LOCUS       NM_172853               4269 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cadherin 7, type 2 (Cdh7), transcript variant 1, mRNA.
ACCESSION   NM_172853
VERSION     NM_172853.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4269)
  AUTHORS   Choi,J.S., Ayupe,A.C., Beckedorff,F., Catanuto,P., McCartan,R.,
            Levay,K. and Park,K.K.
  TITLE     Single-nucleus RNA sequencing of developing superior colliculus
            identifies neuronal diversity and candidate mediators of circuit
            assembly
  JOURNAL   Cell Rep 42 (9), 113037 (2023)
   PUBMED   37624694
REFERENCE   3  (bases 1 to 4269)
  AUTHORS   Filova,I., Pysanenko,K., Tavakoli,M., Vochyanova,S., Dvorakova,M.,
            Bohuslavova,R., Smolik,O., Fabriciova,V., Hrabalova,P.,
            Benesova,S., Valihrach,L., Cerny,J., Yamoah,E.N., Syka,J.,
            Fritzsch,B. and Pavlinkova,G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   4  (bases 1 to 4269)
  AUTHORS   Balendran,V., Skidmore,J.M., Ritter,K.E., Gao,J., Cimerman,J.,
            Beyer,L.A., Hurd,E.A., Raphael,Y. and Martin,D.M.
  TITLE     Chromatin remodeler CHD7 is critical for cochlear morphogenesis and
            neurosensory patterning
  JOURNAL   Dev Biol 477, 11-21 (2021)
   PUBMED   34004180
  REMARK    GeneRIF: Chromatin remodeler CHD7 is critical for cochlear
            morphogenesis and neurosensory patterning.
REFERENCE   5  (bases 1 to 4269)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4269)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   7  (bases 1 to 4269)
  AUTHORS   Palmesino,E., Rousso,D.L., Kao,T.J., Klar,A., Laufer,E., Uemura,O.,
            Okamoto,H., Novitch,B.G. and Kania,A.
  TITLE     Foxp1 and lhx1 coordinate motor neuron migration with axon
            trajectory choice by gating Reelin signalling
  JOURNAL   PLoS Biol 8 (8), e1000446 (2010)
   PUBMED   20711475
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4269)
  AUTHORS   Bergman,J.E., Bosman,E.A., van Ravenswaaij-Arts,C.M. and Steel,K.P.
  TITLE     Study of smell and reproductive organs in a mouse model for CHARGE
            syndrome
  JOURNAL   Eur J Hum Genet 18 (2), 171-177 (2010)
   PUBMED   19809474
REFERENCE   9  (bases 1 to 4269)
  AUTHORS   Moore,R., Champeval,D., Denat,L., Tan,S.S., Faure,F.,
            Julien-Grille,S. and Larue,L.
  TITLE     Involvement of cadherins 7 and 20 in mouse embryogenesis and
            melanocyte transformation
  JOURNAL   Oncogene 23 (40), 6726-6735 (2004)
   PUBMED   15273735
REFERENCE   10 (bases 1 to 4269)
  AUTHORS   Helmbacher,F., Dessaud,E., Arber,S., deLapeyriere,O.,
            Henderson,C.E., Klein,R. and Maina,F.
  TITLE     Met signaling is required for recruitment of motor neurons to
            PEA3-positive motor pools
  JOURNAL   Neuron 39 (5), 767-777 (2003)
   PUBMED   12948444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC083189.1, AC101794.5 and
            AK046426.1.
            
            On Oct 24, 2015 this sequence version replaced NM_172853.2.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. This gene is located adjacent to a
            related cadherin gene on chromosome 1. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137369.1, AK034096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               BC083189.1         422-994
            574-3080            BC083189.1         1150-3656
            3081-3081           AC101794.5         34551-34551         c
            3082-3561           BC083189.1         3658-4137
            3562-4236           AK046426.1         1817-2491
            4237-4237           AC101794.5         33395-33395         c
            4238-4269           AK046426.1         2493-2524
FEATURES             Location/Qualifiers
     source          1..4269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.73 cM"
     gene            1..4269
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /note="cadherin 7, type 2"
                     /db_xref="GeneID:241201"
                     /db_xref="MGI:MGI:2442792"
     exon            1..169
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..573
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2721
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; cadherin-7"
                     /codon_start=1
                     /product="cadherin-7 isoform 1 preproprotein"
                     /protein_id="NP_766441.1"
                     /db_xref="CCDS:CCDS15221.1"
                     /db_xref="GeneID:241201"
                     /db_xref="MGI:MGI:2442792"
                     /translation="MKLGKVELCHFLQLIALFLCFSGMSQAELPRSRSKPYFQSGRSR
                     TKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG
                     DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTA
                     GVPEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNM
                     DREAKDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLP
                     VASVVARIKAADADIGVNAEMEYKIVDGDGLGIFKISADKDTQEGIITIQKELDFEAK
                     TSYTLRIEAANRDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQV
                     GHIIGTVAAHDPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAVHNI
                     TVLAMESQNPSQVGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDK
                     DEPSNGHQFYFSLTTDMTNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVD
                     SGSPSLSSTNTLTIRVCDCDADGIAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLI
                     LLIVTMRRRKKEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNAIRDSKT
                     RRDVTPEIQFLSRPTFKNIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGS
                     VAESLSSLDSISSNSDQNYDYLSDWGPRFKRLAEMYGNGQESLYS"
     exon            574..868
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..988
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1156
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1344
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1598
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1735
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1857
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1975
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2227
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..4269
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattcattct ggacttggac atcttcgtgg gttcacttgg cacaaggcta gttgctggta
       61 ttcagccttc cagcctccca gcgtggattg atacaaaagg accttagctt tgaatggctt
      121 cacggtttag atcattaacc cttcggattt cttagatgtc atagttcagg aacctattag
      181 gccattcctt ggcaacggct actcagcact ggtgacctct tccagtccaa cactctacaa
      241 attattatct ctggactccc atctgacaca ctgccggagg caagagctac gaagccaact
      301 agaactgtgc cttttctctt gtcaaggttt ttttcttaca caggaaaaag gaagaaaaaa
      361 aagatgaagc tgggcaaagt ggagttgtgc cattttctac agcttatagc tctcttcctt
      421 tgcttctctg gaatgagtca agctgagctg ccacggtcca gatccaagcc atacttccag
      481 tcaggaaggt cccggaccaa gcgcagctgg gtttggaatc agttcttcgt gctggaagaa
      541 tacatgggtt cagatcccct ctatgtaggg aagctccact ctgatgttga taaaggagac
      601 ggttccatca agtacatctt gtcaggcgaa ggggcaagtt caattttcat tattgatgag
      661 aacactggtg atatccatgc taccaagaga ctggatcggg aggagcaggc ctattataca
      721 ctgagagccc aagctctgga cagactcacc aacaagcctg tggagcctga atcagagttt
      781 gttatcaaga ttcaggatat caatgacaat gaacccaaat ttctagatgg tccatacaca
      841 gcaggagttc ctgagatgtc tcctgtaggg acttcagtgg tacaagtgac agcaacagat
      901 gccgatgatc ctacatatgg caacagtgct cgagtggtgt atagtattct tcaaggacag
      961 ccatatttct cagtggaacc caaaacagga gtcatcaaga ctgcccttcc aaacatggat
     1021 agagaggcta aagaccagta tttgcttgtc attcaggcaa aggatatggt tggtcaaaat
     1081 ggcggactgt ctggaaccac ctcagttact gtgaccctaa ctgatgtcaa tgataaccca
     1141 cctcgatttc cacgaagatc ttatcagtat aatgttccag aatctttgcc tgtggcatca
     1201 gttgtggcca gaattaaagc tgcagatgca gatataggag tcaatgcaga aatggaatac
     1261 aaaatagtgg atggtgatgg actgggcatt ttcaagatat ctgctgacaa agacacacaa
     1321 gaaggaatca ttacaataca aaaggaactc gattttgaag ccaaaacgag ttatacactg
     1381 cgcatagaag ctgcaaatcg agatgctgat ccccggtttc tgagcttggg tccattcagt
     1441 gacacaacaa cggttaagat aattgtggaa gatgtggatg agccccctgt tttttcttca
     1501 cccttgtatc ccatggaggt gtcagaagcg acacaggtgg ggcatatcat tggcactgta
     1561 gcagctcatg acccagattc ttccaacagc cctgtgagat attcaattga cagaaacaca
     1621 gacttggaga gatatttcaa tattgatgcc aacagtggag ttattactac tgccaaatca
     1681 ttggatcgag agacaaatgc ggttcataac attacagtcc ttgcaatgga gagccagaat
     1741 ccatcccagg tggggagagg ctacgtggcc attactatac tggatattaa cgacaacgca
     1801 cctgagttcg ccatggacta tgaaaccact gtctgtgaaa acgctcagcc agggcaggtt
     1861 atccagaaaa tcagtgcagt agataaagat gagccatcca atggacacca gttttacttc
     1921 agcttaacaa cagacatgac aaataaccac aacttttcat tgaaagataa caaagacaat
     1981 acagcctcaa tactcacgag aagaaatggc ttccgaagac aggaacaatc agtttattat
     2041 ctgcccattt tcattgtgga cagtggatct ccttcactaa gcagtaccaa cacacttacc
     2101 atccgtgtat gtgactgtga tgctgatggc atagcccaga cctgcaatgc agaggcctat
     2161 gttctacctg ctggcctcag cactggggcc ttgatagcaa tactggcctg tgtcctgaca
     2221 ctattggtgc tgatcctcct cattgtcact atgagaagac gaaaaaaaga gcctctcatt
     2281 tttgatgagg agagggatat cagagaaaac atagtcagat atgatgatga aggcggggga
     2341 gaagaagaca cagaagcctt tgacatggct gcgctgagaa acctcaatgc cataagagac
     2401 agcaaaactc ggagagatgt gactcctgaa attcagttct tgagtcgacc gacttttaaa
     2461 aacatcccag ataatgtcat ttttagggaa tttatttggg aaagactgaa agaagctgat
     2521 gtggatccag gggctccacc atatgactct cttcagactt atgcatttga aggaaatggc
     2581 tcagtagctg aatctctcag ttctttagat tccatcagct caaactctga tcagaattat
     2641 gactacctta gtgactgggg tccccgtttt aaacgactag ctgaaatgta tggaaatggc
     2701 caagagagtt tgtactcata gccttggacc cttactttgg aatgcactgc atagaaagtc
     2761 agcaggaaaa aattcaaaag gaaagaaaag tggaaaatac tacatatagt aaacagaaat
     2821 tccacttctg ggacaaaagg aggttgtaaa tatgtctcca tttttaattg ttaaggcttc
     2881 tgcccttgtg aaacattcat taggttatcc aagggatttc tctgaccaca gactaaacat
     2941 ttgtagttgt gttttttgtt tgtttgcttg ttttgttttt tctgtttgtg gtttcatata
     3001 aaagaaatgc ttagtggttt gtgaatagat agcaactttc atatacctgc aaaggcacct
     3061 aacctgcctg ataaagtaat gtcctgtgtt gtcagggagc caaaggcacc tggatctaac
     3121 tttcatggta ccctctgtaa gaataatagt gcctggtaca ccattcgaaa aatctgagac
     3181 cttcttgcct atcaaaactt ggaagaattt tatctctact gaagctttta agattgctat
     3241 aaaaggtaga gttcaacaga attttatcac tgttggtgca cataaatatt ttattttatt
     3301 tatcaatata tacattcttg taataacttc cctaagtgaa aaatggaata aaaaccaata
     3361 atttaacaaa acataagtca ctgttttgcc aataaattat atgcagtgtt ccaagtaaga
     3421 aaaatggtaa ataattctcc aagtttgaag tagttttgaa actctcatgt atgtaagatt
     3481 taaaccagta gttgctgtct atttgttaat ttttattatc tcttctgatt tgtacaggag
     3541 aatatatttt tatttaaaac atagtgttgt gtttattttg gagctcaagt ctccactcag
     3601 ttcaggttgt tcttactgcc tcatggtatt aagctcatac gcaggtgctg gcttttctca
     3661 tcatgaacta caggaaggac atgaagcatt gaaaatggag tgacagagca cagcagtaga
     3721 gcatcattgc tacacacatc tcaaagaaaa gcatggctct aaggacacac acacacacac
     3781 acacacacac acacacacac acacacacat tgtccttctg agccacagag tgtacaaaac
     3841 tgtgggaaca aagtatttga atttcagtaa gacttgggga gtattgaggt ttttctttga
     3901 cttagaaata aatttccaaa atgaagtgtt ctatatgctc caaagacttt caaggacctg
     3961 ttgctcagcc ttctttgctc taaacacatt gagtgaaaga ctgaaattta agtatatttt
     4021 acaaagtatg gtgtcataca tttcaatcca ttgtgccgtg ccagcattga atgatgtgta
     4081 agttctctag ctgttaagat gtgccaaagt gaagagagca atttcaagta atcatatttg
     4141 ttcaatgttg agatgaatgt ctcagaatcc gatgactttt taaaacaaaa tgatatttct
     4201 acttattttt cctagattaa tactagttga ttgtgcacat aatcaaataa gaatgaattt
     4261 atttgcctt
//
