LOCUS       NM_001081299            2744 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus cadherin 18 (Cdh18), mRNA.
ACCESSION   NM_001081299 XM_888056
VERSION     NM_001081299.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Safieh,M., Liraz,O., Ovadia,M. and Michaelson,D.
  TITLE     The Role of Impaired Receptor Trafficking in Mediating the
            Pathological Effects of APOE4 in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 97 (2), 753-775 (2024)
   PUBMED   38217595
  REMARK    GeneRIF: The Role of Impaired Receptor Trafficking in Mediating the
            Pathological Effects of APOE4 in Alzheimer's Disease.
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Tan,K., Kim,M.E., Song,H.W., Skarbrevik,D., Babajanian,E.,
            Bedrosian,T.A., Gage,F.H. and Wilkinson,M.F.
  TITLE     The Rhox gene cluster suppresses germline LINE1 transposition
  JOURNAL   Proc Natl Acad Sci U S A 118 (23) (2021)
   PUBMED   34083437
  REMARK    GeneRIF: The Rhox gene cluster suppresses germline LINE1
            transposition.
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Polanco,J., Reyes-Vigil,F., Weisberg,S.D., Dhimitruka,I. and
            Bruses,J.L.
  TITLE     Differential Spatiotemporal Expression of Type I and Type II
            Cadherins Associated With the Segmentation of the Central Nervous
            System and Formation of Brain Nuclei in the Developing Mouse
  JOURNAL   Front Mol Neurosci 14, 633719 (2021)
   PUBMED   33833667
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Pandey,R.S., Graham,L., Uyar,A., Preuss,C., Howell,G.R. and
            Carter,G.W.
  TITLE     Genetic perturbations of disease risk genes in mice capture
            transcriptomic signatures of late-onset Alzheimer's disease
  JOURNAL   Mol Neurodegener 14 (1), 50 (2019)
   PUBMED   31878951
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
REFERENCE   7  (bases 1 to 2744)
  AUTHORS   Koistinaho,M., Kettunen,M.I., Holtzman,D.M., Kauppinen,R.A.,
            Higgins,L.S. and Koistinaho,J.
  TITLE     Expression of human apolipoprotein E downregulates amyloid
            precursor protein-induced ischemic susceptibility
  JOURNAL   Stroke 33 (7), 1905-1910 (2002)
   PUBMED   12105373
REFERENCE   8  (bases 1 to 2744)
  AUTHORS   Fagan,A.M., Holtzman,D.M., Munson,G., Mathur,T., Schneider,D.,
            Chang,L.K., Getz,G.S., Reardon,C.A., Lukens,J., Shah,J.A. and
            LaDu,M.J.
  TITLE     Unique lipoproteins secreted by primary astrocytes from wild type,
            apoE (-/-), and human apoE transgenic mice
  JOURNAL   J Biol Chem 274 (42), 30001-30007 (1999)
   PUBMED   10514484
REFERENCE   9  (bases 1 to 2744)
  AUTHORS   Faulkner-Jones,B.E., Godinho,L.N. and Tan,S.S.
  TITLE     Multiple cadherin mRNA expression and developmental regulation of a
            novel cadherin in the developing mouse eye
  JOURNAL   Exp Neurol 156 (2), 316-325 (1999)
   PUBMED   10328938
REFERENCE   10 (bases 1 to 2744)
  AUTHORS   Sun,Y., Wu,S., Bu,G., Onifade,M.K., Patel,S.N., LaDu,M.J.,
            Fagan,A.M. and Holtzman,D.M.
  TITLE     Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic
            mice: astrocyte-specific expression and differing biological
            effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
  JOURNAL   J Neurosci 18 (9), 3261-3272 (1998)
   PUBMED   9547235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134595.3, AC157478.3, AC134864.5 and AC121357.14.
            
            On Apr 21, 2007 this sequence version replaced XM_888056.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC134595.3         82243-82362         c
            121-599             AC157478.3         93986-94464
            600-894             AC157478.3         147218-147512
            895-1014            AC157478.3         180144-180263
            1015-1182           AC134864.5         99379-99546         c
            1183-1370           AC134864.5         83429-83616         c
            1371-1624           AC134864.5         65591-65844         c
            1625-1761           AC134864.5         55579-55715         c
            1762-1883           AC134864.5         29828-29949         c
            1884-2001           AC134864.5         20304-20421         c
            2002-2253           AC134864.5         5832-6083           c
            2254-2744           AC121357.14        140011-140501       c
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 8.54 cM"
     gene            1..2744
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /note="cadherin 18"
                     /db_xref="GeneID:320865"
                     /db_xref="MGI:MGI:1344366"
     exon            1..120
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            121..599
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2744
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /note="Tg(GFAP-APOE4)1Hol; GFAP-apoE4 line1;
                     Tg(GFAP-APOE*4)1Hol"
                     /codon_start=1
                     /product="cadherin-18 precursor"
                     /protein_id="NP_001074768.1"
                     /db_xref="CCDS:CCDS49585.1"
                     /db_xref="GeneID:320865"
                     /db_xref="MGI:MGI:1344366"
                     /translation="MRITSTSCICPVLVCLCFVQRCYGTAHHSSIKVTRNQTKHTEGE
                     TEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFI
                     IDDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFT
                     DGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIR
                     TALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLY
                     VPESAQVGSAVGKIKANDADTGSNADMTYSITNGDGIGVFSISTDKDTREGILSLKKP
                     LNYEKKKSYTLNIEGANTHLDFRFSHLGPFKDATMLKVIVGDVDEPPLFSMPSYVMEV
                     YENAKIGTIVGTVLAQDPDSANSLVRYFINHSTEEERFFNIDANTGTIKTSKVLDREE
                     TPWYNITVTASENDNPDLLSHVSVGIRVLDVNDNPPELAREYDIVVCENSKPGQVIHT
                     ITATDKDDFANGPRFHFFLDERLPMNPNFTLKDNEDNTASILTRRRRFSRTMQDVYYL
                     PIMISDGGIPSLSSSSTLTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVV
                     ILLAIVVLFITLRRGKKEPLIISEEDVRENVVTYDDEGGGEEDTEAFDITALRNPAAA
                     EEFTYRRDIRPEVKLTPRHQTLSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAY
                     EGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAELYGEIESERTT"
     exon            600..894
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1014
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1182
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1370
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1624
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1761
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1883
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2001
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2253
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2744
                     /gene="Cdh18"
                     /gene_synonym="B230220E17Rik; Cdh14l;
                     Tg(GFAP-APOE_i4)1Hol"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccggag cctgggctct ccgaggaccg tgagcagcag tgcccagagc tctgagaaag
       61 tgccccctgt gcttctcata aattaagttc ctttccagca gttagggcaa gtcagccaag
      121 gtggaaaatg atgatctgtg ctaacctaca gtgacaactt gggatacaat ggctgcccct
      181 gtgtttctac tcatgcatag gatgtgaata tggtctgacc tttccctgat gggcagctaa
      241 atcatggaca gattaaatga cttactttgg actgtccttc caaaagatgc tttggcttgt
      301 ctcttgaatg catactgagc ccttgcaggc cacgaagaca agaaggactg tgaacgggaa
      361 gcgatcttac aatgagaatt acgagcacat cttgcatctg tccagtcctc gtgtgtctct
      421 gttttgtgca gaggtgttat ggaactgctc accacagctc cattaaggtg accagaaacc
      481 aaaccaaaca cactgaaggg gaaactgaag tacaccatcg tcccaagagg ggatgggtat
      541 ggaaccagtt ctttgtttta gaagaacata tgggaccaga cccacagtat gttggaaaac
      601 tgcactccaa ctccgacaaa ggtgatggtt ctgtcaagta catcctgact ggagaagggg
      661 ccgggactat atttatcatt gatgacacca caggtgacat ccactcaacc aaaagcctgg
      721 acagagagca gaagactcac tatgtgctcc atgcccaggc tattgacaga cggacaaaca
      781 agcctcttga acctgagtct gagttcatca tcaaagtgca agatattaat gacaatgccc
      841 caaagttcac agatggacca tacatcgtta ctgtgcctga aatgtcagat atgggtacct
      901 ctgttctgca ggtgacagct acagatgcag atgaccccac ctatgggaac agtgctcgag
      961 ttgtttacag tatcctgcaa ggacaacctt atttctctgt agatcctaaa acaggagtca
     1021 ttcgaacagc tttacacaac atggatagag aagccagaga gcattactca gtggtcattc
     1081 aagccaaaga catggctggg caagttggcg gactttctgg atccaccact gtcaatatta
     1141 ccttgactga tgtcaatgac aacccaccac ggttcccaca gaaacactat caactgtatg
     1201 ttcctgagtc tgctcaagtt ggttcagctg ttgggaaaat caaagcaaat gatgcagaca
     1261 caggatcaaa tgcagatatg acctactcca tcactaatgg agacgggatt ggagtgttct
     1321 ctatctccac ggacaaggac accagagaag gaatactttc cttaaaaaag ccactgaact
     1381 atgagaaaaa gaagtcttac acactcaaca ttgaaggagc aaacacacat ctggatttcc
     1441 gtttttccca cttgggtcca tttaaggatg ccaccatgct gaaggttatt gttggggatg
     1501 tggatgagcc accactcttt tctatgcctt cctatgtcat ggaagtctat gaaaatgcca
     1561 agattgggac aattgttggc actgtcttgg ctcaggatcc agacagtgct aacagcttag
     1621 taaggtattt catcaatcac agtactgaag aggagagatt tttcaatatt gatgccaata
     1681 ctggaaccat taagacatca aaagtactgg atagagaaga aacaccatgg tacaatatca
     1741 cagtgactgc ttcagaaaac gacaatcctg atttgctgag ccatgtctcc gtgggtatta
     1801 gagttctgga tgtcaatgac aatccacctg aacttgccag ggaatatgat attgttgtct
     1861 gtgagaattc taagcctggt caggttatcc acaccatcac tgccactgat aaagatgact
     1921 ttgccaatgg accgagattt catttttttc ttgatgagcg cctgcccatg aacccaaatt
     1981 tcacacttaa ggacaatgaa gataacacag ccagcattct gacaaggcgg aggagattta
     2041 gtcgaactat gcaggatgtg tattatctgc ccattatgat ctctgacggt ggaatcccct
     2101 ctctcagcag cagcagcacc ctcaccatca gggtttgtgc atgcgagaga gatgggcgcg
     2161 tgcggacctg ccatgcagaa gccttcctgt cctccgctgg tttgagcaca ggagccctaa
     2221 tcgctattct tctctgtgtt gtcattcttc ttgccattgt ggtccttttt atcaccttga
     2281 ggcgtggcaa aaaagagccc ttgatcattt ccgaggagga tgtgcgagag aatgtggtga
     2341 catatgatga cgagggagga ggggaggaag acaccgaagc cttcgacatc acagctttgc
     2401 ggaatcctgc cgcagcagag gagttcacgt accgcagaga cattcggcct gaagtgaagc
     2461 tcactccgag acatcagacc ttgtccaccc tggagagcat agacgttcag gagtttatta
     2521 agcaaagact cgcagaagcc gacctggacc ccagcgtgcc cccttatgac tctcttcaga
     2581 cttatgccta cgagggccag cggtcagaag ctgggtctat cagctcactg gactccgcaa
     2641 ccacgcaatc agaccaggat tatcactacc ttggagactg ggggcccgag tttaagaagt
     2701 tagctgaact ctatggagaa atagaatctg aaagaacaac ttag
//
