LOCUS       NM_009868               4004 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cadherin 5 (Cdh5), mRNA.
ACCESSION   NM_009868
VERSION     NM_009868.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4004)
  AUTHORS   Vitali,H.E., Kuschel,B., Sherpa,C., Jones,B.W., Jacob,N.,
            Madiha,S.A., Elliott,S., Dziennik,E., Kreun,L., Conatser,C.,
            Bhetwal,B.P. and Sharma,B.
  TITLE     Hypoxia regulate developmental coronary angiogenesis potentially
            through VEGF-R2- and SOX17-mediated signaling
  JOURNAL   Dev Dyn 254 (2), 174-188 (2025)
   PUBMED   39360476
REFERENCE   2  (bases 1 to 4004)
  AUTHORS   Nasim,S., Abujamra,B.A., Chaparro,D., Nogueira,P.D.S., Riva,A.,
            Hutcheson,J.D. and Kos,L.
  TITLE     Multiple cell types including melanocytes contribute to
            elastogenesis in the developing murine aortic valve
  JOURNAL   Sci Rep 14 (1), 25481 (2024)
   PUBMED   39461968
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4004)
  AUTHORS   Cai,S. and Yin,N.
  TITLE     Single-cell transcriptome and chromatin accessibility mapping of
            upper lip and primary palate fusion
  JOURNAL   J Cell Mol Med 28 (19), e70128 (2024)
   PUBMED   39392189
REFERENCE   4  (bases 1 to 4004)
  AUTHORS   Lin,M., Xian,H., Chen,Z., Wang,S., Liu,M., Liang,W., Tang,Q.,
            Liu,Y., Huang,W., Che,D., Guo,C., Idiiatullina,E., Fang,R.,
            Al-Azab,M., Chang,J., Wang,R., Li,X., Zuo,X., Zhang,Y., Zhao,J.,
            Tang,Y., Jin,S., He,Z., Feng,D., Lu,L., Zhang,K., Wu,Y., Bai,F.,
            Lew,A.M., Cui,J., Wu,Y., Gu,X. and Zhang,Y.
  TITLE     MCM8-mediated mitophagy protects vascular health in response to
            nitric oxide signaling in a mouse model of Kawasaki disease
  JOURNAL   Nat Cardiovasc Res 2 (8), 778-792 (2023)
   PUBMED   39195969
REFERENCE   5  (bases 1 to 4004)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   6  (bases 1 to 4004)
  AUTHORS   Nishikawa,S.I., Nishikawa,S., Kawamoto,H., Yoshida,H., Kizumoto,M.,
            Kataoka,H. and Katsura,Y.
  TITLE     In vitro generation of lymphohematopoietic cells from endothelial
            cells purified from murine embryos
  JOURNAL   Immunity 8 (6), 761-769 (1998)
   PUBMED   9655490
REFERENCE   7  (bases 1 to 4004)
  AUTHORS   Matsuyoshi,N., Toda,K., Horiguchi,Y., Tanaka,T., Nakagawa,S.,
            Takeichi,M. and Imamura,S.
  TITLE     In vivo evidence of the critical role of cadherin-5 in murine
            vascular integrity
  JOURNAL   Proc Assoc Am Physicians 109 (4), 362-371 (1997)
   PUBMED   9220534
REFERENCE   8  (bases 1 to 4004)
  AUTHORS   Vittet,D., Buchou,T., Schweitzer,A., Dejana,E. and Huber,P.
  TITLE     Targeted null-mutation in the vascular endothelial-cadherin gene
            impairs the organization of vascular-like structures in embryoid
            bodies
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6273-6278 (1997)
   PUBMED   9177207
REFERENCE   9  (bases 1 to 4004)
  AUTHORS   Huber,P., Dalmon,J., Engiles,J., Breviario,F., Gory,S.,
            Siracusa,L.D., Buchberg,A.M. and Dejana,E.
  TITLE     Genomic structure and chromosomal mapping of the mouse VE-cadherin
            gene (Cdh5)
  JOURNAL   Genomics 32 (1), 21-28 (1996)
   PUBMED   8786117
REFERENCE   10 (bases 1 to 4004)
  AUTHORS   Breier,G., Breviario,F., Caveda,L., Berthier,R., Schnurch,H.,
            Gotsch,U., Vestweber,D., Risau,W. and Dejana,E.
  TITLE     Molecular cloning and expression of murine vascular
            endothelial-cadherin in early stage development of cardiovascular
            system
  JOURNAL   Blood 87 (2), 630-641 (1996)
   PUBMED   8555485
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY078746.1, BC054790.1 and
            BP768525.1.
            
            On Nov 15, 2007 this sequence version replaced NM_009868.3.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            Mice lacking the encoded protein die in utero due to vascular
            insufficiency, caused by increased endothelial apoptosis. Multiple
            distinct genes of the cadherin family, including this gene, are
            found on chromosome 8. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164474.1, BC054790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY078746.1         2-75
            75-3662             BC054790.1         1-3588
            3663-4004           BP768525.1         28-369              c
FEATURES             Location/Qualifiers
     source          1..4004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..4004
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /note="cadherin 5"
                     /db_xref="GeneID:12562"
                     /db_xref="MGI:MGI:105057"
     exon            1..108
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            109..331
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2482
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /note="vascular endothelial cadherin; VE-cadherin;
                     7B4/cadherin-5"
                     /codon_start=1
                     /product="cadherin-5 preproprotein"
                     /protein_id="NP_033998.2"
                     /db_xref="CCDS:CCDS22572.1"
                     /db_xref="GeneID:12562"
                     /db_xref="MGI:MGI:105057"
                     /translation="MQRLTELATALGAFLGLLAVAAMAGPNFPQIDTPNMLPAHHRQK
                     RDWIWNQMHIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLA
                     YERLDREKVSEYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPE
                     MSAIGTSVIRVTAVDADDPTVAGHATVLYQIVKGNEYFSIDNSGLIFTKIKNLDREKQ
                     AEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKPLG
                     FLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFY
                     IEATDPTIRYEYLSSTSGKNKAMVTINVLDVDEPPVFQRHFYHFKLPENQKKPLIGTV
                     VAKDPDKAQRSIGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVEANELD
                     SRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKDVVP
                     VNPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLT
                     GTSTLTVGVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRI
                     RKQAHAHSKSALEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRGGSTKPLRSTMDARP
                     AVYTQVQKPPRLAPGLHGGPREMATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESIA
                     ESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII"
     exon            332..620
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            621..737
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            738..902
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1090
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1341
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1484
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1609
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1718
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1964
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..3986
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3965..3970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /note="hexamer: AATAAA"
     polyA_site      3985
                     /gene="Cdh5"
                     /gene_synonym="7B4; Cd144; VE-Cad; Vec; VEcad; VECD"
                     /note="major polyA site"
ORIGIN      
        1 agcctgggtg tggctcccct ctcccctcct gaggcaatca actgtgctct ccacaaagct
       61 cggccctgga cagactgcag tggagagagc cttctgctca cggacaagat cagctcctcc
      121 acgaaggatg cagaggctca cagagctggc cactgctttg ggagccttcc tgggcctcct
      181 ggcagtggca gcaatggcag gccctaactt tccccagata gacaccccca acatgctacc
      241 tgcccaccat cgccaaaaga gagactggat ttggaatcaa atgcacatcg atgaagagaa
      301 aaatgaatcg ctgccccact atgtgggaaa gatcaagtcc aacgtgaacc gccagaatgc
      361 taagtatgtg ctccaaggag agtttgctgg caagatcttc ggggtcgatg ctaacacagg
      421 gaatgtgctt gcctatgaga ggctagaccg ggagaaagtc tctgagtact tccttactgc
      481 cctcattgtg gacaagaaca ccaacaaaaa cctggaacaa ccttccagct tcactgtcaa
      541 ggtgcatgat ataaatgaca attggcctgt gttttcgcac caggtattca acgcatctgt
      601 gccagagatg tcagctatag ggacctctgt catccgtgtg acagcagtgg atgcagatga
      661 ccccactgtg gccggccacg ccactgtctt gtaccaaatc gtgaaaggaa atgagtattt
      721 cagcattgat aattctggac tcattttcac aaagatcaaa aacttggacc gagagaaaca
      781 ggctgaatac aagatcgtgg tggaaacaca agatgccctg ggtctgcggg gagagtcagg
      841 cacagccact gtgatgatca gactggagga catcaatgac aacttccccg tctttactca
      901 atccacatac acattttcgg tgcctgaaga catccgagtg ggcaagccct tgggctttct
      961 gactgttgtg gacccagatg agcctcagaa ccggatgacc aagtacagca tcatgcaggg
     1021 cgagtacagg gacaccttca ccattgagac agaccccaaa cgtaacgagg gtatcatcaa
     1081 acccacgaag tccctggact atgaagtcat ccagcagtac acattctaca ttgaggccac
     1141 agaccccact atccgatacg aatacctgag cagcacttca ggcaaaaaca aagccatggt
     1201 caccatcaac gtcctagatg tggatgagcc ccctgtcttc cagcgacact tctaccactt
     1261 caagctgcca gaaaaccaga agaaaccgct gatcggcact gtggtggcca aagaccctga
     1321 caaggctcag cgcagcatcg ggtactccat ccgcaagacc agtgacagag gccaattctt
     1381 ccgaataacc aagcagggaa acatctataa cgagaaagaa ctggacagag aaacctacgc
     1441 ctggtataac ctgactgtgg aggccaacga actggattct cggggtaacc ctgtagggaa
     1501 agagtccatt gtgcaggttt acattgaagt cttggatgag aatgacaacc ctccggaatt
     1561 tgcccagccc tacgaaccta aagtgtgtga gaatgctgcc cagggcaagc tggtagtaca
     1621 gatctctgca acagacaagg atgtggtgcc agtaaaccca aagttcaagt ttgccctgaa
     1681 gaacgaggac agcaacttca ccctcataaa caaccatgac aacaccgcca acatcacggt
     1741 caagtatggg cagtttaatc gggagcatgc caagttccac tacctgcccg tgctcatctc
     1801 agacaacggg gtgcccagcc tgactggaac cagcacgcta accgtgggtg tgtgcaagtg
     1861 caacgagcag ggcgagttca ccttctgtga ggagatggca gcccaggcgg gtgtcagcat
     1921 ccaggcgctg gtggccatct tcctctgcat cctcaccatc acagtgatta ccttgctgat
     1981 catcctgcgg aggcggatcc ggaagcaggc gcatgctcat agcaagagtg cgctggagat
     2041 tcacgagcag ttggtcactt acgatgagga gggcggtggt gagatggaca ccaccagcta
     2101 tgatgtgtca gtgcttaatt ctgtgcgcgg tggctccact aagcccctgc gctccacgat
     2161 ggacgcccgg ccggcagtgt acacgcaggt gcagaagccg ccgcgcctgg cgcctggact
     2221 gcacggaggg cccagggaga tggccaccat gatcgacgtg aagaaagaag aggcagacaa
     2281 tgacggcggt ggccccccat acgacacact gcacatctac ggctacgagg gcgcagagtc
     2341 catcgcagag tccctcagtt ccctgagcac caattcctcc gactctgaca tcgattatga
     2401 cttcctcaac gactggggac ccaggttcaa gatgctggct gagctgtacg gctcagatcc
     2461 ccaggaggaa ctcatcatct agggttctgg tctttgggcc tggggaccca acctcattgc
     2521 aacctggatc agacaccgga cactgtcttc cctgatttcc aaggagtgac accagactct
     2581 tcaacccagc gccccttcca tccccaaggt agcaaattcc aggcccctta aatatccagg
     2641 aacagagaca tatcttattg atggccactc caaaaactgg aagagtgaga gtagtattct
     2701 gtctgggctc ctcccacccc cacccccacc ccgcacccct ccctcctcat atacacacat
     2761 acacactcct gatctattcg agacctccag tcccttcaac gctaccaagc aaactgacta
     2821 tgctgaactt ttagtcttcc ccaagggtcc ctgagcccct ggtaaggatc aagtccaatc
     2881 taaagggagg ctgtaactca tccatcatgc ctgccctcag gagacccagc actgctgagc
     2941 ctccctcaca cctacccagt gcccagcccc tacccaggcc tgtccaggga ggaaggagac
     3001 tgtccgcagc tcctgacctt gggtcctgag gtgatccggc aggcctgagc cccatgcact
     3061 gctttgatga gcaatgactc attccgtcaa cttcaggaaa atggcttgtc gaatttgaag
     3121 caactgtgaa ttcacccagg gaggactgtg gagaccatag gtgacaggtc ataggtgaca
     3181 ggtcatagag caaggatagc ctctaaccca ctcaccagaa agatcccaga agagctaaga
     3241 ggaccctctg ctactcagcc ctgctctggt tgcctgcagg aggcagccgc ctcgcctggt
     3301 cactcactct tccttttctc ttgctgtcca cttatatctc ttgggggcgc ccaagacaca
     3361 gcctctgcaa gcctggctga accgtaactg caccacagag ccaccacgcc actcgccttt
     3421 tgcctagttg ccacatctca gggaatgaac ctcaccccca gggcacacct tgcagaatgc
     3481 aagacccctg ccctttccag gggcagtgtg gcctctctgc atctctccct tggagagagt
     3541 tgagtaactt tccactgagt gacagctgga ggaaggggca tacagacaca aagaggccca
     3601 agcgaggcgg aaatgtgcct tcaactcacc ctccttgtgg aatcctcccc caacaaggcc
     3661 tttctgcagg ggactatcga tagctctgac atttgtctaa tcaataatta gtttctctta
     3721 tttttttttt tttactaatg atacttatta taagactcta gttctcacag acatagaata
     3781 aggtttgctg tgtgataagc agtttgctat ttaggttaac aatttttttt taattcgggt
     3841 ttcttagtta gaggaacaat tcctgtaagt ttttatttcc tttctgtagt cattgctgta
     3901 aggataatga ctatctatta gtcaccctgg tgcatgagat gtactgtacc tttttttata
     3961 tctaaataaa gacatcttga aattctaaaa aaaaaaaaaa aaaa
//
