LOCUS       NM_001081386            4144 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cadherin 19, type 2 (Cdh19), transcript variant 1,
            mRNA.
ACCESSION   NM_001081386 XM_911655
VERSION     NM_001081386.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Huang,T., Hou,Y., Wang,X., Wang,L., Yi,C., Wang,C., Sun,X.,
            Tam,P.K.H., Ngai,S.M., Sham,M.H., Burns,A.J. and Chan,W.Y.
  TITLE     Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral
            Neural Crest Cell Migration: Implications for Enteric Nervous
            System Development Defects
  JOURNAL   Gastroenterology 162 (1), 179-192 (2022)
   PUBMED   34425092
  REMARK    GeneRIF: Direct Interaction of Sox10 With Cadherin-19 Mediates
            Early Sacral Neural Crest Cell Migration: Implications for Enteric
            Nervous System Development Defects.
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Vagnozzi,A.N., Garg,K., Dewitz,C., Moore,M.T., Cregg,J.M.,
            Jeannotte,L., Zampieri,N., Landmesser,L.T. and Philippidou,P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Espinosa-Medina,I., Jevans,B., Boismoreau,F., Chettouh,Z.,
            Enomoto,H., Muller,T., Birchmeier,C., Burns,A.J. and Brunet,J.F.
  TITLE     Dual origin of enteric neurons in vagal Schwann cell precursors and
            the sympathetic neural crest
  JOURNAL   Proc Natl Acad Sci U S A 114 (45), 11980-11985 (2017)
   PUBMED   29078343
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Espinosa-Medina,I., Outin,E., Picard,C.A., Chettouh,Z., Dymecki,S.,
            Consalez,G.G., Coppola,E. and Brunet,J.F.
  TITLE     Neurodevelopment. Parasympathetic ganglia derive from Schwann cell
            precursors
  JOURNAL   Science 345 (6192), 87-90 (2014)
   PUBMED   24925912
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Lefkovics,K., Mayer,M., Bercsenyi,K., Szabo,G. and Lele,Z.
  TITLE     Comparative analysis of type II classic cadherin mRNA distribution
            patterns in the developing and adult mouse somatosensory cortex and
            hippocampus suggests significant functional redundancy
  JOURNAL   J Comp Neurol 520 (7), 1387-1405 (2012)
   PUBMED   22102170
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162899.5 and AC101787.11.
            
            On Oct 4, 2017 this sequence version replaced NM_001081386.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC157927.1, SRR1660811.182004.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AC162899.5         818-1164
            348-651             AC162899.5         23539-23842
            652-943             AC162899.5         28996-29287
            944-1063            AC101787.11        159148-159267       c
            1064-1228           AC101787.11        156836-157000       c
            1229-1413           AC101787.11        152758-152942       c
            1414-1667           AC101787.11        151998-152251       c
            1668-1789           AC101787.11        146550-146671       c
            1790-1911           AC101787.11        135061-135182       c
            1912-2029           AC101787.11        122385-122502       c
            2030-2281           AC101787.11        120187-120438       c
            2282-4144           AC101787.11        115328-117190       c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 50.78 cM"
     gene            1..4144
                     /gene="Cdh19"
                     /note="cadherin 19, type 2"
                     /db_xref="GeneID:227485"
                     /db_xref="MGI:MGI:3588198"
     exon            1..347
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            348..651
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..2772
                     /gene="Cdh19"
                     /codon_start=1
                     /product="cadherin-19"
                     /protein_id="NP_001074855.1"
                     /db_xref="CCDS:CCDS35687.1"
                     /db_xref="GeneID:227485"
                     /db_xref="MGI:MGI:3588198"
                     /translation="MNYCFLKHWILMIPLLWPCLKVSETLKAEKARRTVPSTWRAKRA
                     WVWRPFVVLEEMDDIQCVGKLRSDLDNGNNSFQYKLLGIGAGSFSINERTGEICAIQK
                     LDREEKSLYILRAQVIDTTIGKAVETESEFVIRVLDINDNEPRFLDEPYEAIVPEMSP
                     EGTFVIKVTANDADDPSTGYHARILYNLERGQPYFSVEPTTGVIRISSKMDRELQDTY
                     CVIIQAKDMLGQPGALSGTTTVSIKLSDINDNKPIFKESFYRFTISESAPIGTSIGKI
                     MAYDDDIGENAEMEYSIEDDDSKIFDIIIDNDTQEGIVILKKKVDFEQQSYYGIRAKV
                     KNCHVDEELAPAHVNASTTYIKVQVEDEDEPPVFLLPYYILEIPEGKPYGTIVGTVSA
                     TDPDRRQSPMRYYLTGSKMFDINDNGTIITTNMLDREVSAWYNLTVTATETYNVQQIS
                     SAHVYVQVFNINDNAPEFSQFYETYVCENAESGEIVQIISAIDRDESIEDHHFYFNHS
                     LEDTNNSSFMLTDNQDNTAVILSNRTGFNLKEEPVFYMIILIADNGIPSLTSTNTLTI
                     QVCDCGDSRNTETCANKGLLFIMGFRTEAIIAIMICVMVIFGFFFLILALKQRRKETL
                     FPEKTEDFRENIFCYDDEGGGEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYRQ
                     SLQVGPDSAIFRKFILEKLEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTD
                     QEDDFDYLNDLGPRFKRLASMFGSAVQPNN"
     exon            652..943
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1063
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1228
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1413
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1667
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1789
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1911
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2029
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2281
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..4144
                     /gene="Cdh19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4125..4130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh19"
                     /note="hexamer: AATAAA"
     polyA_site      4144
                     /gene="Cdh19"
                     /note="major polyA site"
ORIGIN      
        1 gagagagaga gagagagaga gagagagaga gagagagaaa gttggatctt acaacttgtt
       61 tagctgtctc cattttaacc tcagactaag aacggacatc agaatgccct tatggtactt
      121 tgaacaaaag gctcagtgtt catgatttta cttggagaac cgaaaatagc attgagtaag
      181 cactgacata ctgacgtgtt gtgctactaa aagcccagca cagtaatcca cggagattct
      241 gctgagaagc ctgtaaaagc aaatcagttc ttctacttct tttctcaagt aactgctaag
      301 aagctgcaga ctcagtttct ggagtcctaa gagttaaacc tgacaaggaa catacaggat
      361 acttaaaatt atacaggaga attgagaaac aaacacattt ggcttggatc agttctgttc
      421 ctttctagaa taagagctgg aatcctaata cacaccagaa tgaattattg cttcttgaaa
      481 cactggatat tgatgattcc tcttctatgg ccttgcctta aagtttcaga gaccttgaaa
      541 gctgagaagg ctcggagaac agtaccttcc acttggagag ctaagcgtgc ctgggtgtgg
      601 agaccatttg ttgttctaga agaaatggat gatatacaat gtgttggaaa gctaagatct
      661 gacttagaca atggaaacaa ctctttccag tacaagctac tggggattgg cgctggaagc
      721 tttagcatta atgaaagaac aggtgaaata tgtgccatac agaagcttga tagagaggaa
      781 aaatccctct acattctgag agcccaggta atagacacca ctattgggaa ggctgtggaa
      841 actgaatccg agtttgtcat cagagttttg gatatcaatg acaatgaacc cagattccta
      901 gatgaaccat atgaggccat tgtacctgag atgtctccag aaggaacatt tgtcatcaag
      961 gtgacagcca atgacgcaga tgatccttca actggctatc atgctcgcat cctatacaac
     1021 ttagaacgag gtcaaccata cttttctgtt gagccaacaa caggagtcat aaggatatct
     1081 tctaagatgg atagagagtt gcaagataca tactgtgtaa ttattcaagc caaggacatg
     1141 ctcggtcagc ctggagcctt gtctggaaca acaaccgtat caattaagct gtcagatatt
     1201 aatgacaaca agccaatatt caaagaaagt ttctaccgct tcactatatc tgaatctgca
     1261 cccattggaa catcaatagg gaaaattatg gcatatgatg atgacatagg ggagaatgca
     1321 gagatggagt acagcattga agatgatgat tcaaaaatat ttgacataat cattgacaat
     1381 gacacccaag aagggatagt tatacttaaa aagaaagttg attttgagca gcagagctat
     1441 tatggcatta gagctaaggt taaaaactgc catgtggatg aagagcttgc acctgcccat
     1501 gttaacgctt ccacaaccta cattaaagtt caagtagaag atgaagatga acctcctgtt
     1561 ttcctcttac catattacat acttgaaatt cctgaaggaa aaccatatgg aacaattgtg
     1621 gggacggttt ctgccacaga cccagatcga agacaatctc ctatgagata ttatctcact
     1681 ggaagcaaaa tgtttgatat caatgacaat ggaacaataa tcaccactaa catgcttgac
     1741 agagaggtca gtgcttggta caacttgact gtcacagcta ctgaaacata caatgtacaa
     1801 cagatctctt cagcccatgt ttatgtacaa gtctttaaca ttaacgacaa tgctccagag
     1861 ttctctcaat tctatgagac ttatgtttgt gaaaatgctg aatctggtga gatagttcag
     1921 atcatcagtg caattgatag agatgagtcc atagaagatc accattttta ctttaatcac
     1981 tctctggaag acacaaacaa ctcaagtttt atgctaacag acaatcaaga taacacagct
     2041 gtaattctga gtaatagaac tggtttcaat cttaaagaag agcctgtctt ctacatgatc
     2101 atcttgattg ctgataacgg gatcccatct ctcacaagca caaacactct cactatccaa
     2161 gtctgtgact gtggagacag tagaaacaca gaaacttgtg ctaacaaggg acttctcttt
     2221 atcatgggat tcagaacaga ggcaataatt gccatcatga tatgtgttat ggtaatattt
     2281 gggtttttct ttttgattct tgctctgaaa cagcgaagaa aggagactct atttccagag
     2341 aagactgaag actttaggga gaatatattt tgctatgatg atgaaggcgg cggggaagaa
     2401 gactcggaag cctttgacat cgtagagctg agacaaagta cagtaatgag agaaagaaag
     2461 cctcagagaa gcaagagtgc ggagatcagg agcttgtaca ggcagtccct gcaggtgggc
     2521 ccagacagtg ccatatttcg aaaatttatc ctagagaagc ttgaagaagc caacacagac
     2581 ccatgtgctc ccccctttga ttcactacag acgtttgcct atgagggaac agggtcatca
     2641 gctggctctc tgagctcctt ggcatccaga gacactgatc aggaggatga cttcgactac
     2701 cttaatgacc tgggacctcg ttttaaaaga ttagcaagca tgtttggctc tgcagtacaa
     2761 cccaacaatt aaggctttct taatatcagc atgcaataaa tattaaggta tatttatata
     2821 aaatgacagg ttttggggag aatttcctcc tctggatttc tgctggcagg agacctgatt
     2881 tgtaaaatta tgatctcttc aagtacacag tgatagtgat ttgttattca acacagaggt
     2941 tgggagggag gcagccaatc agagttgata tgtcactgca aagaatgagt actacaacat
     3001 tgaaatggtc attgagaaat tttccgtgta atccaatgta gattttcaac aattctgaag
     3061 gacaaaatga gaaatttgcc aaagaaagct atccacgtac aaagtaagta ggaagcctct
     3121 atgtgtacta tgctcttgat actgtgcaga gatcaatttt taacaacaag gagaattctg
     3181 ggtggtttca taaaggaaca caaatatttt tatatgaata accagttttc tgattgatat
     3241 agtatgcatt attagaaacg gttaaaatgt tttcagagat tactctttaa tactccaaat
     3301 ttggctctat ttaatatata aattaatcag agttacataa caacctgtgt tgtttgatta
     3361 ttctgagttt gcacaaagaa agaaatcaag tgatatgcct aggggctttc atagatttat
     3421 atttttagca actccaaatg cctttccttt tcatgtgaaa ttaaaatgac caaatacatg
     3481 tcaacattta cttatgatta aattatgaat agtgggactg atggaaagta cagaaaaatt
     3541 ttaaggacat tttgttttct aatgaggtta agatagctaa ataacatctc tactggattc
     3601 aaatttgaat tattatttac ctcaaatatt ataattacct gcactgtcta tctctattct
     3661 cagaaataaa agcatggtgc cactctcttc gttacttttc tgttaggagc ttaggatgtg
     3721 gcttattacc cagtgtcatt ttaaaaatat tgaaatagaa ataagacaca atggaaacat
     3781 ctcattatag cattatggaa gaactaagct gtcagtcata aaacttcagg gtaaattagg
     3841 ctacatggta attggtaata aaacacagta ttttaaactg actttaaaag aatgtttctt
     3901 tttatatcca agtcaagatg gagttcaaat ttgatatttc atttgtaaat aatgtattga
     3961 gtacaatggt tttaaaatgt ataatgtgtc cttttcttac tgtatggcct tgaactaaac
     4021 tatgtatatg tatatgaaat atttcacata attttatatg taattgagca gttgaatagc
     4081 tatatttttc tgtgtaatct gaaacatata cacccattta acataataaa gggaaagaat
     4141 atca
//
