LOCUS       NM_007664               4858 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cadherin 2 (Cdh2), mRNA.
ACCESSION   NM_007664 XM_904135 XM_918688
VERSION     NM_007664.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4858)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (bases 1 to 4858)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4858)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   4  (bases 1 to 4858)
  AUTHORS   Rehmani,T., Dias,A.P., Applin,B.D., Salih,M. and Tuana,B.S.
  TITLE     SLMAP3 is essential for neurulation through mechanisms involving
            cytoskeletal elements, ABP, and PCP
  JOURNAL   Life Sci Alliance 7 (12), e202302545 (2024)
   PUBMED   39366759
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4858)
  AUTHORS   Zhu,Y., Huang,Y., Tang,T. and Xie,Y.
  TITLE     HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural
            progenitor transition during brain development
  JOURNAL   iScience 27 (9), 110600 (2024)
   PUBMED   39224519
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4858)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   7  (bases 1 to 4858)
  AUTHORS   Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Takeichi,M.
  TITLE     Genomic structure and chromosomal mapping of the mouse N-cadherin
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8443-8447 (1992)
   PUBMED   1528849
REFERENCE   8  (bases 1 to 4858)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   9  (bases 1 to 4858)
  AUTHORS   Moller,C.J., Christgau,S., Williamson,M.R., Madsen,O.D., Niu,Z.P.,
            Bock,E. and Baekkeskov,S.
  TITLE     Differential expression of neural cell adhesion molecule and
            cadherins in pancreatic islets, glucagonomas, and insulinomas
  JOURNAL   Mol Endocrinol 6 (8), 1332-1342 (1992)
   PUBMED   1406710
REFERENCE   10 (bases 1 to 4858)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146981.1, AC134570.5,
            AK032826.1, AA242226.1 and CB246984.1.
            
            On Oct 22, 2015 this sequence version replaced NM_007664.4.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion. The
            encoded preproprotein undergoes proteolytic processing to generate
            a mature protein. Mice lacking the encoded protein exhibit severe
            developmental defects resulting in embryonic death. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146981.1, AB008811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AK146981.1         2-129
            129-129             AC134570.5         86604-86604         c
            130-2775            AK146981.1         130-2775
            2776-3846           AK032826.1         2019-3089
            3847-3992           AK146981.1         3847-3992
            3993-4486           AA242226.1         1-494
            4487-4586           CB246984.1         303-402             c
            4587-4858           CB246984.1         30-301              c
FEATURES             Location/Qualifiers
     source          1..4858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 10.1 cM"
     gene            1..4858
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /note="cadherin 2"
                     /db_xref="GeneID:12558"
                     /db_xref="MGI:MGI:88355"
     exon            1..912
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     CDS             853..3573
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /note="neural cadherin; N-cadherin"
                     /codon_start=1
                     /product="cadherin-2 preproprotein"
                     /protein_id="NP_031690.3"
                     /db_xref="CCDS:CCDS29076.1"
                     /db_xref="GeneID:12558"
                     /db_xref="MGI:MGI:88355"
                     /translation="MCRIAGAPRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAV
                     LPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLTAEQAKF
                     LIYAQDKETQEKWQVAVNLSREPTLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRD
                     WVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQ
                     LSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSV
                     PEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVA
                     AGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP
                     ENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPI
                     DFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEE
                     GLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNV
                     KNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINIT
                     ALDYDIDPNAGPFAFDLPLSPVTIKRNWTINRLNGDFAQLNLKIKFLEAGIYEVPIII
                     TDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVL
                     MFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEP
                     DAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLL
                     VFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD"
     exon            913..1024
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1251
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1398
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1554
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1699
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1872
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2010
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2196
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2450
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2593
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2827
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3061
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3201
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3366
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..4843
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4819..4824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /note="hexamer: AATAAA"
     polyA_site      4843
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /note="major polyA site"
ORIGIN      
        1 agtggagaac cttcgcggtg cgcgcgagcg acgaggagca ggcggccggg gccgacgcgc
       61 gcaggcggcg aggggcacgg ccaccgcagc tctccccccc cccccatcac accgctcccc
      121 ccccccccca cgcttcgtga cacccctcac gcggccgcag ccggagaaca gtctccaagt
      181 ggccaggaaa cggggaaggg aaagccgcgg aggcctggcc agcaggaccg tcgccctttg
      241 tgggcgcaac gcgcacggcc tcgagcaccc ttcccccgag gcgctctacg cccggaagct
      301 ttgtcgcacc gctcggcccc ggcgaggacg cccagggaag ggaaaagcgg gggctcgaaa
      361 gctcgcgtgg ggcgggggga gggtgctgct gagagcgcca cccgcccagc cgccacctcc
      421 gtatcctcca tccgccgcat ctctggggct gcctccgcac tcccggccgg agctcagcct
      481 cctgtgctgc ggcccgcaca cacgcacacg cgtgcacaca cacacacgca cacacacaca
      541 cacacacact tctcggcgcg cacgcacgcc cgcccttctc cccgccccct ccccagctcc
      601 ttgatctccc gtctgtttta ttactcctgg tgcgagtccg gcggactccg aggcccgcta
      661 tttgttacca gctcgctctc attggcgggg agcgcagagc agcggagaag ggggtgggga
      721 ggggagggga agggaagggg tggccactgc ccggagccga ctccgcgctg ctgttggtgc
      781 cgctgccgct tctgctgcct ctgctgccgc cgccgccgcc tccggctcct cgctcggccc
      841 ctctccgcct ccatgtgccg gatagcggga gcgccgcgga ccctgctgcc gcttctggcg
      901 gccttgcttc aggcgtctgt ggaggcttct ggtgaaattg cattatgcaa gactggattt
      961 cctgaagatg tttacagcgc agtcttaccg aaggatgtgc acgaaggaca gccccttctc
     1021 aatgtgaaat tcagcaactg caatagaaaa aggaaagttc agtatgaaag cagcgagcca
     1081 gcagatttca aggtggacga ggacggcacg gtgtatgctg tgagaagctt ccctctcact
     1141 gcagagcagg caaagttcct gatatatgcc caagacaaag aaacccagga aaagtggcag
     1201 gtagctgtaa acctgagccg ggagccaacc ctgactgagg agcctatgaa ggaaccacat
     1261 gaaattgaag aaatagtatt ccctagacaa cttgccaagc acagtggagc tctacaaagg
     1321 cagaagagag actgggtcat cccgccaatc aacttgccag aaaactccag aggacccttt
     1381 cctcaagagc ttgtcagaat caggtctgat agagataaaa acctttccct gagatacagc
     1441 gtcactgggc caggagctga ccagcctcca acgggcatct tcattatcaa ccccatctca
     1501 ggacagctgt cagtcacaaa gcctctggat cgagagctga tagcccggtt tcacttgaga
     1561 gcacatgcag tggacatcaa tggcaatcaa gtggagaacc ccattgacat tgtcatcaat
     1621 gttattgaca tgaatgataa cagacctgag tttctgcacc aggtttggaa tgggtctgtt
     1681 ccagagggat caaagcctgg gacgtatgtg atgacggtca ctgccattga tgcggatgat
     1741 ccaaatgccc tgaatggaat gctgcggtac aggatcctgt cccaggcgcc cagcacacct
     1801 tcacccaaca tgtttacaat caacaatgag actggggaca tcatcactgt ggcagctggt
     1861 ctggatcgag agaaagtgca acagtatacg ttaataattc aagccacaga catggaaggc
     1921 aatcccactt atggcctttc aaacacagcc acagccgtca tcacggtgac agatgtcaat
     1981 gacaatcctc cagagtttac tgccatgact ttctacggag aagtccctga gaacagggtg
     2041 gacgtcattg tagccaacct aactgtcacg gacaaagatc agccccacac gccggcctgg
     2101 aatgcggcat acagaatcag tggtggagac cctacaggaa ggtttgccat cctgacagac
     2161 cccaacagca atgatgggct agtcacagtg gtaaaaccaa ttgactttga aacgaatagg
     2221 atgtttgtcc ttactgttgc tgcagaaaac caagtgccat tagctaaagg cattcagcac
     2281 ccacctcagt cgacagccac tgtgtctgtg acagttattg atgtcaatga aaatccttat
     2341 tttgccccaa atcctaaaat cattcgccaa gaggaaggcc tccacgcagg taccatgctg
     2401 accacgctca ctgctcagga ccccgatcga tatatgcaac agaatatcag atacacaaaa
     2461 ttgtctgatc ctgccaactg gctgaaaata gaccccgtga atgggcagat cactactatt
     2521 gccgttttgg acagagaatc gccaaatgta aaaaacaaca tctataatgc taccttcctt
     2581 gcttctgaca atggaatccc gcctatgagt gggacaggaa cactgcaaat ctatttactt
     2641 gatatcaatg acaacgcccc tcaggtgtta cctcaagagg cggagacctg tgaaactcca
     2701 gaacccaact caattaacat cacagcactt gattatgaca tagacccaaa cgccgggccg
     2761 ttcgcgtttg atcttccctt atctccagtg actattaaaa gaaactggac catcaaccgg
     2821 cttaatggtg attttgctca gctcaattta aagataaaat ttttggaagc tggtatctat
     2881 gaagttccca tcattatcac agattcaggg aatcccccca agtccaacat ttccatcctg
     2941 cgtgtgaaag tttgtcagtg tgactccaat ggagactgca cggacgtgga caggatcgtg
     3001 ggtgcagggc ttggcacggg cgccatcatc gctatccttc tgtgtatcat catcctgctg
     3061 atccttgttc tcatgtttgt ggtatggatg aaacggcggg ataaagagcg ccaagccaag
     3121 cagcttttaa ttgacccaga agatgatgta agagataata tattgaaata tgatgaagaa
     3181 ggtggaggag aagaagacca ggactatgac ttgagccagc tccagcaacc agatactgtg
     3241 gagcctgatg ccatcaagcc cgtgggaatc agacggctag acgagaggcc tatccatgct
     3301 gagccacagt acccagtccg atccgcagcc ccacaccctg gggatattgg ggacttcatt
     3361 aatgagggcc ttaaagctgc tgacaacgac cccacggcgc caccgtatga ctccctctta
     3421 gtctttgact acgagggcag cggctccacg gctggctcct tgagctccct caactcctcc
     3481 agtagcggtg gggaccagga ctatgactac ctgaatgact ggggaccccg cttcaagaaa
     3541 ctggcggaca tgtacggcgg tggtgacgac tgaacggcag gacggacttg gcttttggac
     3601 aagtatgaac agtttcacct gatattccca aaaaaaagca tacagaagct aggctttaac
     3661 tctgtagtcc actagcaccg tgcttgctgg aggctttggc gtaggctgcg aaccagtttg
     3721 ggctcccagg gaatatcagt gatccaatac tgtctggaaa acaccgagct cagctacact
     3781 tgaattttac agtaaagaag cactgggatt tatgtgcctt tttgtacctt tttcagattg
     3841 gaattagttt tctgtttaag gctttaatgg tactgatttc tgaaatgata aggaaaagac
     3901 aaaatatttt gtggcgggag cagaaagtta aatgtgatac gcttcaaccc acttttgtta
     3961 caatgcattt gcttttgtta agatacagaa cgaaacaacc agattaaaaa aaattaactc
     4021 atggagtgat tttgttacct ttggggtggg ggggatgaga ccacaagata ggaaaatgta
     4081 cattacttct agttttagac tttagatttt tttttttcac taaaatctta aaacttacgc
     4141 agctggttgc agataaaggg agttttcata tcaccaattt gtagcaaaat tgaatttttt
     4201 cataaactag aatgttagac acattttggt cttaatccat gtacactttt ttattttctg
     4261 tattttttcc acctcgctgt aaaaatggtg tgtgtacata atgttttatc agcatagact
     4321 atggaggagt gcagagaact cggaacatgt gtatgtatta tttggacttt ggattcaggt
     4381 tttttgcatg ttaatatctt tcgttatggg taaagtattt acaaaacaaa gtgacatttg
     4441 attcaactgt tgagctgtag ttagaatact caatttttaa ttttttaatt ttttttaaat
     4501 ttttttattt tctttttgtt tgtttcgttt tggggagggg taaaagttct tagcacaagt
     4561 gttttacata atttgtacca aaaaaattac acacaaaaaa aaaaaaagaa aagaaaagaa
     4621 aagtgaaagg ggtggcctgg tactggcagc actagcaagt gtgtgttttt aaaaaacaaa
     4681 acaaacaaac aaaaaaataa ataaaaagag gaaaaagaaa aaaaaaaaag cttttaaact
     4741 ggagagactt ctgaaacagc tttgcgtctg tgttgtgtac cagaatacaa acaatacacc
     4801 tctgacccca gcgttctgaa taaaaagcta attttggatc tggaaaaaaa aaaaaaaa
//
