LOCUS       NM_025670               3904 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell death inducing Trp53 target 1 (Cdip1), transcript
            variant 6, mRNA.
ACCESSION   NM_025670
VERSION     NM_025670.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3904)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3904)
  AUTHORS   Liu,J., Zuo,Z., Sastalla,I., Liu,C., Jang,J.Y., Sekine,Y., Li,Y.,
            Pirooznia,M., Leppla,S.H., Finkel,T. and Liu,S.
  TITLE     Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the
            Bacillus cereus Hemolysin BL Toxin Host Receptors
  JOURNAL   Cell Host Microbe 28 (3), 402-410 (2020)
   PUBMED   32544461
  REMARK    GeneRIF: Sequential CRISPR-Based Screens Identify LITAF and CDIP1
            as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
REFERENCE   3  (bases 1 to 3904)
  AUTHORS   Li,M., Ding,W., Tariq,M.A., Chang,W., Zhang,X., Xu,W., Hou,L.,
            Wang,Y. and Wang,J.
  TITLE     A circular transcript of ncx1 gene mediates ischemic myocardial
            injury by targeting miR-133a-3p
  JOURNAL   Theranostics 8 (21), 5855-5869 (2018)
   PUBMED   30613267
  REMARK    GeneRIF: These findings reveal a novel regulatory pathway that
            comprises circular transcript of NCX1, miR-133a-3p and CDIP1, that
            is involved in cardiomyocyte apoptosis during ischemic cardiac
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3904)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3904)
  AUTHORS   Namba,T., Tian,F., Chu,K., Hwang,S.Y., Yoon,K.W., Byun,S.,
            Hiraki,M., Mandinova,A. and Lee,S.W.
  TITLE     CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic
            reticulum to mitochondria under endoplasmic reticulum stress
  JOURNAL   Cell Rep 5 (2), 331-339 (2013)
   PUBMED   24139803
  REMARK    GeneRIF: CDIP1 Promotes Bax Oligomerization and Mitochondrial
            Translocation during endoplasmic reticulum Stress.
REFERENCE   6  (bases 1 to 3904)
  AUTHORS   Brown,L., Ongusaha,P.P., Kim,H.G., Nuti,S., Mandinova,A., Lee,J.W.,
            Khosravi-Far,R., Aaronson,S.A. and Lee,S.W.
  TITLE     CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated
            apoptosis in a p53-dependent manner
  JOURNAL   EMBO J 26 (14), 3410-3422 (2007)
   PUBMED   17599062
REFERENCE   7  (bases 1 to 3904)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166903.2.
            
            On Mar 19, 2018 this sequence version replaced NM_025670.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031705.1, AK005157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC166903.2         8718-8828
            112-176             AC166903.2         27924-27988
            177-285             AC166903.2         28508-28616
            286-441             AC166903.2         28864-29019
            442-715             AC166903.2         29641-29914
            716-3904            AC166903.2         30010-33198
FEATURES             Location/Qualifiers
     source          1..3904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.47 cM"
     gene            1..3904
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /note="cell death inducing Trp53 target 1"
                     /db_xref="GeneID:66626"
                     /db_xref="MGI:MGI:1913876"
     exon            1..111
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     exon            112..176
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     exon            177..285
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..827
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /note="isoform 4 is encoded by transcript variant 6;
                     LITAF-like protein; cell death-inducing p53-target protein
                     1"
                     /codon_start=1
                     /product="cell death-inducing p53-target protein 1 isoform
                     4"
                     /protein_id="NP_079946.2"
                     /db_xref="CCDS:CCDS27925.1"
                     /db_xref="GeneID:66626"
                     /db_xref="MGI:MGI:1913876"
                     /translation="MSNEPPPPYPGGPTAPLLEEKSGAPLTPGRTSPAVMQPPPGMPL
                     PSADIAPPPYEPPGQPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPP
                     GPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLM
                     NFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC"
     exon            286..441
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     exon            442..715
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     exon            716..3904
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /note="hexamer: AATGAA"
     polyA_site      1617
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /note="hexamer: AATAAA"
     polyA_site      2525
                     /gene="Cdip1"
                     /gene_synonym="2700048O17Rik; 5730403B10Rik; CDIP"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcggggg cggtgagtgc tgcgagtcct ctggtagagg ggctcctcgg agcagcgggc
       61 cggaccactg cagatctctg tccctctggc ctcaggcttc tggatttcga gcctcctaga
      121 tctgcctccg ctgaattact ctcacctact tctgttctct gcaccagaaa tctgagatcc
      181 aggagtatca gcaggcaaag atgtctaatg agccaccccc tccttatcca ggaggtccta
      241 cagccccact actggaggaa aaaagtggag ccccacttac cccaggccga acctcaccag
      301 ctgtgatgca gcctccacca ggcatgccac tgccttctgc tgacattgcc cctccaccct
      361 atgagccacc tggccaacca gtgcctcagc ctggctttgt gcccccccat atgaatgcag
      421 atggcaccta catgcctgca ggtttctacc ctcctccagg gcctcaccca cctatgggct
      481 attatccacc aggaccctac ccaccagggc cctaccctgg ccctgggggc cacacggcca
      541 cagtattggt cccatcaggg gcagccacca cggtgacagt actgcaggga gagatctttg
      601 aaggcgcacc agtgcagaca gtgtgtcctc actgccagca ggccatcacc accaagatct
      661 cctacgagat aggcctgatg aactttgtgc tgggtttctt ctgctgcttc atggggtgtg
      721 acctgggctg ctgtttgatc ccctgcctca tcaatgactt caaggatgtg acgcacacat
      781 gtcccagctg caaagcctac atctgcacat acaagcgctt gtgctaacag agccagactt
      841 ggactcccct acctattagt ctggccccca tgtgctttgc tccccatgct cagtggtcac
      901 tatcccctca actccccact tagggttgga agttctgcca ctgtactctg gaaatcctgt
      961 cctcaccttg cccttccctg agcatccgac tcttccagca acaattctgt tggatttaag
     1021 gccaagggcc agtgggtggc atggggtggc actaatcttg tgtgttgctt ggacatttgc
     1081 aattcagaag ataagctaga gaggctctta ctagggccct catttctcct tttctgtata
     1141 agtataaggt ccaggctggt ccttactctt cctgggacca aaagcaccca gaggcattaa
     1201 caggtcccca gactagggcc tacactgagg gtagaacctg gaaccacagt tgttgctgac
     1261 ctgctggaat gaagtcagag tatcatctaa agttaagtag acccaagcaa gacagggtct
     1321 taaggcctgg gtttaagtgg ggcttcttgt ctggggtacc aagataggga aagaaagaaa
     1381 taatgactgc cagccctgga cctcagaatt ctcaggtatg gaaacactca agagctgcct
     1441 ggtatgaagc aaagaggatc ctgggctatt taaagctctg gtaaccgaga agaacttgcc
     1501 cctgttctta cctagcttct ttgagtcagt cagtgtgcag agctcctttc tggccacacc
     1561 tctgtgaacc cctatatttt ctgggactgg aaggaatgaa tgcccatgtc ctgtctactt
     1621 ctgtgtctgt gctatgtggg ggtgcaactt ctgcctggtg gtttgtgaca tggcagatca
     1681 gaagtgcctc cttgtaggtt cattggtctc tggaataagt gccagccttt ttgccatagt
     1741 tgacttgctt ccatattgga gctcctcagt aggaacagct gtggcactgg gctggggacc
     1801 aggaagaagt cacaagtggt gggagtatcc tagggacatg agtcgtgccc agggtataaa
     1861 cccaaacctg gtcatttctt gaacagtctg tgaatatgcc tgtgtggacg ctgtatcctg
     1921 ctgctgtccc tctcctggtc tctcacactg catggcctcc tatcactgtg aattgtggcc
     1981 tggtcgcagt ttgtagtttc attaaatggc cctttcactc ccctgccctg ggcctctgct
     2041 gtcttgcctg gcttccttct tttctgagag acagggtggg actataggta gtctagtggc
     2101 aggcaggagc ccgggcctgg gaaacaacac atttaagaac ccaattacac caaaccagaa
     2161 tttatatata tagacctgcc ctggggaaac ccagctgttc tgggccaggg cattggtttc
     2221 tgccatttgc ataattagat gtccaggctg cagaacctga gaactggagc cccgtcttag
     2281 cttagtaact tcttaaccta tagctattgc tctttcgtcc ttaaacaaga cagcactact
     2341 ggactaagac ctgatagtct gaagatgaca cactgaagtc tcggcactca gttcttggta
     2401 aatcaatctt ctgaactgtg aaggtggtgg gctcagtctc tttgagtttc cctgctgttc
     2461 taccattttt tcacacaaag acttttatag gaatagattc ctactaataa aaatgtttaa
     2521 cttcatattt ctattttaga ccatgcattg tttaaatcta agtatgtgct tttgaaataa
     2581 gaaacctcaa agattttgag ttaggaaaaa tcacaggtcc aagcagatat taaggatctt
     2641 tatggtattt agcatgaata catggaaata gaaggtgcta ggaagttggc aaggagtgcc
     2701 atgaaagagg atgtccattt gtatgctgtt tctgagggac tctatcctat cccaggaagg
     2761 agggaagtgt gtggcgtttg tttttagagt gttatggcag gcacaccagt cagctgagac
     2821 acatcaggct aatagactta ttagggagat cccggttatg cagaataagc tctttagact
     2881 atcaaaaggc ctagaaaact gagccatcat cagctggcat gaccctttcc cacaaaccct
     2941 gtgtgtatgg gcatctcact cccagcatgg caatgaccat tccaagcact gctaagaaag
     3001 caatgtaccc aggcctccta aatggcaaaa ttcctagagc actggctgtt aatagagtga
     3061 cagcctttat ctggtgtata tctggctggc agagaaaatg ctgttaggca gaggctctag
     3121 tgtctggctt ttattggttg cttgttttct caaacccagc attaaaaaaa agtcacctga
     3181 ggtggtagtt ttaggcagag gtggagatgg ggatagaaca ggtcacttgg ggtaggatgc
     3241 aaacaacatg acaggtcctt cacatgtagt accaggccaa gagtccagct accaaggcca
     3301 cactggcagc cagaatgagc tgcaggctag gcttcctcag cacagccacg gttgtctgga
     3361 aggggcagtt gctgcctcct agtgtacctg catgcaacac aacataagac atggcatcaa
     3421 tggaaggcac tgatatacct gctccagaaa tgttagttca ggacccacaa cctacctttg
     3481 tctggctgag cagcataaaa ggggcattta cgtatatctc ccttcccatc atgtaccggg
     3541 agcccatcct ccagggtttc tcttgctagc atggagccag cctggtccag ttcactgaat
     3601 atctgaggaa cagaagtcat cagaggccat ccctaaacta agaagactca gaatttacac
     3661 tctacagatg acccatggag aagctagagc ccagatacac ctgatgagga ctgcaaacca
     3721 gctgaacatc aaaccagaaa agtgaacact atcctgcatg tcttagtgag agctcaagtg
     3781 actgctacta aggacttgag tgcccacagc tatcctctcc caacactgag gtactaggga
     3841 cagaaatggt ttctgtaaga tcagccctac ctgagactta taaaacctac ttattctact
     3901 tccc
//
