LOCUS       NM_001037809            4037 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cadherin 3 (Cdh3), transcript variant 1, mRNA.
ACCESSION   NM_001037809 XM_001000165
VERSION     NM_001037809.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4037)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4037)
  AUTHORS   Beaulac,H.J. and Munnamalai,V.
  TITLE     Localization of cadherins in the postnatal cochlear epithelium and
            their relation to space formation
  JOURNAL   Dev Dyn 253 (8), 771-780 (2024)
   PUBMED   38264972
REFERENCE   3  (bases 1 to 4037)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   4  (bases 1 to 4037)
  AUTHORS   Faraldo,M.L. and Cano,A.
  TITLE     The 5' flanking sequences of the mouse P-cadherin gene. Homologies
            to 5' sequences of the E-cadherin gene and identification of a
            first 215 base-pair intron
  JOURNAL   J Mol Biol 231 (3), 935-941 (1993)
   PUBMED   8515462
REFERENCE   5  (bases 1 to 4037)
  AUTHORS   Hatta,M., Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Takeichi,M.
  TITLE     Genomic organization and chromosomal mapping of the mouse
            P-cadherin gene
  JOURNAL   Nucleic Acids Res 19 (16), 4437-4441 (1991)
   PUBMED   1886768
REFERENCE   6  (bases 1 to 4037)
  AUTHORS   Nagafuchi,A., Takeichi,M. and Tsukita,S.
  TITLE     The 102 kd cadherin-associated protein: similarity to vinculin and
            posttranscriptional regulation of expression
  JOURNAL   Cell 65 (5), 849-857 (1991)
   PUBMED   1904011
REFERENCE   7  (bases 1 to 4037)
  AUTHORS   Nose,A., Tsuji,K. and Takeichi,M.
  TITLE     Localization of specificity determining sites in cadherin cell
            adhesion molecules
  JOURNAL   Cell 61 (1), 147-155 (1990)
   PUBMED   2317870
REFERENCE   8  (bases 1 to 4037)
  AUTHORS   Shimoyama,Y., Yoshida,T., Terada,M., Shimosato,Y., Abe,O. and
            Hirohashi,S.
  TITLE     Molecular cloning of a human Ca2+-dependent cell-cell adhesion
            molecule homologous to mouse placental cadherin: its low expression
            in human placental tissues
  JOURNAL   J Cell Biol 109 (4 Pt 1), 1787-1794 (1989)
   PUBMED   2793940
REFERENCE   9  (bases 1 to 4037)
  AUTHORS   Nose,A., Nagafuchi,A. and Takeichi,M.
  TITLE     Isolation of placental cadherin cDNA: identification of a novel
            gene family of cell-cell adhesion molecules
  JOURNAL   EMBO J 6 (12), 3655-3661 (1987)
   PUBMED   3428270
REFERENCE   10 (bases 1 to 4037)
  AUTHORS   Nose,A. and Takeichi,M.
  TITLE     A novel cadherin cell adhesion molecule: its expression patterns
            associated with implantation and organogenesis of mouse embryos
  JOURNAL   J Cell Biol 103 (6 Pt 2), 2649-2658 (1986)
   PUBMED   3539943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC164096.3, BC098459.1,
            AK045041.1 and AC132132.4.
            
            On Mar 29, 2013 this sequence version replaced NM_001037809.4.
            
            Summary: This gene encodes a calcium-dependent cell-cell adhesion
            protein containing five cadherin domains. The encoded protein plays
            a role in epithelial outgrowth, such as that which occurs during
            the development of hair follicles and limb buds. Loss of function
            of the related gene in humans results in ectodermal dysplasia,
            ectrodactyly, and macular dystrophy and congential hypotrichosis
            with juvenile macular dystrophy. This gene is located in the
            vicinity of similar cadherin genes on chromosome 8. The proprotein
            is further cleaved into a functional chain. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031265.1, BC098459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC164096.3         45965-46058         c
            95-283              BC098459.1         1-189
            284-3273            AK045041.1         244-3233
            3274-4035           AC164096.3         1-762               c
            4036-4037           AC132132.4         86224-86225
FEATURES             Location/Qualifiers
     source          1..4037
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.16 cM"
     gene            1..4037
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /note="cadherin 3"
                     /db_xref="GeneID:12560"
                     /db_xref="MGI:MGI:88356"
     exon            1..155
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2576
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 1; placental cadherin; RPE-specific cadherin"
                     /codon_start=1
                     /product="cadherin-3 isoform a preproprotein"
                     /protein_id="NP_001032898.1"
                     /db_xref="CCDS:CCDS22637.1"
                     /db_xref="GeneID:12560"
                     /db_xref="MGI:MGI:88356"
                     /translation="MELLSGPHAFLLLLLQVCWLRSVVSEPYRAGFIGEAGVTLEVEG
                     TDLEPSQVLGKVALAGQGMHHADNGDIIMLTRGTVQGGKDAMHSPPTRILRRRKREWV
                     MPPIFVPENGKGPFPQRLNQLKSNKDRGTKIFYSITGPGADSPPEGVFTIEKESGWLL
                     LHMPLDREKIVKYELYGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVLE
                     GVMPGTSVMQVTATDEDDAVNTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISS
                     GLDREKVPEYRLTVQATDMDGEGSTTTAEAVVQILDANDNAPEFEPQKYEAWVPENEV
                     GHEVQRLTVTDLDVPNSPAWRATYHIVGGDDGDHFTITTHPETNQGVLTTKKGLDFEA
                     QDQHTLYVEVTNEAPFAVKLPTATATVVVHVKDVNEAPVFVPPSKVIEAQEGISIGEL
                     VCIYTAQDPDKEDQKISYTISRDPANWLAVDPDSGQITAAGILDREDEQFVKNNVYEV
                     MVLATDSGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSP
                     NSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTM
                     IRATVCDCHGQVFNDCPRPWKGGFILPILGAVLALLTLLLALLLLVRKKRKVKEPLLL
                     PEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVVPTFIPTPMYRPR
                     PANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTTSASDQDQD
                     YNYLNEWGSRFKKLADMYGGGEDD"
     exon            156..273
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            274..347
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            348..473
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            474..629
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            630..774
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            775..950
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1079
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1265
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1507
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1653
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1878
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2088
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2219
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2366
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..4037
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3226..3231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /note="hexamer: ATTAAA"
     polyA_site      3251
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /note="major polyA site"
     polyA_site      3292
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
ORIGIN      
        1 ctggcctcct cccgcgggct ccagcgagcc gcggtgctca aagctgcacc cggagcttag
       61 cagagcgcgc cccaccgtcg cggcagcctt ctcacctccc ttcagttatg gagcttctta
      121 gtgggcctca cgccttcctg ctcctcctgc tccaggtttg ctggctacgc agcgtggtct
      181 ccgagcccta ccgagcgggc ttcatcgggg aggctggagt gaccttggag gtggaaggaa
      241 ctgacctgga gccgagccaa gttctgggga aagtagcctt ggctggacag ggcatgcacc
      301 atgcagacaa tggagacatc attatgctga ctagggggac agttcaggga gggaaggatg
      361 cgatgcactc cccacccacc cgcatcttaa ggagacgaaa gagagagtgg gtgatgccac
      421 caatattcgt ccccgagaat ggcaagggtc ccttccctca gaggctgaat cagctcaaat
      481 ctaataagga cagaggcacc aagattttct acagcatcac agggcctggc gcagacagtc
      541 cccccgaagg agtcttcacc atagagaagg agtcgggctg gctgttgttg catatgccac
      601 tggacaggga gaagattgtc aagtacgagc tttatggcca cgctgtatct gagaatggtg
      661 cctctgtaga ggagcccatg aacatatcca tcattgtgac agaccagaat gacaacaagc
      721 ccaagttcac tcaagacacc ttcagaggga gtgttctgga gggagtaatg cctggcactt
      781 ctgtgatgca ggtgacagcc acagatgagg acgatgctgt caacacttac aatggggtgg
      841 tggcttactc catccatagc caagagccga aggagccaca cgacctcatg ttcaccatcc
      901 ataaaagcac gggaaccatt agcgtcatat ccagtggcct ggaccgagag aaagtccctg
      961 agtacagact gaccgtccag gccacagaca tggatggaga gggctctacc acgacggcag
     1021 aggccgttgt gcaaatcctt gatgccaacg ataacgctcc ggagtttgag ccgcagaagt
     1081 atgaggcttg ggtgcctgag aacgaagtgg gccatgaggt acagaggctg acagtgactg
     1141 atctcgatgt ccccaactcg ccagcgtggc gtgccaccta ccacatcgtg ggaggtgatg
     1201 atggggacca tttcaccatc accactcacc cagagaccaa ccaaggcgtc ctgacaacca
     1261 agaagggttt ggattttgag gctcaggacc aacacaccct gtatgtagaa gtgaccaacg
     1321 aggctccctt tgcagtgaag ctcccgacag ccactgccac cgtggtggtc catgtgaaag
     1381 atgtcaacga agcccctgtg tttgttccac cttccaaggt cattgaggcc caggaaggca
     1441 tctctattgg ggaactggtc tgcatctata ccgcacagga cccagacaag gaggaccaga
     1501 agatcagcta caccatctcg agagatccag ccaactggct tgctgtggac ccagacagtg
     1561 gtcagataac tgccgcaggc atcttggatc gtgaggacga gcagtttgtg aaaaacaatg
     1621 tctacgaagt catggttttg gccacagaca gtggaaaccc tcccaccacc ggcactggga
     1681 ccctcctgct tacacttact gacatcaacg accatggccc gatccctgaa cccaggcaga
     1741 tcatcatctg taaccaaagc cctgtgcctc aagtgctgaa catcactgac aaggacctgt
     1801 cccccaactc ctcccctttc caggcccagc taacacatga ctcagatatc tactggatgg
     1861 cagaagtcag cgagaaagga gacaccgtgg ccttgtccct gaagaagttc ctgaaacaag
     1921 acacgtatga cttgcatctt tctttgtctg accatggcaa cagggaacag ctaaccatga
     1981 tcagggccac tgtgtgtgac tgccatggcc aagtgttcaa tgactgcccc agaccctgga
     2041 agggtggttt catcctcccc atcctgggtg ctgtcctggc actgctgacc cttctactgg
     2101 cactcctcct gttggtgagg aagaagagga aggtcaaaga gccccttctg ctcccagaag
     2161 atgacacgcg agacaatgtc ttctattatg gagaagaggg tggtggtgaa gaggaccagg
     2221 actatgacat cacccaactc caccggggac tggaggccag gcctgaggtg gttctccgaa
     2281 acgatgtagt gccaaccttc atccccaccc ccatgtaccg accccggccc gccaacccag
     2341 atgaaatcgg gaacttcatc atcgagaacc tgaaggctgc caacactgac cctactgccc
     2401 cgccctacga ctccctgctg gtttttgact acgagggcag cggctctgat gccgcctccc
     2461 tgagctccct caccacctcc gcctccgacc aggatcagga ctacaactac cttaacgagt
     2521 ggggaagtcg attcaagaaa ctggcggaca tgtatggtgg cggtgaggat gactaggctg
     2581 tccctgccaa gctgtccagg caagaactac agacgggtca cagcagcatc tcaagggagc
     2641 ctggctcccg ctccagccag gactctgaag tttgcccaga agtggcctgc gtggcacgct
     2701 gcatctgacc agaaggctgg actgtgagcc tttccgatgg aaggatgtga ctctgacgac
     2761 aacactgatc cccacctcag ccatggctga gcccctctca gagcgggaat gtctaaaggt
     2821 ctcccgcctg ccacacagca ctcagctctg ccctctcagg gcttgaactt gctccgatgc
     2881 cctcggtgac tttccccact tggaatggct ccctctcttt agaaagaggc ccctaactaa
     2941 ggccctgttt ttctttaatg cagttttcaa aaagaggctg gggtgggtgg ggcagggtgc
     3001 ggacatcagt gtcccctcag gccctccaga agagaagcct acagggcact ggccctggta
     3061 catttctctg acatttcttg aggcctcaca ttggggaggg gtcactgcct tttttttttt
     3121 tttaatactg agtatatcta agttgtctcg tattttttta ttttccctgt tatgtgctgt
     3181 agatggagag tgatgacaat cgtgtaaatg tactagaatt tttttattaa aatgaacttt
     3241 tttttttccc agaggtgcta ggggagtgga tttaaaaaga ctttttaacc tagttctcag
     3301 aagtgtttgg cttggtgggt tttagatttt ttacaagatt tgcagacgcc ctcgcttcca
     3361 cccaacttcc cccttgtggc tcaggattca agctgatctc aggccacaaa ggaggaaatg
     3421 atggcatgac tggccggagg tgggatacag actccccccc cccccccccc cccccccccc
     3481 gcagcttcag agctatgaga gcaccacagt taacttcctt ccctggaatt gattgctcca
     3541 cgcccatagt tacaggactt gggaggtgaa atcaggagct cagagtctgg gcgtcagggg
     3601 atgggggttg gggaaggctc atgggtgatg gagctgtaat cctagcacac cacagaggca
     3661 ggagagctca cattggaggt cagcctgggt tacctatcac aactctgtct cagagaacag
     3721 aaatactttc caggccagcc agagctttgt agtgtctcaa acaaacaggt tttctggttg
     3781 agtattgata acctgccacg tggtaagggc taccgctcac tcggaactta gaaagccagc
     3841 agcacttagc tttgatgacg tctttcactt ggcctcacat ccatcctctg aggaggtttt
     3901 cctacattac agagtgacag tgacttcttt gtgagggttg gggttttttg gtttgtttgt
     3961 ttttgctttt gctttgtttt tgttttgttt ttgctttgtt ttaaatgata tgtaaaacag
     4021 aaaattagag aattcac
//
