LOCUS       NM_009867               6384 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus cadherin 4 (Cdh4), transcript variant 1, mRNA.
ACCESSION   NM_009867 XM_989364
VERSION     NM_009867.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6384)
  AUTHORS   Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
            Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
  TITLE     Radially patterned morphogenesis of murine hair follicle placodes
            ensures robust epithelial budding
  JOURNAL   Dev Cell 59 (24), 3272-3289 (2024)
   PUBMED   39413781
REFERENCE   2  (bases 1 to 6384)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   3  (bases 1 to 6384)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6384)
  AUTHORS   Jun,S., Angueira,A.R., Fein,E.C., Tan,J.M.E., Weller,A.H.,
            Cheng,L., Batmanov,K., Ishibashi,J., Sakers,A.P., Stine,R.R. and
            Seale,P.
  TITLE     Control of murine brown adipocyte development by GATA6
  JOURNAL   Dev Cell 58 (21), 2195-2205 (2023)
   PUBMED   37647897
REFERENCE   5  (bases 1 to 6384)
  AUTHORS   Narvaez Del Pilar,O., Gacha Garay,M.J. and Chen,J.
  TITLE     Three-axis classification of mouse lung mesenchymal cells reveals
            two populations of myofibroblasts
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35302583
REFERENCE   6  (bases 1 to 6384)
  AUTHORS   Sjodin,A., Dahl,U. and Semb,H.
  TITLE     Mouse R-cadherin: expression during the organogenesis of pancreas
            and gastrointestinal tract
  JOURNAL   Exp Cell Res 221 (2), 413-425 (1995)
   PUBMED   7493641
REFERENCE   7  (bases 1 to 6384)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   8  (bases 1 to 6384)
  AUTHORS   Matsunami,H., Miyatani,S., Inoue,T., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Takeichi,M.
  TITLE     Cell binding specificity of mouse R-cadherin and chromosomal
            mapping of the gene
  JOURNAL   J Cell Sci 106 (Pt 1), 401-409 (1993)
   PUBMED   8270638
REFERENCE   9  (bases 1 to 6384)
  AUTHORS   Hutton,J.C., Christofori,G., Chi,W.Y., Edman,U., Guest,P.C.,
            Hanahan,D. and Kelly,R.B.
  TITLE     Molecular cloning of mouse pancreatic islet R-cadherin:
            differential expression in endocrine and exocrine tissue
  JOURNAL   Mol Endocrinol 7 (9), 1151-1160 (1993)
   PUBMED   8247017
REFERENCE   10 (bases 1 to 6384)
  AUTHORS   Moller,C.J., Christgau,S., Williamson,M.R., Madsen,O.D., Niu,Z.P.,
            Bock,E. and Baekkeskov,S.
  TITLE     Differential expression of neural cell adhesion molecule and
            cadherins in pancreatic islets, glucagonomas, and insulinomas
  JOURNAL   Mol Endocrinol 6 (8), 1332-1342 (1992)
   PUBMED   1406710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX000474.13, AL663028.12 and
            AL663067.14.
            
            On Feb 22, 2023 this sequence version replaced NM_009867.3.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            The encoded protein is involved in retinal angiogenesis during
            development where it plays a crucial role in the
            endothelial-astrocyte interactions. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Oct 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69966.1, D14888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               BX000474.13        153993-154236
            245-356             BX000474.13        156258-156369
            357-583             AL663028.12        9403-9629
            584-754             AL663028.12        26607-26777
            755-910             AL663028.12        72118-72273
            911-1055            AL663028.12        76369-76513
            1056-1228           AL663028.12        89266-89438
            1229-1366           AL663028.12        103221-103358
            1367-1552           AL663067.14        2684-2869
            1553-1806           AL663067.14        6728-6981
            1807-1949           AL663067.14        7594-7736
            1950-2183           AL663067.14        9963-10196
            2184-2417           AL663067.14        11617-11850
            2418-2557           AL663067.14        14066-14205
            2558-2722           AL663067.14        14902-15066
            2723-6384           AL663067.14        16586-20247
FEATURES             Location/Qualifiers
     source          1..6384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 101.86 cM"
     gene            1..6384
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /note="cadherin 4"
                     /db_xref="GeneID:12561"
                     /db_xref="MGI:MGI:99218"
     exon            1..244
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2929
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; retinal cadherin; retina cadherin; R-cadherin"
                     /codon_start=1
                     /product="cadherin-4 isoform 1 preproprotein"
                     /protein_id="NP_033997.1"
                     /db_xref="CCDS:CCDS17164.1"
                     /db_xref="GeneID:12561"
                     /db_xref="MGI:MGI:99218"
                     /translation="MTTGSVLPLLLLGLSGALRAHREDLTVREACKAGFSEEGYTALI
                     SPNVLEGEKLLKVEFSSCVGTKGMQYETNSLDFKVGADGTVFATRELKIPSEQVAFTV
                     TARERQSAEQWAAMVRLLVAQTSSAHSEHKKGQTVALDPSQPPNDTLLPWPQHQSSGG
                     LRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFN
                     IDSMSGRMYVTRPMDREERASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFIN
                     QVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSET
                     GDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTTS
                     TFAGEVPENRIETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGM
                     VTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISVTDVNEAPYFPSNH
                     KLIRLEEGVPAGTALTTFSAVDPDRFMQQAVRYSKLSDPANWLHINTSNGQITTAAIL
                     DRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPQLLPKEAQICERPG
                     LNAINITAADADMDPNIGPYVFELPFIPTTVRKNWTITRLNGDYAQLSLRILYLEAGV
                     YDVPIIVTDSGNPPLSNTSVIKVKVCPCDENGDCTTVGAVAAAGLGTGAIVAILICIV
                     ILLIMVLLFVVWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQ
                     QPEAMEHVLSKTPGVRRVDERPVGAEPQYPVRPVVPHPGDIGDFINEGLRAADNDPTA
                     PPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED"
     exon            245..356
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            357..583
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            584..754
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            755..910
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1055
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1228
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1366
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1552
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1806
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1949
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2183
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2417
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2557
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2722
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..6384
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6364..6369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /note="hexamer: AATAAA"
     polyA_site      6384
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgg gcggctgcga ggccggcgga cgcaccggcc ggagggagcg cgccgccggc
       61 ccacttggcc tggctcccgg agcccgggcg gcaagtgcgg ggaaaagcag ggcgggcgcg
      121 ggcggagcat cgccgcggcg agggaagccg ggcaccgggc gagcgccggg gcggcgcggc
      181 ggggacgatg accacaggct ctgtgctgcc gctgctgctg ctcgggctct cgggcgcgct
      241 ccgggcccac cgtgaggatc ttacagtcag agaggcctgt aaggctggct tctccgaaga
      301 aggctacact gcgttgatct ccccgaatgt cctggaagga gagaaactac tcaaagtcga
      361 gttcagcagc tgcgtgggca ccaaaggtat gcagtatgag accaacagct tggacttcaa
      421 agtcggggcg gatgggacag tcttcgccac tagggagttg aagatcccct cagagcaggt
      481 ggcctttacc gtcactgcgc gggaacgcca gagtgctgag caatgggctg ctatggtgcg
      541 gctgctggta gcccagacat cgtcagcaca ctctgaacac aagaaagggc agacagtggc
      601 cctagacccc tctcagccgc caaatgacac actgctgcca tggcctcaac atcagagctc
      661 tggtgggctg aggagacaga agcgtgactg ggtcatccca cccatcaacg ttcccgagaa
      721 ctcccgtgga cccttccctc agcagcttgt caggatcagg tcggacaaag acaatgacat
      781 ccccatccgc tacagcatca cgggtgtggg cgccgaccag ccccccatgg aggtcttcaa
      841 catcgactct atgtctggcc ggatgtatgt cactcggccc atggaccggg aggaaagagc
      901 ctcttaccat ctccgagccc acgcggtgga tatgaacggt aacaaggtgg agaatcctat
      961 tgacctgtac atctacgtca ttgacatgaa cgacaaccgt cccgagttca tcaaccaggt
     1021 ctacaacggc tctgtggatg agggctccaa gccaggtaca tatgtgatga ccgtcacagc
     1081 caacgatgca gatgatagca ccacagccaa tggcatggtg aggtacagaa ttgtcaccca
     1141 gacaccccag agcccatccc agaatatgtt caccatcaac agtgaaacag gggacatcgt
     1201 gaccgtggca gcaggcctgg acagagagaa agtccagcag tacaccgtca tcgtccaggc
     1261 cactgacatg gaaggaaacc ttaattatgg tctctcgaac acagccactg ccatcatcac
     1321 ggtgacagac gtaaatgaca accctccgga attcaccaca agcacatttg caggagaggt
     1381 tcctgagaac cgtatagaga cagtagtagc caacctcacg gtgatggacc gagaccagcc
     1441 ccactcaccc aactggaacg ccgtctaccg aatcataagt ggggacccct ctgggcactt
     1501 cagtgtccgc acagaccccg tgaccaatga gggcatggtc accgtggtga aggcagtgga
     1561 ctatgagctg aaccgtgcct tcatgctgac cgtaatggtg tccaaccagg cgcccctggc
     1621 cagtgggatc cagatgtcct tccagtccac agcaggggta accatctctg tcaccgatgt
     1681 caacgaggcc ccctacttcc cctccaacca caaactgatc cgcctggaag agggtgtgcc
     1741 cgctgggaca gcactcacca ctttttctgc agtggaccct gaccggttca tgcagcaagc
     1801 cgtgaggtac tccaaactgt ctgatcccgc caactggctg cacatcaaca catccaatgg
     1861 gcagatcacc acagccgcca ttctggaccg agagtccctc tacaccaaga acaatgtata
     1921 tgaggccacc ttcctggctg ctgacaatgg gatcccccca gccagtggca ctgggaccct
     1981 gcagatctac ctcattgata tcaatgacaa cgcaccacag ctgctaccca aggaggcaca
     2041 gatctgcgag aggcccggcc tcaatgccat caacatcact gcagccgacg ccgatatgga
     2101 ccccaacatt ggcccctatg tctttgagtt gcccttcatc cccactacag tgaggaagaa
     2161 ttggaccatc acccgcctaa atggtgacta tgcccagctc agtctgagaa tcctgtatct
     2221 ggaagcaggg gtgtatgacg tccccatcat cgtcacagac tctggcaacc ctcccttgtc
     2281 caatacatct gtcataaagg tcaaggtgtg cccatgtgat gagaacggcg actgtaccac
     2341 ggtcggcgca gtggctgcag ctggcctggg cacgggcgcc atcgtggcga tcctcatctg
     2401 catcgtgatc ctgctaatca tggttctgct gttcgttgtg tggatgaagc ggagagaaaa
     2461 ggagaggcac acaaagcagc tgctcatcga ccctgaggat gacgtgaggg acaacatcct
     2521 gaagtacgat gaagagggcg gtggcgagga ggaccaagac tacgacctca gccagctgca
     2581 acagccagaa gccatggagc atgtgctgag caaaactcct ggtgtgcggc gggtggatga
     2641 acggccagta ggtgctgaac cccagtaccc agtcaggcct gtggtgccac acccaggaga
     2701 cattggagac ttcattaatg agggactccg agctgctgac aatgacccca ccgcaccccc
     2761 ctacgactcc ctgctagtct tcgactatga aggcagcggt tctactgcgg gctctgtcag
     2821 ctccctaaac tcctccagct ccggggatca agattacgac tacttaaatg actgggggcc
     2881 ccggttcaag aagctggcgg acatgtatgg gggtggcgag gaggactaac caacctcacc
     2941 accaatgcaa gaagggcact ggaggcgagc agcagaactg agccgaggtg ccagcgccgt
     3001 ctggtgtcga gaggtccctc cccgctgccg tcccccatgt ggagctctgc agtatggaca
     3061 taggccaccg ggcacccatc atcactgcgg catctcggta gccacagcca cgtactgcga
     3121 agggagagcc agaggcacag ccctaacttg aatttcttac cacaaaagca ctgttaaaac
     3181 aaaacaaaaa acaaaaaaca aaaacaaaag tgccttttgg tacatgacag attccctaac
     3241 tcaggagtga ctgaaagagg agagacagcc cgaggccccc acctctgtcc accttgcccc
     3301 acagccccag tcccacctgg taccttctaa aggcaacaag caaggagtgg gagacaatgt
     3361 gtcttttttt ttttaaagcc ttttattaag aaaaagaaaa taggtaactt atttgcaaaa
     3421 aaaaaaaaaa aaaatagtag ggggggtcca gatctcaata gtttttgtta tgcacagccg
     3481 gggtctcctg ggccctttag gctccccaag gctgttaggt gaggatctgg ctttccagca
     3541 ccaaaaaaat cactgggcta gcctaaccac atcagcagag ccacttctga gtggactcgg
     3601 ctttcacccg aacttgtgcc ctgccccaat atactgtaaa tagctggagc aggcgcgatg
     3661 cctggagacc ttcccaggag ctctcacctc tctatttggc cacttctgtg ccctcaagcc
     3721 caccataaag cctctctctg gaccagctgt cgcccccaat accaccaagg tccctttttg
     3781 ctttggtcca ggacagtatg ttgtctaaga agccacggca tcctgcaaaa ccttggctca
     3841 gccctccact cttcaagatg agaccctgag ggatcctgtt gaaggcatag caatcacaag
     3901 ctcccctcaa tggaacccct gaatgctctc aacaccctcc ccaggctatg cagatggcag
     3961 aagcagagcc tggctagact ctggcagctg cttggccacc ctggacccgt ttaacctgag
     4021 ctcctgcctg gtcccatgaa ctgctatgga tgtcaggacc taccaagtgg ccggtgagat
     4081 tatcttgctc tgtgcccatg tgaccacaga tgctctggtc tggacccatg tttctgttgc
     4141 tctctggagc tggcagggca ctttaccatg gcagcttgac agcttgacac agggcaaact
     4201 gggcagggtg atcacttcag tagggcagca aataggctgt gtgcaaggac ctacaggaga
     4261 tggcaaagct gccccttttc actggagggg aaaacagacc taggacatcc acatgtctgg
     4321 gcccaagaga gccctgggat ggggcagaaa ggcaggcact gaccgggcat cttgcaccga
     4381 gtcttcctgg cttatcccat gctctaatac actccccgag gaaggggctg aggaatgctg
     4441 atagcttggg aggccttagt atcggagtct tcttagggag acaacagaag tcccagcact
     4501 gatgaaaaat aagtttcttc catatctcta acccatatct actactgggg gctaggaggg
     4561 tttcaaaagg gctgggggtg cccgggagat tgcatgctcc ctagccagaa gtctctaatt
     4621 catagctccc cttggcttct ttaccccatg gctagatccc ccctttccag actgctttgg
     4681 cctcaaagac acacctgagt gaactcacgg gtacccaact tgtgggtgtg acccattgga
     4741 tgtcagggtt ctttcccaaa ccaaacccat tcccacctct aaactcctgg acttgagctg
     4801 ggctgcaagc ttagctgtgt ctactctcac tcctcagaca gctgttctag gaggggggat
     4861 gaataggggc ctctgtagct tcctgggagt ccccctgcct acagccagcc agggcagcag
     4921 agctcatgaa agggttggga gggctgtcct atgcaaattg ctcgaatcgg caaacaattc
     4981 gggtggtgct gagcttggca tggccactgg tgtgtcgtgg gttagggctg gggaattgag
     5041 aatagttttc tgggtttgat tttagaaaac ccaagaaggt tcttggaagt gtgcatatgt
     5101 ttggtaggca tggtagccaa gaactctcct gaagtcccaa ggctttctta aaaagcctgg
     5161 gatgagaggt accaaatcca tcagttacct ggaggcatgg ctcacctgcc tccatctcct
     5221 cctccccact cccaaggcct ctgtcactgc caggcccctg caggaacatc cacggggttt
     5281 cctaaaagct gaacagcttg tccctttcac cctgcacccc agcagcccct agggctggag
     5341 gaaaataggg tcttacacat ccccagaccc atcttggaac tctgttccca ggccaacaag
     5401 ttagcattag ccaagcatac agtcagtgtc aaatgtttct cttctgtagc tcgtagatac
     5461 aacgcgtctg tggtcagggc ccagccaagc taggccagtg gccagctctg tgcagtacaa
     5521 ggctgtggtt tggctccttt aaggagaaac gtacatggct tggaagaaca cctggccatg
     5581 gtcagccttg gtcacacctg actcccggcc agtggcttct ctctctcatg tctttcagca
     5641 aatccataat gctgggtctc ctgccaccaa agtgtcagag taatggccaa aagtcaggcc
     5701 ctcagagatg cctcagtttc cccatagtga gtatgtggtc tgttgagatg acacctctgt
     5761 gctctctaag gtaaacggga ggggaagtct ctatttctac ccacactgaa aggcaaaacc
     5821 aaaaactcac agcagaatca cccagcacag agcaccaggt gtggtagtac atagaccaca
     5881 tacctagcag gctctgccac accagtcggc tggtggaaac cacctccgta tacaccgggg
     5941 acgcatcttg cttttccttc ctctcctgtt ctccattctg atttattttc tgcatgttta
     6001 tttttgaaaa tggacaaatg tgcagcagcc cgcatgaccg tggttgtttc gggaaagata
     6061 ccggagtctg acgtgttcac actgcagctc tgagcgccat gcggtgagac agacgttccg
     6121 actttttttg taatcgtcaa cagcacaaat attttgtatt gtcgtttgta tcattttgta
     6181 cctaaaaaaa aaggaaaaaa aaaaacaaaa caaaaacaaa acaaaaacaa aaagggaaga
     6241 gagttgatgt tttcaatgtg tttttagtgc caggcagtct tggttccgaa gggaacagca
     6301 gctttgcgga attgtcgtgt ccaggagtgg agtcaggcgt tagcacgctg ctccaaagga
     6361 gtaaataaag tcccctttga agta
//
