LOCUS       NP_075859               3354 aa            linear   ROD 03-JUN-2025
DEFINITION  cadherin-23 isoform 1 precursor [Mus musculus].
ACCESSION   NP_075859
VERSION     NP_075859.2
DBSOURCE    REFSEQ: accession NM_023370.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 3354)
  AUTHORS   Kim,M.J., Simms,S., Behnammanesh,G., Chen,W.W., Honkura,Y.,
            Suzuki,J., Park,H.J., Milani,M., Katori,Y., Bird,J.E., Ikeda,A. and
            Someya,S.
  TITLE     A mutation in Tmem135 causes progressive sensorineural hearing loss
  JOURNAL   Hear Res 459, 109221 (2025)
   PUBMED   39970612
REFERENCE   2  (residues 1 to 3354)
  AUTHORS   Basta,L.P., Joyce,B.W., Posfai,E. and Devenport,D.
  TITLE     Epithelial polarization by the planar cell polarity complex is
            exclusively non-cell autonomous
  JOURNAL   Science 387 (6740), eads5704 (2025)
   PUBMED   40112050
REFERENCE   3  (residues 1 to 3354)
  AUTHORS   Niethamer,T.K., Planer,J.D., Morley,M.P., Babu,A., Zhao,G.,
            Basil,M.C., Cantu,E., Frank,D.B., Diamond,J.M., Nottingham,A.N.,
            Li,S., Sharma,A., Hallquist,H., Levin,L.I., Zhou,S., Vaughan,A.E.
            and Morrisey,E.E.
  TITLE     Longitudinal single-cell profiles of lung regeneration after viral
            infection reveal persistent injury-associated cell states
  JOURNAL   Cell Stem Cell 32 (2), 302-321 (2025)
   PUBMED   39818203
REFERENCE   4  (residues 1 to 3354)
  AUTHORS   Sitko,A.A., Frank,M.M., Romero,G.E., Hunt,M. and Goodrich,L.V.
  TITLE     Lateral olivocochlear neurons modulate cochlear responses to noise
            exposure
  JOURNAL   Proc Natl Acad Sci U S A 122 (4), e2404558122 (2025)
   PUBMED   39854232
REFERENCE   5  (residues 1 to 3354)
  AUTHORS   Lee,T.Y., Weissenberger,Y., King,A.J. and Dahmen,J.C.
  TITLE     Midbrain encodes sound detection behavior without auditory cortex
  JOURNAL   Elife 12, 89950 (2024)
   PUBMED   39688376
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 3354)
  AUTHORS   Swank,R.T., Reddington,M., Howlett,O. and Novak,E.K.
  TITLE     Platelet storage pool deficiency associated with inherited
            abnormalities of the inner ear in the mouse pigment mutants muted
            and mocha
  JOURNAL   Blood 78 (8), 2036-2044 (1991)
   PUBMED   1912584
REFERENCE   7  (residues 1 to 3354)
  AUTHORS   Crocker,M. and Cattanach,B.M.
  TITLE     The genetics of Sleek: a possible regulatory mutation of the
            tabby-crinkled-downless syndrome
  JOURNAL   Genet Res 34 (3), 231-238 (1979)
   PUBMED   544312
REFERENCE   8  (residues 1 to 3354)
  AUTHORS   Womack,J.E. and Auerbach,S.B.
  TITLE     An acid phosphatase locus expressed in mouse kidney (Apk) and its
            genetic location on chromosome 10
  JOURNAL   Biochem Genet 16 (3-4), 239-245 (1978)
   PUBMED   678292
REFERENCE   9  (residues 1 to 3354)
  AUTHORS   Lyon,M.F. and Hulse,E.V.
  TITLE     An inherited kidney disease of mice resembling human
            nephronophthisis
  JOURNAL   J Med Genet 8 (1), 41-48 (1971)
   PUBMED   5098070
REFERENCE   10 (residues 1 to 3354)
  AUTHORS   van Abeelen,J.H.
  TITLE     Behavioural profiles of neurological mutant mice
  JOURNAL   Genetica 37 (2), 149-158 (1966)
   PUBMED   5955164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016365.1, AF308939.1 and AEKQ02027206.1.
            
            On Feb 7, 2007 this sequence version replaced NP_075859.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF308939.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3354
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 30.11 cM"
     Protein         1..3354
                     /product="cadherin-23 isoform 1 precursor"
                     /note="bustling; otocadherin; cadherin-23; cadherin 23
                     (otocadherin); waltzer; modifier of deaf waddler; age
                     related hearing loss 1; bobby"
                     /calculated_mol_wt=366966
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2659
     mat_peptide     24..3354
                     /product="Cadherin-23. /id=PRO_0000003825"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PF4.2)"
                     /calculated_mol_wt=366966
     Region          42..128
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(44..45,94,96,124,126..127)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          136..231
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(143..144,194,196,228,230..231)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            206
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          240..344
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(247..248,300,302,340,342..343)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            349
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          352..456
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(359..360,420,422,452,454..455)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            393
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            434
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          465..557
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            466
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            order(471..472,522,524,553,555..556)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            472
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          566..667
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(572..573,628,630,663,665..666)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            602
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          676..774
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(682..683,735,737,770,772..773)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            694
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            765
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          782..886
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(789..790,841,843,882,884..885)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            810
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            827
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          894..990
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(901..902,954,956,987,989..990)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            941
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          999..1098
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            1001
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            order(1006..1007,1059,1061,1094,1096..1097)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1018
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1106..1203
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1113..1114,1167,1169,1200,1202..1203)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1171
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1218..1308
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1220..1221,1272,1274,1305,1307..1308)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1282
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            1315
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1317..1414
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1324..1325,1378,1380,1410,1412..1413)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1426..1523
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1430..1431,1486,1488,1519,1521..1522)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1473
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1533..1630
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            1534
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            order(1539..1540,1593,1595,1626,1628..1629)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1638..1740
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1645..1646,1699,1701,1736,1738..1739)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1651
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            1667
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1752..1847
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1756..1757,1810,1812,1843,1845..1846)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1818
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1855..1955
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            1857
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            order(1862..1863,1915,1917,1951,1953..1954)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            1889
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            1902
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          1963..2065
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1970..1971,2028,2030,2061,2063..2064)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2014
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2050
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2073..2169
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2080..2081,2133,2135,2166,2168..2169)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2129
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2168
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2180..2289
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2185..2186,2247,2249,2285,2287..2288)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2195
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2263
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2301..2398
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2307..2308,2361,2363,2394,2396..2397)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2357
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2406..2504
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2413..2414,2464,2466,2501,2503..2504)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2513..2607
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2520..2521,2572,2603,2605..2606)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2578
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2616
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2620..2718
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2624..2625,2680,2682,2714,2716..2717)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          2735..2841
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(2739..2740,2792,2794,2838,2840..2841)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            2749
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2808
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Region          2850..2951
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            2877
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2896
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2941
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            2981
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99PF4.2)"
     Site            3065..3085
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99PF4.2)"
     CDS             1..3354
                     /gene="Cdh23"
                     /gene_synonym="4930542A03Rik; ahl; ahl1; bob; bus; mdfw;
                     nmf112; nmf181; nmf252; sals; USH1D; v"
                     /coded_by="NM_023370.3:408..10472"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:22295"
                     /db_xref="MGI:MGI:1890219"
ORIGIN      
        1 mryslvtcya vlwllmlvpg swgqvnrlpf ftnhffdtyl lisedtpvgs svtqllardm
       61 dndplvfgvs geeasrffav epdtgvvwlr qpldretkse ftvefsvsdh qgvitrkvni
      121 qvgdvndnap tfhnqpysvr ipentpvgtp ifivnatdpd lgaggsvlys fqppspffai
      181 dsargivtvi qeldyevtqa yqltvnatdq dktrplstla nlaiiitdmq dmdpifinlp
      241 ystniyehsp pgttvrvita vdqdkgrprg igytivsgnt nsifaldyis galtlnglld
      301 renplyshgf iltvkgteln ddrtpsdatv tttfnilvid indnapefns seysvaitel
      361 aqvgfalplf iqvvdkdenl glnsmfevyl vgnnshhfii sptsvqgkad irirvaipld
      421 yetvdrydfd lfanesvpdh vgyakvkitl inendnrpif sqplynvsly enitvgtsvl
      481 tvlatdndvg tfgevnyffs ddpdrfsldk dtglimliar ldyeliqrft ltviardggg
      541 eettgrvrin vldvndnvpt fqkdayvgal renepsvtql vrlratdeds ppnnlitysi
      601 vnasafgsyf disiyegygv isvsrpldye qipngliylt vmakdagnpp lystvpvtie
      661 vfdendnppt fskpayfvsv lenimagatv lflnatdldr sreygqesii yslegssqfr
      721 inarsgeitt tslldretks eyilivravd ggvghnqktg iatvnvtlld indnhptwkd
      781 apyyinlvem tppdsdvttv vavdpdlgen gtlvysihpp nkfyslnstt gkirtthvml
      841 drenpdpvea elmrkiivsv tdcgrpplka tssatvfvnl ldlndndptf rnlpfvaeil
      901 egtpagvsvy qvvaidldeg lnglvsyrmq vgmprmdfvi nstsgvvttt aeldreriae
      961 yqlrvvasda gtptksstst ltvrvldvnd etptffpavy nvsvsedvpr efrvvwlnct
     1021 dndvglnael syfitagnvd gkfsvgyrda vvrtvvgldr ettaaytlvl eaidngpvgk
     1081 rrtgtatvfv tvldvndnrp iflqssyeas vpedipeghs ivqlkatdad egefgrvwyr
     1141 ilhgnhgnnf rihvgsgllm rgprpldrer nsshvlmvea ynhdlgpmrs svrvivyved
     1201 vndeapvftq qqynrlglre tagigtsviv vratdkdtgd gglvnyrils gaegkfeide
     1261 stglivtvdy ldyetktsyl mnvsatdgap pfnqgfcsvy vtllneldea vqfsnasyea
     1321 vimenlalgt eivrvqaysi dnlnqityrf daytsaqaka lfkidaitgv itvkglvdre
     1381 kgdfytltvv addggpkvds tvkvyitvld endnsprfdf tsdsaisvpe dcpvgqrvat
     1441 vkardpdags ngqvvfslas gniagafeii tsndsigevf vakpldreel dhyilkvvas
     1501 drgtpprkkd hilqvtildv ndnppviesp fgynvsvnen vgggtsvvqv ratdrdigin
     1561 svlsyyiteg nedmtfrmdr isgeiatrpa ppdrerqnfy hlvvtvedeg tptlsatthv
     1621 yvtivdendn apvfqqphye vvldegpdti ntslitvqal dldegpngtv tyaivagnii
     1681 ntfrinkhtg vitaakeldy eishgrytli vtatdqcpil shrltstttv lvnvndindn
     1741 vptfprdyeg pfdvtegqpg prvwtflahd rdsgpngqve ysvvdgdplg efvispvegv
     1801 lrvrkdveld retiafynlt icardrgvpp lsstmlvgir vldindndpv llnlpmnvti
     1861 senspvssfv ahvlasdads gcnalltfni tagnreraff inattgivtv nrpldrerip
     1921 eyrltvsvkd npenpriark dfdlllvsla dendnhplft egtyqaevme nspagtpltv
     1981 lngpilalda dedvyavvty qllgthsdlf vidnstgvvt vrsgiiidre afsppflell
     2041 llaedigqln gtahlfitil ddndnwptfs pptytvhlle ncppgfsvlq vtatdedsgl
     2101 ngelvyriea gaqdrflihp vtgvirvgna tidreeqesy rltvvatdrg tvplsgtaiv
     2161 tiliddinds rpeflnpiqt vsvlesaepg tiianvtaid ldlnpkleyh iisivakddt
     2221 drlvpdqeda favnintgsv mvksplnrel vatyevtlsv idnasdlpeh svsvpnaklt
     2281 vnildvndnt pqfkpfgity ytervlegat pgttliavaa vdpdkglngl itytlldltp
     2341 pgyvqledss agkvianrtv dyeevhwlnf tvrasdngsp praaeipvyl eivdindnnp
     2401 ifdqpsyqea vfediavgtv ilrvtatdad sgnfalieys lvdgegkfai npntgdisvl
     2461 ssldrekkdh yiltalakdn pgdvasnrre nsvqvvirvl dvndcrpqfs kpqfstsvye
     2521 nepagtsvit mlatdqdegs nsqltysleg pgmeafsvdm dsglvttqrp lqsyerfnlt
     2581 vvatdggepp lwgttmllve vidvndnrpv fvrppngtil hikeeiplrs nvyevyatdn
     2641 deglngavry sflkttgnrd weyftidpis gliqtaqrld rekqavysli lvasdlgqpv
     2701 pyetmqplqv alediddnep lfvrppkgsp qyqlltvpeh sprgtlvgnv tgavdadegp
     2761 naivyyfiaa gdedknfhlq pdgrllvlrd ldreteatfs fivkassnrs wtpprgpspa
     2821 ldlltdltlq evrvvledin dqpprftkae ytagvatdak vgseliqvla ldadignnsl
     2881 vfygilaihy fralandsed vgqvftmgsv dgilrtfdlf mayspgyfvv divardlagh
     2941 ndtaiigiyi lrddqrvkiv ineipdrvrg feeefirlls nitgaivntd dvqfhvdmkg
     3001 rvnfaqtell ihvvnrdtnr ildvdrviqm idenkeqlrn lfrnynvldv qpaisvqlpd
     3061 dmsalqmaii vlaillflaa mlfvlmnwyy rtihkrklka ivagsagnrg fidimdmpnt
     3121 nkysfdganp vwldpfcrnl elaaqaehed dlpenlseia dlwnsptrth gtfgrepaav
     3181 kpdddrylra aiqeydniak lgqiiregpi kgsllkvvle dylrlkklfa qrmvqkassc
     3241 hssiseliht dleeepgdhs pgqgslrfrh kppmelkgqd gihmvhgstg tllatdlnsl
     3301 peddqkgldr sletltasea tafernarte sakstplhkl rdvimesple itel
//
