      541 ctcttggtca acctggccct gctctaccca cgagccaccc ttctcttcca gctcagcatg
      601 agcttggacg tggccagtca ctggctgcat ctgcacagtt ctgtggtgcg aggcagtgag
      661 agtcacaaga tgatcgacct gtctgggaac cctgtgcttc ggatctacta tacctctagg
      721 cctgctctgt tcaccctgtg tgctggaaat gaactcttct actgcctcct gtatctcttc
      781 aatttctccg agggaccact agtcggctct gtgggccttt tccggatggg cctctgggtc
      841 acagctccca tcgcgctgct caagtccgtc attagtgtca tccacctcat cacggctgca
      901 agaaacatgg ctgccctgga tgcagcagac cgcgccaaga agaaatgatc ctctcccatc
      961 cccagctgtc cacctgccct gggtatctac tgtaccacgt gactcctctc ctcctaagag
     1021 gtcccagtgt catgtctttc tcatgtgttc tctaacctgc tgggattagg ggtcaccttc
     1081 tgtttggtgt tgtcactatc tctttaatcc tgatgattag acccaacctg tgaccccaag
     1141 gacctggcac tgccaagcag gaagggtgct caggaggccc tgcccatcca gctggtgctc
     1201 cgggaggcct gactgaagac tgggtgttgc cacacatcct gctgcctcag tcctggggtc
     1261 tggagtgaga ctttggggac atgtgagggc aaaggagtca gactgatgtc attggacctg
     1321 gggtaccagg ctggggaggg aaggggccag ctagatcctt ccctgaggcc agctcctctc
     1381 tcctgtcctg ctctggaaac ctccacaata aaggggggcc ccttcagtct ttttggatgt
     1441 gtttactttg agacactctt agatgatggc ccagggtcca tgggagctgg attagaatcc
     1501 acctggatgc tttcccaaag gtggctggct cctccctgtc gttccagtga tctcgagagg
     1561 ctttgtggct cctcaggttc acaggcattg tctctgccca cctgctttat gtccctagct
     1621 ggccactttt gattgtaacc ttgatatttt ctaccctcat gagaatgtga gcttcatgag
     1681 agcagactta tgtctttctt gtctctgcct agagtgaaaa ctagcctggc atgtggtagc
     1741 tgcttaataa atattcatgg gaagatg
//
