LOCUS       NP_031690                906 aa            linear   ROD 12-JUN-2025
DEFINITION  cadherin-2 preproprotein [Mus musculus].
ACCESSION   NP_031690 XP_909228 XP_923781
VERSION     NP_031690.3
DBSOURCE    REFSEQ: accession NM_007664.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 906)
  AUTHORS   Bogart,A.H. and Brooks,E.R.
  TITLE     Canonical Wnt pathway modulation is required to correctly execute
            multiple independent cellular dynamic programs during cranial
            neural tube closure
  JOURNAL   Dev Biol 523, 115-131 (2025)
   PUBMED   40280384
REFERENCE   2  (residues 1 to 906)
  AUTHORS   Bottasso-Arias,N., Mohanakrishnan,M., Trovillion,S., Burra,K.,
            Russell,N.X., Wu,Y., Xu,Y. and Sinner,D.
  TITLE     Wnt5a and Notum influence the temporal dynamics of cartilaginous
            mesenchymal condensations in developing trachea
  JOURNAL   Front Cell Dev Biol 13, 1523833 (2025)
   PUBMED   40271154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 906)
  AUTHORS   Brooks,E.R., Moorman,A.R., Bhattacharya,B., Prudhomme,I.S.,
            Land,M., Alcorn,H.L., Sharma,R., Pe'er,D. and Zallen,J.A.
  TITLE     A single-cell atlas of spatial and temporal gene expression in the
            mouse cranial neural plate
  JOURNAL   Elife 13, 102819 (2025)
   PUBMED   40192104
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 906)
  AUTHORS   Shen,Z., Zhang,R., Chen,X., Yang,G., Si,Y., Yan,T., Chen,S.,
            Cheng,B., Wu,X., Chen,D., Zhang,D., Xiao,G., Zhu,J.K. and Wang,S.
  TITLE     An atlas of early human mandibular endochondral and osteogenic
            paracrine signaling regions of Meckel's cartilage
  JOURNAL   Proc Natl Acad Sci U S A 122 (12), e2420466122 (2025)
   PUBMED   40096606
REFERENCE   5  (residues 1 to 906)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Fan,G., Zhang,S., Zhao,L., Wu,C.L.,
            Guo,H., Huyen,T.L.N., Zheng,Y., Fan,Z.C., Shou,W., Schwartz,R.J.,
            Liu,Y., Kumar,A., Sui,H., Serysheva,I.I., Burns,A.R., Wan,L.Q.,
            Zhou,B., Evans,S.M. and Wu,M.
  TITLE     Tunneling nanotube-like structures regulate distant cellular
            interactions during heart formation
  JOURNAL   Science 387 (6739), eadd3417 (2025)
   PUBMED   40080583
REFERENCE   6  (residues 1 to 906)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   7  (residues 1 to 906)
  AUTHORS   Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Takeichi,M.
  TITLE     Genomic structure and chromosomal mapping of the mouse N-cadherin
            gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8443-8447 (1992)
   PUBMED   1528849
REFERENCE   8  (residues 1 to 906)
  AUTHORS   Shimamura,K., Takahashi,T. and Takeichi,M.
  TITLE     E-cadherin expression in a particular subset of sensory neurons
  JOURNAL   Dev Biol 152 (2), 242-254 (1992)
   PUBMED   1644219
REFERENCE   9  (residues 1 to 906)
  AUTHORS   Moller,C.J., Christgau,S., Williamson,M.R., Madsen,O.D., Niu,Z.P.,
            Bock,E. and Baekkeskov,S.
  TITLE     Differential expression of neural cell adhesion molecule and
            cadherins in pancreatic islets, glucagonomas, and insulinomas
  JOURNAL   Mol Endocrinol 6 (8), 1332-1342 (1992)
   PUBMED   1406710
REFERENCE   10 (residues 1 to 906)
  AUTHORS   Suzuki,S., Sano,K. and Tanihara,H.
  TITLE     Diversity of the cadherin family: evidence for eight new cadherins
            in nervous tissue
  JOURNAL   Cell Regul 2 (4), 261-270 (1991)
   PUBMED   2059658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146981.1, AC134570.5,
            AK032826.1, AA242226.1 and CB246984.1.
            
            On Dec 5, 2007 this sequence version replaced NP_031690.2.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion. The
            encoded preproprotein undergoes proteolytic processing to generate
            a mature protein. Mice lacking the encoded protein exhibit severe
            developmental defects resulting in embryonic death. [provided by
            RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146981.1, AB008811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 10.1 cM"
     Protein         1..906
                     /product="cadherin-2 preproprotein"
                     /note="neural cadherin; N-cadherin"
                     /calculated_mol_wt=97236
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2579
     Region          31..121
                     /region_name="Cadherin_pro"
                     /note="Cadherin prodomain like; pfam08758"
                     /db_xref="CDD:462590"
     mat_peptide     160..906
                     /product="Cadherin-2. /id=PRO_0000003734"
                     /note="propagated from UniProtKB/Swiss-Prot (P15116.2)"
                     /calculated_mol_wt=81919
     Region          163..263
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            order(170..171,226,228,259,261..262)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206635"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15116.2)"
     Region          273..378
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            273
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21300292,
                     ECO:0007744|PDB:3Q2W; propagated from UniProtKB/Swiss-Prot
                     (P15116.2)"
     Site            order(278..279,338,340,374,376..377)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21300292,
                     ECO:0007744|PDB:3Q2W; propagated from UniProtKB/Swiss-Prot
                     (P15116.2)"
     Region          386..494
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(393..394,451,453,490,492..493)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            402
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21300292,
                     ECO:0007744|PDB:3Q2W; propagated from UniProtKB/Swiss-Prot
                     (P15116.2)"
     Region          508..601
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(508..509,560,562,597,599..600)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            572
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21300292,
                     ECO:0007744|PDB:3Q2W; propagated from UniProtKB/Swiss-Prot
                     (P15116.2)"
     Region          608..701
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            651
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21300292,
                     ECO:0007744|PDB:3Q2W; propagated from UniProtKB/Swiss-Prot
                     (P15116.2)"
     Site            692
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P15116.2)"
     Site            725..745
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P15116.2)"
     Region          843..902
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     Region          863..883
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15116.2)"
     CDS             1..906
                     /gene="Cdh2"
                     /gene_synonym="CDHN; N-CAD; Ncad"
                     /coded_by="NM_007664.5:853..3573"
                     /db_xref="CCDS:CCDS29076.1"
                     /db_xref="GeneID:12558"
                     /db_xref="MGI:MGI:88355"
ORIGIN      
        1 mcriagaprt llpllaallq asveasgeia lcktgfpedv ysavlpkdvh egqpllnvkf
       61 sncnrkrkvq yessepadfk vdedgtvyav rsfpltaeqa kfliyaqdke tqekwqvavn
      121 lsreptltee pmkepheiee ivfprqlakh sgalqrqkrd wvippinlpe nsrgpfpqel
      181 vrirsdrdkn lslrysvtgp gadqpptgif iinpisgqls vtkpldreli arfhlrahav
      241 dingnqvenp idivinvidm ndnrpeflhq vwngsvpegs kpgtyvmtvt aidaddpnal
      301 ngmlryrils qapstpspnm ftinnetgdi itvaagldre kvqqytliiq atdmegnpty
      361 glsntatavi tvtdvndnpp eftamtfyge vpenrvdviv anltvtdkdq phtpawnaay
      421 risggdptgr failtdpnsn dglvtvvkpi dfetnrmfvl tvaaenqvpl akgiqhppqs
      481 tatvsvtvid vnenpyfapn pkiirqeegl hagtmlttlt aqdpdrymqq nirytklsdp
      541 anwlkidpvn gqittiavld respnvknni ynatflasdn gippmsgtgt lqiylldind
      601 napqvlpqea etcetpepns initaldydi dpnagpfafd lplspvtikr nwtinrlngd
      661 faqlnlkikf leagiyevpi iitdsgnppk snisilrvkv cqcdsngdct dvdrivgagl
      721 gtgaiiaill ciiillilvl mfvvwmkrrd kerqakqlli dpeddvrdni lkydeeggge
      781 edqdydlsql qqpdtvepda ikpvgirrld erpihaepqy pvrsaaphpg digdfinegl
      841 kaadndptap pydsllvfdy egsgstagsl sslnssssgg dqdydylndw gprfkkladm
      901 ygggdd
//
