LOCUS       NM_007667               4786 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cadherin 8 (Cdh8), transcript variant 2, mRNA.
ACCESSION   NM_007667
VERSION     NM_007667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4786)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4786)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   3  (bases 1 to 4786)
  AUTHORS   Mesias,R.E., Zaki,Y., Guevara,C.A., Friedman,L.G., Hussein,A.,
            Therrien,K., Magee,A.R., Tzavaras,N., Del Valle,P., Baxter,M.G.,
            Huntley,G.W. and Benson,D.L.
  TITLE     Development and cadherin-mediated control of prefrontal
            corticostriatal projections in mice
  JOURNAL   iScience 26 (10), 108002 (2023)
   PUBMED   37854688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4786)
  AUTHORS   Sinclair-Wilson,A., Lawrence,A., Ferezou,I., Cartonnet,H.,
            Mailhes,C., Garel,S. and Lokmane,L.
  TITLE     Plasticity of thalamocortical axons is regulated by serotonin
            levels modulated by preterm birth
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2301644120 (2023)
   PUBMED   37549297
REFERENCE   5  (bases 1 to 4786)
  AUTHORS   Wu,S.R., Butts,J.C., Caudill,M.S., Revelli,J.P., Dhindsa,R.S.,
            Durham,M.A. and Zoghbi,H.Y.
  TITLE     Atoh1 drives the heterogeneity of the pontine nuclei neurons and
            promotes their differentiation
  JOURNAL   Sci Adv 9 (26), eadg1671 (2023)
   PUBMED   37390208
REFERENCE   6  (bases 1 to 4786)
  AUTHORS   Garel,S., Marin,F., Grosschedl,R. and Charnay,P.
  TITLE     Ebf1 controls early cell differentiation in the embryonic striatum
  JOURNAL   Development 126 (23), 5285-5294 (1999)
   PUBMED   10556054
REFERENCE   7  (bases 1 to 4786)
  AUTHORS   Kido,M., Obata,S., Tanihara,H., Rochelle,J.M., Seldin,M.F.,
            Taketani,S. and Suzuki,S.T.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
REFERENCE   8  (bases 1 to 4786)
  AUTHORS   Korematsu,K. and Redies,C.
  TITLE     Expression of cadherin-8 mRNA in the developing mouse central
            nervous system
  JOURNAL   J Comp Neurol 387 (2), 291-306 (1997)
   PUBMED   9336230
REFERENCE   9  (bases 1 to 4786)
  AUTHORS   Korematsu,K. and Redies,C.
  TITLE     Restricted expression of cadherin-8 in segmental and functional
            subdivisions of the embryonic mouse brain
  JOURNAL   Dev Dyn 208 (2), 178-189 (1997)
   PUBMED   9022055
REFERENCE   10 (bases 1 to 4786)
  AUTHORS   Munro,S.B., Duclos,A.J., Jackson,A.R., Baines,M.G. and
            Blaschuk,O.W.
  TITLE     Characterization of cadherins expressed by murine thymocytes
  JOURNAL   Cell Immunol 169 (2), 309-312 (1996)
   PUBMED   8620560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU058167.1, BC057581.1 and
            AC103397.7.
            
            On Oct 25, 2013 this sequence version replaced NM_007667.2.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            Mice lacking the encoded protein exhibit reduced behavioral
            responses to cold, but not thermal stimuli. Alternative splicing
            results in multiple transcript variants encoding different isoforms
            that may undergo similar proteolytic processing. Multiple distinct
            genes of the cadherin family, including this gene, are found on
            chromosome 8. [provided by RefSeq, Oct 2015].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest protein (isoform 2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95600.1, SRR1660819.150854.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               BU058167.1         1-257
            258-2496            BC057581.1         163-2401
            2497-4786           AC103397.7         25291-27580
FEATURES             Location/Qualifiers
     source          1..4786
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 49.4 cM"
     gene            1..4786
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="cadherin 8"
                     /db_xref="GeneID:12564"
                     /db_xref="MGI:MGI:107434"
     exon            1..390
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            391..842
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..2990
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="cadherin-8 isoform 2 preproprotein"
                     /protein_id="NP_031693.2"
                     /db_xref="CCDS:CCDS40448.1"
                     /db_xref="GeneID:12564"
                     /db_xref="MGI:MGI:107434"
                     /translation="MPERLAETLMDLWTPLIILWITLPSCVYTAPMNQAHVLTTGSPL
                     ELSRQSEDMRILSRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSG
                     DGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDI
                     NDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSI
                     EPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKF
                     AQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQD
                     GVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSSRGPFKDTATVKIVVEDADEPPVFS
                     SPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITL
                     ATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENG
                     KPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNR
                     QKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGAL
                     IAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDI
                     ATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPP
                     YDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKE
                     T"
     exon            843..1137
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1257
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1425
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1613
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1867
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2004
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2126
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2244
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2496
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..4786
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="hexamer: AATATA"
     polyA_site      4594
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="major polyA site"
     regulatory      4726..4731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="hexamer: AATAAA"
     polyA_site      4748
                     /gene="Cdh8"
                     /gene_synonym="cad8"
                     /note="major polyA site"
ORIGIN      
        1 gaggcacccg gctcactttt ccacatcact tcacagttac atttggcagg caggcgggct
       61 cgcaagccgg agcgctcggc ccagaattag tggatggatt tggaatctcc ctacctcctc
      121 caagctccgc cactgtcact ttgggcatag acctgagcgt caacaccgga gctgtacttt
      181 taggctgtgg acgcagagcc cagcgcgccg gcttcgcatc cccgcaccag gctccacagc
      241 tctgagaggc atgaacgcga cccggaggag attaccctgc gcgcggggat tcgtggacat
      301 tagctgttct cgggaactga ccctcagctc ctccagccat ttatgaaccc agagtcttga
      361 ggcttttccg catcccggag cccgacctga aaaacttcaa tgaaaaggaa ggtcaatgga
      421 tcgtggtctt tgaaaagctg cttagacatg tctgtttccc ggttctctga acacgtggca
      481 gagctgtaag taacccgctt cgcagtgcgt gatgaattgg atggcttcag acccgaggca
      541 aaaaaaataa ttgtctcatt ttcgcgctga tttgcttaac tggtgggacc atgccagaaa
      601 ggctagctga gacgctcatg gacctctgga ctccattaat aatattatgg attaccctcc
      661 cttcttgtgt atacacggct ccgatgaatc aggctcacgt tttaactact ggatcccctt
      721 tggaactaag caggcagagt gaagacatgc ggattttgag ccgctccaaa agaggctggg
      781 tttggaatca aatgtttgtc ctggaagaat tttctggacc tgaaccgatt ctcgttggcc
      841 ggttacacac agatctggat cctggaagca aaaaaatcaa gtatatccta tcgggtgatg
      901 gagctggcac aatctttcaa ataaatgata taactggaga tatccatgct atcaaaagac
      961 ttgaccgaga ggaaaaggct gaatatacgt taacggctca ggcagtggac tttgagacaa
     1021 acaagcccct tgagcctcct tctgaattta ttattaaggt tcaagatatc aacgacaatg
     1081 cacctgagtt cctcaatgga ccttatcatg ctactgttcc agagatgtcc attttgggta
     1141 catctgtcac taatgtaact gccactgatg ctgacgaccc agtttatgga aacagtgcaa
     1201 agttggttta cagtatcttg gagggacagc cgtatttttc cattgagcct gaaacagcca
     1261 ttataaaaac tgcccttcct aacatggaca gagaagccaa ggaggaatac ctggtcgtaa
     1321 tacaagccaa agatatgggt ggacactctg gtggtctgtc tggaaccaca acactcacag
     1381 tgaccctgac tgatgttaat gacaatcctc caaaatttgc tcagagtttg tatcacttct
     1441 cagtaccaga agatgtggtc cttggcactg cgataggaag ggttaaggct aatgatcagg
     1501 atattggtga aaatgcacaa tcatcctatg acatcattga tggagatggg acagcactat
     1561 tcgaaatcac ttctgatgcc caggcccagg atggtgttat aagactgaga aagcctctgg
     1621 actttgagac caaaaaatcc tatactctga aggtggaagc agccaatatc cacatcgacc
     1681 cacgtttcag tagcagggga ccctttaagg atacagcaac agtcaaaatt gtcgtagagg
     1741 atgctgatga gcctccggtc ttctcttcac caacttacct ccttgaagtt catgaaaatg
     1801 ctgctttgaa ctctgtgatt ggccaagtga cagctcgtga ccctgatatc acttccagtc
     1861 caataaggtt ttccattgac cgccacactg acctggaaag acagttcaac atcaatgcag
     1921 atgatgggaa gataacactg gcaactccac tggacagaga actaagtgtt tggcacaaca
     1981 tcaccatcat tgctactgag atcaggaacc acagtcagat atctcgagtg cctgttgcta
     2041 ttaaagtgct ggatgtcaat gacaacgccc ctgaattcgc atccgaatat gaggcatttt
     2101 tatgtgaaaa tggaaaaccc ggccaagtca ttcaaacagt aagtgccatg gacaaagacg
     2161 atcccaaaaa cggacatttt ttcttgtaca gtcttcttcc agaaatggtc aacaacccaa
     2221 atttcaccat caagaaaaat gaagataatt ccctgagcat tctggcaaaa cataatggat
     2281 tcaaccgcca gaagcaagaa gtctaccttc tgcctatagt gatcagtgac agtggaaacc
     2341 cccctctgag tagcaccagt acgttgacca tccgagtctg tggctgtagc aatgatggcg
     2401 tggtccagtc gtgcaatgtt gaagcttatg tccttcctat tggactcagt atgggcgcct
     2461 taattgctat attagcatgc atcattttgc tgctcgtcat tgtggttctg tttgttaccc
     2521 tgaggaggca caaaaatgaa ccacttatta tcaaagatga cgaagacgtt cgagaaaaca
     2581 tcattcgcta cgacgacgaa ggaggagggg aggaggacac agaggctttt gacattgcaa
     2641 ctttgcaaaa cccagatgga attaatggat ttttaccccg taaggatatt aaaccagatt
     2701 tgcagtttat gccaaggcaa gggcttgctc cagttccaaa tggtgttgat gtcgatgaat
     2761 ttataaatgt aaggctgcat gaggcagata atgaccccac ggccccacca tatgactcca
     2821 tacagattta tggctatgaa ggccgagggt ctgtggctgg ctccctcagc tccttggagt
     2881 ccaccacatc agactcagac cagaattttg actacctcag tgactggggt ccccgcttta
     2941 agagactggg cgaactctac tctgttggtg aaagtgacaa agaaacttga cagtggatta
     3001 tataaataat caatggcact gagcattctg taatattcta gggtcactcc ccttagatgc
     3061 aacaaatgtg gctatttgtt ttagaggcaa gtttagcacc aatcatctat aaactcaacc
     3121 acattttaat gttgaaccaa aaaaaataat aaaaataaaa agtatatgtt aggaggtgat
     3181 aaattttgtg gagtgtgaat taagtatgtg gagtgtctag aagtctttgg atatttgata
     3241 ttatcctgac ggccacagtc agagattggg atcctagcta atccttagag agttgtttaa
     3301 gaggagaaaa atcaaaaaca aaatcaaaat taaaaggtgc tttattagaa aaaaatggac
     3361 ttgcaaggac tctgctgctg atatgtgtct tctgtaagga ttcttatgag tgcaaatggt
     3421 ttttatttcc cttcaccaat aaggatcccg tcacaaatga taaagcaata ctttggtctg
     3481 ctgtacgtta tgactttatg gagattgggg aggcctccta gattacatgg tacggtgacc
     3541 atacgttgta tataattgtt ggccccactc aacagagact gaatagcatc tttaaatatt
     3601 gtgtcgagcc ttaaaatatt cacatgttcg taatccattc cagggtgggg attgccaact
     3661 caaaggtggg aggagagaaa tgccattcaa acaggctgtg tctagaagca ggattcttcg
     3721 ttccctccac ttcatcttct tccacaagga cacagagata aacagtattc cacagtggac
     3781 cacatcagag acagatggtt ttattgctag cgtgtgaatt tatttgtcta attctcaaaa
     3841 taaatatttt attgatgtcc aataatgctt ttatttatta aggttggtaa tctatagatt
     3901 aagggattat atggggaaaa ctaaattata tccattaata atcctttaga ttgttttata
     3961 ttaatatcta tacaatgaat gtttaataca tgtacatttt gatgagataa gtatggcagg
     4021 caatattatc aaggggagag gtaatagtct ctttagagta gaaagtgtaa ttgtgactgg
     4081 tgattacagg aacagcattt cccagagaaa cttttggact attttctatt ttcttcataa
     4141 tcctagtatt tggtgttttt actacaagca caaacatctg gaagtatatt gattcctgtg
     4201 aatatttaaa ctctagactt ttagatactt acataatgcc ccacccaata aacatgcttc
     4261 aaattttcct ctcccaaata atttagagca aaaactgatt tgtacataat tttactgctt
     4321 ctgttttttt acacttctgt ccctgtttat ggtgatgcgc agaacgtctt agactacaaa
     4381 agcagatcag cactagaaga tgtgagcata tttaatttgt aatgcaaacc tgccatgtag
     4441 gagtagaaaa tgtatgataa aactcaagta ttacatgcag atcattttac ttttctactt
     4501 tgctttaatg caatattgtt tatttactcc atgtgttgta ttcagagaaa ctcctgtatt
     4561 gtttcctact ttgtgaaata tatttttata aatacctttg ttgtcatcat tttttttcca
     4621 gctacatgaa gatttctgag cagaactatt gactctaact aaaattctaa actgtgcaat
     4681 gaaatctcac tgtgggtcac ttttagcttt aatcatcttt attataataa agagccagag
     4741 aacagaaatg gtttgctatt gatcccatac caagaaaaca tcagac
//
