LOCUS       NP_033997                913 aa            linear   ROD 14-FEB-2025
DEFINITION  cadherin-4 isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_033997 XP_994458
VERSION     NP_033997.1
DBSOURCE    REFSEQ: accession NM_009867.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 913)
  AUTHORS   Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
            Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
  TITLE     Radially patterned morphogenesis of murine hair follicle placodes
            ensures robust epithelial budding
  JOURNAL   Dev Cell 59 (24), 3272-3289 (2024)
   PUBMED   39413781
REFERENCE   2  (residues 1 to 913)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   3  (residues 1 to 913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 913)
  AUTHORS   Jun,S., Angueira,A.R., Fein,E.C., Tan,J.M.E., Weller,A.H.,
            Cheng,L., Batmanov,K., Ishibashi,J., Sakers,A.P., Stine,R.R. and
            Seale,P.
  TITLE     Control of murine brown adipocyte development by GATA6
  JOURNAL   Dev Cell 58 (21), 2195-2205 (2023)
   PUBMED   37647897
REFERENCE   5  (residues 1 to 913)
  AUTHORS   Narvaez Del Pilar,O., Gacha Garay,M.J. and Chen,J.
  TITLE     Three-axis classification of mouse lung mesenchymal cells reveals
            two populations of myofibroblasts
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35302583
REFERENCE   6  (residues 1 to 913)
  AUTHORS   Sjodin,A., Dahl,U. and Semb,H.
  TITLE     Mouse R-cadherin: expression during the organogenesis of pancreas
            and gastrointestinal tract
  JOURNAL   Exp Cell Res 221 (2), 413-425 (1995)
   PUBMED   7493641
REFERENCE   7  (residues 1 to 913)
  AUTHORS   Williamson,C.M., Dutton,E.R., Abbott,C.M., Beechey,C.V., Ball,S.T.
            and Peters,J.
  TITLE     Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1,
            Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal
            imprinting region of mouse chromosome 2 are not monoallelically
            expressed
  JOURNAL   Genet Res 65 (2), 83-93 (1995)
   PUBMED   7781998
REFERENCE   8  (residues 1 to 913)
  AUTHORS   Matsunami,H., Miyatani,S., Inoue,T., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Takeichi,M.
  TITLE     Cell binding specificity of mouse R-cadherin and chromosomal
            mapping of the gene
  JOURNAL   J Cell Sci 106 (Pt 1), 401-409 (1993)
   PUBMED   8270638
REFERENCE   9  (residues 1 to 913)
  AUTHORS   Hutton,J.C., Christofori,G., Chi,W.Y., Edman,U., Guest,P.C.,
            Hanahan,D. and Kelly,R.B.
  TITLE     Molecular cloning of mouse pancreatic islet R-cadherin:
            differential expression in endocrine and exocrine tissue
  JOURNAL   Mol Endocrinol 7 (9), 1151-1160 (1993)
   PUBMED   8247017
REFERENCE   10 (residues 1 to 913)
  AUTHORS   Moller,C.J., Christgau,S., Williamson,M.R., Madsen,O.D., Niu,Z.P.,
            Bock,E. and Baekkeskov,S.
  TITLE     Differential expression of neural cell adhesion molecule and
            cadherins in pancreatic islets, glucagonomas, and insulinomas
  JOURNAL   Mol Endocrinol 6 (8), 1332-1342 (1992)
   PUBMED   1406710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX000474.13, AL663028.12 and
            AL663067.14.
            
            On May 4, 2006 this sequence version replaced XP_994458.1.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            The encoded protein is involved in retinal angiogenesis during
            development where it plays a crucial role in the
            endothelial-astrocyte interactions. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Oct 2015].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69966.1, D14888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..913
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 101.86 cM"
     Protein         1..913
                     /product="cadherin-4 isoform 1 preproprotein"
                     /note="retinal cadherin; retina cadherin; R-cadherin"
                     /calculated_mol_wt=98065
     sig_peptide     1..20
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
                     /calculated_mol_wt=1983
     Region          30..119
                     /region_name="Cadherin_pro"
                     /note="Cadherin prodomain like; pfam08758"
                     /db_xref="CDD:462590"
     Site            146
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     mat_peptide     167..913
                     /product="Cadherin-4. /id=PRO_0000003752"
                     /note="propagated from UniProtKB/Swiss-Prot (P39038.1)"
                     /calculated_mol_wt=81970
     Region          170..270
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            order(177..178,233,235,266,268..269)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206635"
     Region          278..385
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Site            order(285..286,345,347,381,383..384)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          393..500
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(400..401,458,460,497,499..500)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            409
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Region          511..608
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(515..516,567,569,604,606..607)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            554
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Region          616..708
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            629
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Site            658
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Site            699
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P39038.1)"
     Site            732..753
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P39038.1)"
     Region          850..908
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..913
                     /gene="Cdh4"
                     /gene_synonym="R-CAD; R-Cadh; Rcad"
                     /coded_by="NM_009867.4:188..2929"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS17164.1"
                     /db_xref="GeneID:12561"
                     /db_xref="MGI:MGI:99218"
ORIGIN      
        1 mttgsvlpll llglsgalra hredltvrea ckagfseegy talispnvle gekllkvefs
       61 scvgtkgmqy etnsldfkvg adgtvfatre lkipseqvaf tvtarerqsa eqwaamvrll
      121 vaqtssahse hkkgqtvald psqppndtll pwpqhqssgg lrrqkrdwvi ppinvpensr
      181 gpfpqqlvri rsdkdndipi rysitgvgad qppmevfnid smsgrmyvtr pmdreerasy
      241 hlrahavdmn gnkvenpidl yiyvidmndn rpefinqvyn gsvdegskpg tyvmtvtand
      301 addsttangm vryrivtqtp qspsqnmfti nsetgdivtv aagldrekvq qytvivqatd
      361 megnlnygls ntataiitvt dvndnppeft tstfagevpe nrietvvanl tvmdrdqphs
      421 pnwnavyrii sgdpsghfsv rtdpvtnegm vtvvkavdye lnrafmltvm vsnqaplasg
      481 iqmsfqstag vtisvtdvne apyfpsnhkl irleegvpag talttfsavd pdrfmqqavr
      541 ysklsdpanw lhintsngqi ttaaildres lytknnvyea tflaadngip pasgtgtlqi
      601 ylidindnap qllpkeaqic erpglnaini taadadmdpn igpyvfelpf ipttvrknwt
      661 itrlngdyaq lslrilylea gvydvpiivt dsgnpplsnt svikvkvcpc dengdcttvg
      721 avaaaglgtg aivailiciv illimvllfv vwmkrreker htkqllidpe ddvrdnilky
      781 deegggeedq dydlsqlqqp eamehvlskt pgvrrvderp vgaepqypvr pvvphpgdig
      841 dfineglraa dndptappyd sllvfdyegs gstagsvssl nssssgdqdy dylndwgprf
      901 kkladmyggg eed
//
