LOCUS       NP_001032898             822 aa            linear   ROD 24-DEC-2024
DEFINITION  cadherin-3 isoform a preproprotein [Mus musculus].
ACCESSION   NP_001032898 XP_001000165
VERSION     NP_001032898.1
DBSOURCE    REFSEQ: accession NM_001037809.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 822)
  AUTHORS   Beaulac,H.J. and Munnamalai,V.
  TITLE     Localization of cadherins in the postnatal cochlear epithelium and
            their relation to space formation
  JOURNAL   Dev Dyn 253 (8), 771-780 (2024)
   PUBMED   38264972
REFERENCE   3  (residues 1 to 822)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   4  (residues 1 to 822)
  AUTHORS   Faraldo,M.L. and Cano,A.
  TITLE     The 5' flanking sequences of the mouse P-cadherin gene. Homologies
            to 5' sequences of the E-cadherin gene and identification of a
            first 215 base-pair intron
  JOURNAL   J Mol Biol 231 (3), 935-941 (1993)
   PUBMED   8515462
REFERENCE   5  (residues 1 to 822)
  AUTHORS   Hatta,M., Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Takeichi,M.
  TITLE     Genomic organization and chromosomal mapping of the mouse
            P-cadherin gene
  JOURNAL   Nucleic Acids Res 19 (16), 4437-4441 (1991)
   PUBMED   1886768
REFERENCE   6  (residues 1 to 822)
  AUTHORS   Nagafuchi,A., Takeichi,M. and Tsukita,S.
  TITLE     The 102 kd cadherin-associated protein: similarity to vinculin and
            posttranscriptional regulation of expression
  JOURNAL   Cell 65 (5), 849-857 (1991)
   PUBMED   1904011
REFERENCE   7  (residues 1 to 822)
  AUTHORS   Nose,A., Tsuji,K. and Takeichi,M.
  TITLE     Localization of specificity determining sites in cadherin cell
            adhesion molecules
  JOURNAL   Cell 61 (1), 147-155 (1990)
   PUBMED   2317870
REFERENCE   8  (residues 1 to 822)
  AUTHORS   Shimoyama,Y., Yoshida,T., Terada,M., Shimosato,Y., Abe,O. and
            Hirohashi,S.
  TITLE     Molecular cloning of a human Ca2+-dependent cell-cell adhesion
            molecule homologous to mouse placental cadherin: its low expression
            in human placental tissues
  JOURNAL   J Cell Biol 109 (4 Pt 1), 1787-1794 (1989)
   PUBMED   2793940
REFERENCE   9  (residues 1 to 822)
  AUTHORS   Nose,A., Nagafuchi,A. and Takeichi,M.
  TITLE     Isolation of placental cadherin cDNA: identification of a novel
            gene family of cell-cell adhesion molecules
  JOURNAL   EMBO J 6 (12), 3655-3661 (1987)
   PUBMED   3428270
REFERENCE   10 (residues 1 to 822)
  AUTHORS   Nose,A. and Takeichi,M.
  TITLE     A novel cadherin cell adhesion molecule: its expression patterns
            associated with implantation and organogenesis of mouse embryos
  JOURNAL   J Cell Biol 103 (6 Pt 2), 2649-2658 (1986)
   PUBMED   3539943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC164096.3, BC098459.1,
            AK045041.1 and AC132132.4.
            
            On May 4, 2006 this sequence version replaced XP_001000165.1.
            
            Summary: This gene encodes a calcium-dependent cell-cell adhesion
            protein containing five cadherin domains. The encoded protein plays
            a role in epithelial outgrowth, such as that which occurs during
            the development of hair follicles and limb buds. Loss of function
            of the related gene in humans results in ectodermal dysplasia,
            ectrodactyly, and macular dystrophy and congential hypotrichosis
            with juvenile macular dystrophy. This gene is located in the
            vicinity of similar cadherin genes on chromosome 8. The proprotein
            is further cleaved into a functional chain. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031265.1, BC098459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.16 cM"
     Protein         1..822
                     /product="cadherin-3 isoform a preproprotein"
                     /note="placental cadherin; RPE-specific cadherin"
                     /calculated_mol_wt=87805
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2825
     proprotein      26..822
                     /product="cadherin-3 isoform a proprotein"
                     /calculated_mol_wt=87805
     mat_peptide     100..822
                     /product="cadherin-3 isoform a"
                     /calculated_mol_wt=79858
     Region          103..203
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            order(110..111,166,168,199,201..202)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206635"
     Region          211..316
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(218..219,279,281,312,314..315)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          325..428
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(331..332,389,391,425,427..428)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          443..536
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(443..444,494,496,532,534..535)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          536..630
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Region          758..817
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..822
                     /gene="Cdh3"
                     /gene_synonym="Cadp; Cdhp; P-cadherin; Pcad"
                     /coded_by="NM_001037809.5:108..2576"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS22637.1"
                     /db_xref="GeneID:12560"
                     /db_xref="MGI:MGI:88356"
ORIGIN      
        1 mellsgphaf lllllqvcwl rsvvsepyra gfigeagvtl evegtdleps qvlgkvalag
       61 qgmhhadngd iimltrgtvq ggkdamhspp trilrrrkre wvmppifvpe ngkgpfpqrl
      121 nqlksnkdrg tkifysitgp gadsppegvf tiekesgwll lhmpldreki vkyelyghav
      181 sengasveep mnisiivtdq ndnkpkftqd tfrgsvlegv mpgtsvmqvt atdeddavnt
      241 yngvvaysih sqepkephdl mftihkstgt isvissgldr ekvpeyrltv qatdmdgegs
      301 tttaeavvqi ldandnapef epqkyeawvp enevghevqr ltvtdldvpn spawratyhi
      361 vggddgdhft itthpetnqg vlttkkgldf eaqdqhtlyv evtneapfav klptatatvv
      421 vhvkdvneap vfvppskvie aqegisigel vciytaqdpd kedqkisyti srdpanwlav
      481 dpdsgqitaa gildredeqf vknnvyevmv latdsgnppt tgtgtllltl tdindhgpip
      541 eprqiiicnq spvpqvlnit dkdlspnssp fqaqlthdsd iywmaevsek gdtvalslkk
      601 flkqdtydlh lslsdhgnre qltmiratvc dchgqvfndc prpwkggfil pilgavlall
      661 tlllallllv rkkrkvkepl llpeddtrdn vfyygeeggg eedqdyditq lhrglearpe
      721 vvlrndvvpt fiptpmyrpr panpdeignf iienlkaant dptappydsl lvfdyegsgs
      781 daaslssltt sasdqdqdyn ylnewgsrfk kladmyggge dd
//
