LOCUS       NM_130878               4400 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cadherin-related family member 1 (Cdhr1), mRNA.
ACCESSION   NM_130878
VERSION     NM_130878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4400)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   2  (bases 1 to 4400)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4400)
  AUTHORS   Cao,Y., Wang,Y., Dunn,H.A., Orlandi,C., Shultz,N., Kamasawa,N.,
            Fitzpatrick,D., Li,W., Zeitz,C., Hauswirth,W. and Martemyanov,K.A.
  TITLE     Interplay between cell-adhesion molecules governs synaptic wiring
            of cone photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23914-23924 (2020)
   PUBMED   32879010
REFERENCE   4  (bases 1 to 4400)
  AUTHORS   Maheshwari,U., Kraus,D., Vilain,N., Holwerda,S.J.B., Cankovic,V.,
            Maiorano,N.A., Kohler,H., Satoh,D., Sigrist,M., Arber,S.,
            Kratochwil,C.F., Di Meglio,T., Ducret,S. and Rijli,F.M.
  TITLE     Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional
            Identity and Input Connectivity of Cortical Afferent Subsets
  JOURNAL   Cell Rep 31 (11), 107767 (2020)
   PUBMED   32553152
REFERENCE   5  (bases 1 to 4400)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4400)
  AUTHORS   Plageman,T.F. Jr. and Yutzey,K.E.
  TITLE     Microarray analysis of Tbx5-induced genes expressed in the
            developing heart
  JOURNAL   Dev Dyn 235 (10), 2868-2880 (2006)
   PUBMED   16894625
REFERENCE   7  (bases 1 to 4400)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   8  (bases 1 to 4400)
  AUTHORS   Rattner,A. and Nathans,J.
  TITLE     The genomic response to retinal disease and injury: evidence for
            endothelin signaling from photoreceptors to glia
  JOURNAL   J Neurosci 25 (18), 4540-4549 (2005)
   PUBMED   15872101
REFERENCE   9  (bases 1 to 4400)
  AUTHORS   Rattner,A., Chen,J. and Nathans,J.
  TITLE     Proteolytic shedding of the extracellular domain of photoreceptor
            cadherin. Implications for outer segment assembly
  JOURNAL   J Biol Chem 279 (40), 42202-42210 (2004)
   PUBMED   15284225
  REMARK    GeneRIF: prCAD ectodomain cleavage is an integral part of the outer
            segment assembly process, and outer segment assembly might be
            driven, at least in part, by the near irreversibility of
            proteolysis.
REFERENCE   10 (bases 1 to 4400)
  AUTHORS   Rattner,A., Smallwood,P.M., Williams,J., Cooke,C., Savchenko,A.,
            Lyubarsky,A., Pugh,E.N. and Nathans,J.
  TITLE     A photoreceptor-specific cadherin is essential for the structural
            integrity of the outer segment and for photoreceptor survival
  JOURNAL   Neuron 32 (5), 775-786 (2001)
   PUBMED   11738025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF741547.1 and BC058270.1.
            
            On Apr 17, 2018 this sequence version replaced NM_130878.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058270.1, AB093300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CF741547.1         1-36
            37-4400             BC058270.1         1-4364
FEATURES             Location/Qualifiers
     source          1..4400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 21.29 cM"
     gene            1..4400
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /note="cadherin-related family member 1"
                     /db_xref="GeneID:170677"
                     /db_xref="MGI:MGI:2157782"
     exon            1..259
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2784
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /note="photoreceptor cadherin; protocadherin-21"
                     /codon_start=1
                     /product="cadherin-related family member 1 precursor"
                     /protein_id="NP_570948.1"
                     /db_xref="CCDS:CCDS26952.1"
                     /db_xref="GeneID:170677"
                     /db_xref="MGI:MGI:2157782"
                     /translation="MRRGPRVALVLGLLRIYLAQANFAPHFFDNGVGSTNGNMALFSL
                     PEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPNFGNITLVEELDRERED
                     EIEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYIIRVPENIPAGSSIFKVQAE
                     DKDTGSGGSVTYSLQNLHSSKFSMDRHSGVLRLQAGATLDYEKSRAHYITVIAKDGGG
                     RLRGADMVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDR
                     GKPNHILYRLLNESDGIFEINETSGAISVLQSPALLRREVYELHVQVTEVNSPGSPAA
                     QATVPVTIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGA
                     NAKFNLRLVGPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTP
                     EKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENAPGGSNVVAVTAVDPDTGPWGKV
                     HYSIYGTGSDLFLIHPSTGLIYTQPWASLDAEGTSRYNFYVKAEDMDGRYSLAEVFVT
                     LLDVNDHYPQFVQSVQEKTMVLGTPLKIEATDQDAEEPNNLVDYSITRAEPVNVFDID
                     AHTGEIRLKNSIRSLEALHNITPSGDYSWSLQVQAKDRGSPSFSTTALLKIDITDTER
                     LSRGSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVLISTATFWRNKKSNKVLPVRRV
                     LRRRPSPAPHTVRIEWLKFRRAKAATKFILKEDSPNENCNNSRVGVMVPPRAPALPPP
                     PKMASSMVAQQTVPTVSGSLTPQPSPQLPTPKTLGGPVQSSLVSELKQKFEKKSLDNK
                     AYI"
     exon            260..355
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            356..501
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            502..552
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            553..642
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            643..729
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            730..846
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            847..990
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1069
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1170
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1374
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1527
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1692
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1760
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1989
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2247
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..4340
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4310..4315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /note="hexamer: AATAAA"
     polyA_site      4332
                     /gene="Cdhr1"
                     /gene_synonym="mKIAA1775; Pcdh21; Prcad"
                     /note="major polyA site"
ORIGIN      
        1 accggagcca tccagctgtg aggatctgtg agcgctgtca tccgcttaac gccctcgcac
       61 cacccgctct ccctcccttc cgccaccgcc gccgccgcag tcacccacaa cgttccctct
      121 gctctcatcc agcgcccagg gcatgctccg aggtccagca cccggcctcg gcagtggcca
      181 ggctttcgac ccttccgcgg agacatgagg cgtggcccac gggtcgccct ggtcctgggg
      241 ctgctgcgca tttacctagc ccaggccaac tttgcccctc acttctttga caatggagtg
      301 ggcagcacca acgggaacat ggccctgttc agcctcccag aagacactcc tgtaggttct
      361 catgtgtaca ccctaaatgg gacagaccct gagggagacc ctatctccta ccacatcagc
      421 tttgacccca gcactagaag tgtcttttct gttgatccca attttggaaa catcactctg
      481 gtggaagagc tggacagaga aagggaagat gagattgaag ccatcatcag catttccgat
      541 ggcctgaacc tggtggcaga gaaagtcgtg atactggtga cagatgccaa tgatgaagca
      601 cccaggttca tccaggagcc ttacatcatc cgggttccag agaacatacc tgctgggagc
      661 agcatcttta aggtccaggc agaggacaag gacacaggct ctggaggcag tgtcacctac
      721 tcccttcaga acctacactc ctccaagttc tccatggacc gtcacagcgg ggtgctgaga
      781 ctccaggctg gggccacact ggactatgag aagtcgaggg ctcattacat cactgtgatt
      841 gccaaggatg gtgggggcag gcttcgaggg gctgacatgg tgttctcagc caccaccacc
      901 gtcaccatca atgtggaaga tgttcaggac acggccccta tcttcgtggg tacaccctac
      961 tatggttacg tgtatgaaga cacccttcct ggctcagagg tgctgacggt ggttgccata
     1021 gatggagacc gaggcaaacc caaccacatc ctctacaggc tcttgaatga gagtgacgga
     1081 atctttgaaa ttaatgagac atctggagcc atctccgtcc ttcagagccc tgccctgctc
     1141 cgaagagagg tgtatgaact tcatgtacag gtgacagagg tcaactctcc aggaagccca
     1201 gctgctcagg ccacagtccc agtgaccatc aggatcgtgg acctcaacaa ccaccctcca
     1261 accttctatg gagagagtgg gccccagaac aagtttgagc tctctatgtt tgagcaccca
     1321 ccccaggggg agattctccg tggactcaag atcactgtca acgactcaga ccagggagcc
     1381 aatgccaaat tcaacttacg gctggtggga cctggaggca tcttccgagt ggtgccacag
     1441 accgtcctga atgaagccca agtgaccatc atagtggaaa actcagctgc cattgacttt
     1501 gaaaagtcta agttgttgac cttcaagctc ctggccattg aagtgaacac cccagagaag
     1561 ttcagttcca cagcagacat tgtgatccag cttctggaca ccaatgataa tgtccccaag
     1621 ttcacctcgc actactacat tgccaggatc ccagagaatg ctccaggagg ctccaacgtg
     1681 gtggctgtca cagctgtgga tccagataca ggaccatggg gcaaagtcca ctattccatc
     1741 tatgggaccg ggtcagacct gttcttaatt cacccatcca ctgggcttat ctacactcag
     1801 ccctgggcca gcctggatgc tgagggtact tcgaggtaca acttttatgt gaaggcagaa
     1861 gacatggatg gaaggtacag cctggctgag gtgtttgtca ctctcttgga tgtcaatgac
     1921 cactaccccc agtttgtaca gagcgtccag gaaaagacaa tggtactggg gaccccactg
     1981 aaaattgagg caacagacca ggatgcagag gagcctaaca acttggtaga ctactccatt
     2041 acccgtgcag agccagtcaa cgtgtttgac attgatgcac acacagggga aattaggctc
     2101 aagaattcca tccgctcctt ggaggcccta cacaacatca cacccagtgg ggactactca
     2161 tggtccctac aggtgcaggc caaggaccga ggctccccat ctttcagtac aacagcctta
     2221 ctcaagatcg acatcacaga tacagagagg ctatccagag gttccatggc tgccttcctg
     2281 attcagacca aggacaatcc catgaaagcc gtaggtgtac tggctggtgt catggcaatt
     2341 gttgtggcca taactgtcct catctccacg gctaccttct ggcgtaacaa gaagtctaac
     2401 aaggtcctgc ctgtgcggcg tgtgctccgt agaaggccca gccctgctcc ccacacagtt
     2461 cgaatagagt ggctcaaatt caggagggcc aaggctgcta ccaagtttat actcaaagag
     2521 gattctccca atgagaactg caataacagc agagtgggag tcatggtgcc cccaagagct
     2581 ccagctctcc caccaccccc taaaatggca tccagtatgg tggcccaaca gacagtgcct
     2641 actgtctctg gatccctcac cccacagcca tccccacagt tacccacacc caagaccctg
     2701 ggaggccccg ttcagtcttc tttggtgtct gagctcaagc aaaagtttga gaagaagagt
     2761 ttagacaaca aggcctatat ctagagtgtg tcccatgatt tttctcttct cttcccccaa
     2821 ttctgaccct caaggtcacc cctattttgt ataatgttgt aacactatat gcaggactct
     2881 acaaagggct ttgggcaaga gatgcctcag actgtgagat gcagttggca aatacatacc
     2941 cactgcccaa atccttgaca catctataat gctctctatt cttcagagaa tagaagtcca
     3001 caaggagtca agtctgtgta tttctaccca ccaactctag accccacaat cactggagtc
     3061 ctcctggggc cttgtcatct ttagttgaga agtagggccc ctggccacaa gtaacaagag
     3121 tggcaagaat ctggatcccc aagcttcagc caaccaacag gttaatggag gtttgttctc
     3181 agctgaagtt gaaagtcagt gagctttgta ggatgtagcg atacaaacag gtaagaaaag
     3241 ggccaaaatg ctctgaaagc tcatgttgac tgtgcccaaa gccactgagc tatagaatta
     3301 gcatctagat aagactatgc tcctgatggt aggtgtaagg tgacctcttc ctagacagag
     3361 agcagaaatc tccagcctcc cttgaagaga caaggcgagg tggatatcaa gcttgagctt
     3421 agggaaggct cccattctga tccagctctt ctcatatcac gtgttcttgg agatactgtt
     3481 aacatcgtat tgtcttcttc cttgtctgta agatgaagaa agaaaacccc aggaaaatgg
     3541 tgagtctggg ggttttaagc aagtgcaaag cattaggatt acaaagtatt tgttggaagc
     3601 cagtaatctg gctccatctc attcagaaag tgttagcacc caggaaggac tatgatgagg
     3661 ttgggaacag ccagcctgat aatggctttc cctcaactca cataagtttt cttctgttcg
     3721 ccactctcca ccatgtatgt cattgtcaca aagaaccaga gtcaggcagt aagctccagt
     3781 ccaagtctgt ttggctgaga cagggaaatg actctctagg gttattgact ccatgcatgc
     3841 agtgaattgg tggcagggat ctggtctgag agccccccat tccacactgt tgactgtttt
     3901 tctcttcttg ggatttatct tgttcatatg taataatctt gaggagggat atcctgcaaa
     3961 gcagaggatt ttggtgttct tttgagaaaa cattaaggat atcatatgta tactctatga
     4021 agccctctag aattccagag ttactgatgt ggtcagattg tatgaacatg tggttttctt
     4081 gctcaccccc cttaccgccc ccagtctgtg tttggaggcg ttacatagac atacgagcat
     4141 tcagagtcct catctggagg tctgtagtct ctggcccacg tagtattgag ggacaggacc
     4201 taacctgcta aagtccagcc tggaaagtgc tgagctggat catgtttgcc accacaggga
     4261 gttcagcatc ctataatatg catgctgtta acctcttctg taaatggtaa ataaaatcta
     4321 ttattcaaag gataaactga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4381 aaaaaaaaaa aaaaaaaaaa
//
