LOCUS       NM_001114322            2629 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus cadherin-related family member 5 (Cdhr5), transcript
            variant 1, mRNA.
ACCESSION   NM_001114322
VERSION     NM_001114322.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Silverman,J.B., Krystofiak,E.E., Caplan,L.R., Lau,K.S. and
            Tyska,M.J.
  TITLE     Organization of a cytoskeletal superstructure in the apical domain
            of intestinal tuft cells
  JOURNAL   J Cell Biol 223 (12) (2024)
   PUBMED   39352498
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Beck,M., Baranger,M., Moufok-Sadoun,A., Bersuder,E., Hinkel,I.,
            Mellitzer,G., Martin,E., Marisa,L., Duluc,I., de Reynies,A.,
            Gaiddon,C., Freund,J.N. and Gross,I.
  TITLE     The atypical cadherin MUCDHL antagonizes colon cancer formation and
            inhibits oncogenic signaling through multiple mechanisms
  JOURNAL   Oncogene 40 (3), 522-535 (2021)
   PUBMED   33188295
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Garrison,W.D., Battle,M.A., Yang,C., Kaestner,K.H., Sladek,F.M. and
            Duncan,S.A.
  TITLE     Hepatocyte nuclear factor 4alpha is essential for embryonic
            development of the mouse colon
  JOURNAL   Gastroenterology 130 (4), 1207-1220 (2006)
   PUBMED   16618389
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Lu,J., Qian,J., Izvolsky,K.I. and Cardoso,W.V.
  TITLE     Global analysis of genes differentially expressed in branching and
            non-branching regions of the mouse embryonic lung
  JOURNAL   Dev Biol 273 (2), 418-435 (2004)
   PUBMED   15328023
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Goldberg,M., Wei,M., Yuan,L., Murty,V.V. and Tycko,B.
  TITLE     Biallelic expression of HRAS and MUCDHL in human and mouse
  JOURNAL   Hum Genet 112 (4), 334-342 (2003)
   PUBMED   12589428
  REMARK    GeneRIF: MUCDHL genes are biallelically expressed in multiple fetal
            and adult tissues both in humans and in mice
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Goldberg,M., Peshkovsky,C., Shifteh,A. and Al-Awqati,Q.
  TITLE     mu-Protocadherin, a novel developmentally regulated protocadherin
            with mucin-like domains
  JOURNAL   J Biol Chem 275 (32), 24622-24629 (2000)
   PUBMED   10801787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027913.1 and BG063646.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027913.1, BC043336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2619              AK027913.1         2-2620
            2620-2629           BG063646.2         1-10                c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.58 cM"
     gene            1..2629
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /note="cadherin-related family member 5"
                     /db_xref="GeneID:72040"
                     /db_xref="MGI:MGI:1919290"
     exon            1..162
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2564
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mucin and cadherin-like protein;
                     mu-protocadherin; mucin-like protocadherin"
                     /codon_start=1
                     /product="cadherin-related family member 5 isoform 1
                     precursor"
                     /protein_id="NP_001107794.1"
                     /db_xref="CCDS:CCDS52442.1"
                     /db_xref="GeneID:72040"
                     /db_xref="MGI:MGI:1919290"
                     /translation="MGAPALLWPSLLLPWLTVLFGQPPGTLAQTQVCSVNQTIFRVEE
                     NTTVSEPLVNIFVPDGLHVTLGPLSTPYAFRIEGKDLFLNVTPDYEENSLLQADVECK
                     RGDAVVVRLEVFVAVLDINDNAPKFSFEIKTFNVSEDTKVNTTVIPETQLKATDADIN
                     DILVYTLQEVTPNASKFFSLEGVNYPALKLDQTLDYFKNQNMTFMLLARDTWEENVEP
                     SHTATATLVLNTLPADLRTPWFLPCSFTDGYVCIHAQYSAVVPTGHKLPSPLIMSPGP
                     IYAVDGDQAINQSIIYSIIAGNTDGTFIINAHDGNLTMTKSIPSPMKFTLLIRADQED
                     MAQYSVTQAIVEARSVTGNPLQFSQSLYYGTVVLGSEAGTAVKDKTFPSEILRIQAQY
                     PGFPDLNSAVTYRVTNSSEFMMNKDIMLTAVPMEEARTIRVEVEASNTVTKDTATAVV
                     EIQVSERELPSTEFPTPPEAGGTTGPSSNTTMEAPLTSGTSQRPATTSSGGSVGPFPP
                     GGTTLRPPTPASSIPGGSPTLGTSTSPQTTTPGGDSAQTPKPGTSHPTAPTSRTSTSL
                     MTTSSRSDSTQTPKPGTSQPMVPIPGASTSSQPATPSGSSPQTPKPGTSQSTATGPIS
                     GAGEQGDGQRFSTVDMAVLGGVLGALLLLALICLVILVHKHYRHRLACCSGKASEPQP
                     SGYDNLTFLPDHKAKWSPTPNRKPEPSPKLAQPPLRPPSPMSSSPTPPSSTPPSPQPK
                     ASGSPKTVQAGDSPSAVRSILTKERRPEGEGGYKAVWFGKDIGAEADVVVLNEPTADV
                     DSASASGSEGSDDDDPDQKKTLRFGVDADNTYI"
     exon            163..338
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            339..389
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            390..482
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            483..584
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            585..695
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            696..866
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            867..957
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1055
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1256
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1370
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1455
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1941
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2102
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2629
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdhr5"
                     /gene_synonym="1810074H01Rik; Mucdhl; Mupcdh"
                     /note="putative"
ORIGIN      
        1 aaggcaggaa ttgtaccagc cctggaacca agcaagctgg atccttcttc caggtgacag
       61 ctgccgccat gggggctccg gccctcctgt ggccttccct gctgttgcca tggctcacag
      121 tgctgtttgg ccaacctccg gggaccttgg cccagaccca ggtctgctct gtgaaccaga
      181 ccatatttag agtcgaggag aacaccactg tttctgagcc actggtgaac atttttgtcc
      241 cagacggcct gcacgtgacc ttgggaccct tgtccactcc ttatgccttt aggatcgaag
      301 gaaaagatct gtttctcaac gtgactccag attatgagga aaactcattg ctccaggcag
      361 atgtggagtg taagagagga gatgcggtgg tggtacgcct ggaggtgttt gtggctgtcc
      421 tggatatcaa tgacaatgcg ccaaaattct cctttgaaat caagacattt aatgtatcgg
      481 aggacaccaa agtgaataca accgtcatcc ctgagacaca gctgaaggct acagatgctg
      541 acataaatga catcctagtc tacactctgc aggaagtgac ccccaatgcc agcaagttct
      601 tctccctgga gggcgtaaac taccctgctc tgaagttgga ccagaccctg gattacttca
      661 agaatcagaa catgaccttc atgctgctgg cacgggatac ttgggaggaa aatgtagagc
      721 ccagccacac ggccactgcc accctggtct tgaacacgct gccagctgac ctacggaccc
      781 cctggttcct gccatgctcc ttcacagatg gctatgtctg cattcatgcc caatacagtg
      841 cggttgtccc cacgggacac aaactgccgt cccccctcat catgagtcct ggtcccatct
      901 atgctgtgga cggagatcag gccattaacc agtctatcat ctacagcatt atagcgggaa
      961 acacagatgg cacattcatc atcaacgcac acgatggcaa cctcacaatg accaaaagta
     1021 tcccgagccc catgaagttc acccttctga tcagggctga tcaggaagac atggctcaat
     1081 actcagtgac ccaggccatc gtggaggctc gcagtgtcac tggaaaccca ctccagttct
     1141 cccagagcct gtactatggc acagtggtac tgggatctga ggctggcaca gcagtgaagg
     1201 acaagacctt cccttcggag atcctgagga tccaggctca gtacccaggc ttcccggacc
     1261 tcaactcagc tgtcacatat cgagtcacca actcctcaga attcatgatg aataaggata
     1321 tcatgctgac tgctgtgcct atggaggaag caagaaccat ccgtgtagag gtagaagcta
     1381 gcaatactgt gactaaggac acagccaccg ctgttgttga gatccaggtg tcagagcgag
     1441 aactgccctc cacagagttc cccacacccc cagaagctgg aggaacgact gggccttcaa
     1501 gtaacaccac tatggaagcc cccttgacct ctgggacctc tcaaagacct gccaccacca
     1561 gctctggggg aagtgttggc ccattcccac ctggtggcac aactctaaga ccacccaccc
     1621 ctgcctcatc catacctggg gggtccccta ctcttggaac cagcacctct ccccagacaa
     1681 ccactcctgg tggggactca gcacagaccc ccaaaccagg aacctctcat ccaacagccc
     1741 ctacttccag aacaagtacc tccctcatga caacctcatc cagaagtgac tcaacacaga
     1801 cccccaagcc aggaacctct cagccaatgg tccccattcc aggggccagc acctcttctc
     1861 agccagccac acctagtggc agctcaccac agacccccaa gccaggaacc tctcagtcaa
     1921 cagccactgg gcccatctca ggagcaggcg agcagggtga tggccagaga ttttccacgg
     1981 tggacatggc agtgttgggc ggggtgctag gtgcactgct gttgctggcc ctcatctgct
     2041 tggtcatcct cgtccataag cactaccgac atcggctcgc ttgttgctct gggaaggctt
     2101 cggagccaca gccaagtggc tatgacaacc tgaccttcct cccagaccac aaggccaagt
     2161 ggtcgcccac ccccaaccgg aagccagagc cgagccccaa gcttgcccag ccgcccctcc
     2221 ggcctcctag ccccatgtcc tccagtccta cgccccccag ctccacacct cctagccctc
     2281 agcccaaagc ttccgggtct cctaagacag tccaggctgg ggacagccct tcagccgtga
     2341 ggtctatcct gactaaggag cggcggccgg agggggaggg cggctacaag gctgtgtggt
     2401 tcggcaagga catcggggca gaggctgacg tggtggtcct caacgagccc accgccgatg
     2461 tggacagcgc cagtgcctcg ggaagtgagg gcagcgatga tgatgaccct gaccagaaga
     2521 agactctccg ctttggcgtg gatgctgaca acacttacat ctagctcagc gcccgactct
     2581 ctaccccaag ccacttccct ttcctcgtct aattaaagta gcactttcg
//
