LOCUS       NM_174988               3586 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus cadherin 22 (Cdh22), mRNA.
ACCESSION   NM_174988 XM_910140
VERSION     NM_174988.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Choi,J.S., Ayupe,A.C., Beckedorff,F., Catanuto,P., McCartan,R.,
            Levay,K. and Park,K.K.
  TITLE     Single-nucleus RNA sequencing of developing superior colliculus
            identifies neuronal diversity and candidate mediators of circuit
            assembly
  JOURNAL   Cell Rep 42 (9), 113037 (2023)
   PUBMED   37624694
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Vagnozzi,A.N., Garg,K., Dewitz,C., Moore,M.T., Cregg,J.M.,
            Jeannotte,L., Zampieri,N., Landmesser,L.T. and Philippidou,P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Zhang,X., Wei,R., Sun,Y., Xia,Q., Xie,W., Song,H., Wang,W. and
            Zou,K.
  TITLE     AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family
            Receptor-alpha1 Signal Pathways Regulating Self-Renewal in Female
            Germline Stem Cells
  JOURNAL   Stem Cells 37 (8), 1095-1107 (2019)
   PUBMED   31041846
  REMARK    GeneRIF: glial cell line-derived neurotrophic factor (GDNF) was
            identified as an essential factor for FGSCs self-renewal with a
            more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or
            Src family kinase (SFK), and SFK upregulates its target genes,
            Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline
            stem cells.
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Zhang,X., Yang,Y., Xia,Q., Song,H., Wei,R., Wang,J. and Zou,K.
  TITLE     Cadherin 22 participates in the self-renewal of mouse female germ
            line stem cells via interaction with JAK2 and beta-catenin
  JOURNAL   Cell Mol Life Sci 75 (7), 1241-1253 (2018)
   PUBMED   29063123
  REMARK    GeneRIF: Janus kinase 2 protein (JAK2) and beta-catenin were found
            to interact with cadherin-22 (Cdh22) and involved in CDH22
            signaling in female germ line stem cells (FGSCs).
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Hanley,O., Zewdu,R., Cohen,L.J., Jung,H., Lacombe,J.,
            Philippidou,P., Lee,D.H., Selleri,L. and Dasen,J.S.
  TITLE     Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of
            Motor Columns
  JOURNAL   Neuron 91 (5), 1005-1020 (2016)
   PUBMED   27568519
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   Ara,T., Tokoyoda,K., Okamoto,R., Koni,P.A. and Nagasawa,T.
  TITLE     The role of CXCL12 in the organ-specific process of artery
            formation
  JOURNAL   Blood 105 (8), 3155-3161 (2005)
   PUBMED   15626744
REFERENCE   8  (bases 1 to 3586)
  AUTHORS   Trokovic,R., Trokovic,N., Hernesniemi,S., Pirvola,U., Vogt
            Weisenhorn,D.M., Rossant,J., McMahon,A.P., Wurst,W. and Partanen,J.
  TITLE     FGFR1 is independently required in both developing mid- and
            hindbrain for sustained response to isthmic signals
  JOURNAL   EMBO J 22 (8), 1811-1823 (2003)
   PUBMED   12682014
REFERENCE   9  (bases 1 to 3586)
  AUTHORS   Kitajima,K., Koshimizu,U. and Nakamura,T.
  TITLE     Expression of a novel type of classic cadherin, PB-cadherin in
            developing brain and limb buds
  JOURNAL   Dev Dyn 215 (3), 206-214 (1999)
   PUBMED   10398531
REFERENCE   10 (bases 1 to 3586)
  AUTHORS   Sugimoto,K., Honda,S., Yamamoto,T., Ueki,T., Monden,M., Kaji,A.,
            Matsumoto,K. and Nakamura,T.
  TITLE     Molecular cloning and characterization of a newly identified member
            of the cadherin family, PB-cadherin
  JOURNAL   J Biol Chem 271 (19), 11548-11556 (1996)
   PUBMED   8626716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140248.1, BC112407.1 and AL591411.14.
            
            On Jan 15, 2008 this sequence version replaced NM_174988.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019618.1, AK140248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AK140248.1         118-469
            353-1708            BC112407.1         48-1403
            1709-2668           AK140248.1         1827-2786
            2669-3586           AL591411.14        98605-99522
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.43 cM"
     gene            1..3586
                     /gene="Cdh22"
                     /note="cadherin 22"
                     /db_xref="GeneID:104010"
                     /db_xref="MGI:MGI:1341843"
     exon            1..183
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            184..739
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..2935
                     /gene="Cdh22"
                     /note="pituitary and brain cadherin; PB-cadherin"
                     /codon_start=1
                     /product="cadherin-22 precursor"
                     /protein_id="NP_778153.2"
                     /db_xref="CCDS:CCDS17073.1"
                     /db_xref="GeneID:104010"
                     /db_xref="MGI:MGI:1341843"
                     /translation="MRPRPEGALRAGAALSPVLLFLLLLPLLGHLWAASTPAPSSLSP
                     GAQEDNQLGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGTIKYTISGEG
                     AGTIFLIDELTGDIHATERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDIND
                     SEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDP
                     KTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQ
                     KMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQE
                     AIIVVQKHLDFESQQVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFR
                     PPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLEQIFDIDADTGAIVT
                     GKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDA
                     KPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIEDNTAAVHTQHVGFNR
                     QEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGAL
                     IALLVCVLILVVLALLILTLRRHHKSHLSSDVDEDMRDNVIKYNDEGGGEQDTEAYDM
                     SALRSLYDFGELKGGDPGGGAASPPQAASSSERHSLPRGPSSPEPDFSVFRDFISRKV
                     ALADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLA
                     ALYAGHRGDDEAPAS"
     exon            740..1034
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1154
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1322
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1516
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1770
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1907
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2029
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2147
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2399
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..3586
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3563..3568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh22"
                     /note="hexamer: AATAAA"
     polyA_site      3586
                     /gene="Cdh22"
                     /note="major polyA site"
ORIGIN      
        1 acgcacactc cctcgctctc tcgctcctcc acacacgcgc gcactcgccg ccgcggctcc
       61 ccctctcgct cccgctctcc ctcggctcct ccgagcggac gccagagccg gacctggctg
      121 tgatcctgcc gcttgctggc gtcccaaggc gcggaccagg gtgcagtccg gccgctcccc
      181 aaggttcccg atggctctgg atgaccccta gtcccagaag gactccaaga tccttttgcc
      241 ttcgctgatc acaccgtctg ggcgcaggga ccatggcaca agccctattc aggagcagct
      301 gccaggctgc ctggtgactg gacctggggc ttcagcgagg ggggcgcggg ccaggaccgg
      361 gtgtccatgc ccggatgcgg ccgcgccccc tcccagtcca gcccggcatc cccgaggctg
      421 aggtcatcat gtgacgcagc accgctgcgg tgcctctggt ccatgctcag gggcttggcc
      481 agcgccatca agcatgaggc cacggccaga aggagcgctc cgggcggggg ctgcgctgtc
      541 gcctgtgctg ctgtttctgc tactgctacc gctgctgggg cacctgtggg ccgcaagcac
      601 acctgccccg tcctctttgt cacctggggc tcaggaggac aaccagctgg gtgcaggccg
      661 agtgaagcgc ggttgggtgt ggaaccagtt cttcgtggtg gaggagtaca cggggacaga
      721 acccctgtac gtgggcaaga tccactcgga ttctgacgaa ggggacggga ccatcaagta
      781 caccatctcg ggcgagggtg cagggaccat cttcctgatt gacgagttga caggtgacat
      841 ccatgccacg gagcgcctgg accgggagca gaaaaccttc tacacactcc gggcccaagc
      901 cagggatcga gccaccaacc gtctgctgga gcccgagtcg gagttcatca tcaaagtaca
      961 ggacatcaac gacagtgaac cacgctttct ccacggcccc tacattggca gtgtggccga
     1021 gctgtcacct acaggcacgt ccgtgatgca ggtgatggcc tctgatgcag acgaccctac
     1081 ttacggcagc agtgcccggc tggtgtacag tgtgctggac ggcgagcacc acttcacagt
     1141 ggaccccaag acaggtgtga tccggacagc cgtgcctgac ctcgaccgtg agagccagga
     1201 acgctacgag gtggttattc aagccacaga catggcaggc cagctgggtg gcctctcagg
     1261 ttccactaca gtcaccatcg tggttactga cgtcaacgac aacccacccc gcttcccaca
     1321 aaagatgtac cagttcagca tacaggagtc agcccccatc ggtacggctg tgggccgcgt
     1381 gaaggccgag gactcagatg tgggcgagaa cacggacatg acttatcacc tgagagaaga
     1441 gagcggcagc ggaggagacg cgttcaaggt caccacggac agcgacactc aggaagccat
     1501 catagtggtg cagaagcacc tggactttga gtcgcagcag gtccacacag tggtgctgga
     1561 agccctcaac aagtttgtgg acccccgctt cgccgaccta ggcacattcc gagaccaggc
     1621 aatcgtgcgc gtggccgtga ccgatgtgga tgaacccccc gagttccggc caccctccgg
     1681 cctactggag gtgcaggagg acgcgcaggt gggctccctg gtcggcgtgg tgacggcgcg
     1741 ggaccccgac gccgccaacc ggcccgtccg gtacgccatt gatcgggact cggatttgga
     1801 gcagatcttt gacatcgatg cggacactgg tgccatcgtg actggcaagg ggctggaccg
     1861 tgaaaccgct ggctggcaca acattactgt gctggccatg gaagcagaca atcatgctca
     1921 gctatctcgg gcatccctac ggatccgaat cctggacgtg aacgacaatc ccccggagct
     1981 cgctacaccc tacgaggcag ctgtgtgtga agacgccaag ccaggccagc tcatccaaac
     2041 catcagtgtg gtggacagag acgagcccca gggcggccac cgcttctatt tccgtctggt
     2101 accagaagca cctagcaacc ctcatttctc tctgctggac attgaagata acacagctgc
     2161 ggtgcacacg cagcacgtgg gcttcaaccg gcaagagcag gacgtgttcc tcctgcccat
     2221 cctcgttgtg gacagcgggc cacccaccct gagcagcacg ggcaccctca ccatccgcat
     2281 ctgcggctgt gacagctccg gtaccatcca gtcctgcaac accaccgcct ttgtcatggc
     2341 tgcctccctc agccccggcg cactcatcgc tctcttggtc tgtgttctca tcctggttgt
     2401 tcttgctctg ctgatcctca ctctcaggcg gcaccacaag agccatctga gctcagacgt
     2461 ggatgaagac atgcgggaca atgtgatcaa atacaacgac gagggcggcg gcgagcagga
     2521 caccgaggcc tatgacatgt cagcgctacg gagcctctac gattttgggg agctcaaggg
     2581 tggcgacccg ggcgggggcg cggccagtcc cccgcaggct gcttcctctt ctgagcgcca
     2641 ctcgctgcct cgggggccgt cgagccccga gccggacttc tcggtgttca gggacttcat
     2701 cagccgcaag gtggcgctgg cggacgcgga cctatcggtg cctccctacg acgccttcca
     2761 gacctacgcg ttcgagggcg cgggctcgcc ggccgcctcg ctcagctcgc tgcacagcgg
     2821 ctcgaccggc tcggagcagg acttcgcctt tctccgcgcc tggggcccgc gcttccgacc
     2881 gctggccgcg ctctacgccg gccaccgcgg ggacgacgag gccccggcct cctagcccca
     2941 gcctgcccag tcgggcagcg cagcccgacg ggaggggatc tgcagggtcc ctgctccgcg
     3001 acacgttccc aggggtgtat cttgcggaag actcaggggc gcggcagtga tgaccaatgt
     3061 caggaaaaag gaggggaacc tggcctgtgc ggatctgggg ttggacagga ccacggtagg
     3121 ggaacccggc tctgggaaag gacaatggga ggggaaagca gaggagggcg ctgctgccat
     3181 gcccacccca aggctttctg gcatccaatt aaagatgaag gaagggctgg tcatttacta
     3241 agcacctact gtgtgctgag agctacctgg agaccaactg cattgttgga aaagctatga
     3301 ggtggagtct tgaaggtgtc agatggggaa gctcccccag agaagtggat gtgacttgct
     3361 cagggacacc caggcagcaa gtggtggagc ctctggcact gaccggctgt ctggccttgg
     3421 gcacgtcatg tcatttctct gggcctcagt ttcctcatct gtcaaatgag gttgataaca
     3481 gcacctacct cgaagatttg agaggatcaa aagggttcat gtgtcaagtt gttgggcggt
     3541 gcctggcaca gagtaggtgt tcaataaatg ctcgcctttg ttacaa
//
