LOCUS       NP_766441                785 aa            linear   ROD 30-APR-2024
DEFINITION  cadherin-7 isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_766441
VERSION     NP_766441.1
DBSOURCE    REFSEQ: accession NM_172853.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 785)
  AUTHORS   Choi,J.S., Ayupe,A.C., Beckedorff,F., Catanuto,P., McCartan,R.,
            Levay,K. and Park,K.K.
  TITLE     Single-nucleus RNA sequencing of developing superior colliculus
            identifies neuronal diversity and candidate mediators of circuit
            assembly
  JOURNAL   Cell Rep 42 (9), 113037 (2023)
   PUBMED   37624694
REFERENCE   3  (residues 1 to 785)
  AUTHORS   Filova,I., Pysanenko,K., Tavakoli,M., Vochyanova,S., Dvorakova,M.,
            Bohuslavova,R., Smolik,O., Fabriciova,V., Hrabalova,P.,
            Benesova,S., Valihrach,L., Cerny,J., Yamoah,E.N., Syka,J.,
            Fritzsch,B. and Pavlinkova,G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   4  (residues 1 to 785)
  AUTHORS   Balendran,V., Skidmore,J.M., Ritter,K.E., Gao,J., Cimerman,J.,
            Beyer,L.A., Hurd,E.A., Raphael,Y. and Martin,D.M.
  TITLE     Chromatin remodeler CHD7 is critical for cochlear morphogenesis and
            neurosensory patterning
  JOURNAL   Dev Biol 477, 11-21 (2021)
   PUBMED   34004180
  REMARK    GeneRIF: Chromatin remodeler CHD7 is critical for cochlear
            morphogenesis and neurosensory patterning.
REFERENCE   5  (residues 1 to 785)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 785)
  AUTHORS   Hertel,N. and Redies,C.
  TITLE     Absence of layer-specific cadherin expression profiles in the
            neocortex of the reeler mutant mouse
  JOURNAL   Cereb Cortex 21 (5), 1105-1117 (2011)
   PUBMED   20847152
REFERENCE   7  (residues 1 to 785)
  AUTHORS   Palmesino,E., Rousso,D.L., Kao,T.J., Klar,A., Laufer,E., Uemura,O.,
            Okamoto,H., Novitch,B.G. and Kania,A.
  TITLE     Foxp1 and lhx1 coordinate motor neuron migration with axon
            trajectory choice by gating Reelin signalling
  JOURNAL   PLoS Biol 8 (8), e1000446 (2010)
   PUBMED   20711475
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 785)
  AUTHORS   Bergman,J.E., Bosman,E.A., van Ravenswaaij-Arts,C.M. and Steel,K.P.
  TITLE     Study of smell and reproductive organs in a mouse model for CHARGE
            syndrome
  JOURNAL   Eur J Hum Genet 18 (2), 171-177 (2010)
   PUBMED   19809474
REFERENCE   9  (residues 1 to 785)
  AUTHORS   Moore,R., Champeval,D., Denat,L., Tan,S.S., Faure,F.,
            Julien-Grille,S. and Larue,L.
  TITLE     Involvement of cadherins 7 and 20 in mouse embryogenesis and
            melanocyte transformation
  JOURNAL   Oncogene 23 (40), 6726-6735 (2004)
   PUBMED   15273735
REFERENCE   10 (residues 1 to 785)
  AUTHORS   Helmbacher,F., Dessaud,E., Arber,S., deLapeyriere,O.,
            Henderson,C.E., Klein,R. and Maina,F.
  TITLE     Met signaling is required for recruitment of motor neurons to
            PEA3-positive motor pools
  JOURNAL   Neuron 39 (5), 767-777 (2003)
   PUBMED   12948444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC083189.1, AC101794.5 and
            AK046426.1.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. This gene is located adjacent to a
            related cadherin gene on chromosome 1. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137369.1, AK034096.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.73 cM"
     Protein         1..785
                     /product="cadherin-7 isoform 1 preproprotein"
                     /note="cadherin-7"
                     /calculated_mol_wt=84191
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3029
     mat_peptide     48..785
                     /product="Cadherin-7. /id=PRO_0000320091"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BM92.1)"
                     /calculated_mol_wt=81772
     Region          73..151
                     /region_name="CA"
                     /note="Cadherin repeats; smart00112"
                     /db_xref="CDD:214520"
     Region          157..258
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(164..165,219,221,254,256..257)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          266..373
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(273..274,330,332,370,372..373)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          382..478
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(388..389,441,443,474,476..477)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            449
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BM92.1)"
     Region          486..584
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            530
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BM92.1)"
     Site            608..628
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BM92.1)"
     Region          718..777
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..785
                     /gene="Cdh7"
                     /gene_synonym="9330156F07Rik; CDH7L1"
                     /coded_by="NM_172853.3:364..2721"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15221.1"
                     /db_xref="GeneID:241201"
                     /db_xref="MGI:MGI:2442792"
ORIGIN      
        1 mklgkvelch flqlialflc fsgmsqaelp rsrskpyfqs grsrtkrswv wnqffvleey
       61 mgsdplyvgk lhsdvdkgdg sikyilsgeg assifiiden tgdihatkrl dreeqayytl
      121 raqaldrltn kpvepesefv ikiqdindne pkfldgpyta gvpemspvgt svvqvtatda
      181 ddptygnsar vvysilqgqp yfsvepktgv iktalpnmdr eakdqyllvi qakdmvgqng
      241 glsgttsvtv tltdvndnpp rfprrsyqyn vpeslpvasv varikaadad igvnaemeyk
      301 ivdgdglgif kisadkdtqe giitiqkeld feaktsytlr ieaanrdadp rflslgpfsd
      361 tttvkiived vdeppvfssp lypmevseat qvghiigtva ahdpdssnsp vrysidrntd
      421 leryfnidan sgvittaksl dretnavhni tvlamesqnp sqvgrgyvai tildindnap
      481 efamdyettv cenaqpgqvi qkisavdkde psnghqfyfs lttdmtnnhn fslkdnkdnt
      541 asiltrrngf rrqeqsvyyl pifivdsgsp slsstntlti rvcdcdadgi aqtcnaeayv
      601 lpaglstgal iailacvltl lvlillivtm rrrkkeplif deerdireni vryddeggge
      661 edteafdmaa lrnlnairds ktrrdvtpei qflsrptfkn ipdnvifref iwerlkeadv
      721 dpgappydsl qtyafegngs vaeslsslds issnsdqnyd ylsdwgprfk rlaemygngq
      781 eslys
//
