LOCUS       NM_019753               3475 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus cadherin 17 (Cdh17), mRNA.
ACCESSION   NM_019753
VERSION     NM_019753.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3475)
  AUTHORS   Liu,X., Huang,Y., Yuan,H., Qi,X., Manjunath,Y., Avella,D.,
            Kaifi,J.T., Miao,Y., Li,M., Jiang,K. and Li,G.
  TITLE     Disruption of oncogenic liver-intestine cadherin (CDH17) drives
            apoptotic pancreatic cancer death
  JOURNAL   Cancer Lett 454, 204-214 (2019)
   PUBMED   31004701
  REMARK    GeneRIF: CDH17 functions as an oncogenic molecule critical to PC
            growth by regulating tumor apoptosis signaling pathways.
REFERENCE   2  (bases 1 to 3475)
  AUTHORS   Chang,Y.Y., Yu,L.C., Yu,I.S., Jhuang,Y.L., Huang,W.J., Yang,C.Y.
            and Jeng,Y.M.
  TITLE     Deletion of cadherin-17 enhances intestinal permeability and
            susceptibility to intestinal tumour formation
  JOURNAL   J Pathol 246 (3), 289-299 (2018)
   PUBMED   30047135
  REMARK    GeneRIF: Cadherin-17 plays a crucial role in intestinal homeostasis
            by limiting the permeability of the intestinal epithelium.
            Cadherin-17 is also a tumour suppressor for intestinal epithelia.
REFERENCE   3  (bases 1 to 3475)
  AUTHORS   Okada,T., Kurabayashi,A., Akimitsu,N. and Furihata,M.
  TITLE     Expression of Cadherin-17 Promotes Metastasis in a Highly Bone
            Marrow Metastatic Murine Breast Cancer Model
  JOURNAL   Biomed Res Int 2017, 8494286 (2017)
   PUBMED   28197418
  REMARK    GeneRIF: These findings suggest that cadherin-17 plays a crucial
            role in mediating breast cancer metastasis to bone marrow.
REFERENCE   4  (bases 1 to 3475)
  AUTHORS   Funakoshi,S., Shimizu,T., Numata,O., Ato,M., Melchers,F. and
            Ohnishi,K.
  TITLE     BILL-cadherin/cadherin-17 contributes to the survival of memory B
            cells
  JOURNAL   PLoS One 10 (1), e0117566 (2015)
   PUBMED   25612318
  REMARK    GeneRIF: these results suggest that CDH17 plays a role in the
            long-term survival of MBCs, presumably via an 'MBC niche'
            comprising, at least in part, BEC in the spleen.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3475)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 3475)
  AUTHORS   Jung,R., Wendeler,M.W., Danevad,M., Himmelbauer,H. and Gessner,R.
  TITLE     Phylogenetic origin of LI-cadherin revealed by protein and gene
            structure analysis
  JOURNAL   Cell Mol Life Sci 61 (10), 1157-1166 (2004)
   PUBMED   15141301
  REMARK    GeneRIF: LI-cadherin originated from an ancestral cadherin with
            five domains by a partial gene duplication event
REFERENCE   7  (bases 1 to 3475)
  AUTHORS   Wendeler,M.W., Praus,M., Jung,R., Hecking,M., Metzig,C. and
            Gessner,R.
  TITLE     Ksp-cadherin is a functional cell-cell adhesion molecule related to
            LI-cadherin
  JOURNAL   Exp Cell Res 294 (2), 345-355 (2004)
   PUBMED   15023525
REFERENCE   8  (bases 1 to 3475)
  AUTHORS   Angres,B., Kim,L., Jung,R., Gessner,R. and Tauber,R.
  TITLE     LI-cadherin gene expression during mouse intestinal development
  JOURNAL   Dev Dyn 221 (2), 182-193 (2001)
   PUBMED   11376485
REFERENCE   9  (bases 1 to 3475)
  AUTHORS   Ohnishi,K., Shimizu,T., Karasuyama,H. and Melchers,F.
  TITLE     The identification of a nonclassical cadherin expressed during B
            cell development and its interaction with surrogate light chain
  JOURNAL   J Biol Chem 275 (40), 31134-31144 (2000)
   PUBMED   10906147
REFERENCE   10 (bases 1 to 3475)
  AUTHORS   Dantzig,A.H., Hoskins,J.A., Tabas,L.B., Bright,S., Shepard,R.L.,
            Jenkins,I.L., Duckworth,D.C., Sportsman,J.R., Mackensen,D.,
            Rosteck,P.R. Jr. et al.
  TITLE     Association of intestinal peptide transport with a protein related
            to the cadherin superfamily
  JOURNAL   Science 264 (5157), 430-433 (1994)
   PUBMED   8153632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155633.1, AL772354.6 and CF383265.1.
            
            On Dec 1, 2007 this sequence version replaced NM_019753.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155633.1, D87912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2038              AK155633.1         2-2039
            2039-2039           AL772354.6         149982-149982
            2040-2432           AK155633.1         2041-2433
            2433-2433           AL772354.6         157315-157315
            2434-2987           AK155633.1         2435-2988
            2988-2988           AL772354.6         159885-159885
            2989-3458           AK155633.1         2990-3459
            3459-3475           CF383265.1         349-365
FEATURES             Location/Qualifiers
     source          1..3475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.35 cM"
     gene            1..3475
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /note="cadherin 17"
                     /db_xref="GeneID:12557"
                     /db_xref="MGI:MGI:1095414"
     exon            1..125
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            126..195
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2631
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /note="liver-intestine cadherin; P130; BILL-cadherin;
                     LI-cadherin"
                     /codon_start=1
                     /product="cadherin-17 precursor"
                     /protein_id="NP_062727.1"
                     /db_xref="CCDS:CCDS17972.1"
                     /db_xref="GeneID:12557"
                     /db_xref="MGI:MGI:1095414"
                     /translation="MVSAQLHFLCLLTLYLTCGYGEEGKFSGPLKPMTFSIFEGQEPS
                     QVIFQFKTNPPAVTFELTGETDGIFKIEKDGLLYHTRALDRETRAVHHLQLAALDSHG
                     AIVDGPVPITIEVKDINDNRPTFLQSKYEGSVRQNSRPGKPFMYVNATDLDDPATPNG
                     QLFYQIVIQLPQINDVMYFQIDSKTGAISLTPEGSQELDPVKNPSYNLVVSVKDMGGQ
                     SENSFSDTTYVDISIRENIWKAPEPVEIRENSTDPHPIKITQVQWNDPGAQYSLVNKE
                     KLSPFPFSIDQEGNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDIND
                     NPPTCLSPVTVFEVQENEPLGNSIGIFEAHDMDEANNINSILKYKLVDQTPKVPSDGL
                     FLIGEYEGKVQLSKQSLKKQDSPQYNLSIEVSDVDFKTLCYIQVNVIDINDQIPIFET
                     SNYGSKTLSEDTAIGSTILIIQATDADEPFTGSSKILYKIVQGDTEGRLEVVTDPTTN
                     AGYVKIKKPLDFETQPVSSIVFQAENPEPLVKGIEYNASSFASFELIVTDVNEVPVFP
                     QRIFQANVSEDAAVGSRVGNVTARDPEGLTVSYSLKGNMRGWLKIDSVTGEIFSAAPL
                     DRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNPPRLAKDYTGLFFCHPLSAP
                     GSLIFEVTDDDQQSLRRPKFTFALGREGLQSDWEVSKINGTHARLSTRHTRFEEQVYN
                     IPIRINDGGQPPMEGTVFLPVTFCQCVEGSCFRPAGRQDGIPTVGMAVGILLTTFLVI
                     GIILAVVFIRMRKDKVENPQSPENKPLRS"
     exon            196..294
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            295..429
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            430..568
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            569..727
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            728..927
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1059
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1210
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1426
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1503
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1695
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1940
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2071
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2311
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2428
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2542
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..3462
                     /gene="Cdh17"
                     /gene_synonym="HPT-1; HPT-1/LI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagaggct agaggagcag aacaggttga ggaagtgtct cttagggttc ttcagccaca
       61 gcaagtgtct ccacggctga atggacgaca aaaacttcta agcagcattt cttacttact
      121 gaaaggagtc caagtgaaga gagcaagatg gtgtctgccc agcttcactt cctgtgtctt
      181 ctcacacttt atttgacctg tggatatggc gaagaaggga agttcagcgg tcccctgaag
      241 cccatgacat tctccatttt tgaaggccaa gaaccgagtc aagtcatatt ccagtttaag
      301 accaaccctc cagctgtgac tttcgagcta acgggagaga cagatggtat atttaagata
      361 gaaaaggatg gacttctgta tcacacaaga gccctggaca gagaaacaag agcggttcat
      421 catctgcagc ttgcagcctt ggattctcat ggagctatag tggacggtcc agtccccatc
      481 accatagaag tcaaggacat caatgacaac cgacccacgt ttctccagtc aaaatatgaa
      541 ggctcagtga ggcagaactc tcgcccagga aagcctttca tgtatgtcaa tgctacagat
      601 ctggatgatc cggctactcc caatggccag cttttttatc aaattgtcat ccaacttccc
      661 caaatcaacg atgttatgta ctttcaaatc gacagcaaaa caggggcaat atcgcttacc
      721 ccagaaggat cccaggaatt ggatccagtg aagaatcctt cctacaacct ggtggtctcg
      781 gtgaaggaca tggggggcca gagtgagaat tccttcagtg atactacata tgtagatatt
      841 tctattagag agaatatctg gaaagcacca gaacccgtgg agattagaga aaactcgact
      901 gatcctcacc ccatcaaaat cactcaggtg cagtggaatg acccaggggc ccagtattcc
      961 ttagtcaaca aggagaagct gtcgccgttc ccattctcga tcgaccaaga aggaaatatt
     1021 tatgtgactc aggccttgga ccgggaggaa aagaactcac atgttttctt tgcaactgcc
     1081 aaggatgaga atggaaaacc acttgcatat ccactggaaa tttatgtgaa agttattgac
     1141 attaatgaca acccaccgac atgtctgtct ccagtgactg tatttgaagt ccaggagaat
     1201 gaaccattgg gtaacagcat cgggatcttt gaggcccatg atatggacga agctaacaac
     1261 atcaacagta ttttgaaata caagcttgta gaccaaacac ccaaagttcc ctcagatgga
     1321 ctttttctca ttggtgaata tgagggaaag gttcagttaa gtaaacagtc cttgaagaag
     1381 caagacagtc ctcagtacaa cttaagtatc gaggtgtctg acgtagattt caagactctc
     1441 tgttatattc aagtcaacgt tattgatatc aatgatcaga ttcccatctt tgaaacatca
     1501 aattatggaa gcaagactct gtctgaagac accgccatcg gatccaccat cctaatcatc
     1561 caagctacag atgctgatga gccctttaca gggagctcta aaatcctgta caagattgta
     1621 cagggagaca cggagggaag actagaagtt gtcacagatc ccacgaccaa tgcaggatat
     1681 gtcaagatca aaaagcctct tgattttgaa actcaaccag ttagcagcat tgtgttccaa
     1741 gcggaaaatc ctgagccact ggtgaaaggc atagagtaca atgctagttc ttttgcctcc
     1801 ttcgagctga ttgtgacgga tgtgaatgaa gtgcctgtgt tcccccagcg aatattccaa
     1861 gcaaacgtca gcgaggatgc tgctgtgggc agtagagtgg gcaacgtgac tgccagggat
     1921 cctgaaggcc tgactgtgag ttattcactg aaaggcaata tgagaggctg gcttaaaatc
     1981 gactctgtca ctggtgagat atttagtgct gctccgctgg atagggaaac agaaagtgtg
     2041 tatcgagtac aagtggtggc cactgaagta ggtgggtcct ctctgagttc tacggcagat
     2101 ttccacctgg tcctcacaga tgtgaatgac aacccccctc gcctagctaa ggactacaca
     2161 ggcttgttct tctgccatcc cctcagtgcc cctgggagcc tcatctttga ggtcactgac
     2221 gatgaccagc agtcacttcg gaggcccaag tttacattcg cccttggcag agaaggctta
     2281 caaagtgact gggaagtttc aaaaatcaat ggtacacatg ctagactctc caccaggcac
     2341 acacgctttg aggaacaagt ttataacatt ccaatccgca tcaatgatgg ggggcagcca
     2401 cccatggaag ggactgtctt cttaccagtt actttctgcc agtgtgtgga aggaagctgt
     2461 ttccggccag caggcagaca ggatgggata cccactgtgg gcatggcagt tggtatactt
     2521 ctgaccacat ttctggtcat tggtataatt ttagcagttg tcttcatccg catgaggaaa
     2581 gataaagttg aaaatccgca gtcccctgag aataagcctc tgagaagctg aatttgaaaa
     2641 gaaatggtca agtctgtgca ccaagcacta tatcaatgcc tcagctgttt aatttcatcc
     2701 aaaatgtgaa ctataattgg tagagtttat gcatcatggg ctatatctgg tccccagctg
     2761 tttaatctca taatttcatc caaaatgtga actgtaattt ctttgatggc atgcccttct
     2821 tgtcctgcaa cattttatgc tacttagata ttttatgttc tgcagacatt agagttattc
     2881 tccatttccc cataacattt tcctccttta caaaagcctt agcttcataa cttgaacctt
     2941 cccctctggg caggaagagg agctgagtac acaccctgtg ttgttgcttc agaggacgta
     3001 gctgttatct atcaccaaat ttcctaggtt ccacttatcc tttctgtttc agcctgtgct
     3061 ccttcatctc ttagcattac actgaattta aaatgtgtca aacagaagaa caaagtgaag
     3121 tcctggttgg gggttggggg gtaagtggga gccttgttct ttaacatggg caacagcttc
     3181 tctgtgctgt taatgttgtt aatggcggtc ctccaacttg gctatggcac agacgctgat
     3241 gaggttatca aattcaactg ctctatttca agaaagatct acttcctacg gcacaggaac
     3301 tggtgagctg tctggtttac tcactaccac atgctttcat acctgctgta cacgttttat
     3361 ttgtatattg aagttttgtt atatatttat catgtggagg aaacaagaaa gtataaagtg
     3421 gtaaagaaat cggaaaaaaa atgttggttt caattgttct taaaaaaaaa aaaaa
//
